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Glial in Medical News

St. Jude Scientists Discover a New Mechanism Controlling Neuronal Migration

... In the experiments, the researchers sought to understand the biological machinery powering a process called glial-guided neuronal migration. glial cells in the brain support and guide neurons, which make up the brain's wiring. During brain development, neurons are born in germinal zones at some d...

CU-Boulder study shows brain's immune system may cause chronic seizures

...ajor role in seizures. Researchers have found that glial cells, which are supportive cells that also consti...ract the damage and repair it," Barth said. "These glial cells migrate to the damaged area and release chem...n our new study, we showed for the first time that glial cells moving in and secreting these cytokines caus...

Popular Alzheimer's theory may be false trail

...glial cells are a subset of a very large population of brain cells known as glial cells. Neurons are the workhorse cells of the brain, enabling thought and m...e their faithful sidekicks, providing physical and nutritional support. glial cells, which outnumber neurons 10-to-1, are at the heart of a popular expla...

Drummer Eddie Cleland Resumes Life After Brain Surgery and Tells About it at Conference

...o knows?" Cleland recalled. They settled on Dec. 20. Cleland's tumor was a diffuse astrocytoma, also called a Grade II glioma. Gliomas arise from glial cells, which provide support for nerve cells in the brain. Low-grade gliomas (Grade I and II) are considered pre-malignant. Although not yet cancers, ...

Ceregene Presents Additional Clinical Data from Phase 2 Trial of CERE-120 for Parkinson's Disease

...r damaged and dying dopamine-secreting neurons, keeping them alive and restoring normal function. Neurturin is a member of the same protein family as glial cell-derived neurotrophic factor (GDNF). The two molecules have similar pharmacological properties, and both have been shown to benefit the midbrain ...

Hard To Treat Diseases (HTDS) Best Technological Innovation Award 2009

...ication, HTDS included extremely encouraging results from the preliminary trial of their Ribavirin product, confirming its combative effective against glial scarring. HTDS Chief Scientist, Dr. Sanja Pekovic was elected as an expert to represent Serbia in the COST (European Cooperation In The Field of Sci...

Astrocytes help separate man from mouse

...," added Nedergaard, who spoke last week at a Gordon Research Conference on glial biology. "Studies in rodents show that non-neuronal cells are part of infor...ks using different languages," said Nedergaard, director of the Division of glial Disease and Therapeutics of the Center for Translational Neuromedicine. "Yo...

Experts examine causes, treatment and prevention of glaucoma

...ontribute to glaucoma. One conference session addressed the function of glial cells, which play many roles in support of neurons throughout the body, including those in the visual system. When glaucoma stress conditions appear, glial cells may not be able to adequately support neurons or perform their other ...

Hormone Drug May Help Drinkers Stay Sober

... counter conditions caused by the body producing too much of the hormone prolactin. The medication had been shown to increase the body's production of glial cell line-derived neurotrophic factor protein (GDNF), which the research team had previously found decreased the desire for alcohol in addicted rodent...

Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers

...ut 77 percent of malignant brain tumors are gliomas and their prognosis is usually bleak. While they rarely spread to elsewhere in the body, cancerous glial cells quickly infiltrate the brain and grow rapidly, which renders them largely incurable even with current therapies. Gliomas originate in brain ...
Glial in Medical Technology

Solace Pharmaceuticals Initiates Phase IIa Trial of Glial Cell Modulator SLC022 in Post-Herpetic Neuralgia

CAMBRIDGE, Mass., Jan. 12 /PRNewswire/ -- Solace Pharmaceuticals, a private biotechnology company discovering and developing innovative treatments for pain, announced the initiation of a proof-of-concept clinical trial of SLC022 in patients with post-herpetic neuralgia (PHN). PHN, a painful co...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

...nt, can significantly reduce this death in an animal model of retinal detachment. In addition, we show that Palomid 529 also reduces the activation of glial cells and subsequently slows the formation of subretinal scar tissue, a condition that can prevent the regeneration of photoreceptors following succes...

Astrocytes Help Separate Man From Mouse

...," added Nedergaard, who spoke last week at a Gordon Research Conference on glial biology. "Studies in rodents show that non-neuronal cells are part of infor...ks using different languages," said Nedergaard, director of the Division of glial Disease and Therapeutics of the Center for Translational Neuromedicine. "Yo...

Groundbreaking Paper Publishes Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinson's Disease

...ovement. This suggests that in humans, Parkinson's disease is more than a chronic dopaminergic dysfunction and involves the GABA-ergic system with its glial environment. The relevance of this discovery cannot be understated because it questions the classical dopaminergic model of Parkinson's disease," says...

Headache Specialists Convene in Boston For 50th Annual American Headache Society Meeting

...covered neurons are not the only carrier of pain signals to the brain. glial cells, which outnumber neurons 20:1, have been shown to prompt chronic...ve damage or even medication. Morphine and other opiates also activate glial cells, which mean those drugs you're taking to alleviate pain might ac...

Ceregene Presents Long Term Follow-Up Data From Phase 1 Trial of CERE-120 Demonstrating Improved Motor Function in Parkinson's Patients

...own to repair damaged and dying dopamine-secreting neurons, keeping them alive and functioning normally. NTN is a member of the same protein family as glial cell-derived neurotrophic factor (GDNF). The two molecules have similar pharmacological properties, and both have been shown to benefit the midbrain d...

Data from Investigator-Sponsored Trial of Oncophage Cancer Vaccine in Glioma Presented at American Association of Neurological Surgeons Annual Meeting

...ophage could have a significant impact." About Brain and Spinal Cord Tumors Glioma is a cancer affecting the central nervous system that begins in glial cells (connective tissue cells that surround and support nerve cells). Malignant glioma is currently a fatal disease. The American Cancer Society esti...

Expert Opinion Highlights Avigen's AV411 as Potential New Therapeutic for Neuropathic Pain and Opioid Withdrawal

...patients with diabetic neuropathic pain, modulates glial cell function, an important contributor to chronic... unique properties, AV411 attenuates or suppresses glial cell activation in brain and spinal cord tissues a...his research adds to the increasing recognition of glial attenuation as a potential new paradigm shift in h...

Molecular Target of Bradmer's Neuradiab Further Validated by Independent Findings

...tments for glioblastoma multiforme (GBM). The researchers identified that the loss of NOTCH2 gene positively predicts survival in subgroups of human glial brain tumors (http://www.plosone.org/doi/pone.0000576 ) and these markers are highl...

Ramón Carrillo

...rosurgery and neurobiology Between 1930 and 1945 he contributed valuable original research about the brain cells which are not neurons—named glial cells —and the method for staining and observing them under the microscope , as well as on their evolutionary origin ( phylogeny ), and the comparati...
Glial in Medical Dictionary

Optic glioma

...as , which affect one or both the optic nerves, or the optic chiasma. An optic pathway glioma is a tumor arising from a specific type of glial cell ... This hormone center can be affected by a glioma of the optic pathway system. ... Rarely, a malignant optic glioma can occur i...

Gliomas

... A glioma is a type of cancer that starts in the brain or spine. It is called a glioma because it arises from glial cells. The most common site of gliomas is the brain. Offers intensive chemotherapy for the treatment of brain gliomas , lung cancer, mesoth...
Glial in Biological News

Penn study finds direct role for glial cells in brain cross-talk

Findings may help elucidate mechanisms of wake-sleep transitions and epileptic seizures Researchers at the University of Pennsylvania School of Medicine have demonstrated that star-shaped glial cells in the brain called astrocytes are directly involved in regulating communication between neurons...

Work in mice will contribute to the study of hereditary diseases that lead to blindness

...onal scientific meetings: VIII European Meeting on glial Cell Functions in Health and Disease (Londres), VII European Meeting on glial Cell Functions in Health and Disease (Amsterdam), IV Meeting of the Spanish glial Network (Madrid), etc. ...

Cell's split personality is a major discovery into neurological diseases

... cell death involves another vital player namely, glial cells," says Dr. Adriana Di Polo, neuroscientist a...now that glutamate activates signaling pathways in glial cells that then lead to neuronal death." glial cells are the most abundant cell type in the nervo...

Fluorescent cancer cells to guide brain surgeons

... Gliomas are malignant brain tumors that arise from glial (supporting) cells of the brain. Gliomas are often resistant to chemotherapy. These tumors grow fine extensions that infiltrate normal brain tissue an...

Rett Syndrome Research Trust advisor makes significant discovery

...toms and the ongoing struggles to address them. glial cells, which reside throughout the nervous system,...g protective insulation for axons. These and other glial functions are essential to the health of neurons. ...ew study adds to the growing body of evidence that glial cells are critically important contributors to neu...

Transplanted fat cells restore function after spinal cord injury

...atient) tissue," said Ohta. "DFAT cells, with none of the features of adipocytes, do have the potential to differentiate into endothelial, neuronal or glial lineages." The research team reported that DFAT cells expressed neurotrophic factors, such as BDNF and GDNF, prior to and after transplantation and ...

Claudin 11 stops the leaks in neuronal myelin sheaths

... 1, 2008 issue of the Journal of Cell Biology ( www.jcb.org ). Like the rubber coating on a copper wire, the myelin sheatha membrane extension of glial cells that spirals around the axons of neuronscreates an insulation layer that prevents current leakage from axons and aids electrical conduction alon...

Swamping bad cells with good in ALS animal models helps sustain breathing

...atory decline." Also significant is that the transplanted cells, called glial restricted precursors (GRPs), address a well-known flaw in people with ALS ...he nervous system. In their research, the team transplanted some 900,000 glial restricted precursors overall to specific sites in the cervical spinal cord...

2 Alexander von Humboldt professorships go to LMU Munich

...hose work on the fruit fly drosophila has contributed enormously to our understanding of gene regulation during organismic development and the role of glial cells in the nervous system. Her laboratory has discovered many new genes that control the formation of the blood-brain barrier and the efficient elim...

Songbirds may hold key to advances in treatment of brain degeneration

...opy, Saldanha, along with a team of post-doctoral, graduate and undergraduate students, examines structures and chemicals inside neurons, synapses and glial cells within the brain. Using a variety of testing methods, Saldanha was able to test his synaptic hypothesis, and is ready to start on the next phase...
Glial in Biological Technology

Ceregene Receives Additional Grant From Michael J. Fox Foundation to Expand Long-Term Testing of CERE-120 Patients

...r damaged and dying dopamine-secreting neurons, keeping them alive and restoring normal function. Neurturin is a member of the same protein family as glial cell-derived neurotrophic factor (GDNF). The two molecules have similar pharmacological properties, and both have been shown to benefit the midbrain ...

Solace Pharmaceuticals Appoints Professor David Julius, Renowned Pain Physiologist, to Scientific Advisory Board

...lementary to those of Solace, especially with respect to his recent work in glial cells, and we share his dedication to transforming biological insights into...ve disease-modifying potential in two key areas: modulating the activity of glial cells and intervening in the tetrohydrobiopterin (BH4) pathway. SLC022, the...

UW-Madison rat experiment could lead to stem-cell treatment for ALS

...ls not only replace damaged cells but help protect existing motor neurons. The protein that actually protects the motor neurons is called GDNF, for glial cell-line derived neurotrophic factor. "The approach we're taking is a protective approach versus a cell-replacement approach," said Sandra Klein, ...

Stem cells produce anti-disease protein in brain experiment

...ntrol the bodys movement, to recover from the damage caused by disease. The study involved use of a naturally occurring protein in the brain called glial cell-derived neurotrophic factor, or GDNF, which has been found to help the brain keep generating dopamine. Experimental evidence in both animals and ...

Stem cell therapy shows visionary promise

... chemicals that may influence the cells around them. "The idea was to test the cells as a continuous delivery system" to shuttle an agent known as glial cell line-derived neurotrophic factor or GDNF, Lund explains. "It's not a sensible thing to inject the eyes many times over years. The idea was to use...

Your Data: Silencing of a Pro-apoptotic Transcription Factor Using Synthetic siRNA

...were removed from the culture medium, differentiation of the primary neural stem cells, which normally give rise to neuronal and glial cells, was altered in the siRNA treated cells. siRNA-mediated gene silencing is thus proving to be a powerful tool for the study...

Efficient DNA transfection of primary CNS neurons using TransMessenger Transfection Reagent

... www.qbmcellscience.com ), which contain a mixture of neuronal and glial cells. The cultured cells expressed characteristic markers and sho... for neurons, anti-GFAP antibodies for astrocytes, the major subtype of glial cells in the brain). " Excellent Morphology of CryoCell C...

Effectene Transfection Reagent provides efficient gene delivery to primary neuronal cell cultures

...ontaining a confluent layer of collicular glial cells and were cultured for up to 3 weeks. On the ...o, cytosine arabinoside (4 M) was added to inhibit glial cell proliferation. Transfection was perf...slips containing the neurons were removed from the glial cell culture and placed cell-side up in 3...
Glial in Biological Products

rNeural Stem Cell (rNSC)Kit from AlphaGenix, Inc.

Description:... Rat neural stem cell kits are intended for the in vitro growth and commitment to neuronal and glial lineage differentiation, of cultured fetal rat neural stem and progenitor cells expanded using FGF-2....
Company:AlphaGenix, Inc.

Human Neural Stem Cell Functional Identification Kit from R&D Systems

Description:...d the induction of NSCs into astrocyte, neuron and oligodendrocyte lineages. An antibody panel consisting of mouse anti-human Nestin, mouse anti-human glial Fibrillary Acidic Protein (GFAP), mouse anti-Neuron-specific beta-III Tubulin, and mouse anti-Oligodendrocyte Marker O4 are also included to identify ...
Company:R&D Systems

Mouse/Rat Neural Stem Cell Functional Identification Kit from R&D Systems

Description:...he differentiation of NSCs into astrocyte, neuron and oligodendrocyte lineages. An antibody panel consisting of goat anti-rat Nestin, sheep anti-human glial Fibrillary Acidic Protein (GFAP), mouse anti-Neuron-specific beta-III Tubulin, and mouse anti-Oligodendrocyte Marker O4 are also included to identify ...
Company:R&D Systems

Immunodetection of Specific Proteins from QualTek Molecular Laboratories

Description:...nic Animals Hundreds of Specialty Markers, Including: Vector Detection with - Galactosidase Proliferation Markers - PCNA, Brdu, Ki67 Neural and glial Markers Apoptosis Related Proteins Visualization of Low Expresser Proteins...
Company:QualTek Molecular Laboratories

Neural Stem Cell Expansion Kit - Monolayer from R&D Systems

Description:... the antibodies Tuj1, O4 and anti-GFAP, respectively. Neural stem cells (NSCs), with the potential to self-renew and to differentiate into neurons and glial cells, have been isolated from different regions of the developing and adult brain (1 - 6). NSCs can be grown in vitro , in the presence of mitogen, ...
Company:R&D Systems

Neural Stem Cell Expansion Kit - Neurosphere from R&D Systems

Description:... the antibodies Tuj1, O4 and anti-GFAP, respectively. Neural stem cells (NSCs), with the potential to self-renew and to differentiate into neurons and glial cells, have been isolated from different regions of the developing and adult brain (1 - 6). NSCs can be grown in vitro , in the presence of mitogen, ...
Company:R&D Systems

Neural Stem Cell Expansion Kit - Monolayer Plus from R&D Systems

Description:... the antibodies Tuj1, O4 and anti-GFAP, respectively. Neural stem cells (NSCs), with the potential to self-renew and to differentiate into neurons and glial cells, have been isolated from different regions of the developing and adult brain (1 - 6). NSCs can be grown in vitro , in the presence of mitogen, ...
Company:R&D Systems

NeuroCyte - Rat Neural Stem Cell Kit from Orion BioSolutions, Inc.

Description:...rts a unique mix of nestin expressing neuroepithelial stem cells and radial glial cell-like neuroglial progenitors, which retain the capacity for multi-linea...differentiated neuroepithelial sheets provide an anchor for directed radial glial cell process extension and subsequent neuroglial progenitor and neuroblast ...
Company:Orion BioSolutions, Inc.

Histology Services - Special Stains from Mass Histology Service

Description:...tain for melanin Gridley`s Stain for ameba Grimelius Argyrophil Stain (Pascual`s Method) Grocott`s Methenamine Silver (GMS) Stain Holzer`s glial Fiber Stain Hortega`s Pineal Stain Jones` Silver Stain Nissl Stain Orcein Stain Reticulin Stain Spirochete Stain (Steiner & Steiner ...
Company:Mass Histology Service
Glial in Biological Definition

Axon

...metre or even longer. In vertebrates generally, the axons of many neurons are sheathed in myelin , which is formed by either of two types of glial cells : Schwann cells ensheathing peripheral neurons and oligodendrocytes insulating those of the central nervous system . Along myelinated ne...

Intermediate filament

... some organelles in a fixed place within the cytoplasm . Peripherin found in peripheral neurons. GFAP (glial fibrillary acidic protein) in glial cells . Neurofilaments These are found in nerve cells and are implicated in the radial growth of the axon . α-Internexin Neu...

Ion channel

...g manner. They are involved in important physiological processes such as the pacemaker activity in the heart, insulin release, and potassium uptake in glial cells. Certain channels respond to multiple influences. For instance, the NMDA receptor is partially activated by interaction with its ligand, ...

Neuron

...nmyelinated axons of the same diameter. Formed by glial cells in the central nervous system and Schwann c...f the central nervous system. There are far more glial cells than neurons, and recent experimental results have suggested that glial cells play a vital role in information processing ...
Glial in Biological Dictionary

Schwann cells

...German physiologist Theodor Schwann , Schwann cells are a variety of glial cell that keep peripheral nerve fibres alive. In myelinated axons, Sch.... This report shows that Schwann cells respond to recombinant human glial Growth ... ...

Proto-oncogene

... high levels, helps turn a normal cell into a cancer cell. The RET proto - oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules. RET loss of function mutations are associated with the... ....

Neuroglia

... glial cells, commonly called neuroglia or simply glia,...lia in the free online English dictionary and ... glial cell, neurogliacyte, neuroglial cell - a cell ...lia n. See neuroglia . [Short for NEUROGLIA .] glial gli ' al adj. ... Neuroglia ; the supporting cel...

Myelin sheath

...myelin sheath , usually around only the axon of a neuron. It is essential for the proper functioning of the nervous system. Myelin is an outgrowth glial cell: Schwann... Supports research on myelin repair after it has been destroyed by hereditary disorders such as the leukodystrophies or ... My...

Myelin

...myelin sheath, usually around only the axon of a neuron. It is essential for the proper functioning of the nervous system. Myelin is an outgrowth glial cell: Schwann... myelin also myeline ( ) n. A white fatty material, composed chiefly of lipids and lipoproteins, that encloses certain axons an...

Motor neuron

...t > motor neuron disease definition ... MOTOR NEURON DISEASES ... Degenerating motor neurons contain ubiquitin-positive neuronal and glial ... This causes motor neuron loss by an unkown mechanism. ... Spasticity is found with upper motor neuron injuries and manifests as a marke...

Glial cells

... glial cells , commonly called neuroglia or simply glia...mission in the nervous system. In the human... glial cells , commonly called neuroglia or simply gl... are one of two major ... In the mammalian brain, glial cells are estimated to outnumber neurons by abo...
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