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Glutamine in Medical News

Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration

Although repeating sequences of three nucleotides encoding some of the bodies' 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease. Scientists at E...

Twinlab(R) Teams Up With The Vitamin Shoppe to Debut Mass Fuel(R) Xtreme

...for easy digestibility), multi-sourced proteins to fuel growth and recovery: Whey Concentrates and Isolates, Caseinates, Milk Protein, L-Glutamine and glutamine Peptides and free form BCAAs (L-Leucine, L-Valine, L-Isoleucine) to feed hungry muscles.* Sustained Energy Carb Blend: Maltodextrin, Isomaltulo...

$18 million awarded to TGen and University of Pennsylvania for pancreatic cancer research

...because it is addicted to another molecule, glutamine, rather than glucose. glutamine is an amino acid that helps build muscle mass and is used by some cells for... secrete growth factors that help tumor cells grow. Cancers that use excess glutamine are often resistant to standard forms of chemotherapy, another characterist...

Strategies for preventing gastrointestinal complications in severely burned patients

...ment in recent 30 years, a series of new therapies including fluid resuscitation, early escharectomy, continuous renal replacement therapy, and use of glutamine and growth factor has been adopted in the treatment of severe burns. Although animal experiments available have shown that these new therapies do play...

Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy

...roved for the treatment of HE. About AMMONUL(R) The active compounds of AMMONUL(R), sodium phenylacetate and sodium phenylbutyrate, conjugate with glutamine and glycine respectively to provide an alternative route to urea for waste nitrogen excretion and thus attenuate the risk of ammonia and glumatine-ind...

Chemical signature of manic depression discovered by scientists

...f glutamate, an amino acid which acts as a neurotransmitter in the central nervous system, were increased in post mortem bipolar brain but glutamate / glutamine ratios were decreased following valproate treatment. Levels of another neurotransmitter, gamma-aminobutyric acid, were increased after lithium treatme...

More Energy & Immunity With Vitamin Supplements This Winter

...dering using Vitamin D, NADH, Ginseng, Astragalus, glutamine this winter. ISSA's latest version of its acclaime...nd one that works in conjunction with this herb. glutamine is an amino acid necessary for developing muscle m...lood cells. Studies have also shown depressions in glutamine levels after exercise stress, with glutamine level...

New Insights into Prion Propogation

...etween the two is that the yeast prion proteins are rich in the amino acids glutamine and asparagine in the regions of the protein used to transform them into a ...ous prion propagation is possible. "Surprisingly, the presence of a glutamine and asparagine-rich yeast prion that helps other yeast prions to form also ...

Scientists Discover Non-dietary Therapy For Celiac Diseases

...ous storage protein that is efficiently digested by enzymes. One enzyme, EP-B2, plays a crucial role in this process by breaking gluten proteins after glutamine residues, which comprise one-third of all amino acid residues in gluten." Dr. Khosla's group used recombinant bacteria to produce a form of EP-B...

Transport of Proteins Unravels the Mystery behind Neurodegenerative Diseases

...ut four times as many. Neurodegenerative diseases like SBMA are caused by the lengthening of part of a gene that encodes repetitions of the amino acid glutamine in the protein. Although different genes are affected, all of the polyglutamine-expansion or "polyQ" diseases are characterized by symptoms that begin...
Glutamine in Medical Technology

Research Team Clones Genes Responsible for Amino Acid Absorption

...ators interfere with what substance the body needs to absorb. "We have found the needle for a few of the big ones such as how fat, glucose, salt and glutamine absorption is affected," he said. "The next step would be to find specific treatments for inflammatory bowel disease that avoid all the complications ...
Glutamine in Medical Definition

Proteopathy

...lateral sclerosis (ALS) Superoxide dismutase, TDP-43 Huntington's disease and other triplet repeat disorders (multiple) Proteins with tandem glutamine expansions Familial British dementia ABri Familial Danish dementia ADan Familial encephalopathy with neuroserpin inclusion bodie...
Glutamine in Biological News

Glutamine supplements show promise in treating stomach ulcers

...omach ulcers. "Our findings suggest that extra glutamine in the diet could protect against gastric damage c...n environment conducive to cancer development. glutamine is a nonessential amino acid naturally found in ce...es. L-glutamine the biologically active isomer of glutamine is widely used as a dietary supplement by body bu...

Reversing ecology reveals ancient environments

.... Through the metabolic network, organisms accumulate biochemical compounds from their interactions with the surrounding environment (e.g., oxygen, glutamine or sulfate). These molecules also correlate with other environmental properties like temperature and salinity. "This gives us a way to predict the bio...

'Deranged calcium signaling' contributes to neurological disorder, UT Southwestern researchers find

...ent proteins. The genetic mutations cause repeated units of the amino acid glutamine to appear in the respective proteins. The more repeats there are, the earli...y engineered to overexpress the human ataxin-3 protein containing excessive glutamine repeats. The mutant mice performed poorly on tests of motor coordination co...

A protein sequence associated with Huntington’s disease may become life-saving vaccine component

... In healthy individuals, huntingtin contains less than 35 glutamines in the polyQ segment. However, in neurons of Huntington's patients, the number of glutamine residues in the sequence expands to more than 36. This induces protein self-aggregation, or formation of big protein "chunks", and eventually causes n...

Systems biology approach identifies nutrient regulation of biological clock in plants

...tire genome sequenced. There is existing evidence, on a gene-by-gene basis, that products of nitrogen assimilation, the amino acids glutamate (Glu) or glutamine (Gln), might serve as signals of organic nitrogen status that are sensed and in turn regulate gene expression. To identify genome-wide responses t...

Why the switch stays on

...ion is at the 61st amino acid, which is normally a glutamine known to help in turning the interaction switch of... properties observed in cancer," Mattos says. "For glutamine or the mutations that do not cause cell transforma...us those that do not, as any amino acid other than glutamine at position 61 made turning off the Ras switch onl...

Mechanism for neurodenegerative diseases linked to transport proteins

...four times as many. Neurodegenerative diseases like SBMA are caused by the lengthening of part of a gene that encodes repetitions of the amino acid glutamine in the protein. Although different genes are affected, all of the polyglutamine-expansion or "polyQ" diseases are characterized by symptoms that begin...

Alternatives to the use of nitrate as a fertiliser

...he leaf tissue. Moreover, important changes are observed in relation to the carbon and nitrogen of the majority aminoacids (asparragine in the pea and glutamine in spinach). With respect to the activities of the GS (glutamine synthetase) and GDH (glutamate dehydrogenase) enzymes, responsible for the assimilati...

Scientists crack 40-year-old DNA puzzle and point to 'hot soup' at the origin of life

...o acids that can be excluded from the doublet system and are likely to be relatively recent 'acquisitions' by the genetic code. As these amino acids - glutamine and asparagine - are unable to hold their shape in high temperatures, this suggests that heat prevented them from being acquired by the code at some p...

Pinpointing the cause of a neurodegenerative disorder

...reathe. "We had known that the expansion of the glutamine tract within Ataxin-1 probably interfered with nor... noted that earlier studies yielded hints that the glutamine repeats somehow caused Ataxin-1 function to be alt...cells. "We had been accumulating clues that the glutamine tract expansion is clearly what is important for d...
Glutamine in Biological Technology

Ca++-Induced G Protein Coupled Receptor (GPCR) Activation Monitored via Aequorin Luminescence in the LMax Microplate Luminometer (MaxLine Application Note #42)

...2-1110 5. Hams F-12 Cat. No. 9058, Fetal Bovine Serum Cat. No. 3000, glutamine Pen-Strep Solution Cat. No. 9316, G418 sulfate #98529, and 1 M HEPES buffer...n was maintained in F12 growth medium with 10% fetal bovine serum, 1% glutamine Pen-Strep and 400 g/mL G418. 2. The day before the experiment, cel...

Transfection Reagent Selector Kit Handbook

...wders are available. Most media purchased are guaranteed to be mycoplasma- and endotoxin-free. Supplements to the media must include glutamine and can include nonessential amino acids, sodium pyruvate, and antibiotics. Some common media include DMEM, F12, DMEM/F12, RPMI 1640, MEM, ...
Glutamine in Biological Definition

Amino acid

...ydrophobic 115.13 6.30 1.95 10.64 Can disrupt protein folding structures like α helix or β sheet . Q Gln glutamine hydrophilic 146.15 5.65 2.17 9.13 R Arg Arginine basic 174.20 10.76 1.82 8.99 12.48 S...

Genetic code

... Histidine CAC (His/H) Histidine CAA (Gln/Q) glutamine CAG (Gln/Q) glutamine CGU (Arg/R) Arginine CGC (Arg/R) Argi...ns; e.g. both GAA and GAG code for the amino acid glutamine . A codon is said to be four-fold degenerate if ...

Genetic code

... Histidine CAC (His/H) Histidine CAA (Gln/Q) glutamine CAG (Gln/Q) glutamine CGU (Arg/R) Arginine CGC (Arg/R) Argi...ns; e.g. both GAA and GAG code for the amino acid glutamine . A codon is said to be four-fold degenerate if ...

Prion

...cal analysis of yeast prion proteins. A typical yeast prion proteins contain a region ( protein domain ) with many repeats of the amino acids glutamine (Q) and asparagine (N); these Q/N-rich domains form the core of the prion's structure. Ordinarily, prion domains are flexible and lack a defined st...

Purine

...cleotide inosine monophosphate, which is synthesized on a pre-existing ribose through a complex pathway using atoms from the amino acids glycine , glutamine , and aspartic acid , as well as formate ions transferred from the coenzyme tetrahydrofolate . Purines from food (or from tissue turnover) ar...
Glutamine in Biological Dictionary

His tag

...A complete solution for His - tag removal — optimized vectors, enzymes, and Ni-NTA ... After removal of His - tag dipeptides by DAPase Enzyme, the glutamine residue ... Compare Cheap Prices for Tag Heuer Watches at NexTag.com. Find Bargain Fashions and the Latest Styles from Name-Brand Designers of ...
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