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Glutamic in Medical News

Vegetable Amino Acid Lowers Blood Pressure

...t study shows that a 4.72 percent higher intake of glutamic acid as a portion of total dietary protein correla...t people could take the finding as a reason to pop glutamic acid pills rather than making vegetables a larger ...statement that there are no data on supplements of glutamic acid to tell us anything one way or another about ...

Redesigned protein accelerates blood clotting

...hange it to make the protein more likely to drive clotting. In 2005, he and Wakabayashi published work showing that swapping out a naturally occurring glutamic acid with an alanine at a specific spot in the calcium binding site on factor VIII doubled its ability to bind with factor IX and increased clotting. ...

Schizophrenia linked to dysfunction in molecular brain pathway activated by marijuana

...atched for a number of factors, including age and sex. The researchers evaluated levels of CB1R messenger RNA and protein, and also measured levels of glutamic acid decarboxylase (GAD-67), an enzyme that makes GABA, and cholecystokinin (CCK), a neuropeptide released from GABA neurons that, among other actions...

Gene Therapy for Parkinsons Disease

...cal Center in Manhattan. One woman and 11 men received a surgical infusion of fluid containing a viral vector and genes for a protein called GAD, glutamic acid decarboxylase. This enzyme is critical in controlling a neurotransmitter called GABA. In Parkinsons, GABA is reduced in an area of the brain call...

Bird flu outbreak prevented by Tamiflu

...s of virus collected from Jalgaon and Navapur. The findings showed that the virus was sensitive to Tamiflu due the different types of amino acids like glutamic acid, asparigine, histidine and arvinone present in it. This helped in the prevention of a possible transmission of the lethal virus from birds to ...

Gene therapy Beneficial in Parkinson's Disease

...t. The team, led by Dr. Matthew J During from the Weill Cornell Medical Center in New York, used a gene responsible for the synthesis of enzyme, glutamic acid decarboxylase. This enzyme in turn converts compounds in the cell into the neurotransmitter, GABA that controls muscle movements. Parkinson’s d...

Hope For Stiff-Person Syndrome

... At present, there is no cure for stiff-person syndrome, a disease marked by high levels of antibodies to glutamic acid decarboxylase (GAD65), an enzyme involved in the production of a movement-regulating neurotransmitter.// Patients are usually treated with Valium...
Glutamic in Medical Technology

Diamyd(R) Study Published in Prestigious New England Journal of Medicine

... an autoimmune disease in which the body's own immune system attacks the cells in the body that produce insulin. The active ingredient in Diamyd(R) is glutamic acid decarboxylase (GAD), which is a dominant antigen in type 1 diabetes. By treating with GAD formulated as a vaccine, the patient's immune system is...

Diagnosing Diabetes: Immediate HbA1c Results Improve Glycemic Control

... Inc., Boise, ID, offers a variety of ELISA and RIA kits for the quantitative determination of autoantibodies in serum, like the recently FDA-approved glutamic acid decarboxylase (GAD) Autoantibody RIA Test Kit. Antibodies to GAD have been shown to be the most sensitive single marker for identifying people at...
Glutamic in Medical Products

Glutamic Acid Decarboxylase (GAD65) Autoantibody ELISA

Description:... ELISA kit for the quantitative determination of autoantibodies to glutamic acid decarboxylase (GAD65) in serum...
Company:KRONUS

GAD/IA-2 Autoantibody Screen

Description:...mellitus. During this extended pre-clinical phase, the characteristic circulation of autoantibodies against a variety of islet cell antigens including glutamic acid decarboxylase (GAD65), IA-2 (a tyrosine phosphatase-like protein), and insulin provides early markers of autoimmune disease activity. Measure...
Company:KRONUS

Glutamic Acid Decarboxylase (GAD65) Autoantibody RIA

Description:...lation of autoantibodies against a variety of islet cell antigens including glutamic acid decarboxylase (GAD65), IA-2 (a tyrosine phosphatase-like protein), and...he KRONUS GADAb RIA Assay Kit is for the semi-quantitative determination of glutamic acid decarboxylase antibody in human serum. The KRONUS GADAb RIA Assay is u...
Company:KRONUS
Glutamic in Medical Dictionary

AST

... Aspartate transaminase ( AST ) also called serum glutamic oxaloacetic transaminase (SGOT) or aspartate aminotransferase (ASAT/AAT) (E...amount of this enzyme in the blood. ... AST formerly was called serum glutamic oxaloacetic transaminase (SGOT) ... The Alliance of Action Sports bring...

Aspartic acid

...e L-Aspartic Acid offering in China, reliable China L-Aspartic Acid Manufacturers ... dl- aspartic acid , potassium ... Aspartic Acid . glutamic Acid . 4-Methyldeoxybenzoin. Methyltriethylammonium ... HPLC Separation of Aspartic Acid and Aspargine on Obelisc R Column. Application Notes: .....

ALT

...or ALT is a transaminase enzyme (EC 2.6.1.2). It is also called serum glutamic pyruvic transaminase (SGPT) or alanine aminotransferase (ALAT). The al...es the amount of this enzyme in the ... ALT formerly was called serum glutamic pyruvic transaminase (SGPT) ... The Web Design Group's Feature Article,...
Glutamic in Biological News

Tobacco makes medicine

...mbination with other auto-antigens associated with the disease. The team has a particular auto-antigen in its sights the 65-kDa isoform of the enzyme glutamic acid decarboxylase (GAD65) which they have also produced in transgenic tobacco plants. According to Pezzotti, "Transgenic plants are attractive sy...

Rice lab finds molecular clues to Wilson disease

...P7B is changed. That amino acid is a histidine located at position 1069. In the disease-causing form of the protein, this histidine is replaced with a glutamic acid. "This mutation occurs at a crucial location where the protein typically binds with a molecule called ATP that provides the energy the protein...

Scientists use gene transfer technology and common virus to block neuropathic pain

...ats with nerve damage showed much less pain-related behavior after receiving injections of the HSV-based vector, which contained a gene called GAD, or glutamic acid decarboxylase. The treatment's pain-killing effect lasted up to six weeks, and even longer in rats that received additional injections. The st...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...ats with nerve damage showed much less pain-related behavior after receiving injections of the HSV-based vector, which contained a gene called GAD, or glutamic acid decarboxylase. The treatment's pain-killing effect lasted up to six weeks, and even longer in rats that received additional injections. The st...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

...ed trial, the vector was injected into a specific target site in the brain in order to transfer a gene to treat Parkinson's disease. The gene encodes glutamic acid decarboxylase (GAD), an enzyme which synthesizes the major inhibitory neurotransmitter in the brain, (gamma)-aminobutyric acid (GABA). Under t...

Redesigned protein accelerates blood clotting

...II) with the potential, if replaced, to change the performance of entire protein. Researchers proved the theory in the current study by swapping out a glutamic acid naturally occurring at a specific point in a calcium binding site on factor VIII with 19 different amino acids. One of the replacements, alanine,...
Glutamic in Biological Technology

Fufeng Announces 2008 Interim Results With Strong Sign of Recovery

...ment has rebounded completely. The sales volume of glutamic acid also increased by 15.6% in the 1H of 2008 fro... of 2007. With the Group's strategy of moving from glutamic acid to MSG, the sales volume of MSG continued to ...gust and increase an annual production capacity of glutamic acid of 40,000 tonnes in late 2008. Furthermore, t...

Fufeng Announces 2007 Annual Results

...roves the Group's decision to shift its focus from glutamic acid to MSG production. Besides, fertilisers also ...refore the price may go up. With our self-produced glutamic acid and economies of scale, Fufeng will remain as...roduction. MSG segment includes production of MSG, glutamic acid, fertilisers, corn refined products and sweet...

Glutamine in Urine or Blood Plasma

...L/minute Detector: UV at 210nm Peak Identification 1. L-Glutamine 2. Pyrrolidone carboxylic acid 3. glutamic acid back to top ...

ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System Target Validation and Identification of Novel Disease Indications

...yltransferase) methylates many proteins that modulate transcriptional regulation and is a coactivator of gene transcription for ESR1. Pelp1 (Proline-, glutamic acid-, leucine-rich protein 1) is a scaffold protein that may mediate the rapid cellular proliferation response transduced by ESR1 in response to estr...

Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

... The synthesis of GABA is catalyzed by the enzyme glutamic acid decarboxylase (GAD). Molecular clo... γ-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67, Proc Natl Acad S...pilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase, Proc Natl Acad Sci ...

Rapid Method Development With the BioLogic DuoFlow Chromatography System for the Purification of His-Tagged Proteins

...lectivity for His-tagged proteins, as well as naturally occurring proteins that are rich in histidine, cysteine, aspartic acid, or glutamic acid residues. To obtain highly purified proteins from an IMAC system, a series of method development experiments is typically ...

Production of Full-Length, Biologically Active MEK1WT and MEK1CA

... E. coli are not very active because E. coli lacks MEK activators. Substitution of the two phosphoacceptors (Ser-218 and Ser-222) in MEK1 WT with glutamic acid, in combination with an internal deletion (from amino acid 32 to amino acid 51), produced a mutant MEK that is more active than wild type. 4-...
Glutamic in Biological Products

Anion Exchange ProteinChip Arrays from Ciphergen

Description:...teins directly on the chip. Anionic arrays bind proteins through electrostatic interaction of negatively charged amino acids such as aspartic acid and glutamic acid. Binding occurs at high pH with low salt and binding decreases as pH decreases and salt concentration increases. ProteinChip SAX2: is a strong an...
Company:Ciphergen
Glutamic in Biological Definition

Alpha helix

...nd which is a destabilizing influence. As a result, α helices are often capped at the N-terminal end by a negatively charged amino acid (like glutamic acid ) in order to stabilise the helix dipole. Less common (and less effective) is C-terminal capping with a positively charged protein like lysine ....

Amino acid

...example, this enforces tertiary structure. D Asp Aspartic acid acidic 133.10 2.85 1.99 9.90 3.90 E Glu glutamic acid acidic 147.13 3.15 2.10 9.47 4.07 F Phe Phenylalanine hydrophobic 165.19 5.49 2.20 9.31 ...

Genetic code

... GAU (Asp/D) Aspartic acid GAC (Asp/D) Aspartic acid GAA (Glu/E) glutamic acid GAG (Glu/E) glutamic acid GGU (Gly/G) Glycine GGC (Gly/G) Glycine GGA (Gly/G) Gl...

Diabetes mellitus

... There are several insulin application mechanisms under experimental development as of 2004. There have also been proposed vaccines for type I using glutamic acid decarboxylase (GAD), but these are currently not being tested by the pharmaceutical companies that have sublicensed the patents to them. For...

Genetic code

... GAU (Asp/D) Aspartic acid GAC (Asp/D) Aspartic acid GAA (Glu/E) glutamic acid GAG (Glu/E) glutamic acid GGU (Gly/G) Glycine GGC (Gly/G) Glycine GGA (Gly/G) Gl...

Isozyme

...ffer in other ways. In particular, amino acid substitutions that change the electric charge of the enzyme (such as replacing aspartic acid with glutamic acid ) are simple to identify by Gel electrophoresis , and this forms the basis for the use of isozymes as Molecular markers . To identify isozymes,...
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