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Glutamate in Medical News

Migraine prevention by targeting glutamate receptors?

When migraine strikes, because of severe pain, often accompanied by nausea and sensitivity to light and sound, sufferers are effectively disabled for up to 72 hours. Since they are forced to stop what they are doing until the pain and other symptoms subside, migraine causes a significant loss in p...

TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack

- Research Published in March Issue of Journal of Experimental Medicine - - Findings Underscore Versatility of TorreyPines' AMPA/Kainate Receptor Antagonists as Possible Antithrombotic Agents - LA JOLLA, Calif., May 1 /PRNewswire/ -- TorreyPines Therapeutics, Inc. (Nasdaq: TPTX ) ...

Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds

New approach for treatment of schizophrenia INDIANAPOLIS, Sept. 2 /PRNewswire-FirstCall/ -- An investigational, phase II study published in the scientific journal Nature Medicine demonstrates that for the first time in humans a drug that acts on certain proteins in the brain call...

Webinar on June 25 to Focus on Opportunity for Treating Chronic Pain, Migraine and Muscle Spasticity Through Inhibition of Neurotransmitter Glutamate

TorreyPines Therapeutics' CEO Neil Kurtz, M.D., to Moderate Discussion Following Presentations by Tony Yaksh, Ph.D.; Jerome Goldstein, M.D.; and Alan J. Tuchman, M.D. LA JOLLA, Calif., June 20 /PRNewswire/ -- A Webinar hosted by TorreyPines Therapeutics, Inc. (Nasdaq:...

Raptor Pharmaceuticals Corp. and TorreyPines Therapeutics, Inc. Announce Merger Agreement

... capable of treating a number of acute and chronic diseases and disorders such as migraine and chronic pain. The company currently has two ionotropic glutamate receptor antagonist clinical stage product candidates. Further information is available at www.tptxinc.com . FORWARD LOOKING...

TorreyPines Announces the Adjournment of Its Special Meeting of Stockholders

...h capable of treating a number of acute and chronic diseases and disorders such as migraine and chronic pain. The company currently has two ionotropic glutamate receptor antagonist clinical stage product candidates. Further information is available at www.tptxinc.com . This press release contains fo...

Variants of 'umami' taste receptor contribute to our individualized flavor worlds

...cially the amino acid L-glutamate. High levels of glutamate are present in many protein-rich foods, including ... taste. The subjects tasted five concentrations of glutamate and rated the umami intensity of each on a scale t...eceptor T1R1-T1R3. Comparing DNA structure to the glutamate taste responses of each individual, they found tha...

Animal model for schizophrenia identifies a novel approach for treating cognitive impairments

...ents associated with schizophrenia by enhancing N-methyl-D-aspartate (NMDA) glutamate receptors. Functional deficits in NMDA receptors may contribute to the und...h enhances the efficacy of D-serine in an animal model for deficits in NMDA glutamate receptor function. To put it more simply, although D-serine is used as a...

Wayne State University and Children's Hospital of Michigan Research Team Discover Chemical That Plays a Major Role in Pediatric Obsessive-Compulsive Disorder

... Rosenberg's study, children with OCD had abnormal glutamate levels in key brain regions which were reversible ...ent development studies all converged to show that glutamate has a key role in OCD," said Rosenberg. "If we thi...s analogous to light that lets us see in the dark, glutamate is the brain's light switch or brain modulator whi...

Glutamate Identified As Predictor of Disease Progression in Multiple Sclerosis

...rosis patients. The study is the first to measure glutamate toxicity in the brain over time and suggests an im...t of Radiology and Biomedical Imaging , to measure glutamate levels in clinical trial patients. The technique ...peutic drug development, the identification of the glutamate pathway for MS suggests a new way for clinicians t...
Glutamate in Medical Technology

TorreyPines Therapeutics to Host Webinar at 11 a.m. EDT Today on the Opportunity for Treating Chronic Pain, Migraine and Muscle Spasticity Through Inhibition of Neurotransmitter Glutamate

TorreyPines Therapeutics' CEO Neil Kurtz, M.D., to Moderate Discussion Following Presentations by Tony Yaksh, Ph.D.; Jerome Goldstein, M.D.; and Alan J. Tuchman, M.D. LA JOLLA, Calif., June 25 /PRNewswire/ -- A Webinar hosted by TorreyPines Therapeutics, Inc. (Nasdaq:...

ADHD Genes Found; Known to Play Roles in Neurodevelopment

...D. Another deletion occurred in a gene for a glutamate receptor. glutamate is a neurotransmitter, a protein that carries sign...this new finding may suggest an important role for glutamate as well, at least for some ADHD patients. "As...

TorreyPines Therapeutics Muscarinic Agonist NGX267 Meets Primary Endpoint in a Phase II Clinical Trial in Patients with Xerostomia

...pain, muscle spasticity and rigidity, xerostomia and cognitive disorders. The company is currently developing four product candidates, two ionotropic glutamate receptor antagonists and two muscarinic receptor agonists. Further information is available at www.torreypinestherapeutics.com . This pres...

New Data Highlight Positive Results of Namenda(R) (memantine HCl) Once-Daily Extended-Release Formulation

...ase inhibitors. About Namenda Namenda (memantine HCl) is the first in a class of medications with a unique mechanism of action that focuses on the glutamate pathway, a target for the treatment of Alzheimer's disease. Indicated for the treatment of moderate to severe Alzheimer's disease, the FDA approved Na...

Data Presented at American Headache Society's Annual Scientific Meeting Show Primary Endpoint Met as Well as Improvement on Important Secondary Endpoints in Phase IIb Acute Migraine Trial of TorreyPines Therapeutics' Tezampanel

...at two hours, the company's lead AMPA/kainate-type glutamate receptor antagonist, tezampanel, demonstrated impr...group. Tezampanel is the first AMPA/kainate-type glutamate receptor antagonist to be studied in clinical tria...mportant excitatory neurotransmitter. While normal glutamate production is essential, excess...

TorreyPines Therapeutics Initiates Clinical Trial to Evaluate Analgesic Effect of Oral Prodrug of Tezampanel

...esign. Tezampanel is the first AMPA/kainate-type glutamate receptor antagonist to be studied in clinical trials for chronic pain. glutamate receptors mediate the functioning of glutamate, an...mportant excitatory neurotransmitter. While normal glutamate production is essential, excess glutamate producti...

Eisai's Commitment to Oncology Demonstrated by Clinical Data to be Presented at ASCO Annual Meeting

... dose Melphalan Prior to Stem Cell Transplant Poster 46B GCP II Inhibitor glutamate Carboxypeptidase II May 31, 2008 Abstract No: 9558 Inhibition in Rat Models of 2:00-6:00 p.m. Chemotherapy-...

Multiple Dose Clinical Trial of TorreyPines Therapeutics' Tezampanel Demonstrates Compound is Safe and Well-Tolerated

...ty of persistent conditions in which activation of glutamate receptors initiates or sustains pathophysiological...mpanel and NGX426 are antagonists of a subgroup of glutamate receptors referred to as AMPA and kainate. These r.... For example, during a migraine attack, levels of glutamate increase and activate these receptors, facilitatin...

Novel Mechanism for Long-Term Learning Identified by Carnegie Mellon Researchers

...stimulation. They found that while the NMDA receptor is required to begin neural strengthening, a second neurotransmitter receptor -- the metabotropic glutamate (mGlu) receptor -- comes into play after this first phase of cellular learning. Using an NMDA antagonist to block NMDA receptors after the initiation ...

Pharmacokinetic Data Suggest NGX426, TorreyPines Therapeutics' Oral Prodrug of Tezampanel, May be Effective in Treating Acute Migraine Headache

... including migraine. Tezampanel and NGX426 are antagonists of a subgroup of glutamate receptors referred to as AMPA and kainate. These receptors are found in are...g the transmission of pain impulses. Tezampanel, by blocking the binding of glutamate to these receptors, is believed to inhibit the transmission of pain signals...
Glutamate in Medical Definition

Depolarization-induced suppression of inhibition

...se release is reduced. In the case of DSI, the result is a reduction in inhibitory GABA release, while in DSE the effect is a reduction in excitatory glutamate release. DSE was also found to occur in other regions of the brain, however the evidence for the involvement of the endocannabinoid receptor CB1 in t...
Glutamate in Biological News

Treating chronic pain, migraine & muscle spasticity through inhibition of neurotransmitter glutamate

LA JOLLA, CA, June 20, 2008 A Webinar hosted by TorreyPines Therapeutics, Inc. (NASDAQ: TPTX) at 11 a.m. EDT on June 25 will bring together industry experts to discuss the opportunity of treating chronic pain, migraine and muscle spasticity through the inhibition of the neurotransmitter glutamat...

Short stressful events may improve working memory

...ess increases transmission of the neurotransmitter glutamate and improves working memory. "Stress hormones ...n working memory, a cognitive process depending on glutamate receptor-mediated excitatory signals in prefrontal...cules that link acute stress to the enhancement of glutamate receptors and working memory. "In addition," no...

Protein identified as critical to insulating the body's wiring could also become treatment target

...nsmitter. In 2000, the researchers showed the pair also are at excitatory synapses, communication points between neurons where the neurotransmitter glutamate excites cells to action. Here, neuregulin-1 and ErbB4 suppress excitation. These findings have implications for conditions such as schizophrenia an...

Cell's split personality is a major discovery into neurological diseases

...tem (CNS). Diseases that occur as a result of high glutamate levels include hypoxicischemic brain injury (strok...ars, the main explanation for the toxic effects of glutamate is that it overexcites neuronal cells via activation of glutamate receptors and thereby kills them. "The most in...

Research uncovers promising target to treat chronic abdominal pain

... found that a high level of EAAT2 appears to force glutamate into cells, preventing it from interacting with re...out where these key interactions between EAAT2 and glutamate occur. glutamate is present throughout the body, but Stephens and c...

Rice University study finds possible clues to epilepsy, autism

...ett discovered an unanticipated connection between glutamate an amino acid and neurotransmitter in much of the...nclude neurofibromatosis, and that a mutation in a glutamate receptor gene common to both the fruit fly and hum...sm. Howlett found the Drosophila's metabotropic glutamate receptor (DmGluRA) gene, when mutated, increased t...

House Ear Institute, TGen and Belgian researchers identify gene in age-related hearing loss

..., which the research team believes may be associated with susceptibility to glutamate excitotoxicity and hearing loss. It is the overexpression of glutamate that causes damage to the inner and outer hair cells in the inner ear leadi...

Pitt research identifies new target in brain for treating schizophrenia

...oun, Moghaddam first established that dopamine and glutamate could, separately, produce schizophrenia-like symp...t Yale Universityhave shown that under-functioning glutamate receptors known as NMDA receptors can produce schi...opamineand new experimental drugs that work on the glutamate system. They found that both medications normalize...

Swamping bad cells with good in ALS animal models helps sustain breathing

...d in their ability to clear away the neurotransmitter glutamate. And excess glutamate - common in ALS - overstimulates the motor neurons that spark muscle moveme... Transplanting alternate GRPs - those that the team engineered to lack glutamate transporters - offered none of the protective properties. "Our findings ...

Astrocytes and synaptic plasticity

...t in neuronal transmission, have recently been implicated in long-term modulation of neuronal synapses. For example, they release the neurotransmitter glutamate into the synapse prompting LTP. By specifically mopping up pro-BDNF, astrocytes seem to have another means to assist in LTP. However, while it's likel...
Glutamate in Biological Technology

Preparative Nondenaturing Gel Electrophoresis to Purify NADP-Specific Glutamate Dehydrogenase From Chlorella, Rev B

Contributed by Philip W Miller, Waltraud I Dunn, and Robert R Schmidt, University of Florida, Dept. Microbiology and Cell Science, Gainesville, FL 32611 USA Florida Agricultural Experiment Station Serial Number T-00256 Introd...

SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2009 FINANCIAL RESULTS

...gram Updates: - Savory Enhancer Program: The primary applications of the Company's savory flavor ingredients are to reduce or replace monosodium glutamate (MSG) and to enhance the savory taste of foods by combining Senomyx's savory flavors with other ingredients to create unique new flavors. Nestle is c...

TorreyPines Cancels Special Meeting of Stockholders in Order to Pursue Merger Transaction

... capable of treating a number of acute and chronic diseases and disorders such as migraine and chronic pain. The company currently has two ionotropic glutamate receptor antagonist clinical stage product candidates. Further information is available at www.tptxinc.com . This press release contains...

TorreyPines Receives Notice of Delisting from Nasdaq Global Market

... capable of treating a number of acute and chronic diseases and disorders such as migraine and chronic pain. The company currently has two ionotropic glutamate receptor antagonist clinical stage product candidates. Further information is available at www.tptxinc.com . This press release contains...

TorreyPines Therapeutics Announces its Board of Directors' Approval of Plan of Liquidation and Dissolution

... capable of treating a number of acute and chronic diseases and disorders such as migraine and chronic pain. The company currently has two ionotropic glutamate receptor antagonist clinical stage product candidates. Further information is available at www.tptxinc.com . This press release contains...

SENOMYX ANNOUNCES FIRST QUARTER 2009 FINANCIAL RESULTS

...gram Updates: - Savory Enhancer Program: The primary applications of the Company's savory flavor ingredients are to reduce or replace monosodium glutamate (MSG) and to enhance the savory taste of foods by combining Senomyx's savory flavors with other ingredients to create unique new flavors. Nestle is c...

TorreyPines Therapeutics Reports First Quarter 2009 Financial Results

...disorders such as migraine, acute and chronic pain, and xerostomia. The company currently has three clinical stage product candidates: two ionotropic glutamate receptor antagonists and one muscarinic receptor agonist. Further information is available at www.tptxinc.com . This press release contains for...

TorreyPines Therapeutics Receives Notice of Non-Compliance with Nasdaq Continued Listing Requirements

... disorders such as migraine, acute and chronic pain, and xerostomia. The company currently has three clinical stage product candidates: two ionotropic glutamate receptor antagonists and one muscarinic receptor agonist. Further information is available at www.tptxinc.com . This press release contains f...

Stockholder Suits Related to TorreyPines Therapeutics, Inc. Dismissed

...eases and disorders such as migraine, chronic pain, and xerostomia. The company currently has three clinical stage product candidates: two ionotropic glutamate receptor antagonists and one muscarinic receptor agonist. Further information is available at www.tptxinc.com . This press release conta...

TorreyPines Therapeutics Reports Fourth Quarter and Full Year 2008 Results

...disorders such as migraine, acute and chronic pain, and xerostomia. The company currently has three clinical stage product candidates: two ionotropic glutamate receptor antagonists and one muscarinic receptor agonist. Further information is available at www.tptxinc.com . This press release conta...
Glutamate in Biological Products

Rabbit Anti-Rat Glutamate Receptor 5/1a Polyclonal Antibody, Unconjugated from Exalpha Biologicals, Inc.

Description: Glutamate Receptor 5/1a...
Company:Exalpha Biologicals, Inc.

Mouse Anti-Vesicular Glutamate Transporter 2 (VGLUT2) Antibody, Unconjugated from CHEMICON

Description: Vesicular Glutamate Transporter 2 [VGLUT2]...
Company:CHEMICON

Rabbit Anti-Glutamate receptor 1, phospho (Ser845) Polyclonal Antibody, Unconjugated from GeneTex

Description:... Polyclonal Phosphorylated Anti-GluR1 glutamate is the main excitatory neurotransmitter in the bra...e fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing secon...-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptor...
Company:GeneTex

Rabbit Anti-GluR4 Antibody, Unconjugated from Lab Vision

Description:... glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subu...
Company:Lab Vision

Mouse Anti-Human GRID2 Polyclonal Antibody, Unconjugated from Novus Biologicals

Description:... Mouse polyclonal antibody to GRID2 - glutamate receptor, ionotropic, delta 2...
Company:Novus Biologicals
Glutamate in Biological Definition

Amino acid

...important amino acids, such as the neurotransmitters glycine , GABA and glutamate , as well as carnitine (used in lipid transport within a cell ), orni... - 141 Uses of substances derived from amino acids Monosodium glutamate is a food additive to enhance flavor. L-DOPA (L-dihydroxyphenylalanin...

Genetic code

...wever, the genetic code is not perfect as minor changes such as the single-base substitution in sickle cell anaemia is disasterous. The hydrophilic glutamate (Glu) is substituted by the hydrophobic valine (Val) which reduces the solubility of -globin. This causes haemoglobin to form linear polymers linke...

Enzyme

...ydrofolate reductase : reduces dihydrofolic acid to tetrahydrofolic acid DNA gyrase : catalyzes the negative supercoiling of prokaryotic DNA glutamate decarboxylase : synthesizes the neurotransmitter GABA in the brain Glutathione peroxidase : protects cells by converting hydrogen peroxide to w...

Genetic code

...wever, the genetic code is not perfect as minor changes such as the single-base substitution in sickle cell anaemia is disasterous. The hydrophilic glutamate (Glu) is substituted by the hydrophobic valine (Val) which reduces the solubility of -globin. This causes haemoglobin to form linear polymers linke...

Ion channel

...cells. Certain channels respond to multiple influences. For instance, the NMDA receptor is partially activated by interaction with its ligand, glutamate , but is also voltage-sensitive and only conducts when the membrane is depolarized. Some calcium-sensitive potassium channels respond to both calcium ...

Mitochondrion

...ials into cellular energy in the form of ATP , mitochondria play an important role in many important metabolic tasks, such as: Apoptosis glutamate -mediated excitotoxic neuronal injury Cellular proliferation Regulation of the cellular redox state Heme synthesis Steroid synthes...

Mitochondrion

...ials into cellular energy in the form of ATP , mitochondria play an important role in many important metabolic tasks, such as: Apoptosis glutamate -mediated excitotoxic neuronal injury Cellular proliferation Regulation of the cellular redox state Heme synthesis Steroid synthes...

Neurotransmitter

... from several synapses is usually required to trigger an action potential. glutamate is the most prominent of excitatory transmitters; GABA and glycine are... Common neurotransmitters Derived from amino acids : aspartate glutamate GABA glycine Monoamines (in the order of their synthesis...
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