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Forebrain in Medical News

New Insight Into Most Common Forebrain Malformation

St. Jude researchers identify a molecular mechanism underlying a genetic brain malformation called holoprosencephaly MEMPHIS, Tenn., Aug. 11 /PRNewswire-USNewswire/ -- St. Jude Children's Research Hospital scientists have identified one of the molecular mechanisms underlying the genetic brai...

New insight into most common forebrain malformation

St. Jude Children's Research Hospital scientists have identified one of the molecular mechanisms underlying the genetic brain malformation called holoprosencephaly (HPE). The findings not only yield insights into the most common developmental malformation of the anterior brain and face in newborns...

UCI researchers find new way to fight cocaine addiction

...udy is the first to detail the interaction of MCH and dopamine in cocaine addiction and show that it occurs in the nucleus accumbens, a portion of the forebrain believed to play an important role in addiction and feelings of pleasure and fear. Study results appear in this week's early online edition of the Pr...

USC researchers identify key mechanism that regulates the development of stem cells into neurons

...utgrowth in organisms. Researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC analyzed sections of the forebrain in animal model embryos to investigate Ryk's function in vivo. They found that during neurogenesis, when neural stem cells start to grow into neu...

Penn researchers find key to Sonic hedgehog control of brain development

... brain. It controls cell division of adult stem cells and has been implicated in some cancers. "Elucidating the regulators of Shh expression in the forebrain will not only improve our fundamental understanding of brain development, but may also lead to novel insights into the pathogenesis of holoprosencepha...

EURYI project to understand how the brain wires during embryogenesis

... to young scientists, to pursue her ground breaking research into mammalian forebrain development. She will tackle a number of fundamental questions relating bot...ration. Understanding how neural circuits are elaborated during mammalian forebrain development is essential to gain insights into its normal functioning and t...

Erectile Dysfunction in Diabetes Due to Defect in the NO Mechanisms

...ipheral nervous systems. The site is involved in numerous functions, including erectile function and sexual behavior, and is a primary site within the forebrain that has been implicated in penile erection. The investigators also examined central nitric oxide (NO within the PVN) which plays an important role in...

Mouse Study Suggests Anxiety Disorders Take Root in Infancy

... taking longer to start eating in new environments as compared with normal animals. To determine which of the two receptor populations--the one in the forebrain or the one in the brainstem--is most critical in that regard, the team then crossed the knockout mice with a line engineered to activate receptor expr...

Cellular Cues Identified for Stroke Recovery

... repair and the recovery of function after a stroke. Recent research has revealed that in the adult brain, new neurons form in a region of the forebrain known as the subventricular zone (SVZ). In mice, after a stroke was initiated in a part of the brain located far from the SVZ, the researchers, using ...

Key Gene Controlling Eye Lens Development Identified

... Holoprosencephaly is the most common abnormality of the development of the forebrain (front part of the brain) in humans. A few years ago the St. Jude team demonstrated that Six3 activity is critical for the normal development of the forebrain in mice. St. Jude researchers have now extended these results by show...
Forebrain in Biological News

Researchers see evidence of memory in the songbird brain

...ad snapshot of gene activity in the brain. Using DNA microarray analysis, the researchers measured changes in levels of messenger RNAs in the auditory forebrain of finches exposed to a new song. These mRNAs are templates that allow the cell to translate individual genes into the proteins that do the work of th...

Ex vivo neural stem cell expansion

...coming paper demonstrates that the polycomb group protein, Bmi-1, maintains forebrain neural stem cell self-renewal. Overexpression of Bmi-1 in adult and embryonic forebrain neural progenitor cells increases stem cell self-renewal both in vitro and ...

Social interactions can alter gene expression in the brain, and vice versa

...al insight came in 1992, in a study of songbirds led by David Clayton. He and his colleagues found that expression of a specific gene increases in the forebrain of a zebra finch or canary just after it hears a new song from a male of the same species. This gene, egr1 , codes for a protein that itself regulate...

4 days of REM sleep deprivation contributes to a reduction of cell proliferation in rats

... WESTCHESTER, Ill. Four days exposure to a REM sleep deprivation procedure reduces cell proliferation in the part of the forebrain that contributes to long-term memory of rats, according to a study published in the February 1 issue of the journal SLEEP. The study, authored by D...

Do migratory birds 'see' the magnetic field?

...parts of a migratory birds brain are active when the birds use their magnetic compass showed that the cryptochrome-containing neurons in the eye and a forebrain region (Cluster N; Mouritsen et al., PNAS, 2005; Liedvogel et al., EJN, 2007) are highly active during processing of magnetic compass information in m...

Erectile dysfunction in diabetes is due to selective defect in the brain

...ipheral nervous systems. The site is involved in numerous functions, including erectile function and sexual behavior, and is a primary site within the forebrain that has been implicated in penile erection. The investigators also examined central nitric oxide (NO within the PVN) which plays an important role in...

Need to pull an all-nighter?

...s that nitric oxide production in a specific region of the brain ?the basal forebrain ?is both necessary and sufficient to produce sleep. The findings appear in ...oxide ?mops it up and renders it inactive. In contrast, when the basal forebrain was infused with a nitric oxide "donor" ?an agent that boosts nitric oxide ...

Key gene controlling eye lens development identified

... Holoprosencephaly is the most common abnormality of the development of the forebrain (front part of the brain) in humans. A few years ago the St. Jude team demonstrated that Six3 activity is critical for the normal development of the forebrain in mice. St. Jude researchers have now extended these results by show...

Study charts origins of fear

...tual functions, play a critical role in the development of fear. Previous research had pointed to activation in the hippocampus, an area buried in the forebrain that regulates emotion and memory, as the origin of fear memory. "This is critical as it changes how and where scientists thought fear was develop...

Brain-injury rehabilitation depends on acetylcholine circuitry

...er studies showing that the cholinergic system in a region called the basal forebrain was associated with normal learning of motor control. To determine wheth... makes a significant contribution toward this goal by identifying the basal forebrain cholinergic system as an essential substrate in mediating cortical plastici...
Forebrain in Biological Technology

Prepare siRNA and miRNA Probes in Just 1 Hour

... Figure 1. miR-16 and miR-22 Expression in Mouse Brain. In situ hybridization was performed on coronal mouse forebrain sections. In situ hybridized cells in the mouse brain cortex (A,B,D,E; 20X magnification) and the head of the caudate nucleus (C...
Forebrain in Biological Products

Mouse Dopaminergic Neuron Differentiation Kit, 2nd Generation from R&D Systems

Description:... mainly located in the substantia nigra, the ventral tegmental area, and the retrorubral field. These dopaminergic (DA) neurons give rise to extensive forebrain dopamine innervation ( e.g.projections to the caudate nucleus, putamen nucleus accumbens, olfactory tubercle, and several cortical regions and limbic ...
Company:R&D Systems
Forebrain in Biological Definition

Brain

... vertebrates, a gross division into three major parts is used: hindbrain ( medulla oblongata and metencephalon ), midbrain ( mesencephalon ) and forebrain ( diencephalon and telencephalon ). Varied taxonomies have been used by assorted schools at various times in history for the study of diverse speci...
Forebrain in Biological Dictionary

Forebrain

In the anatomy of the brain of vertebrates, the prosencephalon (or forebrain ) is the rostral-most (forward-most) portion of the brain. The prosencephalon, the mesencephalon (midbrain), and rhombencephalon (hindbrain) are the three primary portions of the brain during... The basal forebrain ...

Thalamus

...s location and its neurological... thalamus n. , pl. -mi ( ). Anatomy. A large ovoid mass of gray matter situated in the posterior part of the forebrain that relays sensory impulses Thalamus Brain: Thalamus MRI cross-section of human brain, with thalamus marked. ... The thalamus surrounds...

Olfactory bulb

... The olfactory bulb is a structure of the vertebrate forebrain involved in olfaction, the perception of odors. Olfaction refers to the sense of smell. This sense is mediated by specialized sensory cells ...

Neural plate

... needles and ... It inhibits ectoderm from differentiating to neural plate tissue. ... Under these conditions, the neural plate develops forebrain characteristics. ... It originates from cells located along the lateral margins of the neural plate . Neural crest cells break away fro...

Hindbrain

... The rhombencephalon (or hindbrain ) is a developmental categorization of portions of the central nervous system in vertebrates. Introduction forebrain Midbrain Hindbrain Spinal Cord Cerebral Vasculature ... Disorders that affect the hindbrain . Region. Disorder. Cerebellum. Medulla ... hindbra...
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