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Variations in detoxifying genes linked to Lou Gehrig's disease

Genetic variations in three enzymes that detoxify insecticides and nerve gas agents as well as metabolize cholesterol-lowering statin drugs may be a risk factor for developing sporadic amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), and possibly responsible for a reported twofold increased risk of ALS in Gulf War veterans. These findings, from a study led Teepu Siddique, M.D...

Human stem cells delay start of Lou Gehrig's disease in rats

Researchers at Johns Hopkins have shown that transplanting human stem cells into spinal cords of rats bred to duplicate Lou Gehrig's disease delays the start of nerve cell damage typical of the disease and slightly prolongs life. The grafted stem cells develop into nerve cells that make substantial connections with existing nerves and do not themselves succumb to Lou Gehrig's, also known as amyot...

Gene hunters close in on Lou Gehrig’s disease

In the first genome-wide search for the genetic roots of the most common form of amyotrophic lateral sclerosis (ALS), Johns Hopkins scientists have newly identified 34 unique variations in the human genetic code among 276 unrelated subjects with ALS. The 34 so-called single nucleotide polymorphisms, or SNPs, represent good candidate genes predisposing people to the non-inherited form of th...
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Study Aims At The Immune System In Patients With Lou Gehrig's Disease

Carolyn Shimek takes cholesterol-decreasing medications like millions of Americans. However she does not have high cholesterol like others//. This is since she is taking part in a different clinical study found only at the Methodist Neurological Institute (NI) to view the benefits of Lipitor on the immune system in patients with Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS)...

Genetic Variations In Detoxifying Genes Lead To Lou Gehrig's diseases

A new study links the genetic variations in detoxifying enzymes for developing Lou Gehrig's diseases//. The study shows that the genetic variations in three enzymes, which are used to detoxify insecticides and nerve gas agents as well as for metabolising cholesterol lowering, statin drugs might be a risk factor for developing irregular ‘Amyotrophic lateral sclerosis’ (ALS, or Lou Gehr...

Clues to the Mystery of Lou Gehrig's Disease

Researchers have recently reported clues to unraveling the mystery of the disease best known for striking down New York Yankees first baseman Lou Gehrig nearly 70 years ago//. According to Virginia Lee, Ph.D., of the University of Pennsylvania a team of researchers has identified the misfolded protein that causes both Lou Gehrig's disease or amyotrophic lateral sclerosis (ALS), as well a...

Human Stem Cells Delay Start of Lou Gehrig’s Disease in Rat

Researchers at Johns Hopkins have shown that transplanting human stem cells into spinal cords of rats bred to duplicate Lou Gehrig’s disease delays the start of nerve// cell damage typical of the disease and slightly prolongs life. The grafted stem cells develop into nerve cells that make substantial connections with existing nerves and do not themselves succumb to Lou Gehrig’s, also know...

Gene Hunters at Johns Hopkins Close In On Lou Gehrig's Disease

In the first genomewide search for the genetic roots of the most common form of amyotrophic lateral sclerosis, Johns Hopkins scientists// have newly identified 34 unique variations in the human genetic code among 276 unrelated subjects with ALS. The 34 so-called single nucleotide polymorphisms, or SNPs, represent good candidate genes predisposing people to the noninherited form of the...

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