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Genotype in Medical News

Surveyed Physicians Will Treat Over 50 Percent of Hepatitis C Genotype 1-Infected Patients With the Protease Inhibitor Telaprevir

WALTHAM, Mass., Aug. 4 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, based on profiles provided to them of emerging protease inhibitors, surveyed physicians indicate that they will prescr...

Human papillomavirus genotype distribution in New Mexico cervical cancers

DNA from human papilloma virus type 16 (HPV16) and HPV type 18 (HPV18) were found in the majority of invasive cervical cancers in New Mexico in the 1980s and 1990s, according to a population-based study published in the March 24 online issue of the Journal of the National Cancer Institute. T...

Tibotec presents interim findings for TMC435, an investigational genotype 1 hepatitis C treatment

SAN FRANCISCO (November 3, 2008) New clinical data show antiviral activity of TMC435, an investigational protease inhibitor (PI) being developed by Tibotec BVBA for the treatment of chronic hepatitis C virus (HCV) infection. Tibotec will present findings from three TMC435 studies, including a lat...

Children's Hospital Contributes Genotype Data to Enhance Autism Research Worldwide

PHILADELPHIA, April 7, 2008 /PRNewswire-USNewswire/ -- The Children's Hospital of Philadelphia has contributed a large genotype dataset to the Autism Genetic Resource Exchange (AGRE), a scientific program of the organization Autism Speaks, dedicated to advancing genetic research in autism. Thi...

Possible Alzheimer's disease marker discovered in rare genotype

Amsterdam, The Netherlands and Sun City, AZ, USA, January 15, 2009 Researchers at Banner Health's Sun Health Research Institute have uncovered evidence that Alzheimer's disease (AD) may be clinically confirmed in patients with apolipoprotein E2 homozygote. The results of their study are published...

Brain Imaging (MRI/PET) and Measurements of Proteins in Spinal Fluid May Improve Alzheimer's Prediction and Diagnosis

...acy was 95.7%. When the researchers also included measures of tau and beta amyloid in CSF and presence or absence of a known Alzheimer's risk genotype (ApoE-e4), they could correctly identify people with MCI who progressed to Alzheimer's within 1.5 years with 95.6% accuracy, but the model including o...
Genotype in Medical Technology

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

48-week investigational regimen yielded nearly double SVR rate compared to standard of care Update on next-generation HCV protease inhibitor SCH 900518 presented at EASL annual meeting COPENHAGEN, Denmark, April 23 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) toda...

Tibotec Presents Interim Findings for TMC435, an Investigational Genotype 1 Hepatitis C Treatment, at the AASLD Liver Meeting 2008

Nearly 90 percent of patients achieve undetectable viral load in Phase IIa trial within 28 days of combined treatment with standard of care SAN FRANCISCO, Nov. 1 /PRNewswire/ -- New clinical data show antiviral activity of TMC435, an investigational protease inhibitor (PI) being developed by...

Boceprevir Phase II Study Showed High Rate of Sustained Response With 28- and 48-Week Regimens in Genotype 1 Treatment-Naive Hepatitis C Patients

Interim results of HCV SPRINT-1 study presented at AASLD annual meeting Pivotal Phase III studies ongoing in treatment naive patients and those who failed prior treatment SAN FRANCISCO, Nov. 1 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today reported that a planned...

Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients

74 percent of patients achieved SVR 12 with 48-week boceprevir-based combination therapy High SVR 24 rate also reported for 28-week boceprevir arm KENILWORTH, N.J., Aug. 4 /PRNewswire-FirstCall/ -- Schering-Plough Corporation (NYSE: SGP ) today reported top-li...

Romark Laboratories Completes Enrollment in U.S. Phase II Study of Nitazoxanide for Chronic Hepatitis C Genotype 1 Non-Responders

TAMPA, Fla., May 21 /PRNewswire/ -- Romark Laboratories, L.C., a privately-owned biopharmaceutical company, today announced the completion of enrollment into its Phase II clinical trial to evaluate the safety and efficacy of nitazoxanide in combination with standard of care therapy in U.S. pat...

Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL

MILAN, Italy, April 26 /PRNewswire/ -- Schering-Plough Corporation (NYSE: SGP ) today reported that results from a planned interim analysis of an ongoing Phase II study of boceprevir, its investigational oral hepatitis C protease inhibitor, in 595 treatment-naive patients with chronic hepatit...
Genotype in Medical Products

Alpha-1-Antitrypsin & Alpha-1-Antitrypsin Genotype with Reflex to Alpha-1-Antitrypsin Phenotype

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Hepatitis C Virus RNA Quantitative by Real-TimePCR with Reflex to Genotype

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Hepatitis C Virus Quantitative with Reflex to Hepatitis C Genotype

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Genotype in Medical Definition

Personalized medicine

... Personalized medicine is the use of detailed information about a patient's genotype or level of gene expression and a patient's clinical data in order to select a medication , therapy or preventative measure that is particularly s...
Genotype in Medical Dictionary

Noninsulin-dependent diabetes mellitus

...ype 2 diabetes (formerly called non-insulin - dependent diabetes or adult-onset ... Non-Insulin - Dependent Diabetes Mellitus : Thrifty genotype or Thrifty ... Type 2 ( non-insulin - dependent ) diabetes mellitus : the thrifty phenotype hypothesis. ... Diabetes ... ClinicalTrials.gov: ...

Aging

... Professional membership association in the field of aging . This page contains information for the public on the subject of aging . ... APOE genotype and Cognitive Functioning in a Large Age -Stratified Population Sample ... Harvard Medical School research on aging , featuring consumer informa...
Genotype in Biological News

Virus-resistant grapevines

...ses and prevent them from spreading in the plant and causing damage." To enable the plant to produce the antibodies, the scientists have to modify its genotype and channel genetic information for the antibodies into it. This task is performed by tiny helpers called agrobacteria, which genetic engineers have b...

CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability

...ogic and combinatorial number-placement rules used in the popular game. The method, which the CSHL team has patented, is currently best suited for genotype analyses that require only short segments of an individual's genome to be sequenced to find out if the individual is carrying a certain variant of a g...

Did the North Atlantic fisheries collapse due to fisheries-induced evolution?

... "There is no direct targeting of specific genotypes. Instead the intense selection results from the interaction of fish that select their habitat by genotype and fishermen choosing to fish in the preferred habitat of the fish," said Einar Arnason, professor of population genetics and lead author. In addi...

Common gene variants influence risk factor for sudden cardiac death

...dies" said Newton-Cheh. The QTGEN investigators examined the effect of a genotype score comprised of all 14 variants tested together. The top 20 percent of the population with the highest genotype scores had 160 to 210 percent higher risk of prolonged QT interval compared...

Female mammals follow their noses to the right mates

...y dissimilar males. Parents with dissimilar genes in a certain part of the genome tend to produce healthier offspring. So male mammals advertise their genotype via scent, and females pick up the signal and preferentially mate with dissimilar males. This ability to sniff out a good genetic match has been found...

Identifying mega-targets for high-yield plant breeding

...o evaluate every single candidate genotype. Predicting the performance of a genotype is difficult due to the multiple breeding objectives and the many environmental conditions of genotype evaluation. Therefore, finding adapted elite genotypes is challenging if th...
Genotype in Biological Technology

Pharmasset Reports Preliminary Results of a 4-week Proof-of-Concept Combination Study of R7128 for the Treatment of Chronic Hepatitis C in Genotype 2 or 3 Non-Responders

- 90% of genotype 2 or 3 patients achieve undetectable HCV RNA levels following 4 weeks of treatment with R7128 1500mg BID with Pegasys(R) plus Copegus(R) - - Safety and tolerability comparable to placebo administered with Pegasys plus ...

Synvista Therapeutics Highlights Newly Published Data Demonstrating the Value of Haptoglobin Genotype Testing In People with Diabetes

Study Shows Statin and Antioxidant Therapy to be Superior to Statins Alone in Decreasing Cardiovascular Events in Diabetics with Haptoglobin 2-2 Genotype MONTVALE, N.J., March 5 /PRNewswire-FirstCall/ -- Synvista Therapeutics, Inc. (Amex: SYI ) announces the p...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

...commence within the next several weeks. In the Phase II study, naive genotype 1 patients will receive ANA598 or placebo in combination with Pegasys(R) (p... antiviral activity and good tolerability. In a monotherapy study in naive genotype 1 patients, treatment with ANA598 for three days led to median declines in ...

Anadys Pharmaceuticals Reports Second Quarter 2009 Financial Results and Program Highlights

...I study of ANA598 in combination with pegylated interferon-alpha and ribavirin for the treatment of chronic hepatitis C. In the Phase II study, naive genotype 1 patients will receive ANA598 or placebo in combination with Pegasys(R) (peginterferon alfa-2a) and Copegus(R) (ribavirin, USP) (a current standard o...

Atherotech Taps Canyons Medical Center Director, Lipidologist as Chief Medical Officer

...ng For." The company also provides more than a dozen cardiovascular and metabolic testing panels, including C-Reactive Protein (hsCRP), ApoE genotype and NT-proBNP for assessment of patients at intermediate to high risk of cardiometabolic diseases. Atherotech continues to add advanced and follow-up ...

Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease

...AC-1202 may produce lasting effects in those patients with this combination of genotypic markers. The combination of the E4(-); IDE_7(C/C)(-) genotype is prevalent in approximately 40% of the AD population, so the number of potential responder patients is substantial. "This pharmacogenomic ...
Genotype in Biological Products

LIGHT DIAGNOSTICS™ Calicivirus Genotype 1&2 OligoDetect® from CHEMICON

Description: The Light Diagnostics Calicivirus Genotype 1&2 Typing OligoDetect assay is applicable for the qualitative detection of calicivirus RNA generated by an in-house validated in vitro nucleic acid amplification of the polymerase gene....
Company:CHEMICON

GenomeLab SNPstream Genotyping System from Beckman Coulter

Description:...ized for seamless genotyping. The system operates at a consistent cost per genotype or per sample, regardless of run throughput, allowing users to cost-effecti...rocess, from primer design to 384-well plate setup, image data analysis and genotype calling. *GenomeLab is a family of genetic analysis tools from Beckman Coul...
Company:Beckman Coulter

SNP Scoring Service from Polymorphic DNA Technologies, Inc.

Description:...ere is a 24 sample minimum. Our price is $3.00 per genotype (this includes both directions). $2.00 per genotype for one direction. There is no "redo" charge. We p... very large. Robust Polymorphic DNA can provide genotype results for any SNP. Sanger sequencing is universa...
Company:Polymorphic DNA Technologies, Inc.
Genotype in Biological Definition

Allele frequency

...quencies of alleles -- in other words, to evolution . Besides selection, these forces include genetic drift , mutation and migration . Compare genotype frequency . Example If there are ten individuals in a population and at a given locus there are two possible alleles, A and a , then if the ...

Epigenetics

...igenomes. Historical notes Some biologists at one time believed that genetics, which seemed to postulate a one-to-one correspondence between genotype and phenotype , could not explain cell differentiation. They developed a theory that each undifferentiated cell underwent a crisis that determined ...

Fitness landscape

... adaptive landscapes are used to visualize the relationship between genotypes (or phenotypes ) and replicatory success. It is assumed that every genotype has a well defined replication rate (often referred to as fitness ). The set of all possible genotypes and their related fitness values is then calle...

Gene

...ween dominant and recessive traits, the distinction between a heterozygote and homozygote, and the difference between what would later be described as genotype and phenotype. Mendel's concept was finally named when Wilhelm Johannsen coined the word gene in 1909 . In the early 1900s , Mendel's work ...

Hardy-Weinberg principle

...ons, after one generation of random mating , the genotype frequencies at a single gene locus will become f...c drift . Assortative mating will only change the genotype frequencies of those genes that are desired. Genet...p ) aa ( q 2 ) So the final three possible genotype frequencies, in the offspring, if the alleles are ...

Homozygote

... on the two corresponding chromosomes (e.g. the genotype is AA or aa ). A homozygous dominant genotype occurs when a particular locus comprises two allel...inant trait (e.g. AA ). A homozygous recessive genotype occurs when a particular locus comprises two allel...
Genotype in Biological Dictionary

Genotype

The genotype is the genetic constitution of a cell, an organism, or an individual usually with reference to a specific character under consideration. For instance, the human albino gene has two allele forms, dominant A and... genotype n. The genetic makeup, as distinguished from th...

Wild-type

... type Xenopus laevis are very ... Lab bred frogs never are exposed to the same rigid standards ... wild type - The most frequent allele or genotype found in nature, or a specified ... Science Magazine (subscription)...(B) A fertilized wild - type ovule. ... Definition of wild type from t...

Wild type

...y, betta ... These are wild type species so there are slight variations between each fish, ... wild type - The most frequent allele or genotype found in nature, or a specified ... Science Magazine (subscription)...(B) A fertilized wild - type ovule. ... ...

Sex cells

.... ... cell is said to be homogametic, because all its cell possess the XX sex chromosomes. ... ... the sex of any resulting zygote, as the genotype of the sex -determining ... Gametes are haploid cells ; that is, they contain half(n) of a complete set of ... Sex cells , and the line­age...

RNA editing

...can also significantly diversify the proteome. ... Protozoan guide RNA -dependent mRNA editing was responsible for the assembly of ... Models of genotype and RNA Editing ... Today, many more RNA editing mechanisms, have been observed. ... The Role of RNA Editing in Dynamic Environments" ... ...

RNA polymerase

... polymerase adds the ribonucleotide in order to the first riboATP and ... The European ... structures of the RNA -dependent RNA polymerase genotype 2a of ... the polymerase - and helicase-like viral RNA synthesis ... RNA polymerase synonyms, RNA polymerase antonyms. Information abou...
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