Targanta Reports Improved Ability of Oritavancin to Stop Bacteria Growth In Vitro Compared With Other Glycopeptide Antibiotics

Three Oritavancin Studies Presented at ECCMID/ICC MUNICH, Germany, April 03, 2007 /PRNewswire/ -- Targanta Therapeutics today announced results from two studies showing the improved potency of oritavancin to stop bacterial growth in vitro when tested with a common wetting agent (polysorbate 80) an...

Glycopeptide in Biological News

Researchers analyze how new anti-MRSA abtibiotics function

...not regulate their internal pressure, bacterial cells would burst apart and die if cross-linking did not occur. β-Lactam (e.g., penicillin) and glycopeptide (e.g., vancomycin) antibiotics are designed to impair the bacterial cell wall and inhibit the process of cross-linking, causing bacterial cells to bur...

Progress toward an antitumor vaccine

...an allyl group (two carbon atoms attached by a double bond) at its end. The glycopeptide is coupled to a building block that causes thiols (sulfur–hydrogen groups) ...de reactions occur at other locations in the peptide chain. “Synthetic glycopeptide antigens containing structural elements typical of tumors in the sugar as w...

Scientists re-engineer a well-known antibiotic to counter drug resistance

...m the molecular structure of vancomycin aglycon, a glycopeptide antibiotic that attacks the bacteria by inhibiting... bacteria that is highly resistant to treatment by glycopeptide antibiotics, including vancomycin and teicoplanin ...logues. "The complex chemical synthesis of the glycopeptide antibiotics was developed with the specific idea t...

Glycopeptide in Biological Technology

Targanta Therapeutics to Have Significant Presence at 47th Annual ICAAC Meeting

... Peptidoglycan Glycosyltransferases by glycopeptide Analogs Wed., 12:15PM- E-1612 Poster Moeck In Vitro Activity Profile Sept. 19 1:15PM of Oritavancin ag...

Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MSn

...MS/MS on the 211-T45 ion at m/z 1064. The glycopeptide fragmented into many different glycoforms. The 210...nable TurboSEQUEST to automatically match glycopeptide structures. From these, TurboSEQUEST was ... full-scan mass spectrum for the targeted glycopeptide are shown in Figure 4. ...

Glycopeptide in Biological Definition

Antibiotic

...porins and cephamycins Cephalexin Cefuroxime Cefadroxil Ceftazidime Monocyclic beta-lactams Penicillins glycopeptide antibiotics Vancomycin Teicoplanin Ramoplanin Decaplanin Oxazolidinones Linezolid Quinupristin/dalfopristin ...

Antibiotic resistance

...ermed GISA (glycopeptide intermediate Staphylococcus aureus ) or VISA (vancomycin intermediate Staphylococcus aureus ), indicating resistance to all glycopeptide antibiotics. A new class of antibiotics, oxazolidinones , became available in the 1990s, and the first commercially available oxazolidinone, linez...

Antibiotic resistance

...ermed GISA (glycopeptide intermediate Staphylococcus aureus ) or VISA (vancomycin intermediate Staphylococcus aureus ), indicating resistance to all glycopeptide antibiotics. A new class of antibiotics, oxazolidinones , became available in the 1990s, and the first commercially available oxazolidinone, linez...

Glycopeptide in Biological Dictionary

Glycosylation

... the N-linked glycosylation system in Campylobacter jejuni (7, 10 – 13) ... Protein Glycosylation Analysis: Use SimGlycan to analyze glycan and glycopeptide structures, in order to study protein glycosylation Glycosylation types are classified according to the identity of the atom of the ......