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HFE in Medical News

Leading Blood Centers, LifeSource and Central Blood Bank, Spotlight a Unique Donor Population During National Hereditary Hemochromatosis Awareness Month

...e iron build-up in the body has already reached toxic levels, causing irreparable damage to internal organs. "After testing positive for the hfe mutation, I was quickly diagnosed with HH," says patient Christopher Jansen. "My doctor wrote me a prescription for regular phlebotomy treatments wh...

Iron overload: An important co-factor in the development of liver disease in alcoholics

...c disorder, mostly resulting from mutations in the hfe gene, with a disturbance in the iron metabolism wh... regarding an association between iron metabolism, hfe mutations and alcoholic liver disease are inconclu...er than 45% was 2.2 (95% CI 1.37-3.54)]. Regarding hfe mutations, only H63D was found to be associated wi...

Gene Mutation Linked With Risks of Stroke

...esearchers followed the health of 9,178 people over 24 years. Of the sample 393 had a stroke during that time. Those with a particular mutation to the hfe gene (also known as the haemochromatosis gene) were found to be two to three times more likely to develop the condition. Yet, the researchers do ...
HFE in Medical Products

NGEN HFE ASRs*

Description: NGEN-brand ASRs* are specifically designed for PCR amplification and target sequence detection with two-color fluorescence detection systems. The NGEN product line includes reagents for the detection of mutations associated with cystic fibrosis, thrombosis, and hereditary hemochromatosis, as well a...
Company:Nanogen, Inc.
HFE in Medical Dictionary

Gene

...n differences between amplification methods (global PCR and IVT ... The hfe gene provides instructions for producing a protein that is located on ... Researchers suspect that hfe gene mutations may trigger this type of porphyria ... Sometimes not...

Ferritin

...ater. A ferritin test indirectly measures the amount of iron in your blood. ... Relationships of serum ferritin , transferrin saturation, and hfe mutations and ... The mean serum ferritin concentration was significantly lower in Asian men with ... Ferritin is a protein found inside c...
HFE in Biological News

Europe's most common genetic disease is a liver disorder

... that mice that are genetically engineered to lack hfe only in liver cells show all central features of t... patients suffer from increased iron absorption. hfe encodes a protein that is likely involved in trans...stream and reduces iron uptake in the intestine. hfe influences hepcidin expression through a series of...

Surprising findings reported about iron overload

...or the presence of mutations in a gene, called the hfe gene, which evidence suggests regulates iron absor...n Caucasians resulted from common mutations in the hfe gene, first discovered in 1996. At that time, litt...ns who had two copies of the C282Y mutation of the hfe gene (4.4 per 1,000 people). * Prevalence of ...
HFE in Biological Technology

QIAGEN Multiplex PCR Handbook

... Generation of Additional PCR Products in Exon-Specific PCR Figure 2. Two exons from the human hfe gene were amplified from human genomic DNA either separately, (Exon 4); (Exon 2), or together (Exon 2 and 4). The PCR products gener...

Fluorescence-Based Single-Tube Assays to Rapidly Detect Human Gene Mutations

...e coagulation factor II (prothrombin) gene and the hfe gene. Each kit includes two allele-specific mole...risk factor for cardiovascular disease. 7 The hfe (C282Y) Mx4000 molecular beacon allelic discrimina... by PCR/RFLP analysis for the factor II and the hfe mutations, were tested, and results of ...
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