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Glycoproteins in Medical News

Recent developments at Burnham Institute for Medical Research, May 2009

...ncer metastasis The surfaces of cells are covered with sugar molecules called glycans, which are linked to proteins and lipids. The sugars of these glycoproteins and glycolipids can take many complex forms. In particular, the glycan makeup of normal and cancerous epithelial cells is very different. Several stud...

Aethlon Medical Confirms Hemopurifier(R) Is a Treatment Candidate Against Swine Flu Virus

...rd Flu), and would likely capture H1N1 swine flu as the technology selectively captures influenza viruses by hemagglutinin (HA) and neuraminidase (NA) glycoproteins that coat the virus, even when influenza mutates to be resistant against drug and vaccine therapies. As an example, H5N1 bird flu virus was documente...

Study Links Blood Type and Pancreatic Cancer

...surface of red blood cells and other cells, including those in the pancreas, help define the four major blood types. A gene called ABO helps put these glycoproteins together by arranging sugar molecules on a protein "backbone" called the H antigen. In people with type O blood, the antigen has no sugars attached to...

Biomarkers detected for Chikungunya fever

...unology Network (SIgN) and the Communicable Disease Centre (CDC) at Singapore's Tan Tock Seng Hospital (TTSH). Cytokines are proteins, peptides or glycoproteins that belong to a category of signaling molecules that, like hormones and neurotransmitters, are used extensively in cellular communication. Chemokines...

Enzyme with a sugar antenna

...oteins, which means that they contain sugar components. In general, natural glycoproteins do not have a homogeneous sugar component. With modern purification techniq...t is practically impossible to isolate sufficient quantities of homogeneous glycoproteins for systematic biomedical studies. Synthesis in the lab is a good alternati...

New study suggests why vaccines directed against cancer, HIV don't work

...ring reproduction. When sperm are made, they specifically label their glycoproteins with Lewis carbohydrate sequences, a specific chain of carbohydrates. When ...en as foreign by the mothers immune system, but she produces other types of glycoproteins that likely block any type of immune response in the womb. These events are...

St. Jude finds mechanism for faulty protein disposal

...s attached). The St. Jude team found that this group of proteins exits the endoplasmic reticulum through a channel that is similar to the one used for glycoproteins but that has different components. The team focused the study on non-glycosylated proteins called light chains and heavy chains, which are the buildin...

New Hope For People With Liver And Kidney Ailments

...hat occur in liver disease," said Shigehisa Hirose, co-author of the study. "Our findings also indicate that the ammonia transport system involving Rh glycoproteins is evolutionally conserved in a broad range of organisms, suggesting an essential role for surviving." For people with kidney and liver damage, th...
Glycoproteins in Medical Technology

ProtoKinetix's AAGP Dramatically Increases Recovery Rate of Cryopreserved Stem Cells

...nd veterinary medicine and the biotechnology and cosmetic industries. Using previously published research on native antifreeze proteins and antifreeze glycoproteins as a guide, and coordinating a vast pool of world-recognized intellectual talent in a networked environment, PKTX is conducting rapid and meaningful r...

Refrigerated Stem Cells Survive 12 Times Longer with ProtoKinetix's AAGP

...n and veterinary medicine, the biotechnology and cosmetic industries. Using previously published research on native antifreeze proteins and antifreeze glycoproteins as a guide, and coordinating a vast pool of world recognized intellectual talent in a networked environment, PKTX is conducting rapid and meaningful r...
Glycoproteins in Medical Products

Anti-Myelin Associated Glycoproteins (MAG) Western Blot

Description: A Western Blot Immunassay for the detection of antibodies to primarily anti-myelin associated glycoproteins (anti-MAG) and other glycolipid autoantibodies in human serum....
Company:IMMCO Diagnostics

Anti-Myelin Associated Glycoproteins (MAG) IFA

Description: For the screening and detection by indirect immunofluorescence (IF) of primarily anti-myelin associated glycoproteins (anti-MAG) and other glycolipid autoantibodies in human serum....
Company:IMMCO Diagnostics

Free Activin AB ELISA Test

Description:...ctors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins. Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are h...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin A ELISA Test

Description:...ctors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins. Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are h...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin B ELISA Test

Description:...ctors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins. Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are h...
Company:Diagnostic Systems Laboratories, Inc.

MIS/AMH ELISA Test

Description:...isulfide bridges (1). MIS/AMH belongs to the transforming growth factor-? (TGF-?) superfamily which includes TGF-? and the various inhibin and activin glycoproteins (2). All members of this superfamily are dimeric glycoproteins, and all are involved in the regulation of tissue growth and differentiation. The human...
Company:Diagnostic Systems Laboratories, Inc.

LH ELISA Test

Description:...anterior pituitary gland. Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique beta-subunit. Both LH and FSH production and secretion are stimulated by gonadot...
Company:Diagnostic Systems Laboratories, Inc.

LH IRMA Test

Description:...anterior pituitary gland. Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique beta-subunit. Both LH and FSH production and secretion are stimulated by gonadot...
Company:Diagnostic Systems Laboratories, Inc.
Glycoproteins in Medical Dictionary

Immunoglobulin

...es of antibody combined; between 3 and 5g is secreted into the intestinal lumen each... immunoglobulin n. ( Abbr. Ig ) Any of a group of large glycoproteins that are secreted by plasma cells and that function as antibodies in the immune More about Immunoglobulin Deficiency Syndromes: Causes and sym...
Glycoproteins in Biological News

University of Saskatchewan and Canadian Synchrotron researchers shed light on esophageal disease

...known as biomarkers - within the individual cells that make up the tissue. It was found that increased concentrations of particular biomarkers such as glycoproteins were associated with the Barrett's tissue. Barrett's Esophagus (BE) occurs when the cells that normally line the esophagus the tube that connects ...

Are you okay to kiss?

...test the color difference between the Gram-positive and Gram-negative bacteria is remarkable. In the top layer of the biofilm, the bacterium take the glycoproteins in the saliva and chop off sugar residues to produce volatile proteins. On the lower layer in the biofilm, which could roughly be compared to one's to...

Scripps research scientists reveal key structure from ebola virus

...ance for Ebola, the new research has broader implications for the study of viruses in general. "Structures of the native, oligomeric forms of viral glycoproteins as they exist on the viral surface are exceedingly difficult to achieve and thus exceedingly rare," notes Ollmann Saphire. "This structure now provide...

Scientists unlock mystery of embryonic stem cell signaling pathway

... of mouse fibroblasts has never made much sense to the scientists forced to do just that. “Stem cells that grow on feeders are contaminated with mouse glycoproteins markers,?Kahn says. “If you use them into humans, you’d potentially have a horrible immune response.? And so, in order to take any eventual stem c...

GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science

... and half-life and to date, have necessitated the expression of therapeutic glycoproteins in mammalian hosts. The accomplishment reported today has the potential to ...iling the genetic engineering of the yeast Pichia pastoris to secrete human glycoproteins with fully complex, terminally sialyated N-glycans today in the September 8...

Researchers discover which organs in Antarctic fish produce antifreeze

... the University of Illinois at Urbana-Champaign first documented antifreeze glycoproteins (AFGPs) in Antarctic notothenioid fishes. This month three colleagues repor...e in the freezing avoidance in these fishes at all." Instead, antifreeze glycoproteins (AFGP) originate primarily from the exocrine pancreas and the stomach, say ...

Novel virus entry mechanism could lead to new drugs against poxviruses

... a naked virus core into the cell. The researchers found that interactions between polyanionic or negatively charged molecules on the cell surface and glycoproteins on the virus particle caused a non-fusogenic disruption of the virus outer envelope, allowing the poxvirus to enter the cell. As well as discoveri...

New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease

...edicine at Harvard Medical School. Present throughout the body, the extracellular matrix (ECM) is made of collagens, proteogylcans, noncollagenous glycoproteins and in some tissues, elastin fibers. The ECM serves a unique role by constructing a "scaffold" for cells, thereby maintaining the structural integrity...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

...fe, tissue distribution and interaction with complement proteins. Currently glycoproteins comprise about 70% of all approved therapeutic proteins and the therapeutic... mammalian cell culture, it should be possible to produce specific designer glycoproteins at large scale using the company's engineered yeasts. GlycoFi has already a...

Scripps research scientists solve structure of a critical innate immune system protein

... "Amazingly there is still this prevalent idea [many scientists have] that glycoproteins don't crystallize," says Wilson. Crystallization of a protein is a crucial ...ystallography, the technique that Wilson and his colleagues employ. Because glycoproteins are covered with sugars, they are heterogenous due to the multiple glycofor...
Glycoproteins in Biological Technology

GlycoVaxyn AG Raises CHF 25 Million in Financing Led by Edmond de Rothschild Investment Partners

...terial infections based on its unique, proprietary in-vivo glycosylation platform. With this platform, the company can develop and produce immunogenic glycoproteins in a simplified biological process that circumvents many of the difficulties involved in current methods. The lead conjugate vaccines in development a...

ProtoKinetix Receives Independent Confirmation of AAGP Anti-Inflammatory Action

...ealth problems." About ProtoKinetix ProtoKinetix, Inc. is a biotechnology company that has developed and patented a family of synthetic anti-aging glycoproteins (AAGP(TM)) for medicine and the biotechnology and cosmetic industries. PKTX is currently in dialogue with major corporations and institutions who have...

Vaxfectin(R)-formulated Measles DNA Vaccine Could Address Unmet Need for Infants

... Vaxfectin(R)-formulated Measles DNA Vaccine The study in juvenile macaques tested a bivalent DNA vaccine encoding measles hemagglutinin and fusion glycoproteins formulated with Vical's patented Vaxfectin(R) adjuvant. Vaccine was delivered by intradermal injection of two 0.5 mg doses or by intramuscular injecti...

Bruker Announces Availability of New HUPO World Congress Proteomics Posters on Web Site

...egy Applied to a Multi Workflow Proteomics Approach Poster W295 -- Software-supported Process Optimization for Magnetic Beads Purification of glycoproteins Poster W296 -- Comprehensive and Reliable Analysis of the Human Serum Glycoproteome Poster W298 -- High-Throughput Data Management of Shotgun IE...

Protein Depletion for Plasma and Serum Proteomic Analysis

...nd serum proteome. Proteomics 2005, 5 :3329-3342.
  • Yang Z, Hancock WS, Richmond-Chew T, Bonilla L: A Study of glycoproteins in Human Serum and Plasma Reference Standards (HUPO) using Multi-Lectin Affi nity Chromatography Coupled with RPLC-MS/MS. Proteomics 2...

    Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MSn

    ...ion In humans, glycoproteins on cell surfaces are important for commun...ruses, bacteria and parasites bind to cell-surface glycoproteins and use them as portals of entry into cel.... Understanding the detailed structure of glycoproteins at the molecular level may provide insights to aid...
  • Glycoproteins in Biological Products

    Mouse Anti-67kD Laminin Receptor Prediluted Monoclonal Antibody, Unconjugated, SPM278 from GeneTex

    Description:...cells (Human). Reactivity / Specificity Cross-reacts with Human. Not yet tested in other species. Background Information Laminin, one of the major glycoproteins of basement membrane, displays multiple biological activities which are mediated through its interaction with specific cell membrane receptors. Overex...
    Company:GeneTex

    Glycoprotein Isolation Kit WGA from Pierce Biotechnology, Inc.

    Description:...eat Germ Agglutinin (WGA), that allow isolation of glycoproteins from complex protein mixtures, including serum, ti...ation in less than an hour Versatile Isolate glycoproteins from various sample types, e.g., human serum and c...s dialysis or protein precipitation of recovered glycoproteins is not required prior to protein assay ...
    Company:Pierce Biotechnology, Inc.

    P/ACE™ MDQ Molecular Characterization System from Beckman Coulter

    Description:...y configured with software, hardware and chemistry. Applications include the analysis of basic drugs, chiral pharmaceuticals, carbohydrates, proteins, glycoproteins and nucleic acids....
    Company:Beckman Coulter

    Tritirachium album Proteinase K from USB Corp.

    Description:...ht DNA and RNA. *Used as a general protease to inactivate DNases, RNases and to degrade proteins. *Specifically modifies cell surface proteins and glycoproteins for analysis of membrane structures for protein localization (5,6) . *Produces characteristic protein fragments used in enzyme/protein structure and...
    Company:USB Corp.

    Free Activin B ELISA Kit from Diagnostic Systems Laboratories, Inc.

    Description:...factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins. Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are h...
    Company:Diagnostic Systems Laboratories, Inc.

    Free Activin AB ELISA Kit from Diagnostic Systems Laboratories, Inc.

    Description:...factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins. Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are h...
    Company:Diagnostic Systems Laboratories, Inc.

    Free Activin A ELISA Kit from Diagnostic Systems Laboratories, Inc.

    Description:...factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) and Inhibins. Activins and Inhibins are structurally related gonadal dimeric glycoproteins defined by their ability to modulate the synthesis and release of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Activins are h...
    Company:Diagnostic Systems Laboratories, Inc.
    Glycoproteins in Biological Definition

    Animal

    ...r animals in general. All animals have eukaryotic cells, surrounded by a characteristic extracellular matrix composed of collagen and elastic glycoproteins . This may be calcified to form structures like shells, bones, and spicules. During development it forms a relatively flexible framework upon whic...

    Antibody

    ...pplications 6 Biochemical applications 7 See also 8 References 9 External links Definition Immunoglobulins (Ig) are glycoproteins that function as antibodies. They are found in the blood and tissue fluids, as well as many secretions . Structurally they are globulins (in the...

    Cell membrane

    ...r peripheral proteins), while others might be said to reside within it or to span it ( intrinsic proteins -- more at integral membrane protein ). glycoproteins have carbohydrates attached to their extracellular domains. Cells may vary the variety and the relative amounts of different lipids to maintain the f...

    Glycoprotein

    ...ist in protein folding or improve its stability. glycoproteins are often used in proteins that are at least in pa...extracellular space (that is, outside the cell ). glycoproteins are important for immune cell recognition, especially in mammals . Examples of glycoproteins in the immune system are: molecules such as ...

    Golgi apparatus

    ...ins reach the trans face, they are embedded into coated transport vesicles and brought to their final destinations. An example is the modification of glycoproteins (used in cell membranes ). Vesicles from the ER contain simplified glycosylated proteins. In the Golgi Apparatus, carbohydrates are attached and rem...

    Animal

    ...r animals in general. All animals have eukaryotic cells, surrounded by a characteristic extracellular matrix composed of collagen and elastic glycoproteins . This may be calcified to form structures like shells, bones, and spicules. During development it forms a relatively flexible framework upon whic...

    Cell membrane

    ...r peripheral proteins), while others might be said to reside within it or to span it ( intrinsic proteins -- more at integral membrane protein ). glycoproteins have carbohydrates attached to their extracellular domains. Cells may vary the variety and the relative amounts of different lipids to maintain the f...

    Blood type

    ...bodies against an antigen they have never been exposed to is unknown. It is believed that some bacterial antigens are similar enough to the A and B glycoproteins , and that antibodies created against the bacteria will react to ABO-incompatible blood cells. Apart from on red blood cells, the ABO antigen is als...

    Varicella zoster virus

    ...hthalmicus, or zoster sine herpete. VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is not equivalent of HSV gD. VZV virons are spherical and 150-200 nm in diame...

    Virus

    ...ed by some form of protective coat consisting of proteins , lipids , and glycoproteins . Importantly viral genomes code not only for the proteins needed to pa...struct the host's endoplasmic reticulum to make certain proteins, called glycoproteins , which then collect in clumps along the cell membrane. The virus is then d...
    Glycoproteins in Biological Dictionary

    Programmed cell death

    ...d to destroy cells that ... on a system of programmed cell death ; for example, in an ... Both light scattering and fluorescence of membrane glycoproteins can be used to detect programmed cell death (apoptosis) quickly and cheaply. Apoptosis articles relating to ' programmed cell death ' ......

    Glycoprotein

    ...dia article about Glycoprotein . Information about Glycoprotein in the Columbia Encyclopedia, Computer Desktop Encyclopedia, computing dictionary. glycoproteins Definition of glycoprotein from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games. ...
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