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GPCR in Medical News

ChanTest to Highlight Expanded Ion Channel and GPCR Services and Cell Lines, Including FDA Critical Path Safety Profiling Tools at ToxExpo, Booth 3056

- Company to host seminar Tuesday, March 17, 2009, from 8:30 to 9:30 AM in Room 337 CLEVELAND, Ohio, March 10 /PRNewswire/ -- ChanTest, the leading expert in ion channels and GPCRs (G-protein coupled receptors) - key to drug discovery, development, and safety - will feature the latest in its...

JCI table of contents: Dec. 20, 2007

...-9687; E-mail: llang@med.unc.edu . View the PDF of this article at: https://www.the-jci.org/article.php?id=33302 RELATED MANUSCRIPT TITLE: The gpcr modulator protein RAMP2 is essential for angiogenesis and vascular integrity AUTHOR CONTACT: Takayuki Shindo Shinshu University Graduate School o...

JCI table of contents: Nov. 8, 2007

...le to determine the function of GPCRs in these specific tissues and cell types. TITLE: Probing cell typespecific functions of Gi in vivo identifies gpcr regulators of insulin secretion AUTHOR CONTACT: Shaun R. Coughlin UCSF School of Medicine, San Francisco, California, USA. Phone: (415) 476-6174...

Pieris and Pepscan to Identify GPCR-Specific Anticalins(R) Using CLIPS(TM) Protein Mimicry Technology

...es to the discovery and development of novel Anticalins(R) able to modulate gpcr function in disease. GPCRs form one of the most important classes of drug ...ively targeted to functional epitopes, yet monoclonal antibodies modulating gpcr action have to date proven technically challenging. Pepscan's CLIPS(TM) tec...
GPCR in Medical Technology

Cara Therapeutics Announces Successful Completion of Phase I Clinical Trial of Novel Analgesic, CR845

...n multiple classes of peripherally-acting analgesics. Cara also plans to develop entirely novel classes of analgesics that emerge from its proprietary gpcr DimerScreen(TM) technology. Forward-Looking Statements Certain statements in this press release are forward-looking statements that involve a numb...

Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis

...ed receptor (GPCR) drug research and the general approach we take toward developing innovative treatments for serious medical conditions. Applying our gpcr focus and expertise, we've developed a pipeline of seven novel development stage drug candidates, five of which are in the clinic," stated Dominic P. ...

Arena Pharmaceuticals, Inc. Announces Initiation of Phase 1 Clinical Trial of Drug Candidate Under Partnership with Taisho Pharmaceutical Co., Ltd.

...t and Chief Executive Officer. Under an amended agreement with Taisho, which was initially executed in May of 2000 to research a number of different gpcr targets of interest to Taisho, Taisho is responsible for development and commercialization of the drug candidate. Arena is entitled to a low single di...
GPCR in Biological News

International collaboration by scientists culminates in novel ion channels database

...iliesForward . IUPHAR also remains committed to the ongoing update of the gpcr database which has been publicly available since 2005. gpcr pages updated in the current release are melanin-concentrating hormone, est...

Shape changes in aroma-producing molecules determine the fragrances we detect

...t that half of all commercial pharmaceuticals work by interaction with proteins within this family. Thus, the findings could also have applications to gpcr drug design, as well. ...

Proteins that stop a major signaling pathway can also generate new proteins

...ompletely unexpected according to the traditional dogma. Ten years ago, nobody would have imagined that beta-arrestins, with their ability to stop the gpcr signals, could exert global control over protein synthesis." ...

Genetic Engineering & Biotechnology News reports on growing use of cell-based assays

...ocesses. Multispan is looking to exploit this area and is collaborating with Promega and Molecular Devices to develop an array of applications for its gpcr cell-based assays. Another field of much R&D interest involves protein-protein interactions. DiscoveRx created a new family of cell-based assays f...

Columbia geneticists uncover new gene involved in determining hair texture and density in humans

... largest known class of molecular targets with proven therapeutic value. It is estimated that more than 40 percent of existing drugs work by targeting gpcr drug targets; this target class represents a large fraction of the total biological targets against which FDA-approved oral drugs are directed. Of the...

Scientists unveil structure of molecular target of many drugs

...is an exciting example of the rewards from the Roadmap investment. Scientists across the country have tried for years to obtain detailed images of gpcr proteins. Theyve succeeded only once before, in 2000, when a research group determined the structure of a visual pigment in cow eyes. Part of the job ...

How does the opioid system control pain, reward and addictive behavior?

...oid-receptors are GPCRs of the nervous system. The DOR-EGFP mouse provides a unique approach to explore receptor localization and function in vivo. gpcr represent the largest and most versatile family of membrane receptors, and each member has a specific cellular life cycle. The EGFP-knocking approach ...

In drug design, a loose fit may be best bet

...munication. When a hormone binds to its designated gpcr on the outside of a cell, a specific G-protein is ... today, so if this finding for TRH holds for other gpcr targets, it could have significant implications fo...uggest that a loose connection between hormone and gpcr may allow a hormone to repetitively dock to and un...

Study in Science holds promise for a new approach to drug therapy

...ection and set the timing of the heartbeat. Faulty gpcr signaling, on the other hand, plays a key role in ...nside the cell sent by the ligand that activates a gpcr on the outside. The free G protein gamma-beta subu...ll either shut down or turn up the function of the gpcr as compared to its natural binding partner, whatev...

Newly discovered genetic disease sheds light on body's water balance

...y. Further characterization of NSIAD may offer additional insights into fluid homeostasis and clinical disease, as well as expand our understanding of gpcr signaling." The group is now conducting a series of further studies in both the clinic and the laboratory to better understand how these mutations ...
GPCR in Biological Technology

Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7

LELYSTAD, The Netherlands, April 6 /PRNewswire/ -- Today, Pepscan reports that it has achieved a major scientific breakthrough through the use of its CLIPS-based synthetic peptide immunogen technology. By constructing synthetic 3D mimics of the ligand binding-site on CXCR7 it has induced funct...

Heptares Secures GBP21 Million in Series A Fund Raising to Accelerate Development of Pipeline of Small Molecules Against High-Value GPCR Drug Targets

LONDON, February 24 /PRNewswire/ -- - Syndicate Comprises Leading Sector Investors Clarus Ventures, MVM Life Science Partners and Novartis Option Fund Heptares Therapeutics Ltd, the drug discovery company focused on drugs targeting G-protein-coupled receptors (GPCRs), announces t...

Odyssey Thera Granted U.S. Patent for Novel GPCR Assay Strategy

Claims extend and strengthen Odyssey Thera's coverage to include GPCR directed screening and drug profiling. SAN RAMON, Calif., Feb. 12 /PRNewswire/ -- Odyssey Thera, Inc. announced today that it has been granted a United States patent entitled "Fragment Complementation Assays for G-Protein-C...

Caliper Life Sciences and DiscoveRx Announce Availability of PathHunter eXpress Reagents for GPCR Assays

- PathHunter eXpress Kits Combined with LabChip Microfluidic Instruments Provide a Comprehensive, High Quality, Easy-to-Use GPCR Assay Solution - HOPKINTON, Mass. and FREMONT, Calif., Oct. 7 /PRNewswire-FirstCall/ -- Caliper Life Sciences, Inc. (Nasdaq: CALP ) and DiscoveRx, today announced...

Caliper Life Sciences and DiscoveRx Collaborate to Offer Solutions for Cell-Based GPCR Profiling and Lead Optimization

- Nearly 40% of Drugs on the Market and 30% of Active R&D Programs Target GPCRs - HOPKINTON, Mass., May 5 /PRNewswire-FirstCall/ -- Caliper Life Sciences, Inc. (Nasdaq: CALP ) today announced a collaboration with DiscoveRx Corporation that enables functional cell...

High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system

METAXPRESS APPLICATION NOTE By Susan Catalano, Ph.D., Acumen Pharmaceuticals, Sylvia de Bruin, Joe Bosworth, Ph.D., Neal Gliksman, Ph.D., Kimberly Best, Ph.D. and Paula Rickert, Ph.D., Molecular Devices Corporation, 1311 Orleans Dr...

Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation

...says has made possible the characterization of the gpcr from the ligand binding, signaling, and dimerizati...a fusion protein comprised of the SNAP/CLIP tagged gpcr is expressed on the cell surface. "Given that...ays is well positioned to serve the unmet needs of gpcr characterization. Considering these receptors are ...

ChanTest Awarded $4.8 Million Through the Ohio Third Frontier Research and Commercialization Program

...to expand its library of validated ion channel and gpcr cell line products and services, enhance its capab...and development research services, ion channel and gpcr cell lines, and membrane products to help our biot...tter, safer drugs. ChanTest offers ion channel and gpcr services (both automated high-throughput and GLP),...

ChanTest Acquires Applied Cell Sciences

...wswire/ -- The leading experts in ion channels and gpcr (G-protein coupled receptors) - key to drug discov...l Sciences products and services include optimized gpcr functional analysis tools, high-throughput screeni... reagents and reagent-development services, stable gpcr cell lines, cell membranes for binding studies, cr...

Metabolex Announces Positive Results From Phase 1a Clinical Trial of MBX-2982

..."We are now focusing our earlier stage research and development programs on gpcr targets," stated Chuck McWherter, Senior Vice President of Research and Pre...nmet medical needs." About MBX-2982 MBX-2982 is an agonist of GPR119, a gpcr that is expressed in pancreatic islets and the gastrointestinal tract. Pre-...
GPCR in Biological Products

Rabbit Anti-GPCR G2A Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to gpcr G2A ( Abpromise for all tested applications). entrezGeneID: 29933 SwissProtID: Q9UNW8...
Company:Abcam

Ion Channel SpliceArray Service from ExonHit Therapeutics Inc.

Description:...ng specificity and signaling of the members of the gpcr family are known to be modified by alternative spl...has important implications for drug research. With gpcr SpliceArrays you can perform a classical expressio...that are expressed in the samples under study. The gpcr SpliceArray monitors 1543 known and potential spli...
Company:ExonHit Therapeutics Inc.

GPCR SpliceArray Service from ExonHit Therapeutics Inc.

Description:...ng specificity and signaling of the members of the gpcr family are known to be modified by alternative spl...has important implications for drug research. With gpcr SpliceArrays you can perform a classical expressio...that are expressed in the samples under study. The gpcr SpliceArray monitors 1543 known and potential spli...
Company:ExonHit Therapeutics Inc.

Rabbit Anti-Human CELSR3 Polyclonal Antibody, Unconjugated from GeneTex

Description:... Rabbit Polyclonal to Human CELSR3 CELSR3 is an Orphan-U gpcr with an unknown ligand. In mouse, this gene is expressed during development at sites of active neurogenesis and in adult mice and rats in brain, spin...
Company:GeneTex
GPCR in Biological Dictionary

Secretin

.... It was the first... Human secretin receptor is a G protein-coupled receptor which binds secretin and is the leading member of the class B gpcr subfamily. Human Secretin Information. ... ChiRhoStim® is Identical to naturally occurring human secretin ... 8/1/08 Updated Secretin Formu...
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