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Glutathione in Medical News

Unique Glutathione Reductase Enzyme Introduced by Bio-Research Products

NORTH LIBERTY, Iowa, Feb. 3 /PRNewswire/ -- Bio-Research Products announced today that it will offer a high specific activity lyophilized grade of the enzyme Glutathione Reductase (GR). Dr. Bryce Cunningham, President and Chief Technology Officer of Bio-Research, reports that this is the first...

Innovative Oxidative Stress Management Protocol Safely and Effectively Enhances Body's Primary Antioxidant

... OSCEOLA, Wis., June 11 /PRNewswire/ -- NeuroScience, Inc. has launched an antioxidant protocol that combines an objective assessment of glutathione levels along with unique antioxidant compounds, including OSR#1, CysNAC, and NeuroVitamins. These products are capable of eliminating free radicals in...

Brain Imaging Study Confirms Cognizin(R) Citicoline Boosts Mental Function; to be Presented at International Society of Sports Nutrition Annual Conference

... array of branded ingredients including Cognizin(R) Citicoline, Kyowa CoQ10(R), Lumistor(R) L-Hydroxyproline, Hydrafend(TM) Hyaluronic Acid, Setria(R) glutathione and Sustamine(TM) L-Alanyl Glutamine. For more information, please visit: http://www.kyowa-usa.com Journal Citation: Citicoline enhanc...

Telik Presents Results at ASCO From ASSIST-5 Trial of TELCYTA in Platinum Refractory and Resistant Ovarian Cancer

...eat cancer and inflammatory diseases. The company's most advanced investigational drug candidates in clinical development are TELINTRA(R), a modified glutathione analog for the treatment of cytopenias due to myelodysplastic syndrome or chemotherapy, and TELCYTA, a tumor-activated prodrug for the treatment of ad...

Kyowa Hakko USA Announces GRAS Self-Affirmation for Novel Brain Health Ingredient Cognizin(R) Citicoline

...owa is the maker of other leading branded ingredients including Hydrafend(TM) Hyaluronic Acid, Lumistor(R) L-Hydroxyproline, Kyowa CoQ10(R), Setria(R) glutathione and Sustamine(TM) Alanyl Glutamine. Kyowa offers manufacturers and formulators one of the industry's most extensive lines of over 50 amino acids and ...

Benefit of grapes may be more than skin deep

...he amount of protective glutathione. However, intake of grapes actually turned on glutathione-regulating genes in the heart and significantly elevated glutathione levels. This may explain why the hearts of grape-fed animals functioned better and had less damage. Although the current study was supported i...

Telik Announces Preclinical Presentations at AACR Annual Meeting

...eat cancer and inflammatory diseases. The company's most advanced investigational drug candidates in clinical development are TELINTRA(R), a modified glutathione analog for the treatment of cytopenias due to myelodysplastic syndrome or chemotherapy, and TELCYTA(R), a tumor-activated prodrug for the treatment of...

Targeting oxidized cysteine through diet could reduce inflammation and lower disease risk

... forms: oxidized and reduced. The higher the level of oxidative stress outside the cell, the more oxidized cysteine there is. Other indicators such as glutathione are more important inside cells. Several studies have shown that levels of oxidized cysteine in the blood tend to rise as people age. Smoking and a...

Telik Announces Fourth Quarter and 2008 Year End Financial Results and 2009 Financial Guidance

...y collaborations. The company's lead compound, TELINTRA, is a modified glutathione analog currently being evaluated in two Phase 2 studies for Myelodysplastic...tigational drug candidates in clinical development are TELINTRA, a modified glutathione analog for the treatment of cytopenias due to myelodysplastic syndrome or c...

A potential drug for ischemia/reperfusion related liver injury

... I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase, and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratrol treated...
Glutathione in Medical Technology

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

...LINTRA has a novel mechanism of action that inhibits a target enzyme called glutathione S- transferase P1-1 which in turn facilitates the activation of JNK kinase,...tigational drug candidates in clinical development are TELINTRA, a modified glutathione analog for the treatment of cytopenias due to myelodysplastic syndrome or c...

National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness

...effects of brostallicin are enhanced by high tumor glutathione levels, a hallmark of drug-resistant tumors. Bros...rther insights into the specific bio-marker (tumor glutathione levels) that increases the probability of achievin...tment with platinum containing regimens where high glutathione levels are associated with chemotherapy resistance...

Telik Announces Presentation at ASCO Annual Meeting

...eat cancer and inflammatory diseases. The company's most advanced investigational drug candidates in clinical development are TELINTRA(R), a modified glutathione analog for the treatment of cytopenias due to myelodysplastic syndrome or chemotherapy, and TELCYTA, a tumor-activated prodrug for the treatment of ad...

Raptor Pharmaceuticals Announces Completion of Patient Enrollment in Phase 2a Clinical Trial in Non-Alcoholic Steatohepatitis (NASH)

...erapeutic indications. Preliminary data suggests that cysteamine is readily taken up by the liver, and is a precursor of the potent liver anti-oxidant glutathione ("GSH"). Raptor's UC San Diego collaborators believe that increasing GSH has the potential to reverse NASH-related liver damage. Ted Daley, Presi...

Synvista Therapeutics Announces First Dosing of SYI-2074 in Clinical Trial for Psoriasis

...09." About SYI-2074 Synvista's GPx mimetic program is based on the rational design of oral and topical drugs that mimic the activity of glutathione peroxidase (GPx), the only enzyme in the human body that reduces oxidized lipids. GPx is a well validated target for drug development. Animal...

Sound Pharmaceuticals Files Second IND with the FDA for the Prevention of Chemotherapy Induced Hearing Loss in Advanced Stage Cancer

... unmet medical need with its first in class first in indication drug. Several different research groups have shown that chemotherapy treatment reduces glutathione peroxidase (GPx) activity in the mammalian inner ear resulting in hearing loss, tinnitus, vertigo and dizziness. GPx is the dominant catalytic antioxi...

Synvista Therapeutics Reports Results of Three Phase 2 Clinical Trials of SYI-2074 in Diabetic Patients with Cardiovascular Disease

...present novel approaches to some of the largest pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit inflammation related to oxidative stress. It currently plans a ...

Synvista Therapeutics Presents New Preclinical Data Demonstrating the Value of Haptoglobin Genotype Testing In Diabetes at ACC Scientific Sessions

...present novel approaches to some of the largest pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Co...

Telik Announces Telintra Presentation at American Society of Hematology Annual Meeting

...ess Center in Atlanta. The presentation (Abstract # 1454, Board # 608) is titled: "Phase 1 Dose Escalation Study of TLK199 Tablets (TELINTRA), a Novel glutathione Analog, in Myelodysplastic Syndrome." It will be presented during the poster session "Myelodysplastic Syndromes: Clinical Studies, Including Transplan...

Synvista Therapeutics Announces Initiation of Phase 2 Study With Alagebrium for Chronic Heart Failure

...present novel approaches to some of the largest pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Co...
Glutathione in Medical Dictionary

Mucosa

...d buccal mucosa and on the floor of the mouth. ... Liver and ileal mucosa were collected for analyses of glutathione, inflammation ... Total glutathione in liver and ileum mucosa . ... This protective function of the intestinal mucosa is called permeability. ... the permeability barrier or t...

Erythrocyte

...ne Zinc (µmol/g Protein) and Other Blood Parameters of the Study Population ... of cardiovascular events associated with base-line erythrocyte glutathione peroxidase 1 ... demonstrated that erythrocyte intracellular gluta ... Antigens induced on erythrocytes by P. falciparum: expression of dive...
Glutathione in Biological News

New high-throughput screening technique makes probing puzzling proteins possible

...e enzyme might bind in normal and cancerous cells. The group had similar success working with an enzyme from a different mechanistic class, called glutathione S-transferase omega 1 (GSTO1), an oxidoreductase enzyme. Enzymes from this class are gaining attention as potential anticancer drug targets because th...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

...d a reversal of nelfinavir induced deleterious effects. Thymoquinone decreased the production of reactive oxygen species, increased the Cu/Zn SOD and glutathione levels, suppressed the UCP-2 protein levels and restored nelfinavir induced decrease in insulin secretion to normal levels in these cells. Dr. Agrawal...

Shared survival mechanism explains why 'good' nerve cells last and 'bad' cancer cells flourish

...turned off if the cellular environment contains high levels of antioxidants. Healthy neurons and cancer cells have increased levels of the antioxidant glutathione (GSH), which is generated by glucose metabolism through the pentose phosphate pathway. Thus, both neurons and cancer cells are able to resist cell dea...

Traits produced by melanin may signal the bearer's capacity to combat free radicals

...to afford the cost of signaling. By chemically inhibiting the production of glutathione at the red blood cells, authors were able to significantly increase the siz...ing combats for territory, food or mates. Furthermore, the reduction of glutathione levels also induced a mobilization of other antioxidant molecules to the bl...

Oxidative stress: Mechanism of cell death clarified

...ce and cells were generated that specifically lack glutathione peroxidase 4 (GPx4), which is emerging as one of t...e were amazed to find that in cells lacking either glutathione or glutathione peroxidase 4, a distinctive signaling pathway is e...

Infection blocks lung's protective response against tobacco smoke

...for 16 weeks doubled the amount of the antioxidant glutathione in the fluid bathing the airways. The antioxidant ...ce with Mp it had a mild effect, slightly lowering glutathione levels in the lungs of mice breathing fresh air. W...re exposed to tobacco smoke then infected with Mp, glutathione levels dropped even lower. "The Mycoplasma inf...

Biosensor for measuring stress in cells

...les within a cell by oxidation. If much of a cells glutathione is present in an oxidized state, this is an import...doxin. This enzyme measures the oxidation state of glutathione and transmits the value to the fluorescent protein...es the slightest changes in the oxidation state of glutathione without destroying the cell. Even more relevant, h...

Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle

...red to the control group, the diaphragms of the 14 case study members revealed: 23 percent lower levels of the free-radical fighting antioxidant, glutathione 154 percent more Caspase-3, a calcium-dependant executioner enzyme that degrades protein molecules and is responsible for programmed cell deaths ...

Antioxidant overload may underlie a heritable human disease

...to kick in. In the diseased animals, however, that pathwayin which oxidized glutathione is recycled to its reduced, antioxidant formsoon got out of hand, producing excess levels of the reduced glutathione and a condition of reductive stress. Moreover, they showed that the offs...

Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless

...s known as green tea catechins in amounts equal to that found in 8-16 cups of green tea − boosted production of the enzymes, which belong to the glutathione S-transferase (GST) family, by as much as 80 percent in some participants. GST enzymes are believed to be crucial to the bodys defense against canc...
Glutathione in Biological Technology

Telik Announces Second Quarter 2009 Financial Results

...eat cancer and inflammatory diseases. The company's most advanced investigational drug candidates in clinical development are TELINTRA(R), a modified glutathione analog for the treatment of cytopenias due to myelodysplastic syndrome or chemotherapy, and TELCYTA(R), a tumor-activated prodrug for the treatment of...

2009: Immunotec announces important clinical research initiative: New study to be launched with the goal of improving the quality of the aging process

...val to market the product in Canada and an NPN (Natural Product Number) on October 31, 2007 for the health claim "Immunocal is a natural source of the glutathione precursor cysteine for the maintenance of a strong immune system". About Immunotec Inc. Immunotec is engaged primarily in the development an...

Telik Reports Preclinical Results at AACR Annual Meeting

...eat cancer and inflammatory diseases. The company's most advanced investigational drug candidates in clinical development are TELINTRA(R), a modified glutathione analog for the treatment of cytopenias due to myelodysplastic syndrome or chemotherapy, and TELCYTA(R), a tumor-activated prodrug for the treatment of...

Telik Implements Reorganization to Focus Resources Toward Drug Development Pipeline

... treat cancer and inflammatory diseases. The company's most advanced investigational drug candidates in clinical development are TELINTRA, a modified glutathione analog for the treatment of cytopenias due to myelodysplastic syndrome or chemotherapy, and TELCYTA(R), a tumor-activated prodrug for the treatment of...

Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes

...s bioluminescent ADME-Tox assays, including the P450-Glo(TM) CYP Assay used to study cytochrome P450 gene induction and inhibition and the GSH-Glo(TM) glutathione Assay for investigating mechanisms of hepatotoxicity. "Researchers are looking for validated solutions that are predictive," said Dr. James Cal...

Synvista Therapeutics Posts Letter to Stockholders on Web Site

... the use of SYI-2074 in the treatment of psoriasis. -- Chosen a lead glutathione peroxidase mimetic generated in a discovery collaboration with Provid ...tudy in this area in October 2008. We also have developed a new family of glutathione peroxidase mimetics with properties that may be more attractive than SYI-20...

Synvista Therapeutics Announces Initiation of the BREAK Study of Alagebrium for Diastolic Heart Failure

...present novel approaches to some of the largest pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Co...

Synvista Therapeutics to Present at Acumen BioFin Rodman & Renshaw 5th Annual Global Healthcare Conference

...present novel approaches to some of the largest pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Co...

Synvista Therapeutics Increases Commercial Focus by Appointing David C. Tantillo Senior Director of Marketing and Sales

...present novel approaches to some of the largest pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Co...

Telik Presents Preclinical Data at 99th Annual Meeting of the American Association for Cancer Research

...Telik researchers conducted studies with data highlighting TLK199, a novel glutathione analog inhibitor of the enzyme glutathione S-transferase P1-1, which induces apoptosis, or programmed cell death, in ...
Glutathione in Biological Products

Rabbit Anti-Human Glutathione S Transferase alpha Polyclonal Antibody, Unconjugated from Abcam

Description: Rabbit polyclonal to Glutathione S Transferase alpha ( Abpromise for all tested applications). Antigen: Full length protein: Human Glutathione S Transferase alpha. Entrez GeneID: 2938 Swiss Protein ID: P08263...
Company:Abcam

Mouse Anti-Mouse Glutathione S-transferase M1 (GSTM1) Monoclonal Antibody, Unconjugated from Lifespan Biosciences

Description: Anti-GSTM1 Monoclonal Antibody Epitope: A BALB/c mouse was immunized with Glutathione-S-Transferase [Schistosoma japonicum]. Recommended Storage: Store vial at -20 C prior to opening. Aliquot contents and freeze at -20 C or below for extended storage. Avoid cycles of freezing and thawing....
Company:Lifespan Biosciences

Origami(DE3) Glycerol Stock from Novagen

Description:... Origami host strains are K-12 derivatives that have mutations in both the thioredoxin reductase (trxB) and glutathione reductase (gor) genes, which greatly enhances disulfide bond formation in the cytoplasm. Studies have shown that expression in Origami(DE3) yielded 10...
Company:Novagen

Origami(DE3)pLysS Glycerol Stock from Novagen

Description:... Origami host strains are K-12 derivatives that have mutations in both the thioredoxin reductase (trxB) and glutathione reductase (gor) genes, which greatly enhances disulfide bond formation in the cytoplasm. Studies have shown that expression in Origami(DE3) yielded 10...
Company:Novagen

L-Selenomethionine from Calbiochem

Description:... SeMet White to off-white solid. Increases the expression of glutathione peroxidase. Purity: ≥98% by HPLC. Soluble in H 2 O. Unstable in aqueous solutions; reconstitute immediately prior to use. RTECS EK7713840, CAS ...
Company:Calbiochem

PolarScreen Progesterone Receptor Competitor Assay Kit, Far Red from Molecular Probes (Invitrogen)

Description:...or studying or screening novel progesterone receptor binding compounds using fluorescence polarization (FP). The homogenous assay utilizes a fusion of glutathione transferase to the ligand binding domain of human progesterone receptor [PR-LBD(GST)] and a proprietary, fluorescently tagged progesterone ligand, Flu...
Company:Molecular Probes (Invitrogen)

MagneGST™ Protein Purification System from Promega

Description:... Purification System provides a simple, rapid and reliable method for the purification of glutathione-S-transferase (GST) fusion proteins. Immobilized glutathione paramagnetic particles (MagneGST™ Particles) are used to isolate GST-tagged protein directly from a crude or cleared lysate using either a manua...
Company:Promega

PR Competitor Assay Green from Invitrogen

Description:...for studying or screening novel progesterone receptor binding compounds using fluorescence polarization (FP) The homogenous assay utilizes a fusion of glutathione transferase to the ligand binding domain of human progesterone receptor [PR-LBD(GST)] and a proprietary, fluorescently-tagged progesterone ligand, Flu...
Company:Invitrogen

Cleland’s REDUCTACRYL™ Reagent from Calbiochem

Description:...xcess of resin in the batch technique, it has been shown that 1 mM oxidized glutathione can be reduced completely to glutathione in 15 minutes at room temperature, pH 7.5. Can be used in either aqueous or...
Company:Calbiochem

Baker's yeast (S. cerevisiae) S-Acetyl-coenzyme A synthetase from Sigma-Aldrich

Description:...ckaging: Package size based on protein content. Physical form: Lyophilized powder containing stabilizers as potassium phosphate, sucrose and reduced glutathione Preparation Unit Definition: One unit will form 1.0 mol of S-acetyl coenzyme A from acetate, ATP and coenzyme A per min at pH 7.5 at 37C....
Company:Sigma-Aldrich
Glutathione in Biological Definition

Affinity chromatography

... chelating agent is used. GST has an affinity for glutathione (commercially available as glutathione sepharose ). For elution purposes glutathione is used. Another use for the procedure is the af...

Down syndrome

...OD. However, the hypothesis says that once SOD activity increases disproportionately to enzymes responsible for removal of hydrogen peroxide (e.g., glutathione peroxidase ), the cells will suffer from a peroxide damage. Some scientists believe that the treatment of Down syndrome neurons with free radical sc...

Enzyme

...A gyrase : catalyzes the negative supercoiling of prokaryotic DNA Glutamate decarboxylase : synthesizes the neurotransmitter GABA in the brain glutathione peroxidase : protects cells by converting hydrogen peroxide to water Isomerase : all those enzymes which convert a molecule into one of its isom...

Kwashiorkor

...particularly those involved with anti-oxidant protection. Important anti-oxidants in the body that are reduced in children with kwashiorkor include glutathione , albumin , vitamin E and polyunsaturated fatty acids. Therefore, if a child with reduced type I nutrients or anti-oxidants is exposed to stress ...
Glutathione in Biological Dictionary

Exons

...ncyclopedia. ... Armstrong, Modular Mutagenesis of Exons 1, 2, and 8 of a glutathione ... Suboptimal exons have a variety of potential uses. ... The defau...Exons mean? ... Armstrong, Modular Mutagenesis of Exons 1, 2, and 8 of a glutathione ... none of the constitutively spliced internal exons had such a hit. ...

Cofactors

...s and Cofactors Metal Ions in Life Sciences... posted to enzymes cofactors by asadrahman on 2009-07-01 16:09:51 as along with 1 ... posted to glutathione cofactors biopterin by grottenolm on 2008-12-19 16:19:50 as ... Limited Time FREE Shipping! SR (Stress Resistance) Cofactors ™ was developed to ...
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