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Glucocorticoid in Medical News

Blocking Glucocorticoid Prevents Stress-Induced Skin Abnormalities

Inhibiting glucocorticoid, a type of steroid, can prevent skin abnormalities induced by psychological stress, according to a new study from the December //issue of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. The new study also shows how psychological stres...

FDA Approves Expanded Use of Lilly's FORTEO(R) [teriparatide (rDNA origin) injection] to Treat Glucocorticoid-Induced Osteoporosis

...t osteoporosis associated with sustained, systemic glucocorticoid therapy in men and women at high risk of fracture. glucocorticoid therapy is the most common cause of secondary oste...racture.(1) "Patients who take long-term glucocorticoid therapy are already dealing with a serious health ...

Nicotine May Help Spur 'Prediabetes'

...he mice with the nicotine-agonist drug mecamylamine blocked this process somewhat, the researchers noted. "Our results suggest that reducing tissue glucocorticoid levels or decreasing insulin resistance may reduce the heart disease seen in smokers," said Friedman. "We anticipate that in the future there will be ...

Once-a-Year Drug Helps Counter Steroid-Linked Bone Loss

...f and/or reverse bone loss among patients taking a glucocorticoid medication (including prednisolone or prednisone) ...ing the risk of bone fracture that can result from glucocorticoid use. The new study was funded by Novartis, whi.... "The important point is that people who take glucocorticoid steroids for asthma or arthritis are all in danger...

Drugs to Treat Lung Damage in Preemies May Harm Brain

...ce MONDAY, Nov. 17 (HealthDay News) -- glucocorticoid drugs used to treat chronic lung damage in prematu...chiatry, said in the news release. If synthetic glucocorticoid drugs can be replaced with hormones made naturally...emy of Pediatrics recommended a halt to post-natal glucocorticoid use unless used in clinical trials. However, it's ...

Do antidepressants enhance immune function?

...ective serotonin reuptake inhibitor (SSRI), a substance P antagonist, and a glucocorticoid antagonist, on their NK cell activity. These drugs were selected because, ... the SSRI citalopram, and the substance P antagonist CP 96,345, but not the glucocorticoid receptor antagonist RU486, increased NK cell activity. According to Dr. Dw...

FORSTEO(R) Receives Approval from the European Commission for the Treatment of Glucocorticoid-Induced Osteoporosis

...at increased risk for fracture in 2007. "Chronic glucocorticoid therapy is the most common cause of secondary oste... GIOP, is bone loss associated with chronic use of glucocorticoid medications. These medications are often prescribe... (1) "Up to 50 percent of individuals on chronic glucocorticoid therapy will develop bone loss leading to an osteo...

Isis Reports Financial Results and Highlights for Fiscal year 2007

...ucagon receptor, GCGR. * Isis identified a development candidate, ISIS 377131, an antisense drug also partnered with OMI that targets the glucocorticoid receptor, GCCR. * Isis added ISIS 388626 to its development pipeline. ISIS 388626 targets SGLT2, a protein that is responsible for glucose re...

Stress hormone impacts memory, learning in diabetic rodents

...e healthy functioning of the hippocampus, the region of the brain responsible for learning and short-term memory. Moreover, when levels of the adrenal glucocorticoid hormone corticosterone (also known as cortisol in humans) are returned to normal, the hippocampus recovers its ability to build new cells and regains ...

JCI online early table of contents: Jan. 10 2008

...uals often benefit from a combination treatment of glucocorticoid and UDCA, although the mechanisms underlying how e...man liver cells with a combination of UDCA and the glucocorticoid dexamethasone, but not with either treatment alone...n of AE2b1 and AE2b2 expression by promoting HNF1, glucocorticoid receptor, and p300 binding to the AE2 alternate pr...
Glucocorticoid in Medical Technology

Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting

... treatment of GBM. The ZFN(TM)-modification of the glucocorticoid receptor (GR) in our engineered T-cells protects t...or kill the T-cells through a protein known as the glucocorticoid receptor (GR), limiting the benefit of this novel ...able of killing tumor cells in the presence of the glucocorticoid dexamethasone. About Gliomas Gliomas are the m...

Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids

... medications are widely used to treat inflammatory conditions but can cause bone loss and osteoporosis(1). Up to 50% of patients receiving long-term glucocorticoid therapy are at increased risk of fracture due to osteoporosis(2). Glucocorticoid-induced osteoporosis (GIO) is the most prevalent form of "secondary o...

Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines

...M). We are developing potential treatments for HIV/AIDS by knocking-out the CCR5 gene in T-cells and for brain cancer (glioblastoma) by disrupting the glucocorticoid receptor (GR) in engineered killer T-cells. We expect to file Investigative New Drug Applications (INDs) for both of these programs to enter the clini...

FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis

...s of treatment (p < 0.001 at all time points).(1) glucocorticoid therapy is the most common cause of secondary oste...(3) and up to 50 percent of individuals on chronic glucocorticoid therapy will eventually have an osteoporotic fract...n treatment choices for patients receiving chronic glucocorticoid medication who are at high risk for fractures," sa...

Norditropin(R) Approved for Treatment of Children with Short Stature Associated with Turner Syndrome

...ly undiagnosed central (secondary) hypoadrenalism may be unmasked requiring glucocorticoid replacement therapy. In addition, patients treated with glucocorticoid replacement therapy especially with cortisone acetate and prednisone for pr...

Norditropin(R) Approved for Treatment of Children with Short Stature Associated with Turner Syndrome

...ly undiagnosed central (secondary) hypoadrenalism may be unmasked requiring glucocorticoid replacement therapy. In addition, patients treated with glucocorticoid replacement therapy especially with cortisone acetate and prednisone for pr...

CombinatoRx Provides Topline Results from Phase 2 RA Study with CRx-139 and Very Low Dose Prednisolone

...2 CRx-102 is an oral synergistic combination drug candidate containing the cardiovascular agent dipyridamole and an unconventionally low dose of the glucocorticoid steroid prednisolone. CRx-102 works through a novel mechanism of action in which dipyridamole selectively amplifies prednisolone's anti-inflammatory a...

DuoCort AB: DuoCort announces Phase I Data Presentation at the European Congress of Endocrinology

...he body's natural cortisol serum profile. About adrenal insufficiency Recent research on adrenal insufficiency patients taking currently available glucocorticoid replacement therapy demonstrates reduced bone density and unfavourable cardiovascular risk profiles. Recent data also suggest an almost 3-fold increas...
Glucocorticoid in Medical Products

Cortisol RIA Test

Description:... Cortisol is the most potent glucocorticoid produced by the human adrenal cortex. In plasma, most cortisol is bound with high affinity to corticosteroid-binding globulin (CBG), with the remainde...
Company:Diagnostic Systems Laboratories, Inc.

Cortisol EIA Kit

Description:... Cortisol is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is secreted with a circadian periodicity, and peaks just prior to...
Company:Cayman Chemical
Glucocorticoid in Medical Dictionary

Cortisol

... Cortisol is a corticosteroid hormone or glucocorticoid produced by the adrenal cortex, that is part of the adrenal gland . It is usually referred to as the "stress hormone" as it is involved in...
Glucocorticoid in Biological News

Researchers find docking sites for glucocorticoid receptor and Hsp90

University of Oregon researchers have identified protein interactions that regulate the response of cells to steroid hormones. The discovery, they say, could lead to new ways to boost the effectiveness and reduce undesired side effects of steroid-hormone treatments and cancer drugs. The study, ...

LSUHSC shows for first time infant inhalation of ultrafine air pollution linked to adult lung disease

...a treatment; however, while the majority of patients with asthma respond to glucocorticoid treatment there are a number of patients who do not," says Dr. Cormier. "In cells, a protein called cofilin-1 appears to inhibit glucocorticoid function. We are currently testing whether cofilin-1 also does this in the ...

DuoCort: New chronotherapy for adrenal insufficiency

...y. The likely cause is the highly un-physiological glucocorticoid replacement delivered by even the best therapy ava...is a drug development company focused on improving glucocorticoid therapy in several areas of medical need. The comp...rsity in Sweden. DuoCort is developing an improved glucocorticoid replacement therapy for patients with adrenal insu...

Stress puts double whammy on reproductive system, fertility

...rmone, a so-called RFamide-related peptide (RFRP), puts the brakes on reproduction by directly inhibiting GnRH. The common thread appears to be the glucocorticoid stress hormones, which not only suppress GnRH but boost the suppressor GnIH - a double whammy for the reproductive system. "We know stress affects ...

Execretion analysis aids primate social studies

...ion for the Advancement of Sciences' 2009 Annual Meeting, to be held in Chicago. For instance, she said, by finding evidence for elevated levels of glucocorticoid stress hormone in the feces of female baboons that had lost a close female companion, researchers deduced that those animals were grieving. "Those sho...

Cortisol and fatty liver: Researchers find cause of severe metabolic disorders

...y to deposit fat in the liver. However, scientists knew that the body's own glucocorticoid hormones such as cortisol promote the development of fatty liver. This can ...KFZ), and his team have now published the mechanism by which the body's own glucocorticoid hormones contribute to this disruption of the lipid metabolism. The res...

Scientists retrace evolution with first atomic structure of an ancient protein

...ncient structure to produce a new function that is crucial to our own bodies today. Nobody's ever done that before." The researchers focused on the glucocorticoid receptor (GR), a protein in humans and other vertebrates that allows cells to respond to the hormone cortisol, which regulates the body's stress respo...

Structure of 450 million year old protein reveals evolution's steps

... the structure in place, Ortlund and his colleagues retraced evolutions path. The researchers examined the precursor to a modern protein known as a glucocorticoid receptor. In humans, the receptor plays a crucial role, responding to the hormone cortisol and regulating the bodys stress response. The two receptor...

Researcher gives hard thoughts on soft inheritance

...rly grooming and nurturing of rat pups by rat moms affects methylation of a glucocorticoid receptor gene in the hippocampus in the brain. If the pups get lots of nurturing the glucocorticoid gene gets turned on and expressed early at a critical period, providing pup...

HIV accessory protein disables host immunity via receptor-protein intermediary

...ne, and colleagues reported that Vpr corrupted the glucocorticoid receptor (GR) pathway of the host cell. Vpr helps ...oteins. Weiner's group found that Vpr binds to the glucocorticoid receptor, but it remained unclear whether the GR p...go that no one had asked the real question: Is the glucocorticoid receptor necessary for Vpr's effects on the host c...
Glucocorticoid in Biological Technology

DOR BioPharma Announces Publication of orBec(R) Clinical Pulmonary Data in Bone Marrow Transplantation

... "This finding has important implications for an alternative method for treatment of pulmonary inflammatory disease, that is, the delivery of a potent glucocorticoid to the pulmonary circulation after ingestion of an oral pro-drug (BDP). Clinical trials examining this novel pulmonary delivery system in patients wit...

FDA Approves Additional Indication for Norditropin(R) for Small for Gestational Age (SGA) in Children

...re breastfeeding; or if you have had a kidney transplant. Be sure to tell your doctor about all medications you are taking especially if they are: a glucocorticoid medication such as hydrocortisone or cortisone acetate, thyroid hormone, insulin and/or oral diabetes medicines, drugs metabolized by the liver (for e...

Sangamo BioSciences Announces Presentation of Phase 1 Data of ZFP Therapeutic at International Society for Cellular Therapy (ISCT) Meeting

...rams in glioblastoma and HIV/AIDS. -- Sunday, May 18: Oral Session: Immunotherapy and Dendritic Cells; "Zinc Finger Nucleases Targeting the glucocorticoid Receptor Allow IL-13 Zetakine Transgenic CTLs to Kill Glioblastoma Cells in vivo in the Presence of Immunosuppressing Glucocorticoids" Phili...

Lilly Reports Solid First-Quarter Results

...on. -- The European Commission approved a new indication for Forsteo(R) for the treatment of osteoporosis associated with sustained, systemic glucocorticoid therapy in women and men at increased risk for fracture. The company has also received an approvable letter from the FDA for Forteo for the sa...

DuoCort Hosts Adrenal Insufficiency Symposium at the 10th European Congress of Endocrinology in Berlin

...apy for adrenal insufficiency, including choice of glucocorticoid and dosing, outcomes from current therapy, and ways to improve glucocorticoid replacement therapy.  DuoCort is developing... insufficiency patients taking currently available glucocorticoid replacement therapy demonstrates reduced bone dens...

Isis Enters Broad Collaboration With Ortho-McNeil, Inc. for the Discovery, Development and Commercialization of Antisense Drugs to Treat Metabolic Diseases

...t targeting glucagon receptor and glucocorticoid receptor - Includes research collaboration to id...c. and J&JPRD to advance our glucagon receptor and glucocorticoid receptor drugs through the clinic and to develop a...ction, thereby enhancing insulin secretion. About glucocorticoid receptor (GCCR), target of ISIS 377131 ...

Performance of Ad-A-Gene EGFP-Glucocorticoid Receptor (EGFP-GCCR): an adenoviral vector gene delivery system

...ication note presents data from an EGFP translocation assay focusing on the glucocorticoid receptor (GCCR), which is a member of the steroid receptor superfamily. GCC...CR adenoviral vector Figure 5 shows agonist responses for a range of glucocorticoid compounds and other steroid analogues. The data show differential potency o...

Detection of antibody-stained cell surface and intracellular protein targets with the Agilent 2100 bioanalyzer

...the 2100 bioanalyzer data with that obtained from the conventional flow cytometer. c) Intracellular glucocorticoid receptor (GR) staining of H4 hepatocytes For intracellular detection of GR proteins H4 rat hepatocy...

Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in Mammalian Cells

...factors. Three amino acids in the EcR DNA-binding domain (DBD) were mutated to change its DNA-binding specificity to that for the glucocorticoid receptor (GR). 3 The GR-EcR (GEcR) fusion protein retains the ability to dimerize with RXR and trans-activate in a ponA-depende...
Glucocorticoid in Biological Products

PolarScreen Glucocorticoid Receptor Competitor Assay Kit, Far Red from Molecular Probes (Invitrogen)

Description: PolarScreen Glucocorticoid Receptor (GR) Competitor Assay Kits are ideal for studying or screening novel GR binding compounds. The PolarScreen GR Competitor Assay Kits contain partially purified GR protein, stabilizing peptide, buffer, and one of the following proprietary fluorescent glucocorticoid...
Company:Molecular Probes (Invitrogen)

Rat Anti-Vitamin D Receptor Monoclonal Antibody, Unconjugated, Clone 9A7 from ABR-Affinity BioReagents

Description:...s vitamin D receptor (VDR) from human, rat, mouse, hamster, chicken, amphibian, and fish tissues. This antibody does not cross-react with estrogen or glucocorticoid receptors. MA1-710 detects both the occupied and unoccupied forms of the receptor. MA1-710 has been successfully used in Western blot, immunocyt...
Company:ABR-Affinity BioReagents
Glucocorticoid in Biological Definition

Hormone

... may be different from responses to naturally occurring amounts and may be therapeutically useful. An example is the ability of pharmacologic doses of glucocorticoid to suppress inflammation. Important human hormones Amine-derived hormones : adrenaline (or epinephrine) dopamine melatonin (N-ace...
Glucocorticoid in Biological Dictionary

Reticulocyte Lysate

... cellular components necessary ... Reticulocyte Lysate System. TNTĀ® T7/T3 Coupled Reticulocyte Lysate System ... Cell-free synthesis of rat glucocorticoid receptor in rabbit reticulocyte lysate . ... synthesized the receptor in a reticulocyte lysate that has been depleted of ... ... tRNAf d...

Corticosteroids

...volved in a wide range of physiologic systems such as stress response, immune response and regulation of... Binding of corticosteroids to the glucocorticoid receptor (GR) stimulates ... Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor ... Corticosteroids - Non-Steroidal A...
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(Date:10/25/2014)... FRIDAY, Oct. 24, 2014 (HealthDay News) -- Interrupting blood supply ... help reduce the risks associated with the surgery, according to ... to stop the blood supply to the heart to be ... blood, the heart will reduce its ability to produce energy ... blood flow to another large muscle, such as an arm ...
(Date:10/25/2014)... A large influx of international aid is needed, and ... thousands of deaths from the widening Ebola crisis, a ... a specially designed mathematical model, the researchers looked at ... densely populated county of hard-hit Liberia -- Montserrado County, ... researchers said that if international aid isn,t delivered to ...
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Breaking Medicine News(10 mins):Health News:Brief Interruption of Blood Supply to Limb Might Aid Heart Surgery: Study 2Health News:Experts Predict 'Catastrophic' Ebola Epidemic in West Africa if Aid Delayed 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 2Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 3Health News:University of Pittsburgh Medical Center Launches Initiative to Emphasize Concussions Are Treatable 4Health News:Isabel Healthcare to Participate in The Association of Schools of Allied Health Professions (ASAHP) 2014 Conference 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3
(Date:10/18/2014)... for evaluation of suspected genetic conditions, whole-exome sequencing ... including detection of a number of rare genetic ... to a study appearing in JAMA . ... the American Society of Human Genetics annual meeting. ... regions of thousands of genes simultaneously using next-generation ...
(Date:10/17/2014)... from the University of Copenhagen have shown for the ... lungs of Cystic fibrosis patients, giving them the opportunity ... in chronic infections. , The study also discovered the ... (CF) patients was halted or slowed down by the ... all the oxygen and helped "suffocate" the bacteria, forcing ...
(Date:10/16/2014)... Washington land managers have a new synthesis of recent ... mixed-conifer (MMC) forests in the two states. , ... Eastern Oregon and Washington: A Synthesis of the Relevant ... general technical report published by the U.S. Forest Service,s ... a request from managers for a synthesis of the ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2
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