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Ganglion in Medical News

Quark Pharmaceuticals Announces Data Indicating Potential Utility of QPI-1007 for Treatment of Glaucoma

...gesting that QPI-1007 prevents progressive retinal ganglion cell (RGC) loss in an increased ocular pressure (I...ct of QPI-1007 in two additional models of retinal ganglion cell (RGC) death - induced by optic nerve crush or...and vision loss are caused by the death of retinal ganglion cells. While existing therapeutics are capable of ...

Growth factor TGF-B helps maintain health of retinal blood vessels

... tissue, and fluid was leaking out of the vessels, which does not happen when the vessels are functioning properly. These defects led to the death of ganglion cells (nerve cells in the innermost part of the retina) and a loss of visual function. According to D'Amore and Walshe, the demonstration of the rol...

Experts examine causes, treatment and prevention of glaucoma

... Although scientists know progressive degeneration of retinal ganglion cells and their axons is the primary cause of glaucoma, researchers have yet to identify a way to stop or prevent the degeneration. The challenge t...

Protein Might One Day Prevent Blindness

... call neuro-protective, in that it has protective benefits on both the photoreceptor layer that gets damaged in macular degeneration as well as on the ganglion cell layer which is damaged by glaucoma. So this finding could actually turn out to be a major accomplishment, affecting a lot of patients down the ro...

5 Brown faculty elected to world's largest scientific body

...in. Specifically, he explores structural and functional diversity among the ganglion cells of the eye, the retinal neurons that communicate directly with the brain. Current research focuses on one very unusual type of ganglion cell that senses light directly. These neurons drive reflexive responses to...

Quark Pharmaceuticals to Present at the 20th Annual Piper Jaffray Health Care Conference

...didate having a novel, proprietary structure covered by Quark's intellectual property. Data has validated its neuroprotective effects on dying retinal ganglion cells, a cause of blindness and glaucoma. About Quark Pharmaceuticals, Inc. Quark Pharmaceuticals, Inc. is a development-stage pharmac...

'Cool' New Treatment for Hot Flashes in Breast Cancer Survivors

...t study of the safety and efficacy of the stellate ganglion block in 13 breast cancer survivors. It is called ...arch on healthy menopausal women that the stellate ganglion block can effectively 'shut off' these troubling s...kenings over time. If the effect of the stellate ganglion block on hot flashes and night awakenings did not ...

'Cool' new treatment for hot flashes in breast cancer survivors

...t study of the safety and efficacy of the stellate ganglion block in 13 breast cancer survivors. It is called ...arch on healthy menopausal women that the stellate ganglion block can effectively shut off these troubling sym...enings over time. If the effect of the stellate ganglion block on hot flashes and night awakenings did not ...

Different processes govern sight, light detection

...ww.nature.com ) and in the May 1 print issue, Hattar and colleagues reported that they genetically modified mice so that a particular set of retinal ganglion cells cells that receive input from the rods and cones of the animals eyes and send information to the brain no longer functioned. The mice were...

Mouse study: Real-time imaging device may improve surgery for congenital colon disease

...imaging does not detect the presence or absence of ganglion cells themselves. Instead, the spectral signature ...estine, although the entire colon can be involved. ganglion cells normally stimulate smooth muscle of the inte...a pathologist looks for the presence or absence of ganglion cells and other features. But this process may tak...
Ganglion in Medical Technology

Scientists Discover a Role for the Growth Factor TGF-beta in Maintaining Health of Retinal Blood Vessels

... tissue, and fluid was leaking out of the vessels, which does not happen when the vessels are functioning properly. These defects led to the death of ganglion cells (nerve cells in the innermost part of the retina) and a loss of visual function. According to D'Amore and Walshe, the demonstration of the ...

Quark Pharmaceuticals Announces First RNAi Drug Candidate Having a Novel, Proprietary Structure Covered by Quark Intellectual Property

...ffect of Quark's New RNAi Product on Dying Retinal ganglion Cells, a Cause of Blindness in Glaucoma FREMONT,...ned QPI-1007's effectiveness in a model of retinal ganglion cell (RGC) death by optic nerve crush (ONC). In a ...re caused by the selective degeneration of retinal ganglion cells. Our results suggest that QPI-1007 may be an...

Vision Deficit in Retinitis Pigmentosa Mice Corrected with DNA Nanoparticles

...ential to provide effective treatments for more complex disorders such as diabetic retinopathy, macular degeneration, and various diseases that injure ganglion cells and the optic nerve." "We are pleased by the promise of these results and look forward to moving these studies forward to a potential human...
Ganglion in Medical Products

Humphrey FDT Visual Field Instrument

Features:...ented WelchAllyn Frequency Doubling Technology isolates a subset of retinal ganglion cell mechanisms in the magnocellular (M-cell) pathway. These M-cells have large diameter fibers and comprise only 3% to 5% of all retinal ganglion cells. The damage of these cells in the disease process makes FDT effic...
Company:Carl Zeiss Meditec, Inc.

Humphrey FDT Perimeter

Features:...ented WelchAllyn Frequency Doubling Technology isolates a subset of retinal ganglion cell mechanisms in the magnocellular (M-cell) pathway. These M-cells have large diameter fibers and comprise only 3% to 5% of all retinal ganglion cells. The damage of these cells in the disease process makes FDT effic...
Company:Carl Zeiss Meditec, Inc.
Ganglion in Medical Definition

Ganglion cyst

... ganglion cyst Classification & external resources ...1229 eMedicine orthoped/493 A ganglion cyst (also known as a bible bump ) is a swelling... Cause The exact cause of the formation of ganglion cysts is still unknown but they are thought to be ...
Ganglion in Medical Dictionary

Ganglion

A dorsal root ganglion (DRG) from a chicken embryo (around stage of day 7) after ... Note the axons growing out of the ganglion ... A ganglion cyst is a swelling that often appears on or around joints and tendons in the hand or foot. The size of the cyst can vary over time. ...

Glaucoma

... Glaucoma refers to a group of diseases that affect the optic nerve and involves a loss of retinal ganglion cells in a characteristic pattern. It is a type of optic neuropathy. Raised intraocular pressure is a significant risk... Publication about the r...

Surgical excision

... sac and prevent ... This fact-filled source of information dealing with foot, ankle, leg, knee, and hip ... The definitive treatment for a ganglion mass is surgical excision . ... This fact-filled source of information dealing with foot, ankle, leg, knee, and hip disorders includes docto...

Ramsay Hunt syndrome

...S) type 2 is a disorder that is caused by the reactivation of pre-existing herpes zoster virus in a nerve cell bundle . The neurons in this ganglion are responsible for the movements of facial muscles,... Ramsay Hunt syndrome information including symptoms, diagnosis, misdiagnosis, treat...

Paracentesis

...ysfunction: Midodrine vs Albumin. ... Finding a Surgeon, Finger Reattachment, Fluoroquinolones, Forehead Lift, Fracture Repair, Gallstone Removal, ganglion Cyst Removal, Gastrectomy, Gastric Acid ... Clinical Radiologists, S.C. (CRSC), is a premier radiology group, based in ... Radiologists generall...

Pallidotomy

...tomy in Advanced Parkinson's Disease Finding a Surgeon, Finger Reattachment, Fluoroquinolones, Forehead Lift, Fracture Repair, Gallstone Removal, ganglion Cyst Removal, Gastrectomy, Gastric Acid ... Deep Brain Stimulator, Pallidotomy , Thalamotomy (frame 3) from Wake Forest University Comprehensive ...

Oophorectomy

...n The surgical removal of a fallopian Finding a Surgeon, Finger Reattachment, Fluoroquinolones, Forehead Lift, Fracture Repair, Gallstone Removal, ganglion Cyst Removal, Gastrectomy, Gastric Acid ... A nonprofit organization for women whose family history and genetic status puts them at high risk fo...

Nerve

... nerve . Anterior superior alveolar nerve . Aortic plexus ... Cervical branch of the facial nerve . Cervical plexus. Chorda tympani. Ciliary ganglion ... NerveMed is the leading online resource for nerve and spine health information. ... Entrapment of the ulnar nerve at the elbow is cubital...

Nephrectomy

...l gland (radical nephrectomy ) ... Finding a Surgeon, Finger Reattachment, Fluoroquinolones, Forehead Lift, Fracture Repair, Gallstone Removal, ganglion Cyst Removal, Gastrectomy, Gastric Acid ... Nephrectomy is the surgical procedure of removing a kidney or section of a kidney. ... Nephrectom...

Myringotomy

...diatric myringotomy outpatients ... Finding a Surgeon, Finger Reattachment, Fluoroquinolones, Forehead Lift, Fracture Repair, Gallstone Removal, ganglion Cyst Removal, Gastrectomy, Gastric Acid ... Myringotomy (Tympanostomy, Tympanotomy, Ear Tubes Surgery) Definition: ... When performed under gene...
Ganglion in Biological News

Case Western Reserve University receives $1.66m grant from NIH for otoprotection research

..., but preservation and a minimal density of spiral ganglion cells are required for an effective implant," said Zheng. Spiral ganglion cells are the cells that provide the sense of hear...e cochlea could promote the survival of the spiral ganglion neurons by release of neurotrophic substances or g...

Mammals can be stimulated to regrow damaged inner retina nerve cells

...s of specific growth factor stimulation on the proliferation of Mller glia cells. The researchers injected a substance into the retina to eliminate ganglion cells (a type of nerve cell found near the surface of the retina) and amacrine cells. Then by injecting the eye with epidermal growth factor (EGF), fi...

Gene therapy restores vision to mice with retinal degeneration

... the light-sensitive protein melanopsin in retinal ganglion cells. These specialized neurons receive light si...anopsin normally produced in 1 percent of retinal ganglion cells was found in about 10 percent of ganglion cells in the treated eyes but not in eyes that rec...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

... were functional for the duration of the study. Scientists observed improvements including pupil response to light and response to light stimuli from ganglion cells, which form the circuitry to the brain. Swaroop explains that photoreceptors constitute "the first line of information capture in vision."...

How Fruitflies Know It's Time for Lunch

...begin both in the mouth and in the pharynx and aim toward the subesophageal ganglion region of the fly's brain. How olfactory and gustatory signals influence fe...ons extend to throat muscles—which is surprising because most subesophageal ganglion neurons have no connection to motor function. All together, these few hug n...

Scientists use gene transfer technology and common virus to block neuropathic pain

...s a carrier to deliver GAD to the nucleus of nerve cells in the dorsal root ganglion near the spine. In previous studies, the researchers have confirmed that th... to deliver other neurotrophic factors and pain-suppressing drugs to spinal ganglion cells. But Fink says the effect of the GAD-expressing vector is substantial...

Retina adapts to seek the unexpected, ignore the commonplace

... his co-authors examined neural signals in retinal ganglion cells, which convey visual images from the eye to ...y: The spatio-temporal receptive fields of retinal ganglion cells change after a few seconds in a new environm... recorded neural signals from the animals' retinal ganglion cells, testing whether adaptation to a different e...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...s a carrier to deliver GAD to the nucleus of nerve cells in the dorsal root ganglion near the spine. In previous studies, the researchers have confirmed that th... to deliver other neurotrophic factors and pain-suppressing drugs to spinal ganglion cells. But Fink says the effect of the GAD-expressing vector is substantial...

The synapse is a shotgun

... create a detailed 3-D map of the synapse of a chick ciliary ganglion. This ganglion is a cluster of neurons that connect the brain to the iris of the eye. It l...provide evidence for a different concept of the synapse. "The image of this ganglion is not one of a simple synapse with a single release site, but multiple rel...

Researchers discover way to make cells in the eye sensitive to light

...psin uses light at different wavelengths to regenerate itself. In some forms of hereditary blindness photoreceptors are lost entirely, but the retinal ganglion cells, the cells which signal to the brain, remain intact. The researchers believe that by activating the melanopsin, these cells may gain the ability...
Ganglion in Biological Technology

Brian Levy, OD, MSc, Named Chief Operating Officer of Danube Pharmaceuticals

... novel mechanisms of action to both lower intraocular pressure (IOP) and to provide direct neuroprotective benefits to the optic nerve and its retinal ganglion cells, providing a dual approach to glaucoma therapy not provided by any currently marketed product. DNB-001 has been tested in a Phase I clinical tri...

Barrett Katz, MD, MBA, Named CEO of Danube Pharmaceuticals

... novel mechanisms of action to both lower intraocular pressure (IOP) and to provide direct neuroprotective benefits to the optic nerve and its retinal ganglion cells, providing a dual approach to glaucoma therapy not provided by any currently marketed product. DNB-001 has been tested in a Phase I clinical tri...

Rutgers neuroscience may hold key to hearing loss remedy

...no and the nerves to which they attach the spiral ganglion neurons that connect to the brain are the pianos ...strings. Our studies have revealed that spiral ganglion auditory neurons possess a rich complexity that is...ence in relative proportions transforms the spiral ganglion neurons into either fast-firing transmitters to ca...
Ganglion in Biological Products

Anti-Vesicular Monoamine Transporter 2 (VMAT2) Polyclonal Antibody, Unconjugated from CHEMICON

Description:...se inhibitors. Higher molecular weight bands may represent glycosylated VMAT2 (2,3). VMAT2 has been localized in adrenal chromaffin cells, sympathetic ganglion cells, enterochromaffin-like cells of the stomach and in CNS (2,5)....
Company:CHEMICON

Rabbit Anti-NPY Y2 Receptor Polyclonal Antibody, Unconjugated from GeneTex

Description:...d in both rat and mouse and appears to work better on mose tissue, although positive staining is seen in rat. For full characterizarion in dorsal root ganglion and spinal cord see: J Comp Neurol. 2005 Aug 29;489(3):328-48....
Company:GeneTex
Ganglion in Biological Dictionary

Ventral root

...· Sympathetic trunk ... Aspects of the topic ventral - root are discussed in the following places at Britannica. Assorted References ganglia ( in ganglion (physiology) ) ...impulses toward the central nervous system); efferent neurons (carrying motor impulses away from the central nervous system) are pre...

Rod cells

...20 million rod cells in the human retina. ... Additionally, multiple rod cells converge on a single interneuron, collecting ... 6 ganglion cell (non- rod non-cone) photoreceptors. 7 See also. 8 Bibliography. 9 References ... In rod cells , these together are called rhodopsin....

Optic nerve

...jury. Hippocrates described optic nerve injuries in De Morbis Vulgaribus' as early as ... The optic nerve originates from the confluence of ganglion cell axons as they ... Optic nerve axons congregate into bundles as they pass through thelamina cribrosa. ... Optic Nerve Head Drusen. Si...

Cone cells

...nto a carbohydrate-rich ... ... of amacrine and ganglion cells ... Visual acuity starts with cone spaci...Cone to midget bipolar cell connections. Midget ganglion cells ... Cone cells are a type of cell ...by cone signals pass through the retina to the ganglion cells is rather ... Conversely the cone bipola...
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