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Glucagon in Medical News

New Diabetes Drug Shows Promise in Trial

...t stimulates insulin production," Madsbad explained. "Then it also promotes glucagon release from the pancreas. It also changes appetite, and therefore you eat less." glucagon is a hormone that helps manage blood sugar levels. "We want more medicat...

Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

Takeda Receives New Information on Alogliptin (SYR-322) NDA

...increased insulin secretion--and it has the potential to improve pancreatic beta-cell function. Furthermore, it is known that because GLP-1 suppresses glucagon secretion from the pancreas, the production of sugar in liver cells is also suppressed. About Takeda Pharmaceutical Company Limited Located i...

Amylin, Lilly Update on FDA Review of BYETTA(R) (exenatide) Injection Monotherapy Submission

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

...g pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to ...s, JANUVIA increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent m...culating levels of active GLP-1 and GIP, decreased glucagon concentrations, and increased responsiveness of in...

UT Southwestern scientists discover leptin can also aid type 1 diabetics

...the pancreas that raises glucose levels. Normally, glucagon is released when the glucose, or sugar, level in the blood is low. In insulin deficiency, however, glucagon levels are inappropriately high and cause the live...t was mediated by complete suppression of the high glucagon levels, said Dr. Xinxin Yu, assistant instructor o...

Discovery of new signal pathway important to diabetes research

...very narrow interval, and we need both insulin and glucagon to remain in good health. "A person with low bl... Much more is known about insulin secretion than glucagon secretion, and so Professor Berggren's team focuse...a cells also secreted glutamate, which facilitates glucagon release and makes it more efficient. The scien...

Isis Reports Financial Results and Highlights for Fiscal year 2007

...oglycemia, weight gain or nausea. * Isis initiated Phase 1 studies of ISIS 325568, an antisense drug partnered with OMI, that targets the glucagon receptor, GCGR. * Isis identified a development candidate, ISIS 377131, an antisense drug also partnered with OMI that targets the glucoc...

Takeda submits new drug application for alogliptin (syr-322) in the US

...esponse to food, and regulate glucose balance, primarily by stimulating glucose-dependent insulin secretion. In addition, GLP-1 suppresses pancreatic glucagon secretion and subsequent liver glucose production, enhances glucose disposal, slows gastric emptying, and elicits satiety, a feeling of fullness. ...

Benefit of exenatide has not yet been proven

...the body, GLP-1. Incretins are hormones that are produced in the gastrointestinal tract. In the pancreas, they stimulate insulin secretion and inhibit glucagon secretion, depending on the blood glucose level. In addition, they affect gastric as well as brain functions: they delay the emptying of the stomach a...
Glucagon in Medical Technology

Isis Initiates Phase 1 Study of ISIS 325568 Targeting Glucagon Receptor to Treat Type 2 Diabetes

*Isis Now Has Two Drugs From Its Metabolic Disease Program In Clinical Development CARLSBAD, Calif., Sept. 4 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced today it has initiated a Phase 1 study of ISIS 325568, an antisense drug de...

Meta-Analysis of Clinical Data Showed No Increased Risk of Cardiovascular Events Associated With Exenatide Use: Data Presented at ADA 2009

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years: DURATION-1 Interim Long-Term Data Presented at ADA 2009

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

Amylin and Lilly Announce Plans to Develop Pen Device for Exenatide Once Weekly

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

New Study First to Confirm Sandostatin LAR(R) Depot Controls Tumor Growth in Patients With Rare Gastrointestinal Tumors

...effects on the human body as the natural hormone somatostatin. However, octreotide is even more potent than somatostatin at inhibiting growth hormone, glucagon and insulin. Based on these attributes, octreotide has been used to treat symptoms associated with metastatic carcinoid tumors (flushing and diarrhea)...

Plans for Exenatide Once Weekly NDA Submission by End of First Half of 2009 Reaffirmed Following FDA Feedback

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

Takeda Submits a New Drug Application in the U.S. for Alogliptin (SYR-322) / ACTOS(R) (pioglitazone HCl) for the Treatment of Type 2 Diabetes

... response to food and regulate glucose balance, primarily by stimulating glucose-dependent insulin secretion. In addition, GLP-1 suppresses pancreatic glucagon secretion and subsequent liver glucose production, enhances glucose disposal, slows gastric emptying, and elicits satiety, a feeling of fullness. Take...

RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors

...effects on the human body as the natural hormone somatostatin. However, octreotide is even more potent than somatostatin at inhibiting growth hormone, glucagon and insulin. Based on these attributes, octreotide has been used to treat the diarrhea and flushing associated with carcinoid syndrome. The active i...

After One Year, Type 2 Diabetes Patients Taking Exenatide Once Weekly Sustained Improvements in Glycemic Control and Weight; DURATION-1 Presented at ADA 2008

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

Type 2 Diabetes Patients Taking Exenatide Once Weekly, a Phase 3 Investigational Diabetes Therapy, Showed Improvements in Glycemic Control, Weight

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...
Glucagon in Medical Products

C-Peptide Chemiluminescence Immunoassay

Description:...on in equimolar concentrations, fasting levels of C-Peptide are 5-10 fold higher than those of insulin owing to the longer half-life of C-Peptide. The glucagon stimulated C-Peptide determination is often used for differential diagnosis of insulin-dependent from non-insulin-dependent diabetic patients....
Company:Diagnostic Automation, Inc.
Glucagon in Medical Dictionary

Glucagon

Glucagon information including symptoms, causes, diseases, symptoms, treatments, and other ... Glucagon is secreted by PANCREATIC ALPHA CELLS and plays ... Glucagon - Definition of Glucagon at Dictionary.com a free online dictionary ... Glucagon Information. Find Free Reference & ...
Glucagon in Biological News

Human hormone blocker found to help prevent obesity and diabetes: study

...le plasma glucose and insulin concentrations were monitored at 5-7 day intervals. Blood was taken on day 50 to measure cholesterol, triglycerides, glucagon (the hormone involved in metabolizing carbohydrate), corticosterone (involved with carbohydrates in the liver) and circulating adipokines (which play ...
Glucagon in Biological Technology

New Drug Application for Exenatide Once Weekly Accepted for Review by FDA

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

Exenatide Clinical Data Analysis Shows No Increased Risk of Cardiovascular Events

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

Novel Diabetes Drug Discovery Has Potential to Reverse Disease

...e of islet restoration as a therapeutic approach. Pancreatic islets contain four primary cell types and are responsible for producing insulin, amylin, glucagon and other hormones critical to maintaining normal glucose regulation. Current diabetes therapies, including insulin, help to control the disease but d...

FDA Continues Review of Takeda's New Drug Application for Alogliptin (SYR-322), a DPP-4 Agent for Type 2 Diabetes

...- and it has also been confirmed that they improve the functioning of the beta cells themselves. Furthermore it is known that because GLP-1 suppresses glucagon secretion from the pancreas, the production of sugar in liver cells is also suppressed and appetite is suppressed as well. About Takeda Pharmaceutic...

Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008

...st and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas and...

DiObex and Camurus Sign License Agreement for the Development of DIO-901 in FluidCrystal(R) Extended Release Technology

... low dose glucagon) in the Camurus drug delivery technology, FluidCrystal(R). The development candidate is an extended release formulation of low dose glucagon for the prevention of insulin-induced hypoglycemia in patients with diabetes. "Intensive glycemic control is beneficial for patients with diabetes, ...

Isis Enters Broad Collaboration With Ortho-McNeil, Inc. for the Discovery, Development and Commercialization of Antisense Drugs to Treat Metabolic Diseases

...se of two antisense drugs in development targeting glucagon receptor and glucocorticoid recep...77131, which selectively inhibit the production of glucagon receptor (GCGR) and glucocorticoid receptor (GCCR)... with Ortho-McNeil, Inc. and J&JPRD to advance our glucagon receptor and glucocorticoid receptor drugs through...

Anesiva Grants Specific-Use License of Its Needle-Free Drug Delivery Technology to Particle Therapeutics for Diabetes Drug

...lowed by needle injection. At present, an estimated 1-1.5 million kits with glucagon powder are sold annually in the U.S. and Europe. Those with Type 1 diabetes... the development, testing and commercialization of needle-free injection of glucagon in the diabetic patient with severe hypoglycemia. Other applications of Par...

Quantitative Analysis of Protein-DNA Associations in Vivo Using Real-Time PCR, Rev A

... we examined two different regions of the glucagon promoter, designated as Gluc(1) and Glu...roximately 300 bp apart in the proximal glucagon promoter. For real-time PCR reactions, ...oters, and the non-β-cell-specific glucagon and albumin gene promoters. Primer pairs (see tabl...
Glucagon in Biological Definition

Anabolism

...ne IGF1 and other insulin-like growth factors Insulin Testosterone Estrogen Classic catabolic hormones include Cortisol glucagon Adrenalin and other catecholamines Cytokines Newer hormones associated with the balance of the catabolic and anabolic states include ...

Anabolism

...ne IGF1 and other insulin-like growth factors Insulin Testosterone Estrogen Classic catabolic hormones include Cortisol glucagon Adrenalin and other catecholamines Cytokines Newer hormones associated with the balance of the catabolic and anabolic states include ...

Diabetes mellitus

... a type of candy disliked by the patient, to prevent concerns about unnecessary use. Other ways of treating hypoglycemia include an injection of glucagon which causes the liver to convert its internal stores of glycogen to be released as glucose into the blood. Oral or intravenous dextrose can also be ...

Homeostasis

...f fat to produce heat. Sweating cools the body with the use of evaporation . Chemical regulation The pancreas produces insulin and glucagon to control blood-sugar concentration. The lungs take in oxygen and give off carbon dioxide . The kidneys remove urea , and adjust the con...

Hormone

... cholecystokinin (CCK) corticotropin-releasing hormone (CRH) erythropoietin ( EPO ) follicle stimulating hormone (FSH) gastrin glucagon gonadotropin-releasing hormone (GnRH) growth hormone-releasing hormone (GHRH) human chorionic gonadotropin (hCG) growth hormone (GH o...

Insulin

...cose levels: hyperglycemic hormones (such as glucagon , growth hormone , and adrenaline ), which incre...elease of hyperglycemic hormones (most prominently glucagon from Islet alpha cells) forces release of glucose ...ge. See also anatomy and physiolology glucagon pancreas islets of Langerhans endoc...

Neurotransmitter

...oids : corticotropin (ACTH) Beta-lipotropin dynorphin endorphin enkephaline leumorphin Secretins: secretin motilin glucagon vasoactive intestinal peptide (VIP) growth hormone-releasing factor (GRF) Somatostatins: somatostatin Tachykinins : neurokinin...
Glucagon in Biological Dictionary

Glucagon

Glucagon is an important hormone involved in carbohydrate metabolism. Produced by the pancreas, it is released when the glucose level in the blood is low (hypoglycemia), causing the liver to convert stored glycogen into... Glucagon rescue is the emergency injection of glucagon in...
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