Blocking Glucocorticoid Prevents Stress-Induced Skin Abnormalities
Inhibiting glucocorticoid, a type of steroid, can prevent skin abnormalities induced by psychological stress, according to a new study from the December //issue of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. The new study also shows how psychological stres...
FDA Approves Expanded Use of Lilly's FORTEO(R) [teriparatide (rDNA origin) injection] to Treat Glucocorticoid-Induced Osteoporosis
...t osteoporosis associated with sustained, systemic glucocorticoid
therapy in men and women at high risk of fracture. glucocorticoid
therapy is the most common cause of secondary oste...racture.(1)
"Patients who take long-term glucocorticoid
therapy are already dealing with a serious health ...
Nicotine May Help Spur 'Prediabetes'
...he mice with the nicotine-agonist drug mecamylamine blocked this process somewhat, the researchers noted.
"Our results suggest that reducing tissue glucocorticoid
levels or decreasing insulin resistance may reduce the heart disease seen in smokers," said Friedman. "We anticipate that in the future there will be ...
Once-a-Year Drug Helps Counter Steroid-Linked Bone Loss
...f and/or reverse bone loss among patients taking a glucocorticoid
medication (including prednisolone or prednisone) ...ing the risk of bone fracture that can result from glucocorticoid
The new study was funded by Novartis, whi....
"The important point is that people who take glucocorticoid
steroids for asthma or arthritis are all in danger...
Drugs to Treat Lung Damage in Preemies May Harm Brain
MONDAY, Nov. 17 (HealthDay News) -- glucocorticoid
drugs used to treat chronic lung damage in prematu...chiatry, said in the news release.
If synthetic glucocorticoid
drugs can be replaced with hormones made naturally...emy of Pediatrics recommended a halt to post-natal glucocorticoid
use unless used in clinical trials. However, it's ...
Do antidepressants enhance immune function?
...ective serotonin reuptake inhibitor (SSRI), a substance P antagonist, and a glucocorticoid
antagonist, on their NK cell activity. These drugs were selected because, ... the SSRI citalopram, and the substance P antagonist CP 96,345, but not the glucocorticoid
receptor antagonist RU486, increased NK cell activity. According to Dr. Dw...
FORSTEO(R) Receives Approval from the European Commission for the Treatment of Glucocorticoid-Induced Osteoporosis
...at increased risk for
fracture in 2007.
therapy is the most common cause of secondary
oste... GIOP, is bone loss associated
with chronic use of glucocorticoid
medications. These medications are often
"Up to 50 percent of individuals on chronic glucocorticoid
develop bone loss leading to an osteo...
Isis Reports Financial Results and Highlights for Fiscal year 2007
...ucagon receptor, GCGR. * Isis identified a development candidate, ISIS 377131, an antisense drug also partnered with OMI that targets the glucocorticoid
receptor, GCCR. * Isis added ISIS 388626 to its development pipeline. ISIS 388626 targets SGLT2, a protein that is responsible for glucose re...
Stress hormone impacts memory, learning in diabetic rodents
...e healthy functioning of the hippocampus, the region of the brain responsible for learning and short-term memory. Moreover, when levels of the adrenal glucocorticoid
hormone corticosterone (also known as cortisol in humans) are returned to normal, the hippocampus recovers its ability to build new cells and regains ...
JCI online early table of contents: Jan. 10 2008
...uals often benefit from a combination treatment of glucocorticoid
and UDCA, although the mechanisms underlying how e...man liver cells with a combination of UDCA and the glucocorticoid
dexamethasone, but not with either treatment alone...n of AE2b1 and AE2b2 expression by promoting HNF1, glucocorticoid
receptor, and p300 binding to the AE2 alternate pr...
Glucocorticoid in Medical Technology
Glucocorticoid in Medical Products
Cortisol RIA Test
Description:... Cortisol is the most potent glucocorticoid
produced by the human adrenal cortex. In plasma, most cortisol is bound with high affinity to corticosteroid-binding globulin (CBG), with the remainde...
Company:Diagnostic Systems Laboratories, Inc.
Cortisol EIA Kit
Description:... Cortisol is a glucocorticoid
produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is secreted with a circadian periodicity, and peaks just prior to...
Glucocorticoid in Medical Dictionary
... Cortisol is a corticosteroid hormone or glucocorticoid
produced by the adrenal cortex, that is part of the adrenal gland . It is usually referred to as the "stress hormone" as it is involved in...
Glucocorticoid in Biological News
Researchers find docking sites for glucocorticoid receptor and Hsp90
University of Oregon researchers have identified protein interactions that regulate the response of cells to steroid hormones. The discovery, they say, could lead to new ways to boost the effectiveness and reduce undesired side effects of steroid-hormone treatments and cancer drugs.
The study, ...
LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease
...a treatment; however, while the majority of patients with asthma respond to glucocorticoid
treatment there are a number of patients who do not," says Dr. Cormier. "In cells, a protein called cofilin-1 appears to inhibit glucocorticoid
function. We are currently testing whether cofilin-1 also does this in the ...
DuoCort: New chronotherapy for adrenal insufficiency
...y. The likely cause is the highly un-physiological glucocorticoid
replacement delivered by even the best therapy ava...is a drug development company focused on improving glucocorticoid
therapy in several areas of medical need. The comp...rsity in Sweden. DuoCort is developing an improved glucocorticoid
replacement therapy for patients with adrenal insu...
Stress puts double whammy on reproductive system, fertility
...rmone, a so-called RFamide-related peptide (RFRP), puts the brakes on reproduction by directly inhibiting GnRH.
The common thread appears to be the glucocorticoid
stress hormones, which not only suppress GnRH but boost the suppressor GnIH - a double whammy for the reproductive system.
"We know stress affects ...
Execretion analysis aids primate social studies
...ion for the Advancement of Sciences' 2009 Annual Meeting, to be held in Chicago.
For instance, she said, by finding evidence for elevated levels of glucocorticoid
stress hormone in the feces of female baboons that had lost a close female companion, researchers deduced that those animals were grieving. "Those sho...
Cortisol and fatty liver: Researchers find cause of severe metabolic disorders
...y to deposit fat in the liver. However, scientists knew that the body's own glucocorticoid
hormones such as cortisol promote the development of fatty liver. This can ...KFZ), and his team have now published the mechanism by which the body's own glucocorticoid
hormones contribute to this disruption of the lipid metabolism.
Scientists retrace evolution with first atomic structure of an ancient protein
...ncient structure to produce a new function that is crucial to our own bodies today. Nobody's ever done that before."
The researchers focused on the glucocorticoid
receptor (GR), a protein in humans and other vertebrates that allows cells to respond to the hormone cortisol, which regulates the body's stress respo...
Structure of 450 million year old protein reveals evolution's steps
... the structure in place, Ortlund and his colleagues retraced evolutions path.
The researchers examined the precursor to a modern protein known as a glucocorticoid
receptor. In humans, the receptor plays a crucial role, responding to the hormone cortisol and regulating the bodys stress response. The two receptor...
Researcher gives hard thoughts on soft inheritance
...rly grooming and nurturing of rat pups by rat moms affects methylation of a glucocorticoid
receptor gene in the hippocampus in the brain. If the pups get lots of nurturing the glucocorticoid
gene gets turned on and expressed early at a critical period, providing pup...
HIV accessory protein disables host immunity via receptor-protein intermediary
...ne, and colleagues reported that Vpr corrupted the glucocorticoid
receptor (GR) pathway of the host cell. Vpr helps ...oteins. Weiner's group found that Vpr binds to the glucocorticoid
receptor, but it remained unclear whether the GR p...go that no one had asked the real question: Is the glucocorticoid
receptor necessary for Vpr's effects on the host c...
Glucocorticoid in Biological Technology
DOR BioPharma Announces Publication of orBec(R) Clinical Pulmonary Data in Bone Marrow Transplantation
... "This finding has important implications for an alternative method for treatment of pulmonary inflammatory disease, that is, the delivery of a potent glucocorticoid
to the pulmonary circulation after ingestion of an oral pro-drug (BDP). Clinical trials examining this novel pulmonary delivery system in patients wit...
FDA Approves Additional Indication for Norditropin(R) for Small for Gestational Age (SGA) in Children
...re breastfeeding; or if you have had a kidney transplant.
Be sure to tell your doctor about all medications you are taking
especially if they are: a glucocorticoid
medication such as hydrocortisone
or cortisone acetate, thyroid hormone, insulin and/or oral diabetes
medicines, drugs metabolized by the liver (for e...
Sangamo BioSciences Announces Presentation of Phase 1 Data of ZFP Therapeutic at International Society for Cellular Therapy (ISCT) Meeting
...rams in glioblastoma and HIV/AIDS.
-- Sunday, May 18: Oral Session: Immunotherapy and Dendritic Cells; "Zinc Finger Nucleases Targeting the glucocorticoid
Receptor Allow IL-13 Zetakine Transgenic CTLs to Kill Glioblastoma Cells in vivo in the Presence of Immunosuppressing Glucocorticoids" Phili...
Lilly Reports Solid First-Quarter Results
...on. -- The European Commission approved a new indication for Forsteo(R) for the treatment of osteoporosis associated with sustained, systemic glucocorticoid
therapy in women and men at increased risk for fracture. The company has also received an approvable letter from the FDA for Forteo for the sa...
DuoCort Hosts Adrenal Insufficiency Symposium at the 10th European Congress of Endocrinology in Berlin
...apy for adrenal insufficiency, including choice of glucocorticoid
and dosing, outcomes from current therapy, and ways to improve glucocorticoid
DuoCort is developing... insufficiency patients taking currently available glucocorticoid
replacement therapy demonstrates reduced bone dens...
Isis Enters Broad Collaboration With Ortho-McNeil, Inc. for the Discovery, Development and Commercialization of Antisense Drugs to Treat Metabolic Diseases
...t targeting glucagon receptor and glucocorticoid
- Includes research collaboration to id...c. and J&JPRD to
advance our glucagon receptor and glucocorticoid
receptor drugs through the
clinic and to develop a...ction,
thereby enhancing insulin secretion. About glucocorticoid
receptor (GCCR), target of ISIS 377131 ...
Performance of Ad-A-Gene EGFP-Glucocorticoid Receptor (EGFP-GCCR): an adenoviral vector gene delivery system
...ication note presents data from an EGFP translocation assay focusing on the glucocorticoid
receptor (GCCR), which is a member of the steroid receptor superfamily. GCC...CR adenoviral vector
Figure 5 shows agonist responses for a range of glucocorticoid
compounds and other steroid analogues. The data show differential potency o...
Detection of antibody-stained cell
surface and intracellular protein targets
with the Agilent 2100 bioanalyzer
...the 2100 bioanalyzer data
with that obtained from the conventional
c) Intracellular glucocorticoid
(GR) staining of H4 hepatocytes
For intracellular detection of GR
proteins H4 rat hepatocy...
Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in
Three amino acids in the EcR DNA-binding domain (DBD) were mutated to
change its DNA-binding specificity to that for the glucocorticoid
(GR). 3 The GR-EcR (GEcR) fusion protein retains the ability
to dimerize with RXR and trans-activate in a ponA-depende...
Glucocorticoid in Biological Products
PolarScreen Glucocorticoid Receptor Competitor Assay Kit, Far Red from Molecular Probes (Invitrogen)
Description: PolarScreen Glucocorticoid
Receptor (GR) Competitor Assay Kits are ideal for studying or screening novel GR binding compounds. The PolarScreen GR Competitor Assay Kits contain partially purified GR protein, stabilizing peptide, buffer, and one of the following proprietary fluorescent glucocorticoid...
Company:Molecular Probes (Invitrogen)
Rat Anti-Vitamin D Receptor Monoclonal Antibody, Unconjugated, Clone 9A7 from ABR-Affinity BioReagents
Description:...s vitamin D receptor (VDR) from human, rat, mouse, hamster, chicken, amphibian, and fish tissues. This antibody does not cross-react with estrogen or glucocorticoid
receptors. MA1-710 detects both the occupied and unoccupied forms of the receptor.
MA1-710 has been successfully used in Western blot, immunocyt...
Glucocorticoid in Biological Definition
... may be different from responses to naturally occurring amounts and may be therapeutically useful. An example is the ability of pharmacologic doses of glucocorticoid
to suppress inflammation.
Important human hormones
Amine-derived hormones :
adrenaline (or epinephrine)
Glucocorticoid in Biological Dictionary
... cellular components necessary ... Reticulocyte Lysate System. TNT® T7/T3 Coupled Reticulocyte Lysate System ... Cell-free synthesis of rat glucocorticoid
receptor in rabbit reticulocyte lysate . ... synthesized the receptor in a reticulocyte lysate that has been depleted of ... ... tRNAf d...
...volved in a wide range of physiologic systems such as stress response, immune response and regulation of... Binding of corticosteroids to the glucocorticoid
receptor (GR) stimulates ... Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor ... Corticosteroids - Non-Steroidal A...