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Her2 in Medical News
NIST, NCI, SAIC partner on new method for detecting HER2 breast cancer
Generations of mothers have served up chicken soup to remedy the common cold, but now the therapeutic fowl may find use in diagnosis as well. Researchers at the National Institute of Standards and Technology (NIST), the National Cancer Institute (NCI) and the scientific research firm SAIC recently...Herceptin helps women with multiple chromosomes containing HER2 gene, study finds
SAN ANTONIO − The targeted therapy Herceptin helps women with HER2+ type of breast cancer independent of whether patients have extra copies of chromosome 17, home to the HER2 gene which produces the HER2 protein that fuels cancer growth. Prior to this report, there were conflicting opinions ...... tumors in three heavily pre-treated patients with her2 neu mutations.(5) Results from this trial warran...l new treatment option for NSCLC patients who have her2 neu mutations.(6) On May 29, Boehr...of BIBW2992, an irreversible inhibitor of EGFR and her2 in adenocarcinoma of the lung with mutations in th...
Mathematical modeling predicts response to Herceptin
...in expression on resistance to Herceptin. PTEN is a protein that acts as a tumor suppressor gene. "Herceptin has benefited thousands of women with her2 positive breast cancer, but only a third to half of patients treated with this agent respond," said Faratian. "We need to know which patients will or ...Study shows PET can measure effectiveness of novel breast cancer treatment
...lls before and after treatment aimed at decreasing her2 expression. This molecular imaging methodology cou... HER2. "Obtaining an accurate assessment of the her2 expression levels in breast cancer tumors is absol... measuring response to treatment. As research into her2 therapies continues, similar techniques could be d...A new take on growth factor signaling in tamoxifen resistance
...activation of GF signaling contributes to this highly proliferative, relatively tamoxifen-insensitive, phenotype and that this exists independently of her2 overexpression. Targeting this pathway and its upstream mediators could prove to be a useful therapeutic strategy". The researchers used a new comp...St. Gallen consensus 2009: A radically different approach to treating early breast cancer
...e mainstay of treatment for patients with triple-negative disease and conventionally is used before or concurrently with trastuzumab for patients with her2 positive disease, while its use is less clear-cut for patients with ER-positive, HER2-negative disease. The increasing use of genetic profiling usi...Research Finds 'New Crop' of Breast Cancer Genes
... most commonly expressed gene, after ERBB2, which is more commonly known as her2 and is found in up to 30 percent of all human breast cancers. In fact, AGTR...the estrogen receptor, known as ER-positive. "AGTR1 is very analogous to her2 or ERBB2," said Chinnaiyan, who is also director of the Michigan Center for...Prometheus Presents Proprietary Oncology Diagnostic Platform at ASCO Annual Meeting
...ect the activation of key cancer pathways EGFR and her2 in CTCs isolated from blood samples of patients wi... tissues demonstrated concordance between reported her2 status based on immunohistochemistry (IHC), a comm...atients showed that more than 50% of patients with her2 negative primary tumors had CTCs with activated...Immune-Based Lymphoma Treatment Shows Promise
...ium. "It reduced the risk of death by 26 percent." Herceptin targets the her2 receptors that are found on breast cancer cells in about a quarter of patie...lly only live a median of nine to 11 months. He recommended testing for her2 in gastric cancer patients right away. Rather than simply repeating the sa...Her2 in Medical Technology
MARSEILLE, France, November 24 /PRNewswire-FirstCall/ -- IPSOGEN SA
(Marseille, France and New Haven, CT, USA), a cancer profiler that markets
molecular diagnostic assays for leukemia and breast cancer announced today
the European launch of MapQuant Dx(TM) HER2 test. Developped on the MapQuant
Dx(...
- Results Demonstrating 95 Percent or Greater Concordance Compared to FISH and IHC Presented at 2008 ASCO Breast - - Company to Include Reporting for HER2 Gene Expression in All Oncotype DX Reports by End of 2008 - REDWOOD CITY, Calif., Sept. 6 /PRNewswire...
... - Data on BIBW 2992, an Irreversible, Dual EGFR / her2 Tyrosine Kinase Inhibitor, Suggests Activity in Se...y of BIBW 2992, a novel irreversible dual EGFR and her2 tyrosine kinase inhibitor (TKI), in patients with ... 2992, an irreversible, dual inhibitor of EGFR and her2 plus best supportive care (BSC) versus placebo plu...
...1 works through direct antitumor activity and through its influence on two of the most important pathways for breast cancer, the erbB receptor and the her2 pathways. "We are encouraged by the benefit RAD001 provided to advanced breast cancer patients in these early trials," said Alessandro Riva, M...
...annually. (ii) In HER2- positive breast cancer, increased quantities of the her2 protein are present on the surface of the tumour cells. This is known as 'HER2-positivity'. High levels of her2 are present in a particularly aggressive form of the disease which responds...
...ay, 12/12/08, 5pm - 7pm CST #3007, Poster Session 3: Detection/Diagnosis - Diagnostic Pathology, "Microarray-based determination of ER, PR and her2 receptor status: validation and comparison with IHC assessments." Presenter: Paul Roepman, PhD, Agendia. Saturday, 12/13/08, 7am - 9am CS...
- Results Demonstrating 95 Percent or Greater Concordance Compared to FISH and IHC Presented at 2008 ASCO Breast - - Company to Include Reporting for HER2 Gene Expression in All Oncotype DX Reports by End of 2008 - REDWOOD CITY, Calif., Sept. 6 /PRNewswire...
... - Data on BIBW 2992, an Irreversible, Dual EGFR / her2 Tyrosine Kinase Inhibitor, Suggests Activity in Se...y of BIBW 2992, a novel irreversible dual EGFR and her2 tyrosine kinase inhibitor (TKI), in patients with ... 2992, an irreversible, dual inhibitor of EGFR and her2 plus best supportive care (BSC) versus placebo plu...
AlphaVax Announces Promising Results in Melanoma Studies
...rategies to be applied to many different products. A phase I/II clinical trial for a CEA tumor vaccine is currently ongoing at Duke University and a her2 breast cancer clinical trial is planned for later this year. In addition to cancer immunotherapy programs, AlphaVax is developing vaccine products for...Karmanos Cancer Institute Researchers Present Breast Cancer Advancements at Conference
...r to inhibit the growth of triple-negative breast cancer cells. "Triple-negative" refers to breast cancer cells that have no estrogen, progesterone or her2 receptors needed for currently-available, targeted anticancer therapies to work effectively. AFP464 is now in Phase I clinical trials at the Karm...BN ImmunoTherapeutics Updates on Phase I/II Studies With Breast Cancer Vaccine
...ta reported in 2008 and show that MVA-BN(R)-based, her2 directed vaccination is a biologically active treatment for patients with her2 positive breast cancer; however the overall immune...cious in additional tumour immunotherapy models in her2 transgenic mice. The immunological situation regar...EntreMed Presents Initial Clinical Results for ENMD-2076
...rcinoma model. Triple-negative breast cancer is a specific subtype of breast cancer that does not express estrogen receptor, progesterone receptor, or her2 genes. This subtype is more aggressive and less responsive to standard treatment and is also associated with poorer patient prognosis. Data show the ......1 works through direct antitumor activity and through its influence on two of the most important pathways for breast cancer, the erbB receptor and the her2 pathways. "We are encouraged by the benefit RAD001 provided to advanced breast cancer patients in these early trials," said Alessandro Riva, M...
...annually. (ii) In HER2- positive breast cancer, increased quantities of the her2 protein are present on the surface of the tumour cells. This is known as 'HER2-positivity'. High levels of her2 are present in a particularly aggressive form of the disease which responds...
...ay, 12/12/08, 5pm - 7pm CST #3007, Poster Session 3: Detection/Diagnosis - Diagnostic Pathology, "Microarray-based determination of ER, PR and her2 receptor status: validation and comparison with IHC assessments." Presenter: Paul Roepman, PhD, Agendia. Saturday, 12/13/08, 7am - 9am CS...
Her2 in Medical Products
Description:... her2 FISH pharmDx Kit is a direct fluorescence in situ ... (FISH) assay designed to quantitatively determine her2 gene amplification in formalin-fixed, paraffin-emb...he number of signals from the hybridization of the her2 gene probe (red signals) and the number of signals...
Company:DakoCytomation California Inc.
Company:DakoCytomation California Inc.
Her2 in Medical Definition
...anostic test. Herceptin treats a category of breast cancer in woman and the test helps identify those patients whose cancer cells express the protein her2 making them eligible. Herceptin sales have grown from $30.5 million in 1998, its year of introduction, to $764 million in 2005. Gleevec treats chron...
Her2 in Biological News
Herceptin and chemo improves response rates without major adverse effects in HER2 breast cancer
Berlin, Germany: Women with a particularly aggressive form of breast cancer seem to do better if they are treated with a combined anthracycline and taxane chemotherapy regimen before surgery, together with trastuzumab (Herceptin) before and after surgery, according to results from the largest mult...Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research
...n 1987, Ullrich and collaborators discovered that the neu/HER2 gene is amplified and overexpressed in more than 30 percent of invasive breast cancers. her2 was chosen for the development of an entirely novel cancer therapy, culminating in the production of an anti-HER2 monoclonal antibody that since 1998 ...Lombardi scientist brings 'dream team' breast cancer research effort to GUMC
...ng efforts in cancer prevention research. Jordan and his Dream Team colleagues will work toward a greater understanding of hormone receptor positive, her2 positive and triple negative subtypes of breast cancer. Breast cancer claims the lives of 40,000 women in the United States each year. While cal...Mayo researchers identify dangerous 'two-faced' protein crucial to breast cancer spread and growth
...ernate growth mechanisms," Dr. Anastasiadis says. "A similar effect would also be expected in EGFR-positive lung cancer and anti-EGFR treatment." Both her2 and EGFR are growth-promotion proteins. A potential solution would be to design an agent that targets the tumor-promoting function of p120 that is ...UC Davis researchers discover a key to aggressive breast cancer
...nter researchers have surprisingly discovered that her2 itself is the culprit. By shutting down its own regulator gene, her2 creates a permissive environment for tumor growth....ificantly suppressed. "This suppression assists her2 in its own over-expression and in driving the grow...Breast cancer treatment resistance linked to signaling pathway
...n human tumors, and their subsequent inhibition, has become a major treatment strategy in many cancers. Herceptin, also known as trastuzumab, targeted her2 in patients with breast cancer and was one of the first therapies to use this approach. Now, many newer cancer drugs have labeling to help oncologists...Vaccine against HER2-positive breast cancer offers complete protection in lab
...to prevent initial development of these tumors. her2 receptors promote normal cell growth, and are foun...ne consists of "naked" DNA genes that produce the her2 receptor as well as an immune stimulant. Both are...n mice, where the gene produced a huge quantity of her2 receptors that activated both antibodies and kille...CSHL scientists identify new drug target against virulent type of breast cancer
... Tumor cells in a particular subset of breast cancer patients churn out too much of a protein called ErbB2 -- also often called her2 -- which drives the cells to proliferate unchecked. Patients unlucky enough to be in this group -- about one in four -- have poorer prognoses and cli...U-M study: Herceptin targets breast cancer stem cells
... stem cells to multiply and spread, explaining why her2 has been linked to a more aggressive type of breas... found that breast cancer cells overexpressing the her2 gene had four to five times more cancer stem cells...ells to invade surrounding tissue, suggesting that her2 is driving the invasiveness and spread of cancer. ...Biomarkers allow doctors to match therapy to patient
...accine based on HER2/neu status: Abstract 2545 A her2 peptide E75 vaccine reduced mortality in patients .... In particular, patients with low-expressing her2 tumors exhibited better response, not only immunol...cal Center in San Antonio, Texas. The fact that her2 low-expressors responded so favorably not only und...Her2 in Biological Technology
TCH (Taxotere, Carboplatin, Herceptin) showed a significant improvement in
Disease-Free Survival (DFS) and Overall Survival (OS), compared to AC-T
(doxorubicin and cyclophosphamide followed by docetaxel) and a 5-fold lower
cardiotoxicity compared to AC-TH (AC-T + Herceptin) in women receivin...
Study Shows TYKERB Combination Reduced the Size of Brain Tumors Associated with HER2-Positive Breast Cancer SAN ANTONIO, Texas, Dec. 17 /PRNewswire/ -- GlaxoSmithKline announced today results from the extension arm of a Phase II study on its first-in-class, oral small molecul...
...tic targets for triple-negative breast cancer, a subtype that does not express estrogen receptor (ER), progesterone receptor (PR) or her2 genes. - Study results demonstrating that quantitative RT-PCR analysis is possible in DCIS that is adjacent to invasive ductal carcino...
... treatment with Herceptin(R) on the basis of prior her2 IHC and/or FISH testing. HERmark measurements of HER2 total protein and her2 homodimer levels will be compared with the results...ue of its ability to make accurate measurements of her2 and its homodimer in actual breast tumors," said I...
... two thirds of all cancers have an activated RAS pathway, including most metastatic disease. A large number of mutations, including mutations in EGFR, her2 or K-RAS along the RAS pathway lead to RAS pathway activation. Recent clinical studies in NSCLC with EGFR-based therapies have shown that patients w...
... two thirds of all cancers have an activated RAS pathway, including most metastatic disease. A large number of mutations, including mutations in EGFR, her2 or K-RAS along the RAS pathway lead to RAS pathway activation. Recent clinical studies in NSCLC with EGFR-based therapies have shown that patients w...
Study Shows TYKERB Combination Reduced the Size of Brain Tumors Associated with HER2-Positive Breast Cancer SAN ANTONIO, Texas, Dec. 17 /PRNewswire/ -- GlaxoSmithKline announced today results from the extension arm of a Phase II study on its first-in-class, oral small molecul...
Sanofi-aventis Announces Second Quarter 2009 Results
...tive breast cancer (mTNBC), i.e. with a tumor that expresses neither the estrogen receptor nor the progesterone receptor and does not over-express the her2 receptor. Enrolment to the Phase III study, evaluating NV1FGF in critical ischemia of the lower legs, is complete. The Phase III study ev...Video: Axel Ullrich Named Winner of 2009 Dr. Paul Janssen Award for Biomedical Research
...n 1987, Ullrich and collaborators discovered that the neu/HER2 gene is amplified and overexpressed in more than 30 percent of invasive breast cancers. her2 was chosen for the development of an entirely novel cancer therapy, culminating in the production of an anti-HER2 monoclonal antibody that since 1998 ......tic targets for triple-negative breast cancer, a subtype that does not express estrogen receptor (ER), progesterone receptor (PR) or her2 genes. - Study results demonstrating that quantitative RT-PCR analysis is possible in DCIS that is adjacent to invasive ductal carcino...
Genomic Health Announces Third Quarter 2008 Financial Results and Business Progress
... - Net Loss Narrows - - Quantitative her2 Scores Now Included in All Oncotype DX Reports - ...ue of Oncotype DX by the inclusion of quantitative her2 scores, while continuing to invest in our commerci... Oncotype DX reports by including quantitative her2 scores; quantitative estrogen receptor and pro...Monogram Announces 2008 Third Quarter Financial Results
... some who have now been reclassified by HERmark as her2 positive. Our commercial goals for HERmark in 2008...provides a precise and quantitative measurement of her2 total protein and her2 homodimer levels. Physicians currently use semi-qu...... treatment with Herceptin(R) on the basis of prior her2 IHC and/or FISH testing. HERmark measurements of HER2 total protein and her2 homodimer levels will be compared with the results...ue of its ability to make accurate measurements of her2 and its homodimer in actual breast tumors," said I...
... two thirds of all cancers have an activated RAS pathway, including most metastatic disease. A large number of mutations, including mutations in EGFR, her2 or K-RAS along the RAS pathway lead to RAS pathway activation. Recent clinical studies in NSCLC with EGFR-based therapies have shown that patients w...
... two thirds of all cancers have an activated RAS pathway, including most metastatic disease. A large number of mutations, including mutations in EGFR, her2 or K-RAS along the RAS pathway lead to RAS pathway activation. Recent clinical studies in NSCLC with EGFR-based therapies have shown that patients w...
Her2 in Biological Products
HER2plus Control Slides from European Collection of Cell Cultures (ECACC)
Description:...f formalin fixed, breast cancer cell lines; MDA-MD-361, T47D, MCF and the ovarian cell line SKOV-3. This range of cell lines provides a gradation of her2 protein level expression around the clinically significant range. When used as part of a validated assay system, the HER2plus control slides provide a...Company:European Collection of Cell Cultures (ECACC)
Her2 in Biological Dictionary
...umber compared to the 2N control . Graphs were generated ... The MCF7 line is a normal copy number control . with normal expression levels of her2 protein. ... Analysis of copy number variation (CNV) and loss of ... 3. Quality Control Analysis. There are two quality control processes...
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