New lead reported in tumor angiogenesis
Scientists supported by the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health, have added a key new piece to the puzzle of how tumor cells induce new blood vessels to form and fuel their abnormal growth, a well-known process called angiogenesis. As published in this month's issue of the journal Cancer Cell, the scientists found that i...Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
Scientists have discovered that a stem cell factor overexpressed both in brain tumor cells and in neurons following brain injury promotes tumor survival by inducing angiogenesis. The research study, published in the April issue of Cancer Cell, examines the interaction between tumor cells and surrounding tissues and may have substantial significance for design of more effective therapeutics for on...Schepens scientists are first to discover angiogenesis switch inside blood vessel cells
Scientists at Schepens Eye Research Institute, an affiliate of Harvard Medical School, are the first to discover a switch inside blood vessel cells that controls angiogenesis (new blood vessel growth). The switch, they learned, is turned on and off by the balance between two enzymes (known as PI3K and PLCg) that compete for the use of the same lipid membrane to fulfill opposite missions, growth a...New angiogenesis finding may help fight cancer growth
A researcher at the University of Wisconsin-Madison School of Medicine and Public Health has discovered a new part of the complicated mechanism that governs the formation of blood vessels, or angiogenesis. The finding may help halt tumor growth in cancer patients, says Emery Bresnick, the senior author on the study, a professor of pharmacology and member of the UW-Madison Paul P. Carbone...Intrinsic eye protein halts angiogenesis
Dr. Jayakrishna Ambati, of the University of Kentucky, and Dr. Balamurali Ambati, of the Medical College of Georgia, have jointly published a paper in the journal Nature detailing major research discoveries in corneal avascularity and angiogenesis. In their paper published online Oct. 18, 2006, the researchers present evidence that unravels the mystery of how a healthy cornea remains clea...In Vitro Osteogenesis Assay Kit from CHEMICON
Description:CHEMICON's In Vitro Osteogenesis Assay Kit contains all reagents necessary to efficiently differentiate MC3T3-E1cells to a mature osteoblastic lineage, as determined by staining for mineralization. In addition this kit provides all the necessary reagents and a protocol for quantifying osteogenesis using a standard plate reader. This product is useful for studying the effects of growth factors, dr...Random DNA mutagenesis Service from Yorkshire Bioscience Ltd
Description:We can introduce random mutations to the gene supplied by a customer. Mutated DNA will be then cloned into a vector of choice to obtain a library of the mutated DNA. Mutation frequency can be set to a desired value within 1-20 mutations per kb. Number of clones 106-108. Mutations can be restricted to a desired region of a gene. 106-108 clones...Breeding and Maintenance (Nonhuman Primates) from Alpha Genesis, Inc.
Description:AGI provides both long and short-term enriched housing for nonhuman primates and other laboratory animals in both quarantine and non-quarantine settings on a per diem basis. Breeding services are also available utilizing our state-of-the-art social housing and nursery facilities. In addition, AGI is equipped with on site CDC quarantine facilities. Primate housing and CDC quarantine systems...Skeletal Myogenesis Assay from CHEMICON
Description:CHEMICON's Skeletal Myogenesis Kit provides the reagents to efficiently differentiate mouse C2C12 myoblasts into mature skeletal myotubes. By efficiently promoting myogenic differentiation, the kit is a valuable tool in studies examining myogenesis, transcription factor regulation, and in developing strategies for muscle cell replacement therapy. By providing the means to obtain and maintain a la...ChemiArray Mouse Lysate Angiogenesis Antibody Array I , 25 cytokines per membrane from CHEMICON
Description:Chemicons protein array systems, known as ChemiArrayTM Mouse Cytokine Antibody Arrays, are particularly useful compared with current methodologies. Besides the ability to detect protein expression, Chemicons systems present a more accurate reflection of active cytokine levels because they only detect secreted cytokines, and no amplification step is needed. Furthermore, it is simpler, faster, envi...Big Blue Rodent Cell Cultures for Mutagenesis Studies
Rat and mouse embryonic cell lines are useful for in vitro mutagenesisstudies Stratagene Cloning Systems, Inc. The Big Blue rat cell line and the Big Blue transgenic mouse embryoniccell line are useful for in vitro mutagenesis studies. These cell lines are partof the Big Blue transgenic rodent mutagenesis assay system...High-Efficiency Site-Directed Mutagenesis of Large Plasmid Vectors
QuikChange XL: a highly versatile kit for site-directed mutagenesis oflarge plasmids Michael Borns Peter Vaillancourt Holly Hogrefe Jeff Braman Stratagene The QuikChange site-directed mutagenesis kit* characteristicallygenerates mutagenesis efficiencies exceeding 80%. We have created a new kit formutagenesis of large plasmid...Randomize Gene Sequences with New PCR Mutagenesis Kit
GeneMorph PCR mutagenesis kit produces a unique mutational spectrum...The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis
Drs. Frank Slack, Steven Johnson, and Helge Grosshans, and Ms. Kristy Reinert at Yale University, in collaboration with Ambion scientists, discovered that the microRNA (miRNA) family regulates the expression of C. elegans...Miracle Baby Boy from a Type 3 osteogenesis imperfecta, Mother
Calif : A woman who is just three feet tall and 37 pound in weight prior to pregnancy, has delivered a healthy baby boy. This baby is her first child. // Eloysa Vasquez, confined to a wheel chair because of Type 3 osteogenesis imperfecta , a disorder that has rendered her bones soft and brittle . She has had two miscarriages as well. During the pregnancy, Vasquez gained 20 po...Enlarged waistline may predict atherogenesis for postmenopausal women
A recent study had suggested that an increasing waistline, along with the elevated levels of triglycerides may// be a strong predictor for atherogenesis and cardiac problems for post menopausal women. The study had looked into 557 women for 8.5 yrs to estimate the risk of cardiovascular mortality and the progression rate atherogenesis. Atherogenesis is the process of plaques etc formi...Artificially made protein to inhibit angiogenesis
Researchers of Medical College of Georgia had successfully made a protein// that will stop the process of angiogenesis. Angiogenesis is the abnormal growth of blood vessels that may lead to obstructed vision or growth of a tumor. The new protein, when applied to animals suffering from corneal injury or skin cancer called melanoma, reduced the blood vessel proliferation by...Role Of MicroRNAs In Angiogenesis Researched
According to recent research, MicroRNAs are fine targets for future therapies.Researchers belonging to the University of Pennsylvania School of Veterinary //Medicine have demonstrated how microRNA molecules are responsible for the growth of blood vessels in a human colon cancer model. This process, known as angiogenesis, is a result of the ravenous cancer cells using blood vessels to gorge on a...Vical Licensee AnGes MG Announces Positive Results of Phase 3 Angiogenesis Trial in Japan
SAN DIEGO, June 18, 2007 /PRNewswire-FirstCall/ -- VicalIncorporated today announced that the company's licensee, AnGes MG,Inc. reported positive results following interim analysis of datafrom the first 41 subjects to complete a Phase 3 trial of anangiogenesis product candidate using Vical's DNA deliverytechnology. Based on the findings that the primary efficacyendpoint in the trial had...