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Guanosine in Medical News

Researchers gain new insight on wonder of cell division

...ivator, targeting protein switches called GTPases, which bind and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When GTPase is bound to GTP it acts as an on switch; whe...

New approach to protect the hearts of patients with muscular dystrophy

...susceptible to stress-induced cell death. These studies suggested that this may be due to a decrease in the formation of a molecule named cGMP (cyclic guanosine monophosphate). In the present study, researchers used two different approaches to increase cGMP production in the heart, with the result that the...

Host of Benefits from Erectile Dysfunction Drugs

...muscle of blood vessels. For the treatment of erectile dysfunction, the drugs’ constraint of the enzyme’s action results in increased levels of cyclic guanosine monophosphate (cGMP) and nitric oxide (NO), biochemicals that promote smooth muscle relaxation and increased blood flow in erectile tissue. Acco...
Guanosine in Medical Technology

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

...4. Idenix is developing IDX184, a novel liver-targeted prodrug of 2'-methyl guanosine nucleotide, for the treatment of HCV. This double-blind, placebo...ar. About IDX184 IDX184 is a novel, liver-targeted 2'-methyl guanosine nucleotide prodrug, which includes Idenix's proprietary liver-targeting tec...

Avalon Pharmaceuticals to Present at the American Association for Cancer Research 2007 Annual Meeting

...gical cancers. The poster is titled, "The Modulation of Gene Expression and guanosine Pools by Inhibition of Inosine Monophosphate Dehydrogenase (IMPDH); correla...nase (IMPDH), an enzyme that is critical for cells to be able to synthesize guanosine triphosphate (GTP), a molecule required for DNA synthesis and cellular sign...

Avalon Updates the AVN944 Phase I Hematologic Malignancies Trial

...small molecule drug candidate that inhibits inosine monosphospate dehydrogenase (IMPDH), an enzyme that is critical for cells to be able to synthesize guanosine triphosphate (GTP), a molecule required for DNA synthesis and cellular signaling. IMPDH is over expressed in some cancer cells, especially in the case...

Avalon Pharmaceuticals Announces Positive Interim Results For AVN944 Phase I Trial

..." Background: AVN944 is an oral small molecule drug that inhibits inosine monosphospate dehydrogenase (IMPDH), a critical enzyme for synthesis of guanosine triphosphate (GTP), a molecule required for DNA synthesis and cellular signaling. IMPDH is over expressed in many cancer cells. Pre-clinical studies s...
Guanosine in Biological News

Viagra improves high altitude exercise performance up to 45% for some

... to support strenuous physical activity than it is at sea level. Sildenafil works by inhibiting phosphodiestrase-5, an enzyme which degrades cyclic guanosine monophosphate (cGMP) a cell messenger that causes the blood vessels to relax, Friedlander explained. By inhibiting the enzyme, the drug allows greater...

The making and breaking of microtubules

...these peculiar structures show how the binding to tubulin of the nucleotide guanosine triphosphate, GTP, controls activity at the growing end of the microtubule....rd means "water splitting"), GTP readily changes to a different nucleotide, guanosine diphosphate, or GDP. GDP-bound tubulin depolymerizes the microtubule by cur...
Guanosine in Biological Technology

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

... Phase 2a trial in patients with controlled hypertension. PL-3994 produced dose-related decreases in blood pressure, increases in plasma cGMP (cyclic guanosine monophosphate), a natural messenger nucleotide, and increases in urine volume and sodium excretion. There were no serious or severe adverse events. ...

Palatin Technologies, Inc. Reports Positive Results of Phase 2a Clinical Study with PL-3994 for the Treatment of Heart Failure

...pertension patients. The evaluations included safety, tolerability, pharmacokinetics and several pharmacodynamic endpoints, including levels of cyclic guanosine monophosphate (cGMP), a natural messenger nucleotide. Dosing concluded with the successful achievement of the primary endpoint of the study, a pre-s...

Novel compound may treat acute diarrhea

...r and also causes travelers' diarrhea. "This newly discovered compound decreases the formation of ever-present cellular messenger molecules, cyclic guanosine monophosphate and cyclic adenosine monophosphate, caused by various bacterial toxins and might prevent or attenuate the intestinal fluid secretion, di...

Palatin Technologies, Inc. Reports Positive Results of a Phase I Clinical Study With PL-3994 for the Treatment of Congestive Heart Failure

...cebo subcutaneously. The evaluations included safety, tolerability, pharmacokinetics and several pharmacodynamic endpoints, including levels of cyclic guanosine monophosphate (cGMP), a natural messenger nucleotide. Dosing concluded with the successful achievement of the primary endpoint of the study, a presp...

Successful PCR amplification and subcloning of a GC-rich DNA fragment

...is a 4500 bp DNA fragment from the first c-myb intron, and has a GC content of about 60%. Sequences that contain a high ratio of guanosine and cytidine base pairs (GC-rich sequences) can form robust secondary structures that resist denaturation and prevent annealing ...
Guanosine in Biological Definition

Adenosine triphosphate

...esis must closely follow its consumption. Other triphosphates Living cells also have other "high-energy" nucleoside triphosphates, such as guanosine triphosphate . Between them and ATP, energy can be easily transferred with reactions such as those catalyzed by nucleoside diphosphokinase : Energy ...

Nucleoside

...Adenine Adenosine A Deoxyadenosine dA Guanine guanosine G Deoxyguanosine dG Thymine Thymidine T Deoxyth...ibose ring. Examples of these include cytidine , uridine , adenosine , guanosine , thymidine and inosine . Nucleosides can be phosphorylated by specifi...

Nucleotide

...phate ADP Adenosine triphosphate ATP guanosine monophosphate GMP guanosine diphosphate GDP guanosine triphosphate GTP Thymidine monophosphate ...

Signal transduction

...ks mainly through activation of its target receptor, the enzyme soluble guanylate cyclase , which when activated, produces the second messenger cyclic guanosine monophosphate (cGMP). NO can also act through covalent modification of proteins or their metal cofactors. Some of these modifications are reversibl...
Guanosine in Biological Dictionary

Guanine

...guanine is a derivative of purine, consisting of a ... The main ones are cytosine, guanine , adenine , thymine and uracil , abbreviated ... guanosine is a nucleoside comprising guanine attached to a ribose ring via a ? ... Calculated Properties of Guanine . Electron Density: relectron ... Li...

Adenosine diphosphate

... nucleotide composed of pyrophosphate of ... ... diphosphate is a derivative of the common nucleic acid ATP, or adenosine ... Adenosine · guanosine · Uridine · Cytidine. Deoxyribonucleosides ... Best ADENOSINE DIPHOSPHATE links & users bookmarks collection on www.supanova.com.au domain!...
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