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Gliomas in Medical News

Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology

Poster presentation highlights response rate in subset of patients with Anaplastic Gliomas NEW YORK, Nov. 19 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX ) today announced that early results of a phase II single agent trial of perifosine (KR...

New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas

Barcelona, Spain: Childhood brainstem gliomas (BSGs) are rare but can be very difficult to treat successfully and they tend to have poor survival rates. However, a team of Spanish researchers have found that a chemotherapy regimen of irinotecan and cisplatin (I/C) produced rapid clinical responses...

New Carrier Developed To Deliver Drugs to Gliomas

A new vehicle for delivering radioactive iodine dose to cure deadly brain tumors such as gliomas is under investigation.// Synthetic scorpion venom is used as carriers for radioactive iodine. The first phase of the clinical trials is successfully complete and was conducted by under Adam N. Mame...

Genome of Leukemia Patient Reveals Common Mutations

...cancer patients. Scientists at the Washington University School of Medicine in St. Louis detected one mutation that's common in brain tumors called gliomas and another that was found in a second patient with AML. Neither of the mutations had been previously linked to leukemia. The fact that these mutat...

Drummer Eddie Cleland Resumes Life After Brain Surgery and Tells About it at Conference

... Cleland's tumor was a diffuse astrocytoma, also called a Grade II glioma. gliomas arise from glial cells, which provide support for nerve cells in the brain. Low-grade gliomas (Grade I and II) are considered pre-malignant. Although not yet cancers, 70...

NCCN Updates Guidelines for Central Nervous System (CNS) Cancers

...the better the patient is able to carry out daily activities. The new NCCN Guidelines adjusted the age range for patients with specific low grade gliomas who may consider fractionated external beam radiation therapy or chemotherapy as additional options to observation following maximal safe resection to...

Delivering Chemo Directly Into Brain Tumors Shows Promise

... Survival times for those with malignant gliomas increased, study found MONDAY, May 4 (... clinical trials, researchers report. Malignant gliomas are difficult to treat using standard chemotherapy...umbers are better than any treatment for recurrent gliomas we have now," said study author Dr. Jeffrey Bruce,...

Reversing effects of altered enzyme may fight brain tumor growth

...hers have known that a mutation in the gene encoding the enzyme, isocitrate dehydrogenase (IDH1), contributed to certain brain tumors called low grade gliomas and secondary glioblastomas, but no one understood how. Guan, Yue Xiong, PhD, at the University of North Carolina and their co-investigators have now ...

Avastin effective at delaying brain tumor progression in recurrent disease

... of the targeted therapies for gliomas, this has been the most promising. And this is practice changing." Therapy for treating recurrent high-grade gliomas is palliative. All patients with these high-grade tumors eventually die of their cancer. However, bevacizumab has the potential to be the best palliat...

Brain Tumor Drug May Help Spur Cancer's Return

...City, have identified cells in brain tumors called gliomas that have stem cell-like qualities and are able to...xpel chemotherapy drugs. "Current treatment for gliomas works for a while and then usually fails," Holland...emozolomide -- which is the standard treatment for gliomas -- actually increased the number of drug-resista...
Gliomas in Medical Technology

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

...ars of age. (NCI SEER Data) There are 12 major types of childhood cancers, and of these leukemias, brain and other central nervous system tumors (ie, gliomas and medulloblastomas) account for over 50% of the new cases. The remainder of new cases include extracranial tumors such as neuroblastomas, Wilms tumo...

New Imaging Analysis Predicts Brain Tumor Survival

...which is amazing for brain tumors," says study author Craig Galban, Ph.D., assistant professor of radiology at the U-M Medical School. High grade gliomas have a high mortality rate, with people surviving only an average of 12 months after diagnosis. Typically, patients receive six to seven weeks of trea...

CHMP Recommends Approval in the European Union (EU) for New Options for Patients With Certain Primary Brain Tumors

...rocarbazine, and for the treatment of newly diagnosed GBM concomitantly with radiotherapy and then as maintenance treatment. About Malignant gliomas The worldwide incidence rate of primary malignant brain and central nervous system tumors, using the world standard population, is 3.7 per 100,00...

Bradmer reports progression free survival data from previous Phase II glioblastoma multiforme trials

...ssion free survival as a predictor of overall survival in glioma patients. The article included data from 597 adult patients with recurrent high-grade gliomas that enrolled in Phase II trial protocols collected by the North American Brain Tumor Consortium between 1998 and 2002. The study concluded that progr...

CuraGen Announces Initiation of Phase II Trial of CR011-vcMMAE in Patients with Advanced Breast Cancer

...ase II study of CR011-vcMMAE in patients with melanoma is currently enrolling patients, and preclinical studies with CR011-vcMMAE for the treatment of gliomas are ongoing. About Breast Cancer Breast cancer is the most common cancer in women and a leading cause of death in the United States. According to ...

St. Jude Finds Young Age May Give Survival Advantage to Children With Certain Brain Tumors

...m to have a better prognosis when compared to older children. Different biological properties also seem to play a role in the latter case. Brainstem gliomas account for 10 to 15 percent of all brain tumors in children; and DPGs account for 80 percent of brainstem tumors in childhood. Although MRI revolutio...

Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting

...model of GBM demonstrating that the T-cells were capable of killing tumor cells in the presence of the glucocorticoid dexamethasone. About Gliomas gliomas are the most common type of primary brain tumors; 20,000 cases are diagnosed and 14,000 glioma-related deaths occur annually in the United States. Gli...

Vion Pharmaceuticals Announces Initiation of a Phase I/II Trial of Cloretazine(R) (VNP40101M) in Combination with Temodar(R) in Adult Brain Tumors

...n with Temodar(R) (temozolomide) in relapsed or progressive adult malignant gliomas had been initiated at the Robert H. Lurie Cancer Center under the direction...s of research, there has been little progress in the treatment of malignant gliomas which recur after primary therapy. We are pleased to support Dr. Raizer's s...

Pharmion to Present Clinical Data on Commercial and Pipeline Products at 2007 American Society of Clinical Oncology (ASCO) Meeting

...k Place Convention Center, S Hall A2 A phase II trial of thalidomide (Thal) and procarbazine (Pro) in adults with recurrent or progressive malignant gliomas (MG) -- G. Lesser, MD; Abstract #2067; June 4, 2007; 1:00-5:00pm; McCormick Place Convention Center, S Hall A2 Satraplatin Oral Presentation: Satr...

Adding Thalidomide to Standard Therapy Improves Survival in Newly Diagnosed Multiple Myeloma Patients Over Age 75

...k Place Convention Center, S Hall A2 A Phase II trial of thalidomide (Thal) and procarbazine (Pro) in adults with recurrent or progressive malignant gliomas (MG) -- G. Lesser, MD; Abstract #2067; June 4, 2007; 1:00-5:00pm; McCormick Place Convention Center, S Hall A2 About Thalidomide Pharmion Thalidom...
Gliomas in Medical Dictionary

Gliomas

A glioma is a type of cancer that starts in the brain or spine. It is called a glioma because it arises from glial cells. The most common site of gliomas is the brain. Offers intensive chemotherapy for the treatment of brain gliomas , lung cancer, mesothelioma, breast cancer, and mor...

Optic glioma

... Comprehensive information about optic gliomas , which affect one or both the optic nerves, or ... (NF1) ... Surgical removal may cure some optic gliomas . ... Optic glioma - Washington Hospital Center is located in Washington DC ... Optic gliomas can affect: ... Surgical removal may cure some o...
Gliomas in Biological News

Fluorescent cancer cells to guide brain surgeons

... gliomas are malignant brain tumors that arise from glial (supporting) cells of the brain. gliomas are often resistant to chemotherapy. These tumors grow fine extensions that...

Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain

...al novel therapies to treat Alzheimer's disease, amyotrophic lateral sclerosis, Huntingtons disease, epilepsy, stroke/ischemia, dementia and malignant gliomas RICHMOND, Va. (May 9, 2008) Virginia Commonwealth University researchers have discovered how an antibiotic works to modulate the activity of a ne...

Veterinary college researcher studying brain tumors in people and animals

...ded by the National Institutes of Health (NIH). gliomas are an aggressive and deadly form of brain cancer ...dog has emerged as an excellent model for studying gliomas in humans. Every year about 120,000 new cases o... loss of balance, blindness and other problems. gliomas arise from glial cells, according to Rossmeisl, wh...

UAB wins $5.7M neurofibromatosis grant

...various therapy regimens, to treat human cancerous tumors associated with NF. Such tumors can grow and damage the nerve sheath, and they can appear as gliomas in and around the optic nerve. In addition to managing the NF Consortium operations center, UAB will be enrolling adults and children in NF clinic...

Last chance for media to register for ECCO 14 -- the European Cancer Conference

... Breast cancer susceptibility gene predicts outcome and response to treatment in lung cancer Improved treatment for difficult childhood brainstem gliomas First molecular profiling of colon cancer patients accurately predicts survival Quality of life after endometrial cancer treatment can be sign...

Invasion of the brain tumors

... gliomas are highly malignant and invasive tumors with tendrils that extend far from...ues at the University of Calgary injected immunocompromised mice with human gliomas and compared invasive cells (which left the primary tumor site) to noninvas...

Targeted virus compels cancer cells to eat themselves

...p was 39 cubic millimeters, while those receiving the other virus had an average tumor volume of 200 cubic millimeters. Among mice with malignant gliomas in the brain, those treated with three injections of hTERT-Ad on average lived 53 days. Those receiving the control adenoviruses lived on average 29 d...

Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer

... more potent viral doses." The glioblastoma multiforme study, which opened today, is designed to test the safety of the virus for the treatment of gliomas and enable biological monitoring of anti-tumor activity. "The measles virus we are using in the glioblastoma multiforme trial provides a noninva...

Unique dual target specificity of kinase inhibitor key for success against cancer

...ive. Importantly, dual inhibition of p110á and mTOR with a low dose of PI-103 elicited no drug-related toxicity and was highly effective against human gliomas transplanted into mice. "These data suggest that combinatorial inhibition of mTOR and p110á represents a safe and effective therapy in the treatme...

Possible birthplace of malignant brain tumors identified

...gression of atypical hyperplasia after PDGF removal described here suggests that inhibition of PDGF signaling could provide a useful therapy for those gliomas in which the pathway is upregulated, especially given the recovery of the normal architecture after regression of the hyperplasia." In a preview o...
Gliomas in Biological Technology

Diffusion Pharmaceuticals Announces Completion of a $2.9 Million Private Placement and Company Presentations at Upcoming Industry Conferences in Geneva, Switzerland and Naples, Florida

...ograms, which include a multi-center Phase I/II clinical trial in peripheral arterial disease patients and a Phase I trial in patients with high-grade gliomas at Johns Hopkins University . These clinical trials are designated NCT00725881 and NCT00826930 , respectively, on the clinicaltrials.gov Website....

Pharmacyclics Reports Fourth Quarter and Fiscal 2008 Financial Results

...esident and chief executive officer of Pharmacyclics. "Enrollment in two Phase 2 trials with motexafin gadolinium for adult brain tumors and childhood gliomas also continues under sponsorship of the National Cancer Institute and we are planning to conduct a pivotal Phase 3 trial with motexafin gadolinium in ...

NIMOTUZUMAB CLINICAL DATA PRESENTED AT ASCO ANNUAL MEETING

...ffects observed with the other drugs in its class." "Phase III trial of nimotuzumab for the treatment of newly diagnosed diffuse intrinsic pontine gliomas in children and adolescents" (Abstract number 2058): This poster reported data from a multi-centre Phase III study evaluating the feasibility and ...

ONCOSCIENCE AG, THE EUROPEAN PARTNER OF YM BIOSCIENCES, ANNOUNCES COMPLETION OF PATIENT ENROLLMENT IN PHASE III BRAIN CANCER TRIAL OF NIMOTUZUMAB

...epresents a unique observation in these end-stage patients and has generated considerable interest. More than half of the high-grade brain cancers or gliomas over-express epidermal growth factor receptor (EGFR) and for the most advanced brain cancers, glioblastoma multiforme (GBM), the level of expression i...

YOUR DATA: Direct Real-time RT-PCR on Sympathetic Neuron Lysates Silencing of Focal Adhesion Kinases with Silencer Validated siRNAs

... used in gene silencing studies. Silencing of Focal Adhesion Kinases Malignant gliomas such as glioblastomas are a leading cause of CNS tumor-related death. At the root of the problem is the high...

YOUR DATA: Direct Real-time RT-PCR on Sympathetic Neuron Lysates Silencing of Focal Adhesion Kinases with Silencer Validated siRNAs

... used in gene silencing studies. Silencing of Focal Adhesion Kinases Malignant gliomas such as glioblastomas are a leading cause of CNS tumor-related death. At the root of the problem is the high...
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