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Glomerular in Medical News

Low Birth Weight Might Raise Adult Kidney Disease Risk

...ociations between low birth weight and both of the principal markers of chronic kidney disease -- protein in the urine (albuminuria) and low estimated glomerular filtration rate (poor kidney function). The researchers also identified an association between low birth weight and subsequent development of kidney f...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

...a removal. The extent of plasma exposure to PAA significantly correlated with MELD score (r2= 0.15; p= 0.03), but did not correlate significantly with glomerular filtration rate (r2= 0.01; p= 0.54) or Child-Pugh score (r2= 0.10; p= 0.08). No consistent differences between cirrhotic subjects and healthy voluntee...

DaVita's Kidney Calculator iPhone App Downloaded in 24 Countries

...ose diagnosed with chronic kidney disease (CKD), today announced the DaVita glomerular Filtration Rate (GFR) Calculator for the Apple iPhone and iPod Touch has be...ish, French, Italian, Spanish and German, the iPhone application calculates glomerular filtration rate (GFR) as a function of a patient's age, serum creatinine le...

A first choice of renal function tests in hepatectomy patients

...lthough creatinine clearance (Ccr) has been measured clinically by a simple method as a preoperative renal function test, Ccr is not strictly equal to glomerular filtration rate (GFR). Recently, an equation for estimated GFR (eGFR) for Japanese individuals has been postulated, and eGFR has been accepted as equa...

Tips from the American Journal of Pathology

...deficient podocytes were more resistant to stress-induced detachment. Sussman et al "have established a causal role for SPARC in the progression of glomerular disease following immune-mediated injury of the podocyte. [These] findings support a causal role for induction of the matricellular protein SPARC in ...

JCI table of contents: March 23, 2009

...y, discuss this possibility and suggest alternative roles for kallikreins in lupus nephritis. TITLE: Kallikrein genes are associated with lupus and glomerular basement membranespecific antibodyinduced nephritis in mice and humans AUTHOR CONTACT: Chandra Mohan University of Texas Southwestern Medical Cen...

Guidelines Suggested for Heart-Kidney Transplants

...people with non-ischemic heart failure also had a high risk of death, the researchers said. "Among patients with combined kidney failure (estimated glomerular filtration rate less than 33 milliliters per minute) and heart failure, those classified by this risk stratification scheme as low-risk should undergo...

Upcoming World Kidney Day Underscores Role of Low-Cost Lab Tests in Combating High-Cost Kidney Disease

...two key laboratory tests. A $10 lab test that determines how well the kidneys remove waste from the blood -- called the estimated glomerular Filtration Rate, or eGFR. A $7.25 lab test that identifies excess protein in the urine--called the urine albumin test. These...

American Kidney Fund Warns of Kidney Disease Risk Factors During Kidney Awareness Month

...c kidney disease begins with no symptoms," said Burton. The American Kidney Fund recommends individuals request a calculation of their estimated glomerular filtration rate (eGFR) , a test that can tell how well the kidneys are working. The American Kidney Fund's website provides downloadable brochure...

IPRO Alerts New Yorkers to 'Silent' Killer; Chronic Kidney Disease Doubling Every Ten Years

...their doctor about these tests: Blood pressure check, Urine Test (micro-albumin), Blood test (with eGFR - estimated glomerular filtration rate). "If you do not have a doctor you see regularly, you should look for free kidney screenings in your community," accord...
Glomerular in Medical Technology

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

...y GL-3 as measured in urine, and an assessment of renal function (including glomerular filtration rate (GFR) and 24-hour urine protein). Additionally, the FD...ing ERT. The recommended primary endpoint is renal function as measured by glomerular filtration rate (GFR) and the recommended primary analysis is a comparison ...

Data From Investigational Use of PROCRIT(R) (Epoetin alfa) Presented at American Society of Nephrology Annual Meeting

...age of the last eight weeks of treatment through Week 22. Additional analyses were performed using data through Week 44. The mean baseline estimated glomerular filtration rate was 30 mL/min/1.73 m2 and the median weekly EPO doses (IU) were 4,382, 4,364 and 6,091 for TIW, QW and Q2W groups, respectively. For t...

CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI

...practice. Primary endpoints were the proportion of patients with treatment failure (BPAR, graft loss, and death) and mean percent change in calculated glomerular filtration rate (GFR; Nankivell equation) at 12 months. Safety endpoints were incidences of adverse events and serious adverse events. Non-inferiority...

Phase 2 Trial Results for Exelixis' XL784 Presented at the 2007 American Society of Nephrology Conference

...p (not significant). There was a clinically relevant mean ACR reduction from baseline of 23% (p=0.0027) in subjects randomized to XL784. The change in glomerular filtration rate (GFR) at Week 12 was -2.5 ml/min/1.73m2 in the XL784 group and -6.2 ml/min/1.73m2 in the placebo group (p=0.077). In an exploratory a...

Isotechnika Announces Interim Three Month Data from Phase 2b Kidney Transplant Trial

...rejection in the tacrolimus group, which is being dosed optimally. As part of the trial, kidney function is being measured on an ongoing basis by glomerular Filtration Rate (GFR). Based on the data generated to date, very good kidney function has been observed in all of the ISA247 dosing groups. Within the...

Early Results of the CellCept Spare the Nephron Study Examine Kidney Function

...hat first-year results in kidney transplant recipients demonstrated that patients on CellCept and sirolimus maintenance therapy showed improvements in glomerular filtration rate (GFR) of their kidneys without increasing rejection rates. A total of 208 of 305 kidney transplant patients completed 12 months of f...

MEDIA ADVISORY: Subsets of Landmark Diabetes Trials Investigating MacroVascular Outcomes Presented at the American Diabetes Association 67th Scientific Sessions

...turday, June 23, from 12:30-2:30 p.m. and 6:00- 7:15 p.m. -- Effects of pioglitazone in patients with type 2 diabetes and reduced glomerular filtration rate: an analysis from PROactive; Poster 0671-P presented on Saturday, June 23, from 12:30-2:30 p.m. and 6:00-7:15 p.m. -- Eff...

Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Mechanism of Action and Clinical Activity of Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American Diabetes Association 67th Scientific Sessions in Chicago, Illinois

... Nashville, TN, Milwaukee, WI, Kansas City, KS, Iowa City, IA, Jerusalem, Israel 0769 - Mechanism and Relevance of Reduced Presence of glomerular Heparan Sulfate for Proteinuria in Overt Diabetic Nephropathy TESSA WIJNHOVEN, MABEL VAN DEN HOVEN, TOIN H. VAN KUPPEVELT, JOHAN VAN DER VLA...
Glomerular in Medical Definition

Nuclear medicine

... in the body and its rate of clearance from the body. Effective doses can range from 6 μSv (0.006 mSv) for a 3 MBq chromium -51 EDTA measurement of glomerular filtration rate to 37 mSv for a 150 MBq thallium -201 non-specific tumour imaging procedure. The common bone scan with 600 MBq of technetium-99m-MDP ...
Glomerular in Medical Dictionary

Renal biopsy

...sy , Biopsy - Renal , Needle Aspiration of the Kidney, ... ... to Renal Biopsy . Agnes B. ... each other in a renal biopsy . They both have glomerular ... in the assessment of renal biopsy specimens: Actual and optimal ... ... is a Renal biopsy ? A kidney biopsy (also known as a renal...

Olfactory

.... is the story of olfactory sensory cells. ... Sema-1a also regulates PN axon targeting in higher olfactory centers. ... Representation of the glomerular Olfactory Map in the Drosophila Brain ... Excitatory Interactions between Olfactory Processing Channels in the Drosophila Antennal Lobe ... Fu...

Membranous nephropathy

...ephropathy is caused by thickening of part of the glomerular basement membrane. ... Kidney Transplant in M...ephropathy is caused by thickening of part of the glomerular basement membrane. ... Membranous nephropat...ephropathy is caused by thickening of part of the glomerular basement membrane. ... membranous glomerulo...

Lupus nephritis

...ef article describes lupus nephritis , an inflammation of the kidney caused by a disease of the immune system. ... Lupus nephritis is a glomerular disease. ... Lupus nephritis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prev...

Kidney function tests

...s show I may have chronic kidney disease? ... is the best test to measure your level of kidney function and determine your ... Estimated glomerular Filtration Rate ( test for kidney function ) ... Rate (eGFR): This test is used to get a better estimate of your kidney function . ... .....

Glomerulonephritis

... Glomerulonephritis , also known as glomerular nephritis, abbreviated GN, is a renal disease ...ephritis . Defines the two major categories of glomerular diseases—glomerulosclerosis and glomerulonephriti...omerulonephritis , chronic glomerulonephritis , glomerular disease ... New England Journal of Medicine --...

Creatinine

...lood, ... Because creatinine is found in stable plasma concentrations, is freely filtered ... The creatinine clearance is an estimate of the glomerular filtration rate, that ... Creatinine - serum - Results, Creatinine is a breakdown product of creatine, ... Females usually have a lower cre...

Creatinine clearance

...f the kidney and its role in renal physiology. glomerular filtration rate (GFR) describes the flow rate of f...The creatinine clearance is an estimate of the glomerular filtration rate, that ... In fact, creatinine c...The creatinine clearance is an estimate of the glomerular filtration rate, that ... Creatinine cleara...

Chronic renal failure

...... Learn about major etiologic causes of chronic renal failure ... Chronic renal failure (CRF) is defined as a permanent reduction in glomerular ... Chronic kidney failure — Comprehensive overview covers symptoms, causes of gradual loss of kidney function. ... stages of chronic k...

Alport syndrome

...in, Chapter 19 (pages 571-591) in Diseases ... Alport Syndrome and Thin glomerular Basement Membrane Disease, DISEASE OF THE ... Alport Syndrome infor... dysfunction in the kidney. ... Alport's Syndrome primarily affects the glomerular membrane and makes it thin and weak. ... Alport syndrome - Overvi...
Glomerular in Biological News

Tips from the American Journal of Pathology

... severity. They then examined human versions of these genes, and found that a subset of these candidates were associated with disease progression and glomerular filtration rate in human patients. The biomarkers identified by Dr. Bttinger, Dr. Kretzler, and colleagues "predict progressive renal fibrosis in...

New findings in taste and smell

...on and controls OSN axon growth Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons mediate axon targeting and glomerular formation Investigations of olfactory receptor internalizations ...

UT Southwestern researchers probe kidney damage, protection in lupus

... damage caused by a different mechanism. For this mouse study, the researchers administered antibodies that attack a part of the kidney called the glomerular basement membrane, the portion of the organ that performs its main function of filtering wastes from blood. They then looked for genes that turned on ...

Updated formula measures kidney function more accurately

...and chemotherapy and more accurately assessing kidney function in children battling chronic kidney disease (CKD). This formula can be used to estimate glomerular filtration rate (GFR) the rate at which fluid is filtered through the kidneys quickly and without infusing any synthetic substances. It was develope...

Genomatix technology facilitates de novo identification of new renal disease associated genes

... Previously unknown molecules and regulatory pathways in human glomerular diseases have been identified by a joint effort of the Medizinische Polikli...s are applied to a set of genes linked to the unique functional unit of the glomerular slit diaphragm. An evolutionarily conserved promoter model was generated. G...

New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease

..."In normal kidneys, a specialized form of extracellular matrix known as the glomerular basement membrane [GBM], composed primarily of type IV collagen, is the key... led to clear improvement in the animal's kidney function and repair of the glomerular architecture defects. "These results offer a possible therapeutic opport...
Glomerular in Biological Technology

Amicus Therapeutics Announces Second Quarter 2009 Financial Results

...histology. Secondary endpoints will include safety and tolerability, kidney GL-3 as measured in urine, and an assessment of renal function (including glomerular filtration rate (GFR) and 24-hour urine protein). Additionally, the FDA and Amicus reached agreement on an improved methodology for the histolo...

Astellas Receives FDA Approval for Use of Prograf(R) (Tacrolimus) in Conjunction With Mycophenolate Mofetil (MMF) in Kidney Transplant Recipients

...icosteroids in combination with low-dose CyA, Prograf or sirolimus (Siro). The primary endpoint of the study was renal function, measured by estimated glomerular filtration rates (GFR), at 12 months after transplantation. Acute rejection, graft survival and overall mortality were also assessed as secondary endp...

First oral uveitis drug reduces both inflammation and recurrence in potentially blinding eye disease

...ble safety profile relative to effect on the disease. The adverse effects on the kidney (8.2% of subjects with decrease from baseline by ≥30% in glomerular filtration rate vs. 4.1 % in placebo) and blood pressure (mean increase in systolic BP by 6 mm Hg) will require monitoring, but were overall moderate ...

Pharmalink AB Completes Phase II Clinical Study With Renal Disease Drug Nefecon(R)

...l results will be presented at the World Congress of Nephrology 2009, 22-26 May in Milan (Smerud et al, Enteric Budesonide Ameliorates Albuminuria and glomerular Filtration Rate in IgA Nephropathy Patients) and at the satellite meeting, IgA Nephropathy, 26-28 May in Stresa, Italy. "It is very gratifying ...

Nile Therapeutics Announces Positive Results from Phase 1b Safety and Pharmacodynamics Study of CD-NP in Patients with Heart Failure

...from evaluable patients was assessed via biomarkers including serum creatinine and creatinine clearance, the most frequently used surrogate measure of glomerular filtration rate (GFR) and renal function. CD-NP treatment resulted in a statistically significant reduction of serum creatinine. After a 24-hour infus...

Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia

...moderate CKD (Stages 3 and 4) to severe CKD (Stage 5). Stages 3 and 4 CKD are characterized by progressively decreasing kidney function as measured by glomerular filtration rate. In Stage 5 CKD, kidney function is altogether absent and patients require regular dialysis or kidney transplant for survival. An esti...

Cytochroma Closes $45 Million Series C Financing

...moderate CKD (Stages 3 and 4) to severe CKD (Stage 5). Stages 3 and 4 CKD are characterized by progressively decreasing kidney function as measured by glomerular filtration rate. In Stage 5, kidney function is altogether absent and patients require regular dialysis or kidney transplant for survival. An estimate...

Cytochroma Appoints R. Richard Wieland II As CFO

...rom moderate CKD (Stages 3 and 4) to severe CKD (Stage 5). Stages 3 and 4 are characterized by progressively decreasing kidney function as measured by glomerular filtration rate. In Stage 5, kidney function is altogether absent and patients require regular dialysis or kidney transplant for survival. An estimate...

Cytochroma opens U.S. headquarters in Illinois

...rom moderate CKD (Stages 3 and 4) to severe CKD (Stage 5). Stages 3 and 4 are characterized by progressively decreasing kidney function as measured by glomerular filtration rate. In Stage 5, kidney function is altogether absent and patients require regular dialysis or kidney transplant for survival. An estimate...

Cytochroma initiates Phase I/II clinical trial of CTAP101 Capsules for vitamin D insufficiency in chronic kidney disease

...nces of a growing obesity epidemic in countries worldwide. Stage 3 and Stage 4 CKD are characterized by level of kidney function in terms of decreased glomerular filtration rate (GFR) - 30-59 ml/min/1.73m(2) for Stage 3 CKD and 15-29 ml/min/1.73m(2) for Stage 4 CKD. As CKD progresses to Stage 5 and GFR decrease...
Glomerular in Biological Definition

Albumin

...otic pressure needed for proper distribution of body fluids between intravascular compartments and body tissues. Albumin is negatively charged. The glomerular basement membrane is also negatively charged, this prevents the filtration of albumin in the urine. In nephrotic syndrome, this property is lost, and ...

Kidney

... neighbouring Bowman's capsule wall to produce the glomerular filtrate, which enter the kidney tubule. Blood lea...ree layers and into the Bowman's space to form the glomerular filtrate. The filtrate is blood plasma without... rate of 1.2 litres per minute, producing 125cc of glomerular filtrate per minute. Measuring the ...

Nephron

...ls , platelets , and large proteins , stay behind. The liquid, known as glomerular filtrate , contains water , glucose , salt , amino acids , and urea . ... are reabsorbed by the blood . The filtrate is now known as urine . The glomerular filtrate has lost about 75% of the original water content and volume. ...

Osmoregulation

...rtebrate kidney) structure known as the glomerulus into Bowman's capsule or glomerular capsule (in the kidney's cortex) and flows down the proximal convoluted tub... in the medulla portion of the kidney. reabsorption - most of the viscous glomerular filtrate is returned to blood vessels which surround the convoluted tubules...
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