'Singing brains' offers epilepsy and schizophrenia clues
...the visual cortex of each person's brain. The more gaba
was present, the higher the frequency or "note" of the oscillation. gaba
is a key inhibitory
neurotransmitter and is essent...indow into the action of neurotransmitters such as gaba
and how their function is compromised in diseases ...
Marinus Pharmaceuticals, Inc. Announces Positive Results of its Phase 2 Clinical Trial of Ganaxolone as Adjunctive Therapy in Adults With Partial Onset Seizures
...fectiveness of ganaxolone, as a novel first in class anticonvulsant drug. Ganaxolone is the only neurosteroid in clinical development and is a unique gaba
modulator that will expand the armamentarium of drugs available to treat epilepsy. The novel mechanism of action and excellent safety profile of this...
The profound effects of numbing agents
...ompounds that either block excitatory NMDA receptors or activate inhibitory gaba
receptors in the brain are clinically useful as anesthetics or for treating... mice with two doses of either the NMDA receptor blocker dizocilpine or the gaba
receptor activator Phenobarbital and then analyzed subsequent changes in br...
Primary Insomnia Tied to Brain Neurochemical Imbalance
...or energy, concentration and mood."
Lower brain gaba
levels also have been found in people with major d...actor in these conditions, the findings could mean gaba
deficiencies seen in people with mood and anxiety ...ntagonists (BzRAs), which increase activity at the gaba
neurons, the study also reported.
Study links primary insomnia to a neurochemical abnormality in young and middle-aged adults
...iate of Harvard Medical School in Boston, Mass.
decreases overall activity in many brain areas, he...copy (1H-MRS) was used to non-invasively determine gaba
levels. For statistical comparison the study inclu....
Significant correlations were found between gaba
levels and both subjective and objective sleep mea...
Circadian Rhythm Plays Role in Memory
...tant production of a neurochemical called GABA, which acts to inhibit brain activity, the researcher said. When they were given a chemical that blocks gaba
from binding to brain synapses, the circadian system-deficient hamsters learned as well as their normal counterparts.
"What our data are showing is...
The secret ingredients behind germinated rice
...arm bath induces germination, or sprouting, which stimulates rice enzymes to produce more nutrients. One such nutrient is the important brain chemical gaba
(PR is thus often referred to as "GABA rice"), and animal studies have shown that a PR-rich diet can improve cognitive function. Other studies have fo...
Scientists identify another piece of the weight-control puzzle
...ex puzzle, demonstrating that the neurotransmitter gaba
--one of the master communicators among neurons p... An alternate theory proposed that release of the gaba
neurotransmitter was mediating the function of AgR...enerated a group of mice with disrupted release of gaba
specifically from the AgRP neurons. As predicted, ...
Scientists Create Mice Resistant to Obesity
...cused on one neurotrasmitter in particular, called gaba
(gamma-aminobutyric acid). They developed transgen...or mutant, mice that lacked the ability to release gaba
in a subset of brain cells in the hypothalamus -- ...earchers said.
"We found that the mice without gaba
release from AgRP neurons have increased energy ex...
Possible Cause of Postpartum Depression Pinpointed
... Mouse study implicates gaba
receptors in the central nervous system
...egulation of a particular class of proteins called gaba
receptors on the surface of certain neurons in the...n .
The protein at the heart of this study, the gaba
receptor (type A), serves an inhibitory role in th...
GABA in Medical Technology
Catalyst Pharmaceutical Partners Begins Enrollment for Its U.S. Phase II Clinical Trial of CPP-109 in Patients with Cocaine Addiction
...9 works by inhibiting an enzyme that normally breaks down gamma
aminobutyric acid (GABA), a dopamine-modulating neurotransmitter. The
resulting excess gaba
suppresses the increase in dopamine release caused by
cocaine. All addictive drugs elevate dopamine levels in the parts of the
brain associated with r...
PET Scans Show Gene Therapy Normalizes Brain Function in Parkinson's Patients
...the senior investigator of the study. "You want to be sure that
the treatment doesn't make things worse." The gene makes an inhibitory
chemical called gaba
that turns down the activity in a key node of the
Parkinson's motor network. The investigators were not expecting to see
changes in cognition, and the...
Tezampanel, TorreyPines Therapeutics' Lead Compound, Reduced Muscle Spasticity and Rigidity in Preclinical Study Conducted at University of California, San Diego
...t-in-class compound." Currently, patients experiencing muscle spasticity and rigidity are
typically treated with muscle relaxants, tranquilizers or a gaba
agonist such as baclofen. Treatment may also include physical therapy
regimens to prevent shrinkage or shortening of muscles. In the study,
Arena Pharmaceuticals Announces Positive Phase 2 Clinical Trial Results of APD125 for the Treatment of Insomnia
...gering a general CNS-suppressive effect. These drugs are
DEA-scheduled, controlled substances due to their potential for abuse.
Common side effects of gaba
activating drugs include the risk of developing
tolerance to the drug, impaired functioning when the drug is at therapeutic
levels, and the potential ...
Diamyd Updates Gene Therapy Program and Outlines Plans for Phase I Clinical Trial for Treatment of Cancer Pain
...the brain to complete the pain pathway. Three main compounds, enkephalins, gaba
and endomorphins, naturally
regulate pain transmission at the first order s... syndrome, there are
differences in their effectiveness. For example, while gaba
produced with the help of the GAD enzyme dampens spinal cord injury...
BioLineRx Presents Phase I Clinical Data of BL-1020 at Upcoming
...ts. We very much look forward to
the initiation of the Phase II trial in the second quarter of
BL-1020 is an orally available gaba
clinical candidate for the treatment of schizophrenia. Data from
preclinical and phase I studies demonstrated that the compound...
BioLineRx Presents Data From Successful Phase I Trial for BL-1020
in Schizophrenia at American Psychiatric Association Conference
BL-1020 is an orally available gaba
clinical candidate for the ...multaneously target the dopamine
hyperactivity and gaba
hypoactivity of schizophrenia. Exogenously
is ineffective as a therapeutic agent due to its
Indevus Announces Presentation of Pagoclone Data at 47th Annual New
Clinical Drug Evaluation Unit Meeting
...dation and withdrawal. The precise mechanism of action is
unknown, however, gaba
is believed to be an important
neurotransmitter in the brain that may be disrupted in people who
stutter. Pagoclone enhances the activity in gaba
circuits in the
brain and thus may help restore more normal function in spe...
Neurologix Announces Publication of Landmark Gene Therapy Study
Demonstrating Safety and Statistically Significant Improvement in
Patients With Advanced Parkinson's Disease
... increased, largely due to a deficit in GABA
(gamma-aminobutyric acid), the major inhibitory neurotransmitter in
the brain. Increasing GAD causes more gaba
to be synthesized, thus
helping to calm the STN over-activity. The value of this strategy
has been demonstrated in previous human studies where reduci...
Neurogen Announces Positive Results for Proprietary Insomnia Drug
in Two Chronic Insomnia Clinical Trials
...ed for treatment of both onset and
maintenance symptoms of insomnia work by modulating the
gamma-aminobutyric acid (GABA) system of neurotransmitters. gaba
a chemical naturally released in certain parts of the brain in
order to inhibit brain activity. Preclinical studies suggest that
NG2-73 is pharmaco...
GABA in Medical Definition
Depolarization-induced suppression of inhibition
... 10 seconds. After the depolarization, inhibitory gaba
mediated neurotransmission is reduced. This has b...esponses of large pyramidal projection neurons to gaba
, the main inhibitory neurotransmitter in the central nervous system. gaba
is typically released by small interneurons in ...
GABA in Biological News
22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey
...ectives for treatment
News on the NewMood project
The educational update sessions at the ECNP Congress will deal with the current knowledge on gaba
and biomarkers in neuropsychopharmacology, treatment of insomnia, bipolar disorders and schizophrenia, as well as the new classification systems ICD-1...
22nd Congress of the European College of Neuropsychopharmacology
...s for treatment
News on the NewMood project
Furthermore, the educational update sessions at the congress will deal with the current knowledge on gaba
and biomarkers in neuropsychopharmacology, treatment of insomnia, bipolar disorders and schizophrenia, and the new classification systems ICD-11 and D...
Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic
...mbrane region of the superfamily of ligand-gated channels that includes the gaba
receptor. Anesthetics are known to positively modulate gaba
Because 1-AMA competes with other anesthetics to bind to apo...
Circadian clock may be critical for remembering what you learn, Stanford researchers say
...our animals were having chronically high levels of gaba
because they had lost their circadian rhythm," Rub... "So instead of rhythmic GABA, it is just constant gaba
To test that idea, Ruby and his colleagues gave the circadian-deficient hamsters a gaba
antagonist called pentylenetetrazole, or PTZ, whic...
New studies on schizophrenia, depression, trauma and autism highlight annual meeting
...00 a.m. EST December 8)
Nicotine Addiction Might be Controlled by Influencing Pleasurable Response Mechanisms in Brain There is a clear link between gaba
a chemical substance of the central nervous system that inhibits neurons in the brain and nicotine dependence. Researchers discovered that nicotine...
How schizophrenia develops: Major clues discovered
...ed GABA. The more the gene is turned on, the more gaba
synthesis can occur, under normal circumstances. gaba
helps regulate the flow of electrical traffic that...rain.
Abnormalities in brain development and in gaba
synthesis are known to play a role in schizophreni...
Gene therapy study shows safety and statistically significant improvement in Parkinson's disease
... disease, STN activity is abnormally increased, largely due to a deficit in gaba
(gamma-aminobutyric acid), the major inhibitory neurotransmitter in the brain. Increasing GAD causes more gaba
to be synthesized, thus helping to calm the STN over-activity. The value of...
Gene therapy inhibits epilepsy in animals
...cur, at least in part, because of an imbalance between two types of neurotransmitters: the glutamate system, which stimulates neurons to fire, and the gaba
system, which inhibits that brain activity.
GABA's inhibitory role is considered particularly important in the dentate gyrus because the dentate g...
Protein shown to rally biological clock
...ies the roles that both VIP and a neurotransmitter gaba
play in synchronizing biological clocks, and sheds...o keep 24-hour time.
It had been thought that gaba
was the prime candidate for the rallying role. All...urotransmitter, and it had been shown that giving gaba
daily at 8 a.m. to SCN cells synchronizes them. ...
Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
.... Neurotransmitters in the hypothalamus, including gaba
(gamma aminobutyric acid), are known to be an impo... reducing Hap1 decreased the level and activity of gaba
receptors in the hypothalamus.
"We concluded t...eases Hap1 levels, and reducing Hap1 decreases the gaba
receptor activity, we believe Hap1 is the link bet...
GABA in Biological Technology
GABA in Biological Products
Rabbit Anti-GABA A Receptor gamma 2 Polyclonal Antibody, Unconjugated from Abcam
Description:... Rabbit polyclonal to gaba
A Receptor gamma 2 ( Abpromise for all tested applications). entrezGeneID: 2566 SwissProtID: P18507...
QPatch 16 from Sophion Bioscience
Description:...tomated gigaseal patch clamping. The system is used for screening against voltage-gated ion channels, such as hERG and ligand-gated channels, such as gaba
channels. The four pipette heads afford more efficient assays and faster throughput for ion channel drug discovery. The glass-coated tunnels of the ...
GABA in Biological Definition
In addition to amino acids for protein synthesis, there are other biologically important amino acids, such as the neurotransmitters glycine , gaba
and glutamate , as well as carnitine (used in lipid transport within a cell ), ornithine , citrulline , homocysteine , hydroxyproline , hy...
DNA gyrase : catalyzes the negative supercoiling of prokaryotic DNA
Glutamate decarboxylase : synthesizes the neurotransmitter gaba
in the brain
Glutathione peroxidase : protects cells by converting hydrogen peroxide to water
Isomerase : all those enzymes which convert a m...
...ffect is determined by its receptor. For example, gaba
can act as a rapid or slow inhibitor , depending...is the most prominent of excitatory transmitters; gaba
and glycine are well-known inhibitory neurotran...from amino acids :
Monoamines (in the order of...
... an impulse in that cell even though the synapses are weak. On the other hand, a pre-synaptic neuron releasing an inhibitory neurotransmitter such as gaba
can cause inhibitory postsynaptic potential in the post-synaptic neuron, decreasing its excitability and therefore decreasing the neuron's likeliho...
GABA in Biological Dictionary
...earch ... Retrieved from "http://en.wikipedia.org /wiki/Talk: Concatemer " ... In cells expressing the concatemer , amphetamine analogs promoted gaba
efflux and ... The concatemer was tagged on its amino terminus with CFP, which afforded the ... Next message: Concatemer Chain Reaction (CCR ...