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GnRH in Medical News

Ferring Pharmaceuticals Announces Trade Name FIRMAGON(R) (degarelix for injection) for Advanced Prostate Cancer Treatment

...the U.S. Food and Drug Administration (FDA) for the treatment of advanced prostate cancer. As a receptor antagonist, FIRMAGON reversibly binds to the gnrh receptors in the pituitary gland, immediately suppressing the secretion of the luteinizing hormone (LH), follicle-stimulating hormone (FSH), and subse...

Neurocrine Announces Full Year Results from 603 Study (Petal Study) of Elagolix for Treatment of Endometriosis Pain

...tionally, we are seeing for the first time an oral gnrh antagonist with a rapid and sustained symptom redu...ks and uncertainties associated with the Company's gnrh program and Company overall. Specifically, the ris...es the Company faces with respect to the Company's gnrh program include, but are not limited to, risk that...

Ferring Pharmaceuticals Announces Immediate Availability of Degarelix for the Treatment of Advanced Prostate Cancer

...agonist by binding immediately and reversibly to gnrh receptors in the pituitary gland, quickly reducing...rostate cancer can be treated with a direct-acting gnrh receptor antagonist inducing rapid reduction of te...ptor antagonist, degarelix reversibly binds to the gnrh receptors in the pituitary gland, immediately supp...

Indevus Pharmaceuticals Announces First Quarter Fiscal 2009 Financial Results

...dicated in patients with hypersensitivity to GnRH, gnrh agonist analogs, or any components in VANTAS. ...ntraindicated in patients with hypersensitivity to gnrh or gnrh analogs. About DELATESTRYL DELATESTRYL...

Neurocrine Biosciences Reports Fourth Quarter and Year-End 2008 Results

...entific and financial standpoint. We completed the gnrh 603 study with outstanding statistically and clini...lts. Additionally, both the 702 and 703 studies in gnrh were initiated and are on track. The preclinical w...ne new compound into development each year. gnrh Antagonists in Expanded Phase II Clinical Trials f...

Hormone therapy for prostate cancer does not appear to increase cardiac deaths

...as been released online, the researchers note that gnrh agonist treatment has a number of adverse side eff...ting the disease. Most commonly this is done with gnrh agonists that block the production of all sex hormones. gnrh agonist therapy is routinely administered to men w...

Prostate cancer drug reduces testosterone levels in as little as 3 days

...agonist. It works by binding to, and blocking, the gnrh receptors in the pituitary gland, reducing the amo...ved a monthly 7.5mg dose of leuprolide, which is a gnrh agonist. At the start of the trial the study p...ons, in contrast to other reported trials of other gnrh antagonists" points out Dr Klotz. "The aim of ...

Internationally adopted children hit puberty earlier

...e that plays a key role in regulating appetite. When calorie intake increases, leptin levels also increase which in turn provokes the secretion of gnrh (Gonadotropin Releasing Hormone). This hormone regulates the development of ovulation and the menstrual cycle in women and spermatogenesis in men. ...

Indevus Pharmaceuticals Announces Third Quarter Fiscal 2008 Financial Results

...dicated in patients with hypersensitivity to GnRH, gnrh agonist analogs, or any components in VANTAS. Ab...ntraindicated in patients with hypersensitivity to gnrh or gnrh analogs. About SANCTURA and SANCTURA XR SANCTU...

JCI online early table of contents: July 1, 2008

...slightly different symptoms and varying degrees of gnrh deficiency. When mice expressing markedly reduced ...yzed they were found to lack nerve cells producing gnrh in a region of the brain known as the hypothalamus... slightly more FGF8 did have nerve cells producing gnrh in the hypothalamus, although fewer than normal mi...
GnRH in Medical Technology

Neurocrine Biosciences Presents Elagolix Data

...en, daily transient inhibition of androgens with a gnrh antagonist may constitute a new paradigm for the t...e course of therapy. Most importantly, because all gnrh agonists suppress estrogen to very low levels, lon...ks and uncertainties associated with the Company's gnrh program and Company overall. Specifically, the ris...

Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy

...rug Administration (FDA) for the treatment of hormone sensitive advanced prostate cancer. As a receptor antagonist, degarelix reversibly binds to the gnrh receptors in the pituitary gland, immediately suppressing the secretion of the luteinizing hormone (LH), follicle-stimulating hormone (FSH), and subse...

Neurocrine Announces Top-Line Results From 702 Study (Lilac PETAL Study) of Elagolix for Treatment of Endometriosis Pain

...n general, as well as risks and uncertainties associated with the Company's gnrh program and Company overall. Specifically, the risks and uncertainties the Company faces with respect to the Company's gnrh program include, but are not limited to, risk that the Company's elagolix P...

Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis

...gan this program nine years ago with the hope of selectively modulating the gnrh system with an oral antagonist. This trial and our previous Phase II studie...the risks and uncertainties the Company faces with respect to the Company's gnrh program include, but are not limited to, risk that the Company's elagolix P...

Meditrina Pharmaceuticals, Inc. Opens Investigational New Drug (IND) Application for Phase IIb Clinical Trial With MPI-676 in Endometriosis

...and dyspareunia (painful intercourse) are common symptoms of women with endometriosis. There are several medical treatment options, including danazol, gnrh agonists and progestins, each of which have limitations associated with patient response, tolerability, side-effect profile and duration of treatment....

Schering-Plough Announces Phase III Data for Sustained Follicle Stimulant

...es and pregnancy in women participating in an Assisted Reproductive Technology (ART) program. The corifollitropin alfa regimen is being developed in a gnrh antagonist protocol. About Schering-Plough Schering-Plough is an innovation-driven, science-centered global health care company. Through its own b...

Neurocrine Biosciences Reports First Quarter 2008 Results

... "We have made significant strides in moving our gnrh program forward with three active Phase II clinica... we have treated approximately 500 subjects in our gnrh trials with elagolix. Elagolix has been generally ...s dysmenorrhea, in most study participants. On the gnrh partnering front, we continue in collaboration dis...

Clinical Update - Decapeptyl(R)/Trelstar(R) 6-Month Formulation in Advanced Prostate Cancer

...eutical development specialist focusing on serious medical conditions and particularly oncology, presented today at the 9th International Symposium on gnrh in Berlin, Germany, the results of a phase III study with its new 6-month formulation of Decapeptyl(R)/Trelstar(R) (triptorelin), a luteinizing hormon...

Neurocrine Biosciences Reports Fourth Quarter and Year-End 2007 Results

...d higher external development costs related to the gnrh clinical program, offset by lower laboratory and p...g one new compound into development each year. gnrh Antagonists in Expanded Phase II Clinical Trials f...lth. Partnership discussions are ongoing for our gnrh program. Corticotropin Releasing Factor (CRF1) R...

Ozarelix Phase 2 Data Presented at 29th Congress of the Societe Internationale d'Urologie

...nue to believe that ozarelix could help serve the large unmet medical need for more effective BPH treatments." The efficacy and safety of ozarelix, a gnrh antagonist, given intramuscularly (IM) was assessed in men with moderate to severe Lower Urinary Tract Symptoms (LUTS) due to BPH in a randomized, dou...
GnRH in Medical Products

FSH ELISA Test

Description:... stimulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. gnrh release is normally pulsatile, resulting in episodic release of both FSH an...e exert positive feedback on the hypothalamus and pituitary, resulting in a gnrh surge and a peak of LH and FSH release [2,3]. This surge is followed by rup...
Company:Diagnostic Systems Laboratories, Inc.

FSH IRMA Test

Description:... stimulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. gnrh release is normally pulsatile, resulting in episodic release of both FSH an...e exert positive feedback on the hypothalamus and pituitary, resulting in a gnrh surge and a peak of LH and FSH release [2,3]. This surge is followed by rup...
Company:Diagnostic Systems Laboratories, Inc.

LH ELISA Test

Description:...nulosa cells. In the late follicular phase, the increased amounts of estrogen exert positive feedback on the hypothalamus and pituitary resulting in a gnrh surge and a peak of LH and FSH release [1,2]. The LH surge is followed by rupture of the graafian follicle and ovulation [1,2,3]. During the luteal ph...
Company:Diagnostic Systems Laboratories, Inc.

LH IRMA Test

Description:...nulosa cells. In the late follicular phase, the increased amounts of estrogen exert positive feedback on the hypothalamus and pituitary resulting in a gnrh surge and a peak of LH and FSH release [1,2]. The LH surge is followed by rupture of the graafian follicle and ovulation [1,2,3]. During the luteal ph...
Company:Diagnostic Systems Laboratories, Inc.
GnRH in Medical Dictionary

LH response to GnRH

LH response to GnRH . Contents of this page: Alternative Names. Definition ... LH response to GnRH is a blood test to indirectly determine the pituitary ... Health Library > Health Encyclopedia > LH response to GnRH . Printable Version ... LH response to GnR...
GnRH in Biological News

Stress puts double whammy on reproductive system, fertility

...d appears to be the glucocorticoid stress hormones, which not only suppress gnrh but boost the suppressor GnIH - a double whammy for the reproductive system...onadotropin-inhibitory hormone (GnIH) because it had the opposite effect of gnrh - it inhibited release of gonadotropins, thereby suppressing reproduction. ...

Study identifies pathway required for normal reproductive development

... reproductive development and a sense of smell. PROK2s involvement in these systems led the researchers to investigate the proteins potential role in gnrh deficiency in human and mice. The MGH team analyzed the PROK2 genes of 100 study participants: 50 with Kallmann syndrome and 50 with IHH and a nor...

New brain hormone puts brakes on reproduction

...ve system - gonadotropin releasing hormone (GnRH). gnrh stimulates the pituitary gland to activate the rep...tem, whereas GnIH appears to reduce the effects of gnrh stimulation. Researchers have long sought inhib...s confirmed its role in turning down production of gnrh and thus switching off the gonads. While Bentle...

The brain is broadly wired for reproduction

... hormones from the pituitary gland. Interestingly, gnrh neurons also appear to be involved in the control ...xual behaviors. "Consistent with the idea that gnrh neurons might have additional functions beyond con...the pituitary, other investigators have shown that gnrh axons can be found in many different areas of the ...

A gene's first 'kiss' sets off that affair known as puberty

...ages. Inside the hypothalamus, nerve cells release gnrh in a 'round-the-clock,' pulsatile fashion. With ea...KiSS-1, are key to the initiation of puberty, when gnrh is released," Dr. Plant said. "However, it's unlik...bably yet to be identified in humans, help control gnrh release in primates." Besides learning that GPR...
GnRH in Biological Technology

Neurocrine Biosciences Reports Second Quarter 2009 Results

...n general, as well as risks and uncertainties associated with the Company's gnrh program, R & D pipeline and Company overall. Specifically, the risks and uncertainties the Company faces with respect to the Company's gnrh program include risk that the elagolix clinical trials will fail to demonst...

Elagolix Successful in Six Month Lilac Petal Study; Safety and Efficacy Confirmed in Patients With Endometriosis

...n general, as well as risks and uncertainties associated with the Company's gnrh program and Company overall. Specifically, the risks and uncertainties the Company faces with respect to the Company's gnrh program clinical trials; risk associated with the Company's dependence on c...

Schering-Plough Announces Phase II and III Data for Corifollitropin Alfa

...te that corifollitropin alfa in combination with a gnrh antagonist may be an effective treatment that can ... 100 mcg or 150 mcg corifollitropin alfa in a long gnrh agonist protocol was able to support multifollicul... down-regulated with daily injections of 0.1 mg of gnrh agonist (starting on cycle day 21). Ovarian stimul...

Neurocrine Biosciences Reports First Quarter 2009 Results

...ion, respectively. "We continue to move our gnrh program forward with the most recent twelve month ...e Biosciences. Pipeline Highlights gnrh Antagonists in Phase II Clinical Trials for Endome... continues to investigate the potential of certain gnrh antagonists in treating other hormone-dependent di...

Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results

...dicated in patients with hypersensitivity to GnRH, gnrh agonist analogs, or any components in VANTAS. ...ntraindicated in patients with hypersensitivity to gnrh or gnrh analogs. Forward Looking Statements ...

Neurocrine Biosciences Reports Third Quarter 2008 Results

...ion, respectively. The Company expects to end 2008 with approximately $100 million in cash and investments. "We are pleased with the progress of our gnrh program, especially the recent positive results of our 603 study where once a day elagolix showed profound efficacy with minimal impact on bone minera...

Neurocrine Biosciences Reports Second Quarter 2008 Results

...We have made significant progress during the first half of 2008, moving our gnrh program forward in a large and comprehensive Phase II program, and advancin...ompany-wide goal of bringing one new compound into development each year. gnrh Antagonists for Endometriosis Elagolix in Three Phase II Clinical Trials ...

Indevus Receives Approvable Letter from FDA for NEBIDO(R)

...dicated in patients with hypersensitivity to GnRH, gnrh agonist analogs, or any components in VANTAS. Ab...ntraindicated in patients with hypersensitivity to gnrh or gnrh analogs. About SANCTURA and SANCTURA XR SANCTU...

Two Year Study Confirms SUPPRELIN(R) LA Implant Maintains Profound Suppression of Hormones in Children With Premature Onset Puberty

...berty. SUPPRELIN LA is contraindicated in patients with hypersensitivity to gnrh or gnrh analogs. About Central Precocious Puberty Central precocious puberty (C...

Meditrina Pharmaceuticals, Inc. Announces Exclusive Global License Agreement With AstraZeneca

...and dyspareunia (painful intercourse) are common symptoms of women with endometriosis. There are several medical treatment options, including danazol, gnrh agonists and progestins, each of which have limitations associated with patient response, tolerability, side- effect profile and duration of treatment...
GnRH in Biological Dictionary

Mature transcript

...xpressed transcripts . Databases - Sequences. dbEST ... ... introns are spliced from the primary transcript , resulting in a mature mRNA. ... gnrh primary transcript appears to be more prevalent than the mature mRNA in the ... Reporter constructs to monitor primary transcript and mature...
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