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Guanylate in Medical News

NPs-NPR-B/pGC-cGMP signal pathway is involved in diabetic gastroparesis

...n University College of Medicine, used physiological, radioimmunoassy and histochemistry techniques to study the role of the NPs-NPR-B/pGC(particulate guanylate cyclase)-cGMP signal pathway in the pathophysiology of diabetic gastropathy and gastroparesis in streptozotocin (STZ)-induced diabetic rats. This ...

Ironwood and Forest to Present Additional Phase 2b Data for Novel Gastrointestinal Agent Linaclotide

...e daily, orally delivered peptide that acts locally in the gut with no detectable systemic exposure at therapeutic doses. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. An issued composition of matter patent for linaclotide provides protection to 2025. I...

Sanofi-aventis Delivers 2008 Results Above Guidance

... the NHE3 inhibitor (AVE0657) in sleep apnea; the monoclonal antibody (AVE1642) in the treatment of breast cancer; ataciguat, a guanylate cyclase activator, in neuropathic pain; SAR97276 in the treatment of malaria; a therapeutic vaccine against melanoma; anti-rab...
Guanylate in Medical Technology

Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

...e daily, orally delivered peptide that acts locally in the gut with no detectable systemic exposure at therapeutic doses. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. An issued composition of matter patent for linaclotide provides protection to 2025. I...

Ironwood Announces Linaclotide European Licensing Agreement with Almirall

...e daily, orally delivered peptide that acts locally in the gut with no detectable systemic exposure at therapeutic doses. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. Issued composition of matter patents for linaclotide in the United States and Europe ...

Ironwood and Forest Present Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

...gastrointestinal disorders. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. Linaclotide demonstrated proof of concept in a comprehensive Phase 2b program, compri...

Ironwood and Collaborators Present Preclinical Data Demonstrating That Cyclic GMP Alleviates Intestinal Pain

... mechanism. Ironwood's first cGMP modulator, linaclotide, acts in the intestine to increase intracellular and extracellular cGMP levels by stimulating guanylate cyclase C. Linaclotide is currently being evaluated in a comprehensive Phase 3 program by Ironwood and its partner Forest Laboratories for its potenti...

Ironwood Raises $50 Million to Advance Linaclotide Through Phase 3

...rse event being diarrhea. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical testing, linaclotide was shown to decrease visceral pain, increase flu...

Ironwood and Forest to Present Positive Data From Linaclotide Phase 2b IBS-C Study at ACG Annual Scientific Conference

...ek conference in San Diego. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical testing, linaclotide was shown to decrease visceral pain, increase flu...

Ironwood Pharmaceuticals and Forest Laboratories Announce Presentation of Linaclotide Phase 2b Chronic Constipation Study Results

...a first-in-class compound currently being evaluated for the treatment of IBS-C, CC, and other gastrointestinal disorders. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical testing linaclotide was shown to decrease visceral pain, increase flui...

Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies

...is a first-in-class compound currently being tested for the treatment of IBS-C, CC, and other gastrointestinal disorders. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclinical testing linaclotide was shown to increase fluid secretion into the int...

Callisto Intends to Move Guanilib into Clinical Trials in Ulcerative Colitis

...applications of Guanilib in GI inflammatory diseases and colon cancer. Callisto believes that Guanilib is presently the best physiological ligand of guanylate cyclase receptor with the potential to provide a new way to treat gastrointestinal diseases, while exhibiting minimal side effects or toxicity. Treatm...

Microbia Announces Positive Phase 2 Results for Its Investigational Compound Linaclotide

...CC), and other gastrointestinal disorders. Linaclotide is an agonist of the guanylate cyclase type-C receptor and acts by a different mechanism than agents targe...BS-C, CC and other gastrointestinal disorders. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclin...
Guanylate in Medical Dictionary

Smooth muscle

...by ... Predicted smooth muscle NO concentrations are as high as 430 nM, which is ... In smooth muscle cells, NO activates enzyme soluble guanylate cyclase (sGC) ... Loss of vascular smooth muscle SG-SSPN complex was only detected in Sgcd null ... Administration of a vascular smooth ...
Guanylate in Biological News

Loss of a universal tRNA feature reported

...t two alphaproteobacteria lack the universal extra guanylate nucleotide typically found in the transfer RNA mol...aryotic tRNAs have always been found with an extra guanylate residue at the 5' end of the tRNA molecule. The sc...ulobacter crescentus apparently lack the universal guanylate residue. Kelly Williams, research investigato...
Guanylate in Biological Technology

Microbia and Forest Laboratories Announce Linaclotide Co-Development and Co-Marketing Collaboration

...ed with a low incidence of adverse events. Linaclotide is an agonist of the guanylate cyclase type-C receptor found in the intestine and acts by a mechanism dist...S-C, CC, and other gastrointestinal disorders. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In preclin...
Guanylate in Biological Products

Guanylate Cyclase Blocking Peptide from Cayman Chemical

Description:...sponding to the same sequence used as antigens for guanylate cyclase polyclonal antiserum (Catalog No. 160890) To be used in conjunction with Cayman's guanylate cyclase polyclonal antiserum (Catalog No. 160890) ...ein-antibody complex formation during analysis for guanylate cyclase....
Company:Cayman Chemical
Guanylate in Biological Definition

Signal transduction

... oxygen by the enzyme NO synthase , with citrulline as a by-product. NO works mainly through activation of its target receptor, the enzyme soluble guanylate cyclase , which when activated, produces the second messenger cyclic guanosine monophosphate (cGMP). NO can also act through covalent modification ...
Guanylate in Biological Dictionary

Ribonucleotides

...5, are flavor enhancers which are synergistic with glutamates in creating the taste of umami. It is a mixture of disodium inosinate (IMP) and disodium guanylate (GMP) and is often used where a food already contains natural... ribonucleotide n. A nucleotide that contains ribose as its sugar and ... Ribonu...

Kinase

...6477 Fructosamine/Ketosamine-3 - kinase ... The European ... associated guanylate kinase (MAGUK) scaffold protein ... guanylate kinase /L-type calcium channel region. Zona occludens protein ZO-3 ... ...
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