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Gyrase in Medical Technology

Novexel to Present Five Posters at the Joint Annual Interscience Conference on Antimicrobial Agents and Chemotherapy and the Infectious Disease Society of America (ICAAC/IDSA) Meeting

...luding vancomycin intermediate and resistant isolates (Poster F1-365). A fifth poster covers the anti-staphylococcal activity of NXL101, a bacterial gyrase inhibitor, now discontinued. All posters will be available for download from Novexel's web site ( http://www.novexel.com ) shortly after the close o...
Gyrase in Biological News

Genetic adaptations key to microbe's survival in challenging environment

...ns to investigate the importance of one gene in N. profundicola . That gene, called rgy, allows the bacterium to manufacture a protein called reverse gyrase when it encounters extremely hot fluids from the Earth's interior. Previous studies found the gene only in microorganisms growing in temperatures ...

Energy-saving bacteria resist antibiotics

...cobacterium tuberculosis also stops the enzyme DNA gyrase from working, which in turn stops DNA replication ...ponents does not affect its ability to inhibit DNA gyrase and vice versa. DNA gyrase is involved in DNA replication, which happens when...

Einstein researchers identify new way that bacteria develop resistance to antibiotics

...ns. Until recently, this resistance was due entirely to mutations in DNA gyrase that prevent fluoroquinolones from binding to the complex formed by the enz... than binding with DNA--and becoming a target for the fluoroquinolones--DNA gyrase instead binds with the DNA "mimic" MfpA, rendering the fluoroquinolones ine...
Gyrase in Biological Technology

Trius Awarded $28 Million Contract to Develop Novel Antibiotics

...tics directed against multiple Gram-negative bacterial pathogens. Under the five-year contract, Trius will develop novel drugs targeting bacterial DNA gyrase and Topoisomerase IV, with the aim of optimizing these drugs for activity against relevant biodefense pathogens such as Yersinia pestis, Francisella t...
Gyrase in Biological Definition

Enzyme

...oval of iodine Diastase : break starch into glucose Dihydrofolate reductase : reduces dihydrofolic acid to tetrahydrofolic acid DNA gyrase : catalyzes the negative supercoiling of prokaryotic DNA Glutamate decarboxylase : synthesizes the neurotransmitter GABA in the brain Glutathi...
Gyrase in Biological Dictionary

Gyrase

DNA gyrase , often referred to simply as gyrase , is an enzyme that supercoils DNA. Many antibiotics work by attacking bacterial DNA gyrase . Along with gyrase , most prokaryotes also contain a second type IIA topoisomerase, ... Type I topoisomerase - Type II topoisomerase ( gyra...

DNA gyrase

DNA gyrase , often referred to simply as gyrase , is an enzyme that supercoils DNA . Many antibiotics work by attacking bacterial DNA gyrase . Type II topoisomerases cut both strands of the DNA helix simultaneously in order to change the linking number of the molecule. Information a...

Relaxed DNA

...t you going and ... Relaxed , modified pBR-322 1000 ug -High purity DNA gyrase holoenzyme 2000 units -Assay buffer ... ... enzyme with the amount ...et you going and ... Relaxed , modified pBR-322 500 ug -High purity DNA gyrase holoenzyme 1000 units -Assay buffer ... Relaxation of DNA -loops w...
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