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GLEEVEC in Medical News

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

Novartis Pharmaceuticals Corporation offers a prescription copay assistance program for Ph+ CML (Chronic Myelogenous Leukemia or Chronic Myeloid Leukemia) patients through the My CML Circle Copay Assistance Program ( www.mycmlcircle.com ). East Hanover, NJ (PRWEB) Febru...

Cancer Drug Gleevec Could Fight Stroke

It might extend the effectiveness of clot-busting tPA, researchers say MONDAY, June 23 (HealthDay News) -- A powerful weapon against cancer might also boost stroke patients' survival, new research suggests. Gleevec, long hailed as a "wonder drug" against cancers such as chronic myel...

Cancer Drug Gleevec Linked to Muscle Damage

French researchers say the problem can probably strike small percentage of patients WEDNESDAY, June 18 (HealthDay News) -- French doctors have reported a possible new side effect associated with the cancer drug Gleevec (imatinib), widely used for the treatment of chronic myeloid leukem...

Protein predicts Gleevec resistance in gastrointestinal tumors

Excess amounts of a protein called IGF-1R in patients with gastrointestinal stromal tumors (GISTs) could indicate that the patient would be less responsive to the drug imatinib mesylate (known as Gleevec), according to Andrew K. Godwin, Ph.D., a researcher at the Fox Chase Cancer Center in Philade...

Novartis Gleevec Found Effective in Treating Gastro-intestinal Tumors

The US-based National Cancer Institute (NCI) has commended Novartis' anti-cancer tablet, Gleevec, as an// effective therapy for patients suffering from GISTs, metastatic gastro-intestinal tumors. These tumours do have a rather complicated name. They are found in the digestive system - the g...

"Miracle" Cancer Drug Gleevec Can be Toxic to the Heart

Gleevec, the wildly successful poster-child of a new generation of cancer drugs aimed at specific targets in the cancer cell, can be dangerous to the heart.// Not only that, but other similarly based drugs – called tyrosine kinase inhibitors – could lead to heart problems as well, say researchers a...

The vulnerable cancer cell

...ication of the two kinases as validation of the approaches taken by Elledge and Gilliland. With the dramatic clinical success of cancer drugs, such as gleevec and dasatinib, which target rogue kinases, Sawyers says any screen that turns up new kinases is worthy of further investigation. "The new mantra, q...

Gleevec Prevents Return of Intestinal Cancer, Study Confirms

... THURSDAY, March 19 (HealthDay News) -- Taking gleevec after surgery to remove a gastrointestinal stromal...randomly selected to take either 400 milligrams of gleevec or a placebo once a day for a year after surgery t...up of almost 20 months, 8 percent of people in the gleevec group and 20 percent of those in the placebo group...

Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports

...ival was 98% for Kit-positive GIST patients taking gleevec vs. 83% for patients taking placebo(1) - Hist...hin a median of two years after surgery(3) - gleevec is the only treatment in the US and Switzerland in... an upcoming print issue of The Lancet show that gleevec (R) (imatinib mesylate) tablets*, when taken afte...

Stem cells: Deathly awakening by interferon

...ncer called chronic myelogenous leukemia who are treated with a drug called gleevec almost always relapse after drug treatment has ended. Several patients were given interferon-alpha prior to the gleevec treatment. Surprisingly, these patients experienced long relapse-free phase...

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GLEEVEC in Medical Technology

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...e for responses showed either partial responses to gleevec (3 out of 5) or stable disease (2 out of 5). Respo...ipation, limb pain, chest pain and headache. gleevec important safety information Fetal harm can occ...uld be advised to not become pregnant while taking gleevec tablets and to avoid breast-feeding while taking...

University of California Los Angeles Selects Velos eResearch

...re well-known therapies include: Herceptin , a targeted breast cancer drug and the first approved treatment that attacks cancer at its genetic root; gleevec , a once-a-day pill that targets a common form of adult leukemia called chronic myelogenous leukemia, or CML; Sprycel , also a pill that targets CML;...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

...gnosed Ph+ CML Patients) is evaluating Tasigna vs. gleevec in newly diagnosed patients and is now fully accru... patients with hepatic impairment. About gleevec Gleevec(R) (imatinib mesylate) tablets a...he chronic phase. Follow-up is limited to 5 years. gleevec is also indicated for patients with Ph+ CML in bla...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... of data to be presented at ASH include: gleevec A Phase III, Randomized, Open-L...:00 - 7:00 PM CST) About gleevec gleevec (R) (imatinib mesylate) tablets are indicated for...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

...he chronic phase. Follow-up is limited to 5 years. gleevec is also indicated for the treatment of patients wi... safety information(7) Fetal harm can occur when gleevec is administered to a pregnant woman; therefore, wo...uld be advised to not become pregnant while taking gleevec tablets and to avoid breast-feeding while taking...

MicroRNA First Disclosed by Rosetta Genomics may Increase Efficacy of Imatinib (Gleevec(R)(1)) in Glioblastoma

.... Rosetta does not assume any obligation to update any forward-looking statements unless required by law. --------------------------------- (1) gleevec is a registered trademark of Novartis Contact: Investors Joshua Gordon, M.D. T: +1-201-946-0561 E: investors@rosettagenomics.com Media Ron K...

Stroke Study Reveals a Key Target For Improving Treatment

...rries risks as well as benefits, and suggests that gleevec or other drugs could prevent problems ANN ARBOR,...ain barrier" to become porous, leading to leakage. gleevec inhibits the PDGF-alpha receptor, apparently count...weden bears out the findings seen in mice, perhaps gleevec could be given immediately upon suspicion of strok...

New Nexavar Data Presented in Multiple Tumor Types at 44th American Society of Clinical Oncology Annual Meeting

... 2 study suggest that Nexavar is active and well tolerated in patients with gleevec or gleevec and Sutent resistant GIST. The most common treatment-emergent adverse event...

Northwestern Memorial Study Tests Cancer Drug on Scleroderma Patients

...he clinical trial will receive daily oral doses of gleevec for six months and will be evaluated initially on ...performed by investigators at the Feinberg School, gleevec shows potential efficacy in reducing the abnormal ...g with Scleroderma. "We hope that the use of gleevec for a sustained period of time will decrease the s...

Positive Results Prompt US National Cancer Institute to Make Gleevec Available To Patients in Post-Surgical Gist Study

... - gleevec found to dramatically reduce the risk of cancer re...itive gastrointestinal stromal tumors treated with gleevec following surgery were significantly less likely t...e of cancer in approximately 97% of patients given gleevec for a year after surgery to remove tumors, compare...
GLEEVEC in Medical Definition

Personalized medicine

...zed medicine and cancer 4.1 Herceptin and gleevec 5 Personalized medicine and education ...roven success as is the case with Herceptin and gleevec . Theranostic tests are proving effective in other...c medications or surgery . Herceptin and gleevec Two products, Herceptin supplied by Genentec...
GLEEVEC in Biological News

Stroke study reveals key target for improving treatment and suggests that Gleevec may help

ANN ARBOR, Mich. For over a decade, the drug called tPA has proven its worth as the most effective emergency treatment for the most common kind of stroke. But its promise is blemished by two facts: tPA can cause dangerous bleeding in the brain, and its brain-saving power fades fast after the thir...

JDRF funded research shows promise for prevention, reversal of type 1 diabetes

...betes and potentially other autoimmune disorders," said JDRF Director of Immunology Teodora Staeva, Ph.D. The drugs Imatinib and Sunitnib, sold as gleevec and Sutent, respectively are used to treat cancer by blocking tyrosine kinases, an enzyme that modify cells' signaling proteins through a simple bioc...

Washington University scientists first to sequence genome of cancer patient

...c basis of cancer, an essential first step to developing targeted therapies, says Brian Druker, M.D., whose research helped identify the targeted drug gleevec as a promising therapy for chronic myelogenous leukemia. Druker, the director of the Oregon Health & Science University Cancer Institute and a Howard ...

Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs

... acid (vitamin C) takes to enter cells. They found to their surprise that every chemotherapy drug they tested which included targeted agents like gleevec did not work as well if cells were pretreated with vitamin C, as they did on untreated cancer cells. In the cell culture experiments, 30 to 70 percen...

Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure

... of damaging the heart cells, may actually hurt heart stem cells and prevent repair. Some early results in the laboratory with stem cell cultured with gleevec seem to support the theory. Dr. Forces group will continue to test the tyrosine kinase inhibitor drugs to better understand how they affect cardiac st...

OHSU turns innovations into commercial opportunities at record pace

...e division of hematology and oncology in the OHSU School of Medicine. Druker is internationally recognized for his role in the clinical development of gleevec (Imatinib), the first molecular-targeted medication to prove effective against chronic myelogenous leukemia (CML). Heinrich was the first to identify ...

U-M researchers discover gene switched off in cancer can be turned on

...ould lead to a new class of targeted cancer therapies with potential to benefit many different cancer types. Popular new drugs such as Herceptin and gleevec more effectively treat cancer by targeting genetic mutations that express themselves in large amounts, causing cancer to develop. But cancers also ari...

High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping

... tumors (GISTs), and certain EGFR mutations that are responsible for one form of lung cancer. These cancers can be treated with the targeted therapies gleevec and Tarceva, respectively, which shut down the affected oncogenes. The test involves taking a sample of fresh or frozen tumor, amplifying its DNA, ...

New strategy rapidly identifies cancer targets

...inases are already on the market, including Gleevec, which Druker pioneered for treatment of chronic myelogenous leukemia. Since its approval in 2001, gleevec has made CML a much more manageable disease. A new drug to inhibit JAK3 is already in development elsewhere, and, eventually, Druker sees a marke...

New cellular flaw found in some virulent breast cancers

...using it to unleash a virulent proliferation of cancer cells and creating a tumor with a very poor prognosis. "The development of cancer drugs like gleevec and Iressa have shown that it is possible to block the action of kinases," said Sicinski, "so we hope that these findings will stimulate interest in d...
GLEEVEC in Biological Technology

Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia

- Efficacy and safety profile in large randomized Phase III study consistent with landmark IRIS trial, which established Gleevec as standard of care - Study did not meet primary endpoint at 1 year, yet shows faster time to molecular responses with...

Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.

...ological triggers and pathways, given the tendency of these cells to regroup to recalibrate and spread through new growth paths. Global sales of gleevec are projected to steadily increase between the period 2010 and 2015, as stated by the new market research report. New generation kinase inhibitor dru...

Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting

...port on Form 10-Q and other items throughout the Form 10-K and the company's 2009 Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. gleevec is a registered trademark of Novartis Pharmaceuticals Corporation. All rights reserved. (C) 2005-2009 American Society of Clinical Oncology (ASCO...

Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery

...% reduction in risk of GIST relapse with use of gleevec after surgery are basis for FDA, EMEA, Swissmedic ...imatinib) outside the US, Canada and Israel. The gleevec submissions are based on data from a Phase III, do...urgery (adjuvant setting) in patients treated with gleevec versus placebo(2). In early 2007, the study met ...

SGX Pharmaceuticals Submits Investigational New Drug Application for SGX393

...e standard of care for CML is Gleevec(R). Although gleevec is a highly effective front-line therapy for CML, there are patients who relapse while on gleevec or who are intolerant to the therapy. In the major...hallenging to inhibit is the T315I mutant. Neither gleevec nor the two more recently approved CML treatments,...

Modifying an anti-cancer drug makes it more specific

... Imatinib (marketed as gleevec in the US and Glivec in Europe and Australia) is used to treat various cancers, including chronic myeloid leukemia (CML) and gastrointestinal stromal ...

JCI table of contents: Dec. 3, 2007

... https://www.the-jci.org/article.php?id=34251 EDITOR'S PICK: Modifying an anticancer drug makes it more specific Imatinib (marketed as gleevec in the US and Glivec in Europe and Australia) is used to treat various cancers, including chronic myeloid leukemia (CML) and gastrointestinal stromal ...

FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML

...mized trial of SPRYCEL, 70 mg twice daily, and gleevec 800 mg (400 mg twice daily), study -017. For ...nt chronic phase CML. A total of 670 patients (498 gleevec resistant) were randomized to 100 mg once daily, 1...70 mg twice daily. SPRYCEL and Escalated Doses of gleevec (Study -017): The Phase 2 randomized, open-label s...

Biotech 2004: Cautious optimism

...fore going to the FDA). Not all of these drugs will make it down the home stretch. 11. Finally, the sales success of new biotech drugs. Novartis gleevec and Genentechs Rituxan both were $1 billion drugs last year with the latter reaching sales of $2.1 billion and the former reaching sales of $1.1 billi...
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