Genistein

MEK4, genistein and invasion of human prostate cancer cells

Researchers have identified MEK4 as a pro-invasion protein and the target for genistein, a dietary compound, in prostate cancer cells, according to a new study published online July 28 in the Journal of the National Cancer Institute . Li Xu, M.D., Ph.D., and Raymond C. Bergan, M.D., of the Dep...

New Report In The Journal of Nutrition Shows Soy Is Beneficial For Heart and Bone Health

...elping people lead healthier lives through nutrition education and awareness. ( www.Pharmavite.com ) Sources: 1. Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study. J Clin Endocrinol Metab 2008;93:4787-96. 2. Prospective cohort study of soy food consumpti...

Soy compound may halt spread of prostate cancer

...estigators from Northwestern University found that genistein decreased metastasis of prostate cancer to the lun...r chow - making the study the first to demonstrate genistein can stop prostate cancer metastasis in a living or...sm. These impressive results give us hope that genistein might show some effect in preventing the spread of...

Soy Products a Double-edged Sword for Breast Cancer

...ly contradictory findings. Some found that feeding genistein to female rats prior to puberty reduced the number...leagues demonstrated that like estradiol dietary genistein stimulates the growth of estrogen-responsive tumors. They also found that dietary genistein interferes with treatments, such as tamoxifen, tha...

Soy Isoflavones Linked to Lower Prostate Cancer Risk

...re associated with significant risk reduction for localised prostate cancer. The highest intake of soy isoflavones (at least 32.8 milligrams of genistein per day) had a 40 per cent reduced risk compared to those with the lowest intake (less than 13.2 mg/d), the researchers found. "These results we...

Soya Found To Affect Women's Ability To Conceive: Professor

...ucts, like soya sauce and tofu, when trying to conceive. The chemical genistein causes sperm to lose their acrosomes, the caps that allow them to penetrate... find it appeared more sensitive," she said, saying that even tiny doses of genistein could cause sperm to "burn out". Fraser, a professor of Reproductive ...

Safety of soy under suspicion

...earchers, pregnant rats were fed a diet laced with genistein - a chemical found in soya. The scientists found that male rats exposed to high levels of genistein in the womb grew up to have larger prostate glands...ects were just as severe in males that did not eat genistein after weaning as it was in those that continued ea...

Genistein in Medical Technology

New Proof of Genistein's Efficacy and Safety for Osteopenia and Osteoporosis Published in Annals of Internal Medicine

...ults of a two-year clinical study on the impact of genistein on bone loss. The paper, "Effects of the Phytoestrogen genistein on Bone Metabolism in Osteopenic Postmenopausal Wo...ificant gain in bone density among patients taking genistein at both 12 and 24 months over both baseline and pl...

Genistein in Biological News

The dietary supplement genistein can undermine breast cancer treatment

CHAMPAIGN, Ill. Women taking aromatase inhibitors to treat breast cancer or prevent its recurrence should think twice before also taking a soy-based dietary supplement, researchers report. Genistein, a soy isoflavone that mimics the effects of estrogen in the body, can negate the effectiveness...

NC State researchers find soy may aid in treating canine cancers

...ven Suter, assistant professor of oncology, and NC State colleagues studied genistein - a molecule found in soy that has been shown to be toxic to a wide variety...oma cells. The researchers found that a commercially available form of genistein called GCP was effective in killing canine lymphoid cells in a laboratory s...

Chronic exposure to estrogen impairs some cognitive functions

...e to genistein, a phytoestrogen found in soybeans. genistein is believed to have similar effects in the body as...activities in the cell when it binds to estradiol. genistein also activates ER-beta. Some women take genistein supplements or eat soy-based foods to reduce hot f...

New study shows compounds from soy affect brain and reproductive development

...ysiologically relevant doses of the phytoestrogens genistein and equol, and then looked at reproductive health ...ter stages of pregnancy for humans, Patisaul says. genistein is a phytoestrogen that is found in various plants...ia to produce equol. The study shows that both genistein and equol result in the early disruption of the ra...

Evidence now suggests eating soy foods in puberty protects against breast cancer

...s to why the breast cancer-risk reducing effect of genistein might be strongest during childhood and early adol...ate of knowledge concerning the role of early life genistein exposures in modifying breast cancer risk. She ha...ow that the data regarding prepubertal exposure to genistein are very consistent in showing a reduction in mamm...

Component in soy products causes reproductive problems in laboratory mice

...onstrating the potentially adverse consequences of genistein on the reproductive system. "Although we are not...entirely certain about how these animal studies on genistein translate to the human population, there is some r...indows of development can impact human health." genistein is the primary naturally occurring estrogen in pla...

Environmental chemical cocktail may sabotage sperm

...hey had an even stronger effect. In addition, when she tested one chemical, genistein (found in soya and legumes), on human sperm, she found that the human sperm...al oestrogens was still not clear, but the researchers discovered that both genistein and nonylphenol significantly stimulated the production of cyclic AMP ?a ch...