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Glycogen in Medical News

BioMarin Announces Second Quarter 2009 Financial Results

...-103 is a highly phosphorylated GAA enzyme, which the company believes could result in more efficient uptake in cells and potentially lead to improved glycogen reduction in key affected muscle groups not addressed with current therapy. BioMarin continues to explore partnering options for this program. ...

Glucose metabolism and recidivism of severe violent crimes in alcohol intoxications

...ent crimes. A Finnish study now finds that low glycogen level which means non-oxidative glucose metabolis... deviations lower than non-recidivistic offenders. glycogen levels did not differ among nonrecidivists and 40 ...s in alcohol intoxications when they have very low glycogen stores in the liver. The low activity of the enzym...

Transplanted liver cells function in older animals but do not proliferate as much as in younger ones

... that seen in younger ones. Furthermore, found the scientists, the transplanted cells worked equally well in the old and young animals, as measured by glycogen storage, but the younger animals had significantly higher levels of a growth factor needed for proliferation. The new study is the first to offer a...

Scientists Gain Insight Into Blood Cancer's Progression

...resses into a deadlier stage. The finding may improve patient outcomes, they said. The researchers found that when a molecular off-switch called glycogen synthase kinase (GSK) 3 beta becomes faulty in chronic stage CML cells, it fails to turn off another protein called beta-catenin. This enables pre-leu...

Scientists uncover indicator that warns leukemia is progressing to more dangerous form

... and Regenerative Medicine Institute at the Stanford University School of Medicine, the researchers discovered that when a molecular off-switch called glycogen synthase kinase (GSK) 3 beta becomes faulty in chronic stage CML cells, it fails to turn off another protein, beta-catenin. This in turn enables pre-l...

SoLo's Olympic Success Fuels NBA Preseason

...lidated low glycemic profile delivers energy slowly, allowing athletes to perform at their best for extended periods of time, with the goal of sparing glycogen stores in the process. Athletes can trust that SoLo Bars will keep them powered for longer - to get through an endurance event, training run, or champ...

New leukemia signal could point way to better treatment, Stanford researchers find

...deadly form of leukemia. Their discovery hinges on a novel "double agent" role for a molecular signal that regulates cell growth. The rogue signal, glycogen synthase kinase 3, was previously found to halt uncontrolled cell growth, preventing several forms of cancer. It also keeps growth of healthy cells in...

Hydration Will Be Key For Beijing Bound Olympians, What Every Athlete Must Know

... For two hours after severe exercise, the ingested sugar is moved back into glycogen without insulin. By having more concentrated sugar concentrations in the drink, the glycogen restoration is helped. Athletes should pay close attention to the exa...

Austin Company Makes a Splash at U.S. Olympic Team Swimming Trials

...30 minutes of completing a workout to speed the storage of muscle and liver glycogen and promote muscle tissue repair. "When you exercise," says Ivy, "the mus...30 minutes of completing a workout to speed the storage of muscle and liver glycogen and promote muscle tissue repair. Among the athletes and coaches who are wo...

Gene therapy could save kids from a lifetime of eating cornstarch

...earchers. People born with the disorder, called glycogen storage disease type Ia (GSD-Ia), cant make an enz...ldren's Fund for GSD Research, the Association for glycogen Storage Disease and the Duke Childrens Miracle Net...ung dogs with a naturally-occurring canine form of glycogen storage disease. The original genetic carrier, a M...
Glycogen in Medical Technology

Amicus Therapeutics Suspends Enrollment for Phase 2 Clinical Trial of AT2220 for Pompe Disease

... The study will also explore certain pharmacodynamic and pharmacokinetic measures including the effect of treatment with AT2220 on GAA activity and on glycogen levels in various cells and tissues. Additional objectives include preliminary assessments of pulmonary and skeletal muscle function. Participants who...

Amicus Therapeutics Begins Phase 2 Clinical Trial of AT2220 in Pompe Disease

... The study will also explore certain pharmacodynamic and pharmacokinetic measures including the effect of treatment with AT2220 on GAA activity and on glycogen levels in various cells and tissues. Additional objectives include preliminary assessments of pulmonary and skeletal muscle function. Participants who...

Go Healthy Initiates Additional Clinical Tests on Cholesterade

... the Ohio State University and Duke University. Future centers will be coordinated by CO-PIs, Dr. Hal Goforth, widely acclaimed researcher on muscle glycogen metabolism from Point Loma Nazarene University and the Naval Research Center, and Dr. Fran Pirozzolo, Chairman of the Medical and Scientific Advisory ...

Amicus Therapeutics Announces Positive Results From Two Phase 1 Clinical Studies of AT2220 for Pompe Disease

... selectively bind to and stabilize acid a-glucosidase (GAA), the enzyme deficient in Pompe disease. This deficiency leads to lysosomal accumulation of glycogen inside muscle cells, which is believed to cause the various symptoms of Pompe disease. AT2220 facilitates proper trafficking of the enzyme to the lyso...
Glycogen in Medical Products

Insulin RIA Test

Description:...l-surface receptors [3] and facilitates substrate uptake and intracellular utilization, resulting in net increases in intracellular lipid, protein and glycogen [1,2,3,4]. Insulin is rapidly cleared both by liver uptake, tissue utilization and renal clearance and circulating insulin levels are very low during ...
Company:Diagnostic Systems Laboratories, Inc.
Glycogen in Medical Definition

Pathology

...nosuccinic aciduria , Citrullinemia , Hyperammonemia ) - Glutaric acidemia type 1 - Sarcosinemia Carbohydrate Lactose intolerance - glycogen storage disease ( type I , type II , type III , type IV , type V , type VI , type VII ) - Fructose intolerance - Essential fructosuria - G...
Glycogen in Medical Dictionary

Low blood sugar

...om Low blood sugar ) Jump to: navigation, search ... If the blood sugar level falls too low the liver converts a storage of glycogen ... Blood sugar concentration, or glucose level, refers to the amount of glucose present in the blood of a human or animal. Normally, in...

Cellulose

...nd may be readily separated ... Cellulose is the most abundant macromolecule on Earth. ... Interestingly, cellulose is an isomer of starch and glycogen but these two ... Genetically engineered corn speeds up process of making ethanol. ... To make ethanol, cellulose needs to be "digested" by ...
Glycogen in Biological News

UF makes gene therapy advance in severe genetic disorder

...ing a cure for the disorder in children. Called glycogen storage disease type 1A, the genetic disease stops...David Weinstein, M.D., M.M.Sc., director of the UF glycogen Storage Disease Program and co-investigator on the...t one in 100,000 children have this severe form of glycogen storage disease. Children receive doses of cornsta...

Computational model examines the pathways of Alzheimer's that strikes at the young

...in the study entitled A Computational Model of the Role of Presenilin-1 and glycogen Synthase Kinase-3 in Familial Alzheimer's Disease. They will present their ... The proteins presenilin-1 (PS1) (a mutated gene found in familial AD) and glycogen synthase kinase (GSK-3) (a protein) and amyloid beta (Aβ) plaque (amin...

Computational model examines the pathways of Alzheimer's that strikes at the young

...in the study entitled A Computational Model of the Role of Presenilin-1 and glycogen Synthase Kinase-3 in Familial Alzheimer's Disease. They will present their ... The proteins presenilin-1 (PS1) (a mutated gene found in familial AD) and glycogen synthase kinase (GSK-3) (a protein) and amyloid beta (Aβ) plaque (amin...

Post-exercise caffeine helps muscles refuel

...o ingested caffeine with carbohydrate had 66% more glycogen in their muscles four hours after finishing intens...ical Society. The study, "High rates of muscle glycogen resynthesis after exhaustive exercise when carbohy...e bout was designed to reduce the athletes' muscle glycogen stores prior to the experimental trial the next da...

SEX4, starch and phosphorylation

...he soluble storage carbohydrate accumulated in animals, fungi, and bacteria. The SEX4 phosphatase is related to laforin, a protein involved in animal glycogen metabolism. When laforin is missing, insoluble starch-like polyglucosans (Lafora bodies) accumulate, which results in neuronal dysfunction, severe ep...

Single-celled bacterium works 24-7

...he atmosphere, and water, Cyanothece produces glucose, a sugar it stores in glycogen granules, filling its chemical gas tank. At night, the Cyanothece ramps up ...cted. Since nitrogen fixation requires a lot of energy, Cyanothece uses the glycogen stored in its chemical gas tank through a process called respiration. Becau...

The accumulation of sugar in neurons may explain the origin of several neurodegenerative diseases

... this disease arises. Joan J. Guinovart, expert in glycogen metabolism explains, We have observed that laforin and malin act jointly as guardians of glycogen levels in neurons and are stimulated by the degrad...ses its function, these proteins are not degraded, glycogen accumulates and thus neurons deteriorate and cell ...

Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes

...rains exhibited significant differences related to energy metabolism and storage. One rat strain exhibited impaired glucose tolerance, reduced muscle glycogen synthesis, decreased skeletal muscle ATP (energy) levels, and decreased activity of an energy-producing enzyme called cytochrome c oxidase, when compa...

Researchers seek to design first treatment for neuroAIDS

...MDA antagonists like the Alzheimer's drug Memantine, platelet activating factor (PAF) inhibitors, and in the case of the new grant, drugs that inhibit glycogen synthase kinase 3 beta (GSK-3b) and mixed lineage kinase (MLK). "The number of HIV patients that suffer brain damage is usually estimated at one in...

UF scientists test improved gene therapy method for hereditary heart conditions

...enzyme that normally breaks down the carbohydrate glycogen, used to store energy. The disease causes gradual weakening of muscle and heart tissue when glycogen accumulates in muscles, limiting their ability to contract. "This is a way of delivering gene therapy to the heart that is aimed at treating genet...
Glycogen in Biological Technology

BioMarin Announces First Quarter 2009 Financial Results

...-103 is a highly phosphorylated GAA enzyme, which the company believes could result in more efficient uptake in cells and potentially lead to improved glycogen reduction in key affected muscle groups not addressed with current therapy. BMN-168 - 6R-BH4 Prodrug: BioMarin is proceeding with important ...

Catalyst Biosciences Expands Scientific Advisory Board With Leading Experts in Protease Therapeutic Discovery and Development

...ors. Among a total of approximately three hundred scientific papers, he has published 50 manuscripts on protease structure and function. His work on glycogen phosphorylase revealed the first mechanism of phosphorylation control of protein function. Professor Fletterick's laboratory solved the first structu...

Rapid, Reproducible Real-Time Quantitative RT-PCR Using the iCycler iQ Real-Time PCR Detection System and iQ Supermix, Rev A

...ula and the midperiphery, using Trizol reagent (Invitrogen) with glycogen added as a carrier as described by Bracete et al. (1999) with the following modification: 0.9 ml Trizol reagent plus 13.5 l glycogen (20 mg/ml, Roche Molecular Biochemicals) was added to flash-froz...

Total RNA Isolation: 100 l Viral Sample From Cultured-Cell Supernatant Containing Virus

...ol (2-propanol). If RNA yield is expected to be low (<1 mg), add glycogen as a carrier to the isopropanol. We recommend adding 1 l of glycogen solution (20 mg/ml) per 600 l isopropanol. 2. Cap the tube and mi...

Total RNA Isolation From 500 l Body Fluid

...opanol (2-propanol). If RNA yields are expected to be low, add a glycogen solution as a carrier to the isopropanol (5 l of 20 mg/ml glycogen per 3 ml isopropanol). 2. Mix the sample by capping and inverting...

High Electrotransformation Efficiencies Obtained With DNA From Ligation Mixtures

...s with a 0.1 volume of 3 M sodium acetate, 20 g of glycogen (except where noted), and 2.5 volumes o...ted ligation mixture in the presence of glycogen achieved nearly the same high electro-transformati... the control supercoiled pUC18 plasmid (Figure 1). glycogen was used as a carrier to reduce the los...

Genomic DNA Isolation From 1 ml of Body Fluid

...A yield is expected to be low (<20 g), add a DNA carrier such as glycogen (10 l of 20 mg/ml glycogen per 6 ml isopro p a n o l ) . 2. Mix the sample by inv...

DNA Isolation From 50 to 20 mg of Paraffin-Embedded Tissue

...clean 1.5 ml microfuge tube containing 300 l 100% isopropanol (2-propanol). If DNA yield is expected to be low (<1 g), add 0.5 l glycogen solution (20 mg/ml) to the isopropanol. 2. Cap the tube and mix by inverting gently 50 times. 3. Centrifuge at 13,00016,000 x g fo...

RNAi as a Tool for Mammalian Gene Analysis: Applications of siRNAs

...d glucose uptake in two different cell lines, whereas Akt1 and Akt2 contribute equally to insulin-stimulated glycogen synthesis. Functional Screening Libraries of siRNAs targeting broad collections of genes will enable...

Setting up a kinase profiler with IMAP

... J.A. Bibb, G.L. Snyder, P. Greengard, J. Biernat, Y.Z. Wu, E.M. Mandelkow, G. Eisenbrand, L. Meijer. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimers disease....
Glycogen in Biological Products

PPase-2A from Promega

Description:...tic subunit, PPase-2A has broad substrate specificity and may play a regulatory role in DNA replication, transcription, protein synthesis, mitosis and glycogen metabolism. PPase-2A is stimulated in vitro by basic proteins such as protamine, histones and polylysine. The enzyme is inhibited by several environme...
Company:Promega
Glycogen in Biological Definition

Cellular respiration

... 4 H + The individual steps of the conversion of glucose into pyruvate are (in brief): A glucose molecule from the hydrolysation of starch or glycogen is phosphorylated using one ATP molecule to give glucose-6-phosphate. The glucose-6-phosphate is converted to fructose-6-phosphate by isomerisation....

Diabetes mellitus

...conversion of glucose (the basic sugar unit) to glycogen for storage in liver and muscle cells. Lowered insulin levels result in the reverse conversion of glycogen to glucose when glucose levels fall -- though only...causes the liver to convert its internal stores of glycogen to be released as glucose into the blood. Oral or ...

Glucose

...ctose form sucrose . Starch , cellulose , and glycogen are common glucose polymers ( polysaccharides )...the liver and skeletal muscle by the breakdown of glycogen stores (glucose polymers ). Synthesized in li... the liver and muscles , where it is stored as glycogen ("animal starch"), and to fat cells , where it i...

Insulin

...tions of insulin on cells include: increased glycogen synthesis – insulin forces storage of gluco...red levels of insulin cause liver cells to convert glycogen to glucose and excrete it into the blood. This is ...el causes glucose absorption and storage, reducing glycogen to glucose conversion, reducing blood glucose leve...

Isozyme

...o serve different functions in cells of specific organs, such as control of insulin release by the beta cells of the pancreas , or initiation of glycogen synthesis by liver cells. Both of these processes must only occur when glucose is abundant, or problems occur. Distinguishing isozymes Isoz...

Liver

... functions in the body including detoxification, glycogen storage and plasma protein synthesis. It also p... Glycogenolysis (the formation of glucose from glycogen ) Glycogenesis (the formation of glycogen from glucose) The breakdown of insulin and o...

Metabolism

...uel molecules . These pathways are also involved in the digestion of food . Carbohydrate catabolism Glycogenolysis , the conversion of glycogen into glucose . Glycolysis , the conversion of glucose into pyruvate and ATP, does not require oxygen . Embden-Meyerhof pathway , the...

Muscle

...lcholine . Muscles and muscular activity account for most of the body's energy consumption. Muscles store energy for their own use in the form of glycogen , which represents about 1% of their mass. This can be rapidly converted to glucose when more energy is necessary. Nervous control Efferent...

Polysaccharide

...lude storage polysaccharides such as starch and glycogen and structural polysaccharides such as cellulose...wTocToggle("show","hide") 1 Starches 2 glycogen 3 Cellulose 4 Acidic polysaccharides ...e major sources of starch in the human diet. glycogen ...

Starch

... wash away along with the starch. Then, after each laundering, the starch would be reapplied. Livestock Animal starch is the common name of glycogen . It is not the same as ordinary starch. Tests for Starch A solution of Iodine and Potassium iodide in water, when added to a sample cont...
Glycogen in Biological Dictionary

Glycogen

Glycogen is the molecule which functions as the secondary short term energy storage in animal cells. It is made primarily by the liver and the muscles, but can also be made by glycogenesis within the brain and stomach.... glycogen n. A polysaccharide, (C 6 H 10 O 5 ) n , that is the ma...

Polysaccharides

... billions of web pages to find the most... A look at the structural polysaccharides ; cellulose and chitin and the storage polysaccharides ; glycogen and starch. ... Polysaccharides are the complex ... Ah, the sweet taste of sugar. Most of us love and adore its taste. ... Some examples of pol...

Glycolysis

...aphics) ... The glycolysis page describes the process and regulation of glucose breakdown ... Entry of Non-Glucose Carbons into Glycolysis . glycogen Metabolism ... This process is known as glycolysis . Glycolysis takes place in the cytoplasm and can occur without the presence of ... Glycol...

Glucagon

...tabolism. Produced by the pancreas, it is released when the glucose level in the blood is low (hypoglycemia), causing the liver to convert stored glycogen into... Glucagon rescue is the emergency injection of glucagon in case of severe diabetic hypoglycemia. It is needed during seizures and/or un...
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