Cancer Drug Induces HDAC Inhibitor and Enhance Long-term Memory

University of California scientists have found that cancer drug enhances long-term memory and strengthen neural connections in the brain. A protein complex called chromatin causes genomic DNA to compress much like a telephone cord shortens as it coils. When chromatin loosens, genes associa...

Science Zeroes In on New Alzheimer's Drug Target

...also by Tsai's group. It showed that a nonspecific hdac inhibitor-type drug could improve cognitive functi...ufacturers have developed a number of experimental hdac inhibitor compounds, especially for cancer, which ...se, Tsai's group in 2007 found that a nonspecific hdac inhibitor could restore learning ability and memor...

Experimental drug shows promise against head and neck cancer

...active or not active enough in producing proteins. hdac inhibitors appear to combat cancer by restoring th... The Einstein researchers focused on a particular hdac inhibitor known as LBH589 that has already shown s... in the laboratory. "This report shows that an hdac inhibitor is effective on head and neck cancer cel...

Pharmacyclics Reports Third Quarter Fiscal 2009 Financial Results

... to which Pharmacyclics granted to Servier an exclusive license for its pan hdac inhibitors, including PCI-24781, for territories throughout the world ex-US..., Servier acquired the exclusive right to develop and commercialize the Pan hdac inhibitor product worldwide, except for the United States, and will pay a r...

Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells

...lls, and previous tests with RAD001 showed the same minimal effect, Dr. Gupta says. Panobinostat is a histone deacetylase (HDAC) inhibitor. In cancer, hdac proteins "silence" tumor suppressor genes, so an HADC inhibitor restores expression of these beneficial genes. The agent is also believed to block ang...

Colon cancer shuts down receptor that could shut it down

...he uncontrolled cell growth that is a disease hallmark. "If you block HDAC, you can kill the cancer cell," Dr. Ganapathy says. Several synthetic hdac inhibitors are under study for a variety of cancers at institutions such as the MCG Cancer Center. Unfortunately, just like the newly found GPR109A re...

Scientists Uncover New Weapon Against Huntington's

...s within the cells to degrade as they're supposed to. The strategy worked in worms, mice and the brain cells taken from dead people. Drugs known as hdac inhibitors have the same effect and are already being tested as treatments for Huntington's disease and cancer, Krainc said. The drugs are currently u...

Access Pharmaceuticals Closes Acquisition of MacroChem Corp.

...partnering strategy. About Phenylbutyrate : Sodium phenylbutyrate, an hdac inhibitor, has been investigated in multiple Phase 1/2 NIH and clinician-sp...n to overcome drug resistance. Access is also developing Phenylbutyrate, an hdac inhibitor and differentiating agent currently a Phase 2 clinical candidate....

Access Pharmaceuticals Provides an Update on Advances In Its Cobalamin(TM) Oral Drug Delivery Product Development

...emix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance. Access is also developing Phenylbutyrate ("PB"), an hdac inhibitor and differentiating agent currently a Phase 2 clinical candidate. For additional information on Access Pharmaceuticals, please visit our web...

Pexiganan Phase 3 Clinical Trials Results Published in December Issue of CID

...emix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance. Access is also developing Phenylbutyrate ("PB"), an hdac inhibitor and differentiating agent currently a Phase 2 clinical candidate. For additional information on Access Pharmaceuticals, please visit our web...

HDAC in Medical Technology

Chipscreen and HUYA Bioscience to Present Clinical Data on Novel HDAC Inhibitor at the 2009 ASCO Annual Meeting

SHENZHEN, China and SAN DIEGO, May 28 /PRNewswire/ -- Shenzhen Chipscreen Biosciences, Ltd., and HUYA Bioscience International, LLC, today announced that final data from a Phase 1 trial conducted by Chipscreen of the investigational compound chidamide (CS055/HBI-8000) will be presented at the 2009...

Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer

First Compound Sourced from China Shows Strong Results Presented at Cambridge Healthtech Institute Fall Conference BOSTON, Oct. 23 /PRNewswire/ -- CHI -- Chipscreen Biosciences (Chipscreen) and HUYA Bioscience International (HUYA) today described the preclinical profile and outco...

Pharmacyclics Reports Multiple Presentations at AACR on Its HDAC and Selective HDAC Inhibitors

SAN DIEGO and SUNNYVALE, Calif., April 15 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. (Nasdaq: PCYC ) today announced preclinical data from four presentations at the Annual Meeting of the American Association for Cancer Research (AACR) being held this week in San Diego, CA. Results from mul...

Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor

SUNNYVALE, Calif., Feb. 11 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. (Nasdaq: PCYC ) today announced publication of data characterizing the company's novel highly-selective histone deacetylase (HDAC) inhibitor. The study, entitled "A novel histone deacetylase 8 (HDAC8)-specific inhibitor ...

Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier

...lly active, novel, small molecule inhibitor of Pan hdac enzymes, that is currently in Phase I/II clinical ...and commercializing its innovative anti-cancer Pan hdac inhibitor agents. "This alliance with Servier...ly commercialize our unique and differentiated Pan hdac inhibitor product outside of the United States in ...

Access Pharmaceuticals Announces Positive ProLindac(TM) Phase 2 Ovarian Cancer Clinical Trial Results

...emix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance. Access is also developing Phenylbutyrate ("PB"), an hdac inhibitor and differentiating agent currently a Phase 2 clinical candidate. Access recently announced the acquisition of MacroChem Corporation. This a...

Access Pharmaceuticals Presents new Combination Data on the Company's Angiolix(R) Therapeutic Monoclonal Antibody

...emix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance. Access is also developing Phenylbutyrate ("PB"), an hdac inhibitor and differentiating agent currently a Phase 2 clinical candidate. For additional information on Access Pharmaceuticals, please visit our web...

Access Pharmaceuticals Presents New Data on the Company's Angiolix(R) Therapeutic Monoclonal Antibody

...emix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance. Access is also developing Phenylbutyrate ("PB"), an hdac inhibitor and differentiating agent currently a Phase 2 clinical candidate. For additional information on Access Pharmaceuticals, please visit our web...

Novel Approach May Protect Against Heart Attack Injury

...revious work by other researchers, who showed that hdac inhibitors reduce ischemic injury in the brain, th...d dramatic results in the mice," said Gruber. "The hdac inhibitors reduced the area of tissue injury, even...more than half. In further investigating how the hdac inhibitors acted, Gruber's team found they blocked...

Landscape for Lung Cancer Therapies is Focus of New Post-ASCO MedPredict Report

.../VEGF, vascular disrupting agents, anthracyclines, TRAIL / DR4 / DR5, Bcl-2/Bcl-xL, survivin, cyclin dependent kinase, cMET, EGFR (T790M), antifolate, hdac / epigenetics, Hedgehog, HSP90, IGF-1, MAGE-A3, MEK, microtubule, apoptosis, kinesin/EG5, aurora kinase, Polo-like kinase 1, mTOR, PI3/AKT, KRAS, and ...

HDAC in Biological News

'Shock and kill' research gives new hope for HIV-1 eradication

...em, the Italian researchers tested a collection of hdac inhibitors, some of which specifically target only...thways. Moreover, at non-toxic quantities, class I hdac inhibitors were able to induce the 'awakening' of ...wed that BSO recruited cells non-responsive to the hdac inhibitors into the responding cell population. An...

Novel approach may protect against heart attack injury

...revious work by other researchers, who showed that hdac inhibitors reduce ischemic injury in the brain, th...d dramatic results in the mice," said Gruber. "The hdac inhibitors reduced the area of tissue injury, even...ore than half. In further investigating how the hdac inhibitors acted, Gruber's team found they blocked...

Pitt and University of Chicago researchers uncover process behind heart muscle contraction

...ts that often are energy-starved to begin with. In contrast, inhibiting hdac alters a natural process to make heart muscle more sensitive to the prevail...nipulating what is already there, Shroff explained. The physiology to block hdac is already there, and we just took advantage of that. This perturbation doe...

U-M researchers discover gene switched off in cancer can be turned on

...of drugs called histone deacetylase inhibitors, or hdac inhibitors, can affect gene expression, the resear...ipping the switch back on. While the existing hdac inhibitors did return BRM expression, the effect w...re taken away, BRM expression decreased. “The hdac inhibitors are not the perfect answer, but in prin...

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

...colleagues looked for phosphorylation sites in the hdac protein. They discovered that one of many proteins...ossibility that SIK1 is the enzyme controlling the hdac brake in muscle cells, the researchers reduced SIK...ess phosphorylated HDAC. With the unphosphorylated hdac brake now firmly in place, expression of muscle-sp...

Massey researchers induce cell death in leukemia

...ledge, this is the first report describing synergistic interactions between hdac inhibitors and Bortezomib combinations in the setting of CLL," said Grant. ...body of preclinical and early clinical data suggesting interactions between hdac inhibitors and bortezomib in other tumor cell types, particularly hematolog...

'Smart' genetic therapy helps the body to heal itself

...sion of ALDR in the mouse and in human cell lines, we became interested by the work of Professor Wirth's laboratory on valproate, which belongs to the hdac class and enters the brain ", said Professor Pujol. The scientists tested valproate and found that it could indeed induce ALDR gene expression in h...

Loosen up, DNA: Leukemia gene changes genetic packaging

...its in squarely with pharmaceutical research on experimental drugs known as hdac (histone deacetylase) inhibitors, which affect chromatin structure and play...athway may offer a new strategy for altering chromatin structure, much like hdac inhibitors do. "We hope that others will take what we have learned from...

HDAC in Biological Technology

Repligen Announces Publication of Positive Results with Proprietary HDAC Inhibitor in Huntington's Disease Model

Study Published in the Proceedings of the National Academy of Sciences WALTHAM, Mass., Sept. 16 /PRNewswire-FirstCall/ -- Repligen Corporation (Nasdaq: RGEN ) today reported publication of a preclinical study demonstrating that a novel histone deacetylase (HDAC) inhibitor improved disease sy...

Repligen Reports First Quarter Fiscal Year 2010 Financial Results

...velopment expenses associated with our preclinical hdac inhibitor program for Friedreich's ataxia. ...on adults worldwide have bipolar disorder. hdac Inhibitors for Friedreich's Ataxia We are curre...xia. Preclinical studies have shown that specific hdac inhibitors increase production of the protein frat...

Palkion Selects Novel Oral Development Candidate for the Treatment of Anemia

...eneration NSAID with high safety and efficacy, which recently completed phase IIa of 248 patients for osteoarthritis in Europe. CG200745 is an oral/IV hdac inhibitor for cancer and CG400549 is a novel antibiotic against MRSA and VRSA, both of which are in pre-clinical studies in Europe. The company has co...

Repligen Reports Fourth Quarter and Fiscal Year 2009 Financial Results

...velopment expenses associated with our preclinical hdac inhibitor program for Friedreich's ataxia. These ...on adults in the U.S. have bipolar disorder. hdac Inhibitors for Friedreich's Ataxia and Huntington'...on's disease. Preclinical studies have shown that hdac inhibitors have the potential to arrest disease pr...

Access Pharmaceuticals Announces the European Launch of MuGard(TM) by its European Partner, SpePharm

...emix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance. Access is also developing Phenylbutyrate ("PB"), an hdac inhibitor and differentiating agent currently a Phase 2 clinical candidate. Access recently announced the acquisition of MacroChem Corporation. This a...

Access Pharmaceuticals Presents New Data on ProLindac(TM) at the 2009 AACR Annual Meeting

...emix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance. Access is also developing Phenylbutyrate ("PB"), an hdac inhibitor and differentiating agent currently a Phase 2 clinical candidate. Access recently announced the acquisition of MacroChem Corporation. This a...

FDA Accepts IND for Arno Therapeutics' Pan-DAC / Akt Inhibitor, AR-42

...l, potent, small molecule that modifies the acetylation of histones and other molecules, and is a targeted inhibitor of the Pan-DAC and Akt pathways. hdac inhibitors disrupt HDAC-PP1 complexes and cause signaling kinase dephosphorylation. In preclinical studies, AR-42 has demonstrated greater potency an...

S*BIO Receives BioSpectrum Editor's Choice, Emerging BioScience Company of Singapore Award

...e at S*BIO whose combined efforts led to the significant progress we made in moving our leading candidates, the JAK2 inhibitors SB1518 and SB1578, the hdac inhibitor SB939, and the multi-kinase inhibitor SB1317, through pre-clinical and clinical development." About BioSpectrum Launched in 2003 by A...

Access Pharmaceuticals to Present at the Rodman & Renshaw Annual Global Investment Conference

...emix, a chemotherapeutic agent that combines multiple modes of action to overcome drug resistance. Access is also developing Phenylbutyrate ("PB"), an hdac inhibitor and differentiating agent currently a Phase 2 clinical candidate. For additional information on Access Pharmaceuticals, please visit our web...

S*BIO Completes US$26 Million Equity Financing

... primarily fund the development efforts of its two lead compounds, SB939, a hdac inhibitor, and SB1518, a JAK 2 inhibitor, both in Phase 1 clinical trials. ...) inhibitors. SB939 is designed to be a "best-in-class" therapeutic amongst hdac inhibitors being developed worldwide, and has demonstrated the potential to...

HDAC in Biological Products

HDAC Fluorometric (Blue) Assay Kit from BioVision

Description:... Contains 100 positive controls for effective screening of hdac inhibitors by fluorometric method....
Company:BioVision

Rabbit Anti-HDAC4 Polyclonal Antibody, Unconjugated from GeneTex

Description:...uclear export. Association of HDAC4 with 14-3-3 results in sequestration of hdac 4 protein in the cytoplasm. In the nucleus, HDAC4 associates with the myocy... detects ~140 kDa histone deacetylase 4. It does not cross-react with other hdac proteins including HDAC1, 2, 3, 5, 6, 7, and 8....
Company:GeneTex