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GPCRs in Medical News

Sundia MediTech Appoints Dr. Chen Chen as Senior VP of Chemistry

...erous agonists and antagonists for the melanocortin-4 receptor for eating disorders. Dr. Chen has extensive experience in CNS drug research and gpcrs as drug targets. His knowledge also includes neuropathic pain and metabolic disorders. His research interests extend to clinic and preclinic pharmacok...

ChanTest to Highlight Expanded Ion Channel and GPCR Services and Cell Lines, Including FDA Critical Path Safety Profiling Tools at ToxExpo, Booth 3056

...- ChanTest, the leading expert in ion channels and gpcrs (G-protein coupled receptors) - key to drug discov... about the interrelated nature of ion channels and gpcrs in cell signaling, many of our customers have been...leads against an extensive set of ion channels and gpcrs in functional, cell-based assays. ChanTest can scr...

Trevena, Inc. Announces $24 Million Series A Financing

...building a premier drug discovery organization," said Maxine Gowen, Ph.D., President and Chief Executive Officer. "Pharmaceutical products that target gpcrs represent over 40% of marketed drugs today and these targets provide an attractive starting point for new pharmaceutical agents. Trevena's mission wil...

JCI table of contents: Nov. 8, 2007

...CHNICAL ADVANCE: New mouse strain teaches us about gpcrs All mammals, including humans, have hundreds ...eins known as GPCRs. The function of some of these gpcrs is known and in many cases has been shown to regu...ease processes. However, the function of very many gpcrs remains incompletely understood. A new tool to det...

Pieris and Pepscan to Identify GPCR-Specific Anticalins(R) Using CLIPS(TM) Protein Mimicry Technology

...ins(R) able to modulate GPCR function in disease. gpcrs form one of the most important classes of drug tar...ted: "Functional binding proteins directed against gpcrs are in great demand as disease-targeting agents. T...Pepscan to apply its protein mimicry technology to gpcrs for the identification of Anticalins(R) with thera...

Super Fruit Fly may Harbor Hope for Human Longevity

...hould work in all such receptors, known as class B gpcrs (for G protein-coupled receptors). Many gpcrs figure prominently in disease as well as in normal... added. And generally powerful, given that gpcrs are extremely unstable and difficult to work with....
GPCRs in Medical Technology

Faust Pharmaceuticals' Phase IIa Results for Parkinson's Disease Presented at International Congress of Parkinson's Disease and Movement Disorders

...nally has pre-clinical programs on targets such as mGluR (metabotropic glutamate receptor), as well as a proprietary drug discovery platform targeting gpcrs (G-Protein Coupled Receptors). For further information, please contact: Andrew Lloyd & Associates Andrew Lloyd / Neil Hunter Tel: +44 1273 6751...
GPCRs in Biological News

Proteins that stop a major signaling pathway can also generate new proteins

... cranking out a particular protein. These receptors regulate virtually all physiological processes, everything from heart rate to mood. Research on gpcrs has led to numerous successful drugs, including beta blockers which help relieve hypertension, angina and coronary disease, as well as new antihistami...

Like sweets? You're more like a fruit fly than you think...

...y of receptors known as G-protein coupled receptors (GPCRs), which are involved in biological processes throughout the body. Human and fly sweet taste gpcrs are presumed to have markedly different structures, an assumption that is based on differences in the genes that code for them. Since substances w...

Columbia geneticists uncover new gene involved in determining hair texture and density in humans

...own as a G-protein coupled receptor (GPCR) implicated in a human hair disorder thereby making it possible to develop drugs that target this receptor. gpcrs represent the largest known class of molecular targets with proven therapeutic value. It is estimated that more than 40 percent of existing drugs work...

Scientists unveil structure of molecular target of many drugs

...ame daunting scientific obstacles. Many of these difficulties arise because gpcrs are membrane proteinssome of the trickiest molecules to capture in three-di...o similar proteins, paving the way for more structures from the hundreds of gpcrs encoded in the human genome. This is an absolutely remarkable advance, s...

How does the opioid system control pain, reward and addictive behavior?

... and are therapeutically essential, representing targets for 50% of marketed drugs (Scherrer et al., 2006). mu-, delta- and kappa-opioid-receptors are gpcrs of the nervous system. The DOR-EGFP mouse provides a unique approach to explore receptor localization and function in vivo. GPCR represent the larg...

Study in Science holds promise for a new approach to drug therapy

... and even the light particles they are exposed to. gpcrs are a key part of such signaling cascades, passing...nt points. Where most drugs change the behavior of gpcrs on the outside of cells, the new class of drugs se...e used in the clinic. Signaling Workhorse gpcrs are a part of a process where cells convert one ki...

Purdue researchers find key to rice blast fungus

...on. These feelers are called G-protein-coupled receptors (GPCR). In humans, gpcrs are found on the tongue and in the nose and are part of what makes foods ta...erent. The scientists discovered that rice blast fungus has more than 40 gpcrs that probably are regulating the signals at the beginning of the penetratio...

Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments

... receptors, which are part of the G protein-coupled receptor (GPCR) family. gpcrs are proteins found in a cell's membrane and play a critical role in transfe... signals from outside of a cell to the molecular machinery within the cell. gpcrs are the largest family of proteins that serve as drug targets. It has been ...
GPCRs in Biological Technology

The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR

Introduction CypHer5 TM is a red-excited, pH-sensitive cyanine dye that is non-fluorescent at pH 7.4 and maximally fluorescent at pH 5.5. It is therefore ideally suited for monitoring internalization of cell surface receptors via acidic endosomal vesicles upon agonist...

Debiopharm and MSM Protein Technologies Sign Agreement for Research and Development of Debio 0929, a Novel Oncology Biologic

...m's caliber. There is a great need in targeting of gpcrs with functionally active, high quality and potent ...se functional human antibodies against a number of gpcrs and other membrane proteins. MSM was formed... About G-protein Coupled Receptors (GPCRs) gpcrs comprise a large protein family of transmembrane r...

Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation

...xiety, and pain, among others. The contribution of gpcrs to disease pathways has resulted in this class of ...drug targets. With more than 1,000 genes, the gpcrs make up the single largest gene family of the human genome. As cell surface receptors, gpcrs are easily amenable to targeting without the issue...

ChanTest Awarded $4.8 Million Through the Ohio Third Frontier Research and Commercialization Program

...- ChanTest, the leading expert in ion channels and gpcrs (G-protein coupled receptors) -- key to drug disco... ) The leading experts in ion channels and gpcrs (G-protein coupled receptors), ChanTest helps its ...leads against an extensive set of ion channels and gpcrs in functional, cell-based assays. ChanTest can scr...

Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7

...th alternative commercially available technologies. This can be due to either it being unavailable as recombinant product (e.g. membrane proteins like gpcrs and ion channels) or the target proteins already being patented. The CLIPS technology makes it possible to derive immunogens from intractable targets ...

ChanTest Acquires Applied Cell Sciences

...ne company, they really do apply. Ion channels and gpcrs are natural partners, critical and often-interrelated components of cell signaling. gpcrs are implicated in many diseases and targets of man... other. Understanding the mechanisms of action for gpcrs and ion channels individually and together is ther...

Heptares Secures GBP21 Million in Series A Fund Raising to Accelerate Development of Pipeline of Small Molecules Against High-Value GPCR Drug Targets

...es will be developed against currently intractable gpcrs that are highly validated targets for the treatmen...roved therapeutic antibodies against GPCRs. gpcrs play a crucial role in many diseases and are the s... and this has severely restricted efforts to study gpcrs using modern drug discovery techniques. Hep...

Caliper Life Sciences and DiscoveRx Collaborate to Offer Solutions for Cell-Based GPCR Profiling and Lead Optimization

... - Nearly 40% of Drugs on the Market and 30% of Active R&D Programs Target gpcrs - HOPKINTON, Mass., May 5 /PRNewswire-FirstCall/ -- Caliper Life Sciences, Inc. (Nasdaq: CALP ) today announced a collaboration with DiscoveRx Corp...

Invitrogen boosts drug development capability

...comprised of " G-protein coupled receptors ," is large and diverse. Because gpcrs are involved in a wide range of cellular functions, they are implicated in ...h a mixture is analyzed. According to some studies , there are over 800 gpcrs in the human genome, covering a diversity of biological processes. They are...

Biotech talent drew venture-funded firm to Madison

...late a range of internal cellular functions. Since gpcrs are involved in a number of cell functions, they a...t the moment, there are anywhere from 800 to 1,000 gpcrs on the human genome. Of those, roughly 400 are tho...d that Caden has a different approach to screening gpcrs that will allow drug companies to develop novel co...
GPCRs in Biological Dictionary

Second messenger

...2005, a 524 second long burn ('Deep-Space Maneuver' or 'DSM-1' ... Among targets of interest for the pharmaceutical industry, gpcrs account for more ... The use of an accumulation second messenger assay to screen a library of ... Most second - messenger systems that have...

Rhodopsin

...the vision ... in absorption: rhodopsin in rod cells, and blue, red, and green ... The European Bioinformatics Institute ... The rhodopsin -like gpcrs themselves represent ... Rhodopsin . EDG-1 sphingosine 1-phosphate receptor. Opioid receptor ... A description of the current concept of the chr...

Deuterostome

... lin ... Phylogenetic position of the protostome and deuterostome genomes analysed. ... Sequences of the protostome and deuterostome family 2 gpcrs TM domains used in ... Textbook Reference - Figure 34.2, p. 656 ... What is a deuterostome , definition of deuterostome , meaning of deuteros...
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