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Glucocorticoids in Medical News

Harmful Effects Of Glucocorticoids On Newborns Owing To Prenatal Exposure

It has been found by the scientists from the University of Edinburgh in UK that when nonhuman primate African vervet monkeys (Chloroceus aethiops) //in their prenatal stage were exposed to glucocorticoids it had a life long destabilizing effect on cardiovascular, metabolic, and neuroendocrine funct...

Nicotine May Help Spur 'Prediabetes'

...e heart disease seen in smokers," said Friedman. "We anticipate that in the future there will be drugs to specifically block the effect of nicotine on glucocorticoids [such as cortisol] and insulin resistance." More information There's more on prediabetes at the glucocorticoids for one condition or another, Saag said, and many ... with drug-caused osteoporosis who had been taking glucocorticoids for at least three months. Half were assigned to t...

Blood pressure drug curbs brain damage from PTSD

... Center researchers have found. Elevated levels of glucocorticoids are associated with atrophy in nerve branches wher...response in the brain that triggers the release of glucocorticoids in the brain, and that high levels of glucocorticoids in blood serum are associated with such psychiatri...

Glucocorticoid in ‘bad Light’ During Fertility Treatmet

...ings by Dutch researchers suggest that the hormone glucocorticoids may not be as beneficial as it is thought to be//....tments in women. The steroid hormones called glucocorticoids are employed by many specialists to treat infertil...etween success rates of expectant mothers who took glucocorticoids to aid embryo implantation and those who did not. ...
Glucocorticoids in Medical Technology

Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids

- Glucocorticoids, commonly known as steroids, widely used to treat inflammatory conditions but can increase the risk of osteoporotic fractures with up to 50% of patients on long-term therapy at risk(1,2) - Study of more than 800 men and women shows higher bone mineral density with Rec...

Study Reveals Potential for NT-proBNP as a Marker to Predict Cardiovascular Risks From Anti-Inflammatory Drugs

...The risk for CV-AE in patients with NT-proBNP values .100 ng/L was 1.95-fold higher (p<0.05) for patients treated with any of the inhibitors (tNSAIDs, glucocorticoids or coxibs), 7.41-fold higher (p<0.01) for patients treated with coxibs (alone or in addition to tNSAIDs or glucocorticoids), and 3.74-fold higher (p<0...

Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting

...this cancer, is rendered ineffective by the use of glucocorticoids to control inflammation of the brain due to the tu...he brain-swelling caused by the tumor and surgery. glucocorticoids inactivate or kill the T-cells through a protein k... T-cells allows them to be used in the presence of glucocorticoids and to be developed as an "off the shelf" or allog...

FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis

...leading to bone loss and an increased risk for fracture. Data indicate that glucocorticoids are used by up to three out of every 100 adults (3 percent) over age 50,(3)...ic glucocorticoid therapy will eventually have an osteoporotic fracture.(4) glucocorticoids are prescribed to treat many conditions, including rheumatoid arthritis, ch...

Additional Data on CombinatoRx Drug Candidates CRx-102 and CRx-139 Presented at EULAR

... Infirmary in the UK and principal investigator in the CRx-102 phase 2a rheumatoid arthritis (RA) trial, gave a talk entitled "A Therapy Rejuvenation: glucocorticoids in Arthritis". Additional analysis from the trial indicated that CRx-102 treated patients experienced significantly less fatigue than those on placebo...
Glucocorticoids in Medical Products

ACTH RIA Test

Description:... catecholamines and cytokines, may also play an important role in ACTH secretion. Both CRF and ACTH production and secretion are directly inhibited by glucocorticoids [1,2]. ACTH stimulates adrenal steroidogenesis, mainly cortisol production, but also aldosterone and adrenal androgen synthesis. Decreased ACTH secret...
Company:Diagnostic Systems Laboratories, Inc.
Glucocorticoids in Biological News

Stress puts double whammy on reproductive system, fertility

...now that stress boosts levels of stress hormones - glucocorticoids such as cortisol - that inhibit the body's main se...stress effect on sexual function to an increase in glucocorticoids - stress hormones - produced by the adrenal gland. In the brain, these glucocorticoids suppress the main reproductive hormone, GnRH, whic...

Small protein may have big role in making more bone and less fat

... "The bones of elderly people or those who take glucocorticoids are yellow inside instead of red," he says. And it...hma, infections and organ transplants. Ironically, glucocorticoids also induce a short burst of GILZ. GILZ, in turn, ...point of controversy is that, at least in the lab, glucocorticoids seem to enhance bone formation. But Dr. Shi believ...

Research with squirrels provides clues on hormone's role in human learning

...women at risk of pre-term birth deliver healthy babies, doctors sometimes treat them with synthetic glucocorticoids, which raise cortisol levels. The glucocorticoids facilitate fetal lung development. We know almost nothing about the neurobiological implications of these treatments on cognitive development of ...

Researchers find docking sites for glucocorticoid receptor and Hsp90

...her in the Institute of Molecular Biology at the University of Oregon. glucocorticoids are naturally produced by the adrenal glands and are important for a variet...epending on the cells involved. The treatments are extremely effective, and glucocorticoids have been used in huge amounts in the last 40 years. Unfortunately, they ar...

Scientists use gene signatures to match cancer and other diseases with potentially effective drugs

...ls are resistant to the drugs, which often can lead to fatal results. "We took cells from ALL patients that were either resistant or sensitive to glucocorticoids and put them through the Connectivity Map database, and it predicted that one of the best drugs would be rapamycin," said Armstrong, who is also an as...

Tamoxifen-like drug suggests new ways to selectively block estrogen

...orts of small molecules that mimic the actions of various hormones," Greene said. "We could create designer androgens for prostate cancer, or designer glucocorticoids to treat inflammation." Since "the primary regulator of cofactor recruitment is receptor conformation," added study co-author Donald McDonnell of D...
Glucocorticoids in Biological Technology

FDA Approves Additional Indication for Norditropin(R) for Small for Gestational Age (SGA) in Children

...closporine), or oral estrogen replacement. Adult height can be influenced if you are on Norditropin(R) for growth failure and at the same time using glucocorticoids or thyroid hormone. If you are treated with insulin and/or oral diabetes medicines, the dose of your insulin/oral diabetes medicines may need to be ...

Performance of Ad-A-Gene EGFP-Glucocorticoid Receptor (EGFP-GCCR): an adenoviral vector gene delivery system

...ing on the glucocorticoid receptor (GCCR), which is a member of the steroid receptor superfamily. GCCR resides predominantly in the cytoplasm and when glucocorticoids bind to a defined ligand-binding site, the ligand-occupied GCCR translocates to the nucleus.

Translocation of GCCR was monitored by analyzin...

Glucocorticoids in Biological Definition

Diabetes mellitus

...inherited forms of neonatal hyperinsulinism and many others. Risk of diabetes is higher with chronic use of several medications, including high dose glucocorticoids , some chemotherapy agents (especially L-asparaginase), and some of the antipsychotics and mood stabilizers (especially phenothiazines and some a...

Hormone

...etin somatostatin thrombopoietin thyroid-stimulating hormone (TSH) thyrotropin-releasing hormone (TRH) Steroid hormones : glucocorticoids cortisol Mineralocorticoids aldosterone Sex steroids Androgens testosterone dehydroepiandrosterone (DHEA) dehydro...

Muscle

...ism") is an inflammatory condition that mainly occurs in the elderly; it is associated with giant-cell arteritis . It often responds dramatically to glucocorticoids (e.g. prednisolone ). Polymyositis , dermatomyositis and inclusion-body myositis are autoimmune conditions in which the muscle is affected....
Glucocorticoids in Biological Dictionary

Corticosteroids

...rticosteroids ... The indications for use, side effects, dose, contraindications, drug or food interactions, toxicity, and signs of an overdose of glucocorticoids ( corticosteroids ) What are corticosteroids ? Author: Nancy Ross-Flanigan. From The Gale Encyclopedia of Medicine. Definition and examples of the...
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