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GenomeWide in Medical News

Two Fred Hutchinson Cancer Research Center Scientists Receive Presidential Early Career Award

...udies genetic variants across the entire genome and is currently conducting genomewide association studies for colon and breast cancer. The goal is to identify ne...eases. As part of this work, she leads a large international consortium for genomewide association studies of colorectal cancer that combines data from several we...

Genetic Links to Rare Liver Disease Found

...ts with primary biliary cirrhosis as well as samples from people who did not have the condition. In the first phase of the study, researchers did a genomewide analysis, comparing the genotypes of 536 patients with primary biliary cirrhosis with 1,536 people who did not have the disease. In the next phase, re...

2 gene mutations linked to most common brain cancers -- and longer survival

...m targeted therapies in the future," says Parsons. IDH1, which stands for isocitrate dehydrogenase 1, was first spotted last year in results from a genomewide scan of brain cancer mutations led by the Johns Hopkins scientists. At the time, the scientists linked mutations in the IDH1 gene to roughly 12 perce...

Obesity chokes up the cellular power plant

...y the pancreas. The research employed a gene-chip technology that enabled the scientists to measure the activity of all human genes. By employing a genomewide method, biostatistics and the unique set-up of these identical twins, we were able to uncover new mechanisms behind obesity and the early diabetic cha...

NEJM editorial on significance and limitations of new lupus gene expression research

...ributes to the disease. Two of the studies are comprehensive reports of genomewide analyses looking for these types of small changes, specifically for those t...mplex diseases. However, three of the four studies, including both large genomewide association studies, are also missing a critical component they dont take ...

Top10 research advances include studies on genetics and stem cell research, stents

... principle funding source of this study. 2. genomewide association analysis of coronary artery disease This study included a joint analysis of two genomewide association studies of coronary artery disease. R...eplicate the genetic patterning for CAD in another genomewide association study - the German MI [Myocardial Infa...

Gene Hunters at Johns Hopkins Close In On Lou Gehrig's Disease

... In the first genomewide search for the genetic roots of the most common form of amyotrophic lateral sclerosis, Johns Hopkins scientists// have newly identified 34 unique vari...
GenomeWide in Biological News

2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award

...udies genetic variants across the entire genome and is currently conducting genomewide association studies for colon and breast cancer. The goal is to identify ne...eases. As part of this work, she leads a large international consortium for genomewide association studies of colorectal cancer that combines data from several we...

Researchers identify 4 genetic hotspots associated with psoriasis

... SALT LAKE CITY A genomewide scan of millions of genetic mutations has revealed four new DNA "hotspots" ...g to Krueger. The researchers took advantage of a new technology called genomewide association studies (GWAS). At the heart of this is selecting from the mor...

Studies examine genetic determinants of ADHD

...sorder in the hopes that gene discovery will lead to better treatments for the disorder. Among the many studies in the issue are two from the first genomewide association study of individual ADHD patients. The study examined more than 600,000 genetic markers in over 900 families from the largest genetic stud...

Improved statistical tools reveal many linked loci

... interlocking pathways that make up the gene regulatory network. Citation: Storey JD, Akey JM, Kruglyak L (2005) Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol 3(8): e267. ...
GenomeWide in Biological Technology

The NIHR Biomedical Research Centre for Mental Health London has Joined the MetaMiner CNS Partnership Program

...hensive pathway annotation is necessary for us to discern the biological mechanisms revealed by large scale omics approaches to CNS disorders, such as genomewide association and expression array studies." Julie Bryant, GeneGo's VP of Business Development, comments, "The BRC-MH at KCL has world class expert...

deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women

...HP-3 known to be crucial for the success of recombination in other organisms. The paper, entitled 'Sequence Variants in the RNF212 Gene Associate with genomewide Recombination Rate,' is published today in the online edition of Science, at http://www.sciencemag.org/sciencexpress . deCODE has made a number of ...

FlexiPlate siRNA

...ific requirements. siRNAs for any human or mouse gene can be selected as well as any positive and negative controls required. HP genomewide siRNAs, for human or mouse genes or HP Validated siRNAs, which have been shown by real-time RT-PCR to provide at least 70% knock...
GenomeWide in Biological Products

HP GenomeWide siRNA from QIAGEN

Description: For knockdown of all human, mouse, and rat genes using predesigned siRNAs Genomewide, predesigned siRNAs for a direct route to successful RNAi Ready-to-use, convenient matching solutions for SYBR Green based quantitative RT-PCR Cost-effective RNAi and downstream analysis Convenient...
Company:QIAGEN
GenomeWide in Biological Dictionary

Helix-loop-helix

...oop - Helix Motifs :: physiology :: The pore helix dipole has a minor role in inward rectifier channel function. Coordinate expression ... A genomewide survey of basic helix - loop - helix factors ... Dm Usf has a loop and a second helix region, high in serines, which is greatly ... The basic...
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