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GABA in Medical News

'Singing brains' offers epilepsy and schizophrenia clues

...the visual cortex of each person's brain. The more gaba was present, the higher the frequency or "note" of the oscillation. gaba is a key inhibitory neurotransmitter and is essent...indow into the action of neurotransmitters such as gaba and how their function is compromised in diseases ...

Marinus Pharmaceuticals, Inc. Announces Positive Results of its Phase 2 Clinical Trial of Ganaxolone as Adjunctive Therapy in Adults With Partial Onset Seizures

...fectiveness of ganaxolone, as a novel first in class anticonvulsant drug. Ganaxolone is the only neurosteroid in clinical development and is a unique gaba modulator that will expand the armamentarium of drugs available to treat epilepsy. The novel mechanism of action and excellent safety profile of this...

The profound effects of numbing agents

...ompounds that either block excitatory NMDA receptors or activate inhibitory gaba receptors in the brain are clinically useful as anesthetics or for treating... mice with two doses of either the NMDA receptor blocker dizocilpine or the gaba receptor activator Phenobarbital and then analyzed subsequent changes in br...

Primary Insomnia Tied to Brain Neurochemical Imbalance

...or energy, concentration and mood." Lower brain gaba levels also have been found in people with major d...actor in these conditions, the findings could mean gaba deficiencies seen in people with mood and anxiety ...ntagonists (BzRAs), which increase activity at the gaba neurons, the study also reported. More inform...

Study links primary insomnia to a neurochemical abnormality in young and middle-aged adults

...iate of Harvard Medical School in Boston, Mass. gaba decreases overall activity in many brain areas, he...copy (1H-MRS) was used to non-invasively determine gaba levels. For statistical comparison the study inclu.... Significant correlations were found between gaba levels and both subjective and objective sleep mea...

Circadian Rhythm Plays Role in Memory

...tant production of a neurochemical called GABA, which acts to inhibit brain activity, the researcher said. When they were given a chemical that blocks gaba from binding to brain synapses, the circadian system-deficient hamsters learned as well as their normal counterparts. "What our data are showing is...

The secret ingredients behind germinated rice

...arm bath induces germination, or sprouting, which stimulates rice enzymes to produce more nutrients. One such nutrient is the important brain chemical gaba (PR is thus often referred to as "GABA rice"), and animal studies have shown that a PR-rich diet can improve cognitive function. Other studies have fo...

Scientists identify another piece of the weight-control puzzle

...ex puzzle, demonstrating that the neurotransmitter gaba --one of the master communicators among neurons p... An alternate theory proposed that release of the gaba neurotransmitter was mediating the function of AgR...enerated a group of mice with disrupted release of gaba specifically from the AgRP neurons. As predicted, ...

Scientists Create Mice Resistant to Obesity

...cused on one neurotrasmitter in particular, called gaba (gamma-aminobutyric acid). They developed transgen...or mutant, mice that lacked the ability to release gaba in a subset of brain cells in the hypothalamus -- ...earchers said. "We found that the mice without gaba release from AgRP neurons have increased energy ex...

Possible Cause of Postpartum Depression Pinpointed

... Mouse study implicates gaba receptors in the central nervous system ...egulation of a particular class of proteins called gaba receptors on the surface of certain neurons in the...n . The protein at the heart of this study, the gaba receptor (type A), serves an inhibitory role in th...
GABA in Medical Technology

Catalyst Pharmaceutical Partners Begins Enrollment for Its U.S. Phase II Clinical Trial of CPP-109 in Patients with Cocaine Addiction

...9 works by inhibiting an enzyme that normally breaks down gamma aminobutyric acid (GABA), a dopamine-modulating neurotransmitter. The resulting excess gaba suppresses the increase in dopamine release caused by cocaine. All addictive drugs elevate dopamine levels in the parts of the brain associated with r...

PET Scans Show Gene Therapy Normalizes Brain Function in Parkinson's Patients

...the senior investigator of the study. "You want to be sure that the treatment doesn't make things worse." The gene makes an inhibitory chemical called gaba that turns down the activity in a key node of the Parkinson's motor network. The investigators were not expecting to see changes in cognition, and the...

Tezampanel, TorreyPines Therapeutics' Lead Compound, Reduced Muscle Spasticity and Rigidity in Preclinical Study Conducted at University of California, San Diego

...t-in-class compound." Currently, patients experiencing muscle spasticity and rigidity are typically treated with muscle relaxants, tranquilizers or a gaba receptor agonist such as baclofen. Treatment may also include physical therapy regimens to prevent shrinkage or shortening of muscles. In the study, a...

Arena Pharmaceuticals Announces Positive Phase 2 Clinical Trial Results of APD125 for the Treatment of Insomnia

...gering a general CNS-suppressive effect. These drugs are DEA-scheduled, controlled substances due to their potential for abuse. Common side effects of gaba activating drugs include the risk of developing tolerance to the drug, impaired functioning when the drug is at therapeutic levels, and the potential ...

Diamyd Updates Gene Therapy Program and Outlines Plans for Phase I Clinical Trial for Treatment of Cancer Pain

...the brain to complete the pain pathway. Three main compounds, enkephalins, gaba and endomorphins, naturally regulate pain transmission at the first order s... syndrome, there are differences in their effectiveness. For example, while gaba that is produced with the help of the GAD enzyme dampens spinal cord injury...

BioLineRx Presents Phase I Clinical Data of BL-1020 at Upcoming Clinical Conferences

...ts. We very much look forward to the initiation of the Phase II trial in the second quarter of 2007." About BL-1020 BL-1020 is an orally available gaba enhanced antipsychotic clinical candidate for the treatment of schizophrenia. Data from preclinical and phase I studies demonstrated that the compound...

BioLineRx Presents Data From Successful Phase I Trial for BL-1020 in Schizophrenia at American Psychiatric Association Conference

.... About BL-1020 BL-1020 is an orally available gaba enhanced antipsychotic clinical candidate for the ...multaneously target the dopamine hyperactivity and gaba hypoactivity of schizophrenia. Exogenously administered gaba is ineffective as a therapeutic agent due to its i...

Indevus Announces Presentation of Pagoclone Data at 47th Annual New Clinical Drug Evaluation Unit Meeting

...dation and withdrawal. The precise mechanism of action is unknown, however, gaba is believed to be an important neurotransmitter in the brain that may be disrupted in people who stutter. Pagoclone enhances the activity in gaba circuits in the brain and thus may help restore more normal function in spe...

Neurologix Announces Publication of Landmark Gene Therapy Study Demonstrating Safety and Statistically Significant Improvement in Patients With Advanced Parkinson's Disease

... increased, largely due to a deficit in GABA (gamma-aminobutyric acid), the major inhibitory neurotransmitter in the brain. Increasing GAD causes more gaba to be synthesized, thus helping to calm the STN over-activity. The value of this strategy has been demonstrated in previous human studies where reduci...

Neurogen Announces Positive Results for Proprietary Insomnia Drug in Two Chronic Insomnia Clinical Trials

...ed for treatment of both onset and maintenance symptoms of insomnia work by modulating the gamma-aminobutyric acid (GABA) system of neurotransmitters. gaba is a chemical naturally released in certain parts of the brain in order to inhibit brain activity. Preclinical studies suggest that NG2-73 is pharmaco...
GABA in Medical Definition

Depolarization-induced suppression of inhibition

... 10 seconds. After the depolarization, inhibitory gaba mediated neurotransmission is reduced. This has b...esponses of large pyramidal projection neurons to gaba , the main inhibitory neurotransmitter in the central nervous system. gaba is typically released by small interneurons in ...
GABA in Biological News

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

...ectives for treatment News on the NewMood project The educational update sessions at the ECNP Congress will deal with the current knowledge on gaba and biomarkers in neuropsychopharmacology, treatment of insomnia, bipolar disorders and schizophrenia, as well as the new classification systems ICD-1...

22nd Congress of the European College of Neuropsychopharmacology

...s for treatment News on the NewMood project Furthermore, the educational update sessions at the congress will deal with the current knowledge on gaba and biomarkers in neuropsychopharmacology, treatment of insomnia, bipolar disorders and schizophrenia, and the new classification systems ICD-11 and D...

Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic

...mbrane region of the superfamily of ligand-gated channels that includes the gaba receptor. Anesthetics are known to positively modulate gaba signaling. Because 1-AMA competes with other anesthetics to bind to apo...

Circadian clock may be critical for remembering what you learn, Stanford researchers say

...our animals were having chronically high levels of gaba because they had lost their circadian rhythm," Rub... "So instead of rhythmic GABA, it is just constant gaba output." To test that idea, Ruby and his colleagues gave the circadian-deficient hamsters a gaba antagonist called pentylenetetrazole, or PTZ, whic...

New studies on schizophrenia, depression, trauma and autism highlight annual meeting

...00 a.m. EST December 8) Nicotine Addiction Might be Controlled by Influencing Pleasurable Response Mechanisms in Brain There is a clear link between gaba a chemical substance of the central nervous system that inhibits neurons in the brain and nicotine dependence. Researchers discovered that nicotine...

How schizophrenia develops: Major clues discovered

...ed GABA. The more the gene is turned on, the more gaba synthesis can occur, under normal circumstances. gaba helps regulate the flow of electrical traffic that...rain. Abnormalities in brain development and in gaba synthesis are known to play a role in schizophreni...

Gene therapy study shows safety and statistically significant improvement in Parkinson's disease

... disease, STN activity is abnormally increased, largely due to a deficit in gaba (gamma-aminobutyric acid), the major inhibitory neurotransmitter in the brain. Increasing GAD causes more gaba to be synthesized, thus helping to calm the STN over-activity. The value of...

Gene therapy inhibits epilepsy in animals

...cur, at least in part, because of an imbalance between two types of neurotransmitters: the glutamate system, which stimulates neurons to fire, and the gaba system, which inhibits that brain activity. GABA's inhibitory role is considered particularly important in the dentate gyrus because the dentate g...

Protein shown to rally biological clock

...ies the roles that both VIP and a neurotransmitter gaba play in synchronizing biological clocks, and sheds...o keep 24-hour time. It had been thought that gaba was the prime candidate for the rallying role. All...urotransmitter, and it had been shown that giving gaba daily at 8 a.m. to SCN cells synchronizes them. ...

Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice

.... Neurotransmitters in the hypothalamus, including gaba (gamma aminobutyric acid), are known to be an impo... reducing Hap1 decreased the level and activity of gaba receptors in the hypothalamus. "We concluded t...eases Hap1 levels, and reducing Hap1 decreases the gaba receptor activity, we believe Hap1 is the link bet...
GABA in Biological Technology

US Neuropathic Pain Market Value Doubles to $5 Billion by 2018

...nd a dual cannabinoid receptor agonist (GW/Bayer), and fentanyl buccal (Cephalon). Eighteen drugs are in Phase III development in the US including two gaba receptor agonists pregabalin (Pfizer) and gabapentin GR (Depomed); a sodium channel antagonist mexiletine (Boehringer Ingelheim); three glutamate / NM...

Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A

...butyric acid or GABA). The synthesis of gaba is catalyzed by the enzyme glutamic acid decarboxy...esponsible for the maintenance of basal gaba levels in cells, whereas GAD65 can be rapidly activated in times of high gaba demand. The goal of our study was to com...
GABA in Biological Products

Rabbit Anti-GABA A Receptor gamma 2 Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to gaba A Receptor gamma 2 ( Abpromise for all tested applications). entrezGeneID: 2566 SwissProtID: P18507...
Company:Abcam

QPatch 16 from Sophion Bioscience

Description:...tomated gigaseal patch clamping. The system is used for screening against voltage-gated ion channels, such as hERG and ligand-gated channels, such as gaba channels. The four pipette heads afford more efficient assays and faster throughput for ion channel drug discovery. The glass-coated tunnels of the ...
Company:Sophion Bioscience
GABA in Biological Definition

Amino acid

...ne . In addition to amino acids for protein synthesis, there are other biologically important amino acids, such as the neurotransmitters glycine , gaba and glutamate , as well as carnitine (used in lipid transport within a cell ), ornithine , citrulline , homocysteine , hydroxyproline , hy...

Enzyme

...hydrofolic acid DNA gyrase : catalyzes the negative supercoiling of prokaryotic DNA Glutamate decarboxylase : synthesizes the neurotransmitter gaba in the brain Glutathione peroxidase : protects cells by converting hydrogen peroxide to water Isomerase : all those enzymes which convert a m...

Neurotransmitter

...ffect is determined by its receptor. For example, gaba can act as a rapid or slow inhibitor , depending...is the most prominent of excitatory transmitters; gaba and glycine are well-known inhibitory neurotran...from amino acids : aspartate glutamate gaba glycine Monoamines (in the order of...

Synapse

... an impulse in that cell even though the synapses are weak. On the other hand, a pre-synaptic neuron releasing an inhibitory neurotransmitter such as gaba can cause inhibitory postsynaptic potential in the post-synaptic neuron, decreasing its excitability and therefore decreasing the neuron's likeliho...
GABA in Biological Dictionary

Concatemer

...earch ... Retrieved from "http://en.wikipedia.org /wiki/Talk: Concatemer " ... In cells expressing the concatemer , amphetamine analogs promoted gaba efflux and ... The concatemer was tagged on its amino terminus with CFP, which afforded the ... Next message: Concatemer Chain Reaction (CCR ...
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