Two-Year Data Show Investigational Drug Liraglutide More Effective at Lowering Blood Sugar Than Glimepiride
NEW ORLEANS, June 8 /PRNewswire-FirstCall/ -- Novo Nordisk (NVO) data presented at the 69th Annual Scientific Sessions of the American Diabetes Association (ADA) showed that once-daily liraglutide, taken as monotherapy, leads to statistically significant and sustained reductions in blood sugar and...
New Diabetes Drug Shows Promise in Trial
...milar trial, published in The Lancet last September, which found liraglutide performed better than a now-standard medication from a different class, glimepiride
(Amaryl). That trial was also sponsored by Novo Nordisk.
Like the other GLP-1 versions, liraglutide has all the advantages of the natural molecule,...
New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes
...ith metformin, one with pioglitazone, and one with glimepiride
with or without metformin, were also conducted. In...e dose of metformin, pioglitazone, glimepiride, or glimepiride
and metformin, patients whose diabetes was not ade...or Add-on Combination Therapy with Pioglitazone or glimepiride
+/- Metformin: Adverse Reactions Reported in >=5% ...
New data showed Actos prevented progression of atherosclerotic plaque volume in patients
... in coronary artery atheroma volume in favor of ACTOS treatment compared to glimepiride
The data showed that patients treated with glimepiride, a s...cardiovascular mortality, non-fatal MI, or non-fatal stroke was 6 (2.2%) in glimepiride
patients and 5 (1.9%) in ACTOS-treated patients. The number of hospitaliza...
Mayo Clinic researchers: Insulin-boosting medication does not impair ability to survive heart attack
... several commonly used pills to increase insulin release to lower blood sugar. Second-generation sulfonylureas -- known collectively as SU2 -- include glimepiride
(Amaryl), glipizide (Glucotrol, Glucotrol XL), and glyburide (DiaBeta, Micronase, Glynase).(1)
Significance of the Mayo Clinic Study
Diabetes Drug Benefits vs. Risks
...a and heart failure.
The researchers also concluded that taking pioglitazone in combination with the sulfonylureas such as tolbutamide, glipizide and glimepiride
may cause dangerous drops in blood glucose.
Richter, an assistant professor in the department of endocrinology, diabetes and rheumatology at Heinr...
Widely Prescribed Diabetes Drug Falls Short of Promise, Says New Review
...sulin or another class of diabetes drugs called “sulfonylureas,” which are marketed in the United States under the generic names glipizide, glyburide, glimepiride
"The kernel from this review is that pioglitazone is effective in glucose-lowering, has some other beneficial and potentiall...
Glimepiride in the medical management of Type 2 diabetes
...dinediones, a-glucosidase inhibitors, and insulin. The unique properties of glimepiride
may provide advantages over other currently available insulin secretagogues...everal properties that may overcome some of these limitations. In addition, glimepiride
has been found to effectively reduce PPG and FPG levels and A1C concentrati...
Two-Year Data Show Investigational Drug Liraglutide More Effective at Lowering Blood Sugar Than Glimepiride: Oral 162
...C less than 7% versus 37% of patients treated with glimepiride
8 mg once daily.
"The fact that liraglutide c...2.7 kg) compared to overall weight increase in the glimepiride
group (+1.1 kg).
Hypoglycemia is a condition...the liraglutide treatment groups compared with the glimepiride
About LEAD (TM) 3 Extension
Boehringer Ingelheim Unveils Diabetes Pipeline
... patients received double-blind treatment with linagliptin (1 mg, n=65; 5 mg, n=66; 10 mg, n=66) or placebo.(1) An open-label arm with 65 patients on glimepiride
was added for descriptive control.(1)
Additional results from the study
The addition of linagliptin to metformin treatment for 12 weeks re...
Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes
...icacy and safety of two doses of liraglutide (1.2 and 1.8 mg once daily)
(8 mg once daily) in patients with type 2 diabetes treated
Monotherapy Liraglutide Liraglutide glimepiride
1.8 mg 1.2 mg
New Data Showed ACTOS(R) (pioglitazone HCl) Prevented Progression of Atherosclerotic Plaque Volume in Patients With Type 2 Diabetes
...ilure (CHF). The number of
episodes of a common cardiovascular endpoint of cardiovascular mortality,
non-fatal MI, or non-fatal stroke was 6 (2.2%) in glimepiride
5 (1.9%) in ACTOS-treated patients. The number of hospitalizations due to
CHF was equivalent in both arms. In the ACTOS-treated group, ei...
Data Presented at the American Heart Association Scientific Sessions 2007 Demonstrated Increased HDL with ACTOS(R) (pioglitazone HCl) Slowed the Progression of Carotid Intima-Media Thickness in Patients with Type 2 Diabetes
...double-blind, controlled study enrolled
462 patients with type 2 diabetes. Patients were treated with a 15 to 45 mg
dose of ACTOS or 1 to 4 mg dose of glimepiride
for 72 weeks with evaluation
after 6 months. The results from the CHICAGO study demonstrated significant
improvements on cardiovascular risk markers b...
Liraglutide provides significantly better glucose control than
insulin glargine in phase 3 study
groups was on average 3.5 kg, statistically significant in favour
Liraglutide in combination with metformin and glimepiride
tolerated. The most frequently reported adverse event in the
liraglutide arm was nausea at an absolute level of between 10 and
15%. As expect...
MEDIA ADVISORY: Subsets of Landmark Diabetes Trials Investigating
MacroVascular Outcomes Presented at the American Diabetes
Association 67th Scientific Sessions
Poster 0905-P presented on Sunday, June 24, from 12-2 p.m. and 6:15-
-- Comparative effects of pioglitazone and glimepiride
subfractions: results from the CHICAGO Trial; Poster 0906-P presented
on Sunday, June 24, from 12-2 p.m. and 6:15-7:30 ...
Late Breaking Data Released at ADA Showed that the Investigational
Use of Januvia and Metformin as Initial Combination Therapy
Provided Significant Glucose Lowering Efficacy over 54 Weeks in
Patients with Type 2 Diabetes
...with type 2 diabetes when added to a
(dual combination therapy), or when added
to a sul... from placebo in A1C of
0.9 percent in patients on glimepiride
and metformin and 0.6
percent in patients on glimepiride
alone (p less than 0.001 for
both comparisons to t...