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Fragment in Medical News

Structures from the human immune system's oldest branch shed light on a range of diseases

... Netherlands, have determined the structure of C3 convertase and of the C3b fragment in complex with factor H. The work appears this month in two companion pape...ber of immune-related diseases. "It was a surprise to see that the factor H fragment is spread across the entire C3b complex," notes Lambris. Factor H bindin...

RNA snippet suppresses spread of aggressive breast cancer

... CAMBRIDGE, Mass. (June 11, 2009) A low cellular level of a tiny fragment of RNA appears to increase the spread of breast cancer in mouse models of the disease, according to researchers at Whitehead Institute for Biomedical ...

Why do people with Down syndrome have less cancer?

... of the DSCR1 protein blocks calcineurin and is testing to see whether that fragment can be delivered specifically to endothelial cells, to prevent them from fo...c compound made by the body. Discovered in the Folkman lab, endostatin is a fragment of collagen 18 -- whose gene is also on chromosome 21. People with Down syn...

PercSys Introduces Accordion CoAx(TM) Stone Control Device for Facilitating Percutaneous Kidney Stone Treatments

...ble tool during PCNL procedures, as it both facilitates retrograde contrast injections for diagnosis and renal targeting as well as prevents antegrade fragment migration into the ureter," said Demetrius H. Bagley MD, Nathan Lewis Hatfield Professor of Urology, Thomas Jefferson University Hospital, Philadelp...

New P.E. Drug Approved In Europe While Premature Ejaculation Cure Remains Out of Reach to American Men

...ulation cure remains inaccessible in the U.S., it's the inherent risks tied to this solution for how to last longer in bed," adds Baclini. Only a fragment of men who experience lack of climax control seek help for this distressing problem that can disrupt personal relationships and intimacy. Respond...

Discovery may result in new test to determine predisposition to cancer

...adiated cells and then transformed them with a DNA fragment that detects the efficiency and the accuracy of do...epair. The key in this experiment was that the DNA fragment was not irradiated. In this way, the researchers c...mechanism of double strand break repair in the DNA fragment that did not receive any radiation. The effect was...
Fragment in Medical Technology

ESBATech's Antibody Fragment Enters Phase Ib/IIa in Ophthalmology

Topical Delivery of ESBA105, an Anti-TNF Alpha Antibody Fragment in Patients Undergoing Cataract Surgery ZURICH, Switzerland, Feb. 3 /PRNewswire/ -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced the initiation of a Phase Ib/IIa study in patients undergoin...

ESBATech's Antibody Fragment Enters Phase I/IIa Clinical Development in Osteoarthritis with the Potential for Disease-Modifying Activity

ZURICH, Switzerland, Jan. 9/PRNewswire/ -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced the initiation of the Phase I/IIa clinical development of its anti-TNF alpha antibody fragment ESBA105 in osteoarthritis (OA). This double-blind, randomized, placebo-contr...

ESBATech's Lead Antibody Fragment Enters Clinical Development for Ophthalmic Indications

ESBA105 Penetrates all Segments of the Eye via Topical Eye Drops ZURICH, Switzerland, April 24 /PRNewswire/ -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced the initiation of Phase I clinical development of the company's lead product development candid...

Lilly Announces Positive Phase II Data on Investigational Medicine for Patients with Type 2 Diabetes

...65, a once-weekly injection, is a novel-engineered fusion protein, consisting of a dipeptidyl peptidase-IV (DDP-IV) protected GLP-1 analog linked to a fragment of immunoglobulin G4 that is believed to increase the duration of its pharmacological effect. Based on this study presented at this year's ADA meetin...

ExonHit Therapeutics Reports Advancements in the Clinical Development of EHT 0202, its Phase II Drug for Alzheimer's Disease

...mer's disease therapeutics: it stimulates the alpha-secretase pathway, thus enhancing the production of the procognitive and neuroprotective sAPPalpha fragment of APP (Amyloid Precursor Protein). The stimulation of the alpha-secretase pathway being to the detriment of Abeta amyloid peptide production, EHT 020...

Rosetta Genomics Reports First Ever In-Vivo Efficacy Data for a Systemic MicroRNA Therapeutic for Liver Cancer

...nd promotes cell-death of these liver tumor cells. The scientists then used an in-vivo model called Orthotopic Xenograft, in which an artificial tumor fragment derived from a human liver cancer cell line is transplanted into livers of mice, in order to evaluate the efficacy of systemic microRNA-based treatmen...
Fragment in Medical Products

T-Cell Clonality Assessment by Restriction Fragment Southern Blot Hybridization, Tissue

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

T-Cell Clonality Assessment by Restriction Fragment Southern Blot Hybridization, Fluid

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

B-Cell Clonality Assessment by Restriction Fragment Southern Blot Hybridization, Fluid

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

B-Cell Clonality Assessment by Restriction Fragment Southern Blot Hybridization, Tissue

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Small Fragment Plate and Screw System

Description: The Small Fragment Plate and Screw System provides a unique option for the correction of a wide range on angular deformities; particularly the opening wedge osteotomy of the first metatarsal (bunion or hallux valgus correction). The Small Fragment Plate and Screw Set is a complete tray of instrumen...
Company:Arthrex

Basic Fragment Set

Description: Comprehensive range of integrated implants and instruments including - Basic, Small, Mini, Pelvic and Foot Sets....
Company:Biomet Orthopedics, Inc

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Fragment in Biological News

NEWSLETTER: Antibody Fragment Production Breakthrough with 2nd Generation EBA

Hamburg, Germany and Copenhagen, Denmark, May 12th, 2009 / b3c newswire / – Richter-Helm BioLogics GmbH & Co. KG announces today a technological breakthrough in the field of purification of antibody fragments from an E. coli expression system. Richter-Helm BioLogics has finalized ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...nd could theoretically bind. We found just the right one." They collaborated with ESBAtech in Switzerland who created a small single-chain antibody fragment in yeast that would itself bind to the sweet spot, blocking ALK's interaction with PTN. In the present study, the researchers successfully tested the ...

Sex in the Caribbean: Environmental change drives evolutionary change -- eventually

... forms are unmistakable," explained O'Dea. "You can clearly see the first individual that founded a sexual colony, while a clonal colony preserves the fragment from the previous colony from which it cloned." As predicted, clonal bryozoans rapidly disappeared from the record as the Caribbean was isolated. Sp...

The tiny difference in the genes of bacteria

...eristic for every bacterial strain. To identify a certain strain, the HZI researchers use short DNA fragments, marked with certain dyes. Each dyed DNA fragment recognizes a single tandem repeat, binding at it. As a result, the researchers receive, for example, six red fragments binding a tandem of six repetit...

Nursery programs for corals receive TLC from NOAA this Independence Day

...ments, and nursery fragments have already been used to restore four reefs where staghorn corals were depleted. The proposed plan includes expansion of fragment stocks (up to 4,000 fragments at this site) and the restoration of eight additional reefs over the next three years. Florida boasts one of the plan...

The tiny difference in the genes of bacteria

...eristic for every bacterial strain. To identify a certain strain, the HZI researchers use short DNA fragments, marked with certain dyes. Each dyed DNA fragment recognizes a single tandem repeat, binding at it. As a result, the researchers receive, for example, six red fragments binding a tandem of six repetit...
Fragment in Biological Technology

ForteBio Launches New Assay Capabilities for High-Sensitivity Protein Quantitation and Fragment Screening on Its Octet(R) Platform

MENLO PARK, Calif., May 27 /PRNewswire/ -- ForteBio(R), Inc., a leading supplier of label-free technology that accelerates the development of biotherapeutic and pharmaceutical products, today announced that it has launched two new assay modules - for high-sensitivity protein quantitation and fragm...

ESBATech Announces Successful Completion of Phase I Clinical Study for Lead Antibody Fragment in Ophthalmic Indications

Preclinical Pharmacokinetic Data to be Presented at the 7th International Symposium on Uveitis in Germany ZURICH, Switzerland, Sept. 8 /PRNewswire/ -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced that the company has successfully complet...

DNA Sequencing Equipment Market to Fragment and Grow as Competition, New Technologies Develop

NEW YORK, Aug. 24 /PRNewswire/ -- The DNA sequencing equipment market is expected to grow nearly 8% between 2006 and 2012, spiraling upward from $335 million to $528 million as competition intensifies and diversifies, according to DNA Sequencing Equipment and Service Markets, a new report by K...

Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems

Introduction Amplified fragment length polymorphism (AFLP) analysis is a genetic mapping technique that uses selective amplification of a subset of restriction enzyme-digested DNA fragments to generate a unique fingerprint for a particular genome. First developed ...

Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors

Key words: cAMP • GPCR • enzyme fragment complementation • LEADseeker • assay miniaturization G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors and are responsible for the transduction of ...

Detection and Identification of Phosphorylation Sites in Proteins Using LC/MS/MS with Neutral Fragment Loss Mapping

Michaela Scigelova, Gary Woffendin; Thermo Finnigan, Hemel Hempstead, UK. Malcolm Ward, Helen Byers; Proteome Sciences, London, UK. Diane Hanger; Institute of Psychiatry KCL, London, UK. ...

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Fragment in Biological Products

Sheep Anti-Human hCG beta core fragment Polyclonal Antibody, Unconjugated from Abcam

Description: Sheep polyclonal to hCG beta core fragment ( Abpromise for all tested applications). Antigen: Full length native protein (purified) from human urine. Entrez GeneID: 1082 Swiss Protein ID: P01233...
Company:Abcam

Duck Anti-Cobra venom - Fab Fragment Polyclonal Antibody, Unconjugated from Abcam

Description: Duck polyclonal to Cobra venom - Fab Fragment ( Abpromise for all tested applications). Antigen: Snake Venom of N. naja arta...
Company:Abcam

DNA Fragment 2X Precipitation Solution from EPICENTRE Biotechnologies

Description: Enables rapid purification of double-stranded DNA fragments = 200 bp, including, for example, PCR reaction products, DNA fragments obtained in restriction enzyme digests, or double-stranded cDNA...
Company:EPICENTRE Biotechnologies

Anti-Human IgG, Fd Fragment Monoclonal Antibody, Unconjugated from CHEMICON

Description: Human IgG Fd. ELISA Specificity: (4) human IgG subclass 1 100% human IgG subclass 2 100% human IgG subclass 3 100% human IgG subclass 4 99% human IgG Pan 100% human IgG Fc 0.04% human IgG Fab ...
Company:CHEMICON

Rabbit Anti-Chicken IgY, IgG F(ab')2 fragment Antibody, Biotin Conjugated from Biomeda Corporation

Description: Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Company:Biomeda Corporation

Rabbit Anti-Chicken IgY, IgG F(ab')2 fragment Antibody, Rhodamine Conjugated from Biomeda Corporation

Description: Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Company:Biomeda Corporation

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Fragment in Biological Definition

Okazaki fragment

An Okazaki fragment is a relatively short fragment of DNA that is created by primase and Pol III along the lagging strand (see DNA replication ). They are later removed by RNAse H , and the last ribonucleotide is removed by and synthesized by Pol I . The nick, or a broken phosphodi...

Antibody

...therwise known as the complementarity determining region 3 (CDR3). The Fc fragment is the stem of the "Y" and is composed from two heavy chains that each cont...eavy and light chains can be fused together to form a single chain variable fragment (scFv), which retains the original specificity of the parent immunoglobuli...

Sticky end/blunt end

...he complementary region, then the DNA is said to possess an overhang : 5'- ApTpCpTpGpApCpT -3' 3'- TpApGpApCpTpGpApCpTpApCpG -5' If another DNA fragment exists with a complementary overhang, then these two overhangs will tend to associate with each other and each strand is said to possess a sticky end...

Common descent

...rdial form, into which life was first breathed." "The whole history of the world, as at present known, ... will hereafter be recognised as a mere fragment of time, compared with the ages which have elapsed since the first creature, the progenitor of innumerable extinct and living descendants, was created...

Expressed sequence tag

...ery and sequence determination. An EST is produced by one-shot sequencing of a cloned mRNA , and the resulting sequence is a relatively low quality fragment whose length is limited by current technology to approximately 500 to 800 nucleotides . ESTs are also a useful resource for designing probes for DNA...

Genetic fingerprinting

... method is a buccal swab . Next, restriction fragment length polymorphism (RFLP) analysis is performed ...erprinting has been introduced: AFLP, or amplified fragment length polymorphism. This new technique is simila...s year sentences. See also restriction fragment length polymorphism (RFLP) paternity test ...
Fragment in Biological Dictionary

Restriction fragment

A restriction fragment is a DNA fragment resulting from the cutting of a DNA strand by a restriction enzyme, a process called restriction . Each restriction enzyme is highly specific, recognising a particular short DNA sequence, or restriction site, and cutting both DNA... In 1985, ...

Klenow Fragment

The Klenow fragment is a large protein fragment produced when DNA polymerase I from E. coli is enzymatically cleaved by the protease subtilisin. First reported in 1970, it retains the 5’ → 3’ polymerase activity and the 3’ →... The large or Klenow fragment of DNA polymerase I has...

Sub-cloning

...g . ... PLoS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC ... Sub - cloning vector-derived fragments requires the donor fragment to be excised ... China to Try Cloning of Rare Monkeys - Using advanced technology to research ... Online - An online program finding sub - clon...

Subcloning

...imized human gene sequences (E.coli) ... Convenient subcloning of sequences from QIAgenes Expression Constructs ... The subcloning of a DNA fragment from an entry vector into a destination vector ... Schematic overview of the subcloning procedure. ... Subcloning PCR Products the TOPO Way...

Southern blotting

...dure is known as a " Southern blot " after the ... The Southern blot from step 4 is incubated in a solution containing a ... If more than one fragment detected in the Southern blot , it likely indicates ... 5) Southern blotting of PCR products can validate that a given DNA sequence was PCR ....

Southern blot

...ic DNA for Southern blot electrophoresis ... (6) determine the gene fragment sizes in samples on the Southern blot . ... Molecular biology proto...... Southern blotting ... Southern Blotting ... If more than one fragment detected in the Southern blot , it likely indicates ... Can check the re...
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