Covance to Acquire Seattle-Based Gene Expression Laboratory from Merck & Co., Inc.
PRINCETON, N.J., July 29 /PRNewswire-FirstCall/ -- Covance (NYSE: CVD ) today announced it has entered into a definitive agreement with Merck & Co., Inc. relating to the supply of genomic analysis services. Under the terms of the agreement Merck has committed to ...
Developing gene therapy to fight blindness
An international team of scientists and clinicians from the United States and Saudi Arabia are working to develop
gene therapy for treating a rare, hereditary retinal disease. The therapy has been shown to restore lost vision in animal models of retinitis pigmentosa (RP). Their work is being fun...
Bcl6 gene sculpts helper T cell to boost antibody production
HOUSTON - Expression of a single
gene programs an immune system helper T cell that fuels rapid growth and diversification of antibodies in a cellular structure implicated in autoimmune diseases and development of B cell lymphoma, scientists at The University of Texas M. D. Anderson Cancer Center r...
Immune System Gene Discovery Sheds Light on Staph Infections
Findings could lead to better therapies for severe forms of the disease
TUESDAY, July 21 (HealthDay News) -- Researchers at the University of Texas Southwestern Medical Center have figured what genes turn on and off in a person's immune system when he or she has a severe staph infectio...
New Gene May Signal Aggressive Breast Cancer
Finding provides insight into tumor growth, metastasis, researchers say
MONDAY, July 20 (HealthDay News) -- Scientists have identified a new
gene that may contribute to aggressive breast cancer, new research shows.
Using a new method of analyzing "microarray expression profiles" of ...
Catastrophic Epilepsy Caused by Defect in One Gene
Mouse study led to discovery of mutation and could advance treatments
WEDNESDAY, July 8 (HealthDay News) -- A mutation in a single
gene causes catastrophic epilepsy, U.S. scientists say. And that finding, they say, could lead to treatments or a cure for the disorder.
People with cat...
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gene in Medical Technology
Diabetes Gene Raises Odds of Lower Birth Weight
PHILADELPHIA, July 29 /PRNewswire-USNewswire/ -- Pediatric researchers have found that a
gene previously shown to be involved in the development of type 2 diabetes also predisposes children to having a lower birth weight. The finding sheds light on a possible genetic influence on ...
Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity
EMERYVILLE, Calif., July 17 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) announced today that a study of the
gene regulation in multiple cell lines by several of their estrogen receptor beta (ERb) candidates will be published in Public Library of Science One.
...
More Gene Mutations Linked to Autism Risk
--Combination of Inherited and New Genetic Mutations Acting Together--
PHILADELPHIA, June 26 /PRNewswire-USNewswire/ -- More pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from The Children's Hospital of Philadelphia...
Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women
- Largest Genomic Study Comparing
Gene Expression in Female and Male Patients Presented at ASCO Annual Meeting -
ORLANDO, Fla., May 29 /PRNewswire-FirstCall/ -- Genomic Health, Inc. (Nasdaq: GHDX ) today announced results from a study which summarized the
gene signatures identified by the O...
Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting
Phase 1 Data Demonstrate Safety and Evidence of Biological Activity in 9 of 12 Patients;
Phase 2 Study Currently Enrolling in 17 Leading U.S. Medical Centers
SAN DIEGO, May 28 /PRNewswire/ -- Celladon Corporation presented today Phase 1 data from the Calcium Up-Regulation by Percutaneou...
In Rare Disorder, a Familiar Protein Disrupts Gene Function
-Knowledge May Improve Diagnosis for Children with Cornelia deLange Syndrome-
PHILADELPHIA, May 27 /PRNewswire-USNewswire/ -- An international team of scientists studying a rare genetic disease discovered that a bundle of proteins with the long-established function of keeping chromo...
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gene in Medical Products
Prothrombin Nucleotide 20210 G/A Gene Mutation (Factor II), Fetal
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Prothrombin Nucleotide 20210 G/A Gene Mutation (Factor II)
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
mecA Gene by PCR
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Ig Heavy Chain Gene Rearrangement, Tissue
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Ig Heavy Chain Gene Rearrangement, Paraffin
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Ig Heavy Chain Gene Rearrangement, Fluid
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
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gene in Medical Definition
Atransferrinemia
...is inherited in an autosomal recessive pattern, meaning two copies of the
gene in each cell are altered.
A case study was done in 1961 on a 7-ye...reported in the United States [2] and identified mutations in the TF
gene as a probable cause of the disorder.
Treatment
Treatment with i...
Autoimmune regulator
...1 q22.3
The Autoimmune Regulator, abbreviated AIRE , is a human
gene which is expressed in the thymus . It causes transcription of a wide sel...taneous candidiasis. [1] AIRE is expressed primarily in the thymus.
A
gene knockout of the murine homolog Aire has created a transgenic mouse mode...
Familial isolated vitamin e deficiency
...ciency is a rare autosomal recessive neurodegenerative disease. Symptoms are much like those of Friedreich ataxia and is caused by mutations in the
gene for a-tocopherol transfer protein.
...
Medical procedure
...onvulsive therapy
Symptomatic treatment
Fluid replacement therapy
Palliative care
Hyperbaric oxygen therapy
Oxygen therapy
gene therapy
Enzyme replacement therapy
Intravenous therapy
Kinesiotherapy
Phage therapy
Serotherapy
Respiratory therapy
Vision ...
Pathology
...tic process in a tissue, and is marked by persistance of immature, poorly differentiated cell forms. Interestingly, there are many similarities in the
gene pathways activated in cancer cells, and those activated in cells involved in wound healing and inflammation. [8]
Pathology as a medical sp...
Medicine
...idence-based medicine . Many modern molecular tests such as flow cytometry, polymerase chain reaction (PCR), immunohistochemistry , cytogenetics ,
gene rearragements studies and fluorescent in situ hybridization (FISH) fall within the territory of pathology.
Radiology is concerned with ima...
gene in Medical Dictionary
Gene
The main homepage for Human Genome Project information --what the project is; its progress, history, and goals; what issues ...
Gene Gateway. Research Archive ... The analysis of
gene sets has become a popular topic in recent times, with ... While a number of options for
gene set analysis...
Xeroderma Pigmentosum
...eroderma Pigmentosum : symptoms, cause, treatments, complications, prevention, risks ... People with xeroderma pigmentosum have a defect in the
gene that is ... A US Department of Health and Human Service project providing information on genetic and rare diseases. A comprehensive body of res...
Wilson disease
...c disease that leads to copper ... Bull PC et al. The Wilson disease
gene is a putative copper transporting P-type ... Wilson's Disease info...information on Wilson's Disease . ... If both parents carry an abnormal
gene for Wilson's disease there is a: ... Wilson's disease &mda...
Von Hippel-lindau Disease
... Lindau syndrome, is a rare ... At present, this
gene is the only
gene known to cause von Hippel - Lindau disease ..... The von Hippel - Lindau disease (VHL)
gene is a putative tumor suppressor ...
Von Hippel-Lindau
...ndrome, is a rare ... The von Hippel - Lindau
gene is located on the short arm of chromosome 3 (3p...tumor suppressor protein is encoded by the VHL
gene and ... The von Hippel - Lindau Tumor Suppressor
gene and Kidney Cancer" ... Article describes von ...
Vesicle
...in all species, ... GO:0030659 : cytoplasmic vesicle membrane [391
gene products] ... GO:0030120 : vesicle coat [200 ... GO:0030136 : clathrin-coated vesicle [441
gene products] ... vesicle -associated membrane protein synaptobrevin ...
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gene in Biological News
Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
COLD SPRING HARBOR, N.Y. (Wed., Aug. 5, 2009) Vectors derived from retroviruses are useful tools for long-term
gene transfer because they allow stable integration of transgenes and propagation into daughter cells. Lentiviral vectors are preferred because they can transduce non-proliferating ce...
Cancer's distinctive pattern of gene expression could aid early screening and prevention
AUGUSTA, Ga. Distinctive patterns of genes turned off or left on in healthy versus cancerous cells could enable early screening for many common cancers and maybe help avoid them, Medical College of Georgia scientists say.
Researchers are comparing chemical alterations, called DNA methylatio...
Newly discovered gene fusion may lead to improved prostate cancer diagnosis
Researchers from NewYork-Presbyterian Hospital/Weill Cornell Medical Center have discovered a new
gene fusion that is highly expressed in a subset of prostate cancers. The results may lead to more accurate prostate cancer testing and new targets for potential treatments. Experts believe that
gene ...
Scientists discover gene mutation responsible for hereditary neuroendocrine tumor
SALT LAKE CITY University of Utah researchers and their colleagues have identified the
gene that is mutated in a hereditary form of a rare neuroendocrine tumor called paraganglioma (PGL). The gene, called hSDH5, is required for activation of an enzyme complex that plays a critical role in the che...
Reviews of microbial gene language published in special issue of Trends in Microbiology
Blacksburg, Va. -- Ten articles describing how a universal language to describe genes is bringing benefits to the study of the microbial world have been published in a special issue of Trends in Microbiology , co-edited by Virginia Bioinformatics Institute professor Brett Tyler. The
Gene Ontology...
Further gene mutations linked to autism risk
Pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from the University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia (CHOP). The study identified 27 different genetic regions where rare copy n...
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gene in Biological Technology
Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors
SAN DIEGO, July 30 /PRNewswire-FirstCall/ -- Cardium Therapeutics (NYSE Amex: CXM ) today announced plans to develop a DNA-based orthobiologics product portfolio based on research and development by Cardium's Tissue Repair Company that will initially focus on non-union bone fractu...
United States FDA Clears the REGEN Trial to Test Bioheart's Combination Gene and Stem Cell Therapy in Heart Failure Patients
SUNRISE, Fla., July 28 /PRNewswire-FirstCall/ -- Bioheart, Inc., (OTC Bulletin Board: BHRT) a company committed to delivering intelligent devices and biologics that help monitor, diagnose and treat heart failure and cardiovascular diseases announced today that the US FDA cleared a p...
Canadian researchers discover gene related to the appearance of aging
HALIFAX, July 15 /PRNewswire/ - Scientists in Atlantic Canada have found a
gene that may play a role in skin aging. Researchers were investigating the genetic cause of a rare disorder known as cutis laxa type 2 (CL2), which causes skin on the hands, feet and face to be loose and older looking, as ...
Novel gene found for dilated cardiomyopathy
Researchers in the Heart Institute at Cincinnati Children's Hospital Medical Center have discovered a novel
gene responsible for heart muscle disease and chronic heart failure in some children and adults with dilated cardiomyopathy (DCM).
Mutations in the ANKRD1
gene may cause DCM, which is the...
deCODE Discovers a Gene Linked to Risk of Kidney Stones and Osteoporosis
REYKJAVIK, Iceland, June 29 /PRNewswire-FirstCall/ -- A discovery by
scientists at deCODE genetics (Nasdaq: DCGN ) and academic colleagues from
Iceland, the Netherlands and Denmark has pointed to a common biological
mechanism contributing to both kidney stones and decreased bone mineral
densi...
Syngenta Licenses Chromatin Gene Stacking Technology for Sugar Cane
RESEARCH TRIANGLE PARK, N.C., June 26 /PRNewswire/ -- Syngenta Biotechnology, Inc. announced today that it has entered into an exclusive worldwide research and commercial license agreement for Chromatin's proprietary
gene stacking technology in sugar cane.
Chromatin has developed a novel ap...
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gene in Biological Products
Chicken Anti-G4-1 (Hypothetical protein FLJ20644, likely ortholog of mouse phosphatase subunit gene g4-1) Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.
Description: G4-1, Affinity-Purified Polyclonal IgY Antibodies Hypothetical protein FLJ20644, likely ortholog of mouse phosphatase subunit
gene g4-1 Protein Accession #: NP_060387.1 gi number query: 8923600 Genbank Definition: chromosome 14 open reading frame 10; likely ortholog of mouse phosphatase su...
Company:GenWay Biotech, Inc.
21-mer duplex design + syn.; 1 gene from B-Bridge International
Description: siSolutions siRNA Custom Synthesis Service provides you with high-quality, effective duplex RNA to knockdown any gene. We offer standard 21-mers (19 RNA base pairs with terminal dT nucleotides), the recently-published 27-mers, or other lengths of your choice. Each individual sequence includes quali...
Company:B-Bridge International
3x 21-mer duplex design + syn.; 1 gene from B-Bridge International
Description: siSolutions siRNA Custom Synthesis Service provides you with high-quality, effective duplex RNA to knockdown any gene. We offer standard 21-mers (19 RNA base pairs with terminal dT nucleotides), the recently-published 27-mers, or other lengths of your choice. Each individual sequence includes quali...
Company:B-Bridge International
Immunohistochemistry - Gene Discovery from Paragon BioServices
Description: This service involves the optimization of immunostaining. The optimization includes titration of the primary antibody, selection and optimization of secondary reagents (e.g. Alk. Phos., HRP, fluorescence, or biotinylated conjugates), optimization of detection, evaluation by light or fluorescence m...
Company:Paragon BioServices
CopyControl cDNA, Gene and PCR Cloning Kit w/ Chemically Competent E. coli cells from EPICENTRE Biotechnologies
Description: The CopyControl PCR Cloning Kits are designed to speed up the PCR cloning process and to ensure that all PCR products, regardless of sequence or type of polymerase used, are efficiently cloned. All PCR products including those that are difficult to clone by other PCR cloning methods or that m...
Company:EPICENTRE Biotechnologies
steadylite plus Reporter Gene Assay System, 1000 mL from PerkinElmer
Description: The steadylite plus assay system offers the following benefits: High assay sensitivity, Designed for batch-processing systems, Long lasting signal, Suitable for higher density microplates such as 384-well and 1536-well plates, Odor free, Convenient storage conditions ( 2 - 8 C)...
Company:PerkinElmer
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gene in Biological Definition
Gene
Genes are entities that parents pass to offspring during reproduction . These entities encode information essential for the construction and regulation of polypeptides , proteins and other molecules that determine the growth and functioning of the organism .
The word "g...
Albinism
...xternal links
Lack of pigmentation
The
gene which results in albinism prevents the body from m...aneous albinism, individuals inherit an "albinism
gene " from both parents. Where an individual receives one albinism
gene and one normal gene, that person will not show out...
Allele
... one of a number of alternative forms of the same
gene occupying a given locus (position) on a chromosome . An example is the
gene for blossom color in many species of flower - a single
gene controls the color of the petals, but there may be...
Allele frequency
... population , or equivalently the richness of its
gene pool . Allele frequency is defined as follows:
Given a) a particular chromosome locus , b) a
gene occupying that locus, c) a population of individu...
The frequencies of all the alleles of a given
gene often are graphed together as an allele frequency...
Alternative splicing
...to a modification of the definition of a "gene". Some have proposed that a
gene should be considered as a twofold information structure:
A DNA sequenc... of coding.
Others have noted that it is unnecessary to change the DNA of a
gene for the evolution of a new protein. Instead, a new way of regulation coul...
Antibody
...ntigens, it must produce millions of B lymphoyctes. It is important to note that to produce such a diversity of antigen binding sites with a separate
gene for each possible antigen, the immune system would require many more genes than exist in the genome . Instead, as Susumu Tonegawa showed in 1976, ...
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gene in Biological Dictionary
Gene
A
gene is the basic unit of heredity in a living organism. All living things depend on genes. Genes hold the information to build and maintain their cells and pass genetic traits to offspring. A modern working definition of a...
Gene therapy is the insertion of genes into an individual...
Structural gene
A structural
gene is a
gene that codes for any RNA or protein product other than a regulatory factor . It may code for a structural protein, an enzyme, or an RNA molecule not involved in regulation. Aspects of the topic structural -
gene are discussed in the following places at B...
Reporter Gene
In molecular biology, a reporter
gene is a
gene that researchers attach to another
gene of interest in cell culture, animals or plants. Certain genes are chosen as reporters because the characteristics they confer on organisms expressing them are easily identified and... The GUS rep...
Recessive gene
In classical genetics, dominance describes a relationship between different forms (alleles) of a
gene at a particular physical location (locus) on a chromosome. Typical plants and animals have two sets of chromosomes, one set inherited from each parent, and are... In genetics, dominance desc...
Expressed gene
Genes are expressed by being transcribed into RNA, and this transcript may then ... which a particular
gene is expressed within a cell, tissue or organism can give ... ... the transcription machinery when a
gene is about to be transcribed and expressed . ... of the n...
Dominant gene
In classical genetics, dominance describes a relationship between different forms (alleles) of a
gene at a particular physical location (locus) on a chromosome. Typical plants and animals have two sets of chromosomes, one set inherited from each parent, and are... In genetics, dominance desc...
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