Glucocorticoids in Medical Technology
Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids
- Glucocorticoids, commonly known as steroids, widely used to treat
inflammatory conditions but can increase the risk of osteoporotic fractures with up to 50% of patients on long-term therapy at risk(1,2)
- Study of more than 800 men and women shows higher bone mineral density with Rec...
Study Reveals Potential for NT-proBNP as a Marker to Predict Cardiovascular Risks From Anti-Inflammatory Drugs
...The risk for CV-AE in patients with NT-proBNP
values .100 ng/L was 1.95-fold higher (p<0.05) for patients treated with
any of the inhibitors (tNSAIDs, glucocorticoids
or coxibs), 7.41-fold
higher (p<0.01) for patients treated with coxibs (alone or in addition to
tNSAIDs or glucocorticoids), and 3.74-fold higher (p<0...
Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting
is rendered ineffective by the use of glucocorticoids
inflammation of the brain due to the tu...he brain-swelling caused by the tumor and
inactivate or kill the T-cells through a protein
k... T-cells allows them to be
used in the presence of glucocorticoids
and to be developed as an "off the
shelf" or allog...
FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis
...leading to bone loss and an increased risk for fracture.
Data indicate that glucocorticoids
are used by up to three out of every 100
adults (3 percent) over age 50,(3)...ic glucocorticoid therapy will eventually have an osteoporotic
are prescribed to treat many conditions,
including rheumatoid arthritis, ch...
Additional Data on CombinatoRx Drug Candidates CRx-102 and CRx-139
Presented at EULAR
... Infirmary in the UK and principal investigator in the
CRx-102 phase 2a rheumatoid arthritis (RA) trial, gave a talk
entitled "A Therapy Rejuvenation: glucocorticoids
Additional analysis from the trial indicated that CRx-102 treated
patients experienced significantly less fatigue than those on
Glucocorticoids in Medical Products
ACTH RIA Test
Description:... catecholamines and cytokines, may also play an important role in ACTH secretion. Both CRF and ACTH production and secretion are directly inhibited by glucocorticoids
[1,2]. ACTH stimulates adrenal steroidogenesis, mainly cortisol production, but also aldosterone and adrenal androgen synthesis. Decreased ACTH secret...
Company:Diagnostic Systems Laboratories, Inc.
Glucocorticoids in Biological News
Stress puts double whammy on reproductive system, fertility
...now that stress boosts levels of stress hormones - glucocorticoids
such as cortisol - that inhibit the body's main se...stress effect on sexual function to an increase in glucocorticoids
- stress hormones - produced by the adrenal gland. In the brain, these glucocorticoids
suppress the main reproductive hormone, GnRH, whic...
Small protein may have big role in making more bone and less fat
"The bones of elderly people or those who take glucocorticoids
are yellow inside instead of red," he says. And it...hma, infections and organ transplants. Ironically, glucocorticoids
also induce a short burst of GILZ. GILZ, in turn, ...point of controversy is that, at least in the lab, glucocorticoids
seem to enhance bone formation. But Dr. Shi believ...
Research with squirrels provides clues on hormone's role in human learning
...women at risk of pre-term birth deliver healthy babies, doctors sometimes treat them with synthetic glucocorticoids, which raise cortisol levels. The glucocorticoids
facilitate fetal lung development.
We know almost nothing about the neurobiological implications of these treatments on cognitive development of ...
Researchers find docking sites for glucocorticoid receptor and Hsp90
...her in the Institute of Molecular Biology at the University of Oregon.
are naturally produced by the adrenal glands and are important for a variet...epending on the cells involved. The treatments are extremely effective, and glucocorticoids
have been used in huge amounts in the last 40 years. Unfortunately, they ar...
Scientists use gene signatures to match cancer and other diseases with potentially effective drugs
...ls are resistant to the drugs, which often can lead to fatal results.
"We took cells from ALL patients that were either resistant or sensitive to glucocorticoids
and put them through the Connectivity Map database, and it predicted that one of the best drugs would be rapamycin," said Armstrong, who is also an as...
Tamoxifen-like drug suggests new ways to selectively block estrogen
...orts of small molecules that mimic the actions of various hormones," Greene said. "We could create designer androgens for prostate cancer, or designer glucocorticoids
to treat inflammation."
Since "the primary regulator of cofactor recruitment is receptor conformation," added study co-author Donald McDonnell of D...
Glucocorticoids in Biological Technology
Glucocorticoids in Biological Definition
...inherited forms of neonatal hyperinsulinism and many others. Risk of diabetes is higher with chronic use of several medications, including high dose glucocorticoids
, some chemotherapy agents (especially L-asparaginase), and some of the antipsychotics and mood stabilizers (especially phenothiazines and some a...
thyroid-stimulating hormone (TSH)
thyrotropin-releasing hormone (TRH)
Steroid hormones :
...ism") is an inflammatory condition that mainly occurs in the elderly; it is associated with giant-cell arteritis . It often responds dramatically to glucocorticoids
(e.g. prednisolone ).
Polymyositis , dermatomyositis and inclusion-body myositis are autoimmune conditions in which the muscle is affected....
Glucocorticoids in Biological Dictionary
...rticosteroids ... The indications for use, side effects, dose, contraindications, drug or food interactions, toxicity, and signs of an overdose of glucocorticoids
( corticosteroids ) What are corticosteroids ? Author: Nancy Ross-Flanigan. From The Gale Encyclopedia of Medicine. Definition and examples of the...