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Fibroblast in Medical News

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

...esis inhibitor that simultaneously inhibits vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR) and fibroblast growth factor receptors (FGFR). The data presented at the conference come from a Phase II study investigating the efficacy and safety of the compound...

Researchers Discover the Tale Behind Short Dogs

...ut 20 short-legged dog breeds, including dachshunds, corgis and basset hounds, have two copies of a gene that play a role in production of the protein fibroblast growth factor 4 (FGF4). The copies are not identical, though, as one lacks some essential parts of the DNA code, according to the study published July...

New Longevinex Advantage(R) Designed for Americans Who Want to Live Longer and Look Younger

...g, thick hair and extra-flexible joints - the visible signs of youthfulness. A unique source of pure oral hyaluronan is provided which stimulates fibroblast cells in the body to produce more hyaluronan, along with molecules like resveratrol, quercetin, anthocyanins, catechin and ferulic acid (all known as ...

Important Data Presented on Independent Predictors of Mortality in Patients With Idiopathic Pulmonary Fibrosis

...bout Pirfenidone Prior in-vitro evidence has shown that pirfenidone inhibits collagen synthesis, down-regulates profibrotic cytokines and decreases fibroblast proliferation. Data presented from one Phase 3 study and four Phase 2 clinical trials in more than 400 patients suggest that pirfenidone may positive...

UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells

...sed a combination of microRNAs and retrovirus-introduced genes to transform fibroblast cells -- found throughout the body of mice and humans -- into pluripotent c...h a lipid, allowing them to pass through the cell membrane. By labeling the fibroblast cells, they showed that the treated cells could be incorporated into a mous...

UCSF team closer to creating safe embryonic-like stem cells

...sed a combination of microRNAs and retrovirus-introduced genes to transform fibroblast cells -- found throughout the body of mice and humans -- into pluripotent c...h a lipid, allowing them to pass through the cell membrane. By labeling the fibroblast cells, they showed that the treated cells could be incorporated into a mous...

URI scientists reveal mechanism that regulates cancer-causing gene

...ense and respond to oxidation. This sensing system was found to uniquely apply to two families of proteins implicated in numerous cancers: the Src and fibroblast Growth Factor Receptor families of tyrosine kinases. Their results were published online March 9 in the Proceedings of the National Academy of S...

Master molecular switch may prevent the spread of cancer cells to distant sites in the body

...that there can be more than one messenger RNA (mRNA) produced from the same gene. These mRNAs then go on to make different proteins. The mRNA for fibroblast Growth Factor Receptor 2 (FGFR2) is the focus of the Molecular Cell study. FGFR2 mRNA has two forms, one called IIIb, which is expressed in epithelial...

Discovery provides hope for sufferers of disfiguring bone disease

... the UEA scientists focused on Apert Syndrome - the most severe of the craniosynostosis range of diseases that is caused by mutations in a gene called fibroblast Growth Factor Receptor 2 (FGFR2). They identified a key offending molecule FGF10 and demonstrated for the first time that 'dampening down' the levels...

New test may help to ensure that dengue vaccines do no harm

...believe the new test will capture enhancement that the older test misses. To construct the new test of cross-neutralization, researchers took CV-1 fibroblast cells, which share some traits with macrophages, and genetically engineered them to include a gene that directs for the building of an FC receptor on ...
Fibroblast in Medical Technology

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

...iabetic animals, Isis also presented data from its obesity drug discovery program. In an oral presentation, Isis reported that antisense reduction of fibroblast growth factor receptor 4 (FGFR4) lowered adiposity and improved insulin sensitivity in mice, indicating that FGFR4 plays a role in the regulation of e...

Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS)

...nidone Preclinical and in-vitro evidence had shown that pirfenidone inhibits collagen synthesis, down-regulates profibrotic cytokines and decreases fibroblast proliferation. Prior to the current results, data were presented from one Phase 3 study and four Phase 2 clinical trials in more than 400 patients wh...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

...d that works by simultaneously inhibiting vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) -- all factors which are involved in the formation of blood vessels, a process known as angiogenesis.(12,13). "Th...

CVBT Doses First Patient in its Phase II Clinical Trial for Severe Coronary Heart Disease

... participating sites can be found by visiting http://www.cvbt.com . About CVBT-141H CVBT-141H contains and active ingredient -- human fibroblast Growth Factor-1 (FGF-1). FGF-1 is a natural human protein that stimulates angiogenesis in the affected tissue or organ. Angiogenesis refers to the gro...

CVBT Appoints Dr. Nabil Dib as Principal Investigator for Phase II Heart Trial

...em and the MyoStar(TM) injection catheter. These two devices will be used in CVBT's Phase II heart trial, in which the potent angiogenic protein human fibroblast Growth Factor -1 (FGF-1) will be injected into patients' hearts. Dr. Dib serves as the principal trainer for all interventional cardiologists who wish...

Neurobiological Technologies, Inc. and Buck Institute Partner to Develop Novel Treatment for Alzheimer's Disease

...biological Technologies has been collaborating with Buck since December 2007 to develop a new drug for the treatment of Huntington's disease involving fibroblast growth factor-2 (FGF-2), a naturally occurring protein that has been studied extensively for its neuroprotective properties. This agreement is the sec...

Vical Licensee Sanofi-aventis Initiates Phase 3 Trial to Reduce Amputations

...essful completion of the trial, called TAMARIS, sanofi-aventis expects to file for marketing approval in 2010. The plasmid DNA (pDNA) therapy encodes fibroblast Growth Factor 1 (FGF-1), a growth factor that stimulates the growth of blood vessels, and is intended to reduce the need for amputations in patients s...

ImClone Systems Showcases Extensive Research and Development Program at the AACR Annual Meeting

...ctor receptor-1 (VEGFR-1), VEGFR-2, VEGFR-3, platelet-derived growth factor receptor alpha (PDGFR(alpha)), FMS-like tyrosine kinase 3 receptor (FLT3), fibroblast growth factor receptor 3 (FGFR3), among others. "Our pipeline consists of a robust collection of IgG1 monoclonal antibodies targeted against cell...

Phase I Results for ImClone Pipeline Anti-IGF-1R Monoclonal Antibody IMC-A12 Presented at ASCO

...ctor receptor-1 (VEGFR-1), VEGFR-2, VEGFR-3, platelet-derived growth factor receptor alpha (PDGFR(alpha)), FMS-like tyrosine kinase 3 receptor (FLT3), fibroblast growth factor receptor 3 (FGFR3), among others. "Our pipeline consists of a robust collection of IgG1 monoclonal antibodies targeted against cell...
Fibroblast in Medical Products

Bard® Dermal Allograft

Features:... Bard® Dermal Allograft is processed using a patent-pending method that helps promote fibroblast infiltration and generation of host collagen within the implant No bacterial growth Collagen fibrils are intact to ensure durability and longevit...
Company:C. R. Bard, Inc.

Bard Dermal Allograft

Features:...on of fibrils (determined by biomechanical and enzymatic testing). Bard Dermal Allograft is processed using a patent-pending method that helps promote fibroblast infiltration and generation of host collagen within the implant. Quality screening test confirms that collagen fibrils are intact to ensure durability...
Company:C. R. Bard, Inc.
Fibroblast in Medical Dictionary

Apert syndrome

...inherited) ... Apert syndrome is caused by mutations in a gene called fibroblast growth factor ... Apert syndrome is transmitted as an autosomal do...inherited) ... Apert syndrome is caused by mutations in a gene called fibroblast growth factor ... The incidence of Apert syndrome is approximatel...
Fibroblast in Biological News

Reprogramming human cells without inserting genes

... OCT4, SOX2 and NANOG already in the skin cells by lowering the amount of atmospheric oxygen the cells were exposed to, and by adding a protein called fibroblast growth factor 2 (FGF2) to the culture medium. (FGF2 is a naturally occurring protein that is known to be vital for maintaining the pluripotency of emb...

Pitt team finds molecule that regulates heart size by using zebrafish screening model

...the gene for green fluorescent protein linked to a key signaling pathway of fibroblast growth factors (FGFs), a family of proteins that are essential in embryonic...or cells and, ultimately, larger hearts, Dr. Tsang said. Unraveling the fibroblast growth factor pathway has broad implications for improving wound healing as...

Embryology study offers clues to birth defects

...f mice and zebrafish, the team found that retinoic acid suppresses the gene fibroblast growth factor 8 (Fgf8) during the period when forelimb budding occurs, crea...to rescue fin development by treating such embryos with a drug that reduces fibroblast growth factor activity, thus supporting the hypothesis that retinoic acid n...

Gene activity reveals dynamic stroma microenvironment in prostate cancer

...tmann. "DNA damage could be related to mutations in the stroma." The researchers also found changes in growth factor pathways, including those for fibroblast growth factor and transforming growth factor beta as well as pathways linked to the growth and maintenance of stem cells, said Ittmann. While many...

Heart attacks: The tipping point

...r developed a mathematic model that shows when the proportion of structural fibroblast cells are at dangerous levels, at approximately 70% of the heart's volume. ...Studying the electric coupling tiny electric signals between myocytes and fibroblast cells, he was able to paint a more accurate picture of a heart's health tha...

Findings show insulin -- not genes -- linked to obesity

...at variability in fat storage is due to varied rates of insulin processing among cells." The cell culture used in the research contains cloned mice fibroblast cells. "This particular type of cell culture has been used to study the molecular control of obesity for the past 35 years," Cheng said. "Researche...

UF scientist tapped by Howard Hughes Medical Institute to pursue 'best ideas'

...limb development. At University College London, he discovered that the embryonic master switch for limb formation was a multifunctional protein called fibroblast growth factor. The finding, published in the journal Cell, was later proven true for other animals, including people. After finding the trigger, Co...

Christopher McCulloch receives the IADR Research in Oral Biology Award

...is B.Sc., D.D.S. and Ph.D. degrees from the University of Toronto, and has more than 200 publications on topics including mechanisms that regulate the fibroblast cytoskeleton, collagen remodeling in the periodontium, and the responses of fibroblasts to inflammatory cytokines and mechanosensory signals. This wor...

Mammals can be stimulated to regrow damaged inner retina nerve cells

...on cells (a type of nerve cell found near the surface of the retina) and amacrine cells. Then by injecting the eye with epidermal growth factor (EGF), fibroblast growth factor 1 (FGF1) or a combination of FGF1 and insulin, they were able to stimulate the Mller glia cells to re-start their dividing engines and b...

Scripps research scientists identify compounds for stem-cell production from adult cells

...for Sox2: BIX and BayK. For the first time, the new study showed that BIX, an inhibitor of enzymes involved in regulating gene expression, enables fibroblast cell reprogramming in the absence of Sox2 gene overexpression. However, by itself, BIX's reprogramming efficiency is relatively low. "As a result,...
Fibroblast in Biological Technology

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

... Derived Growth Factor-B (PDGF-B), Insulin like Growth Factor-I (IGF-I) and fibroblast Growth Factor-4 (FGF-4). In addition, researchers at Cardium's Tiss...526); (3) Platelet-derived Growth Factor-B Gene Delivery Sustains Gingival fibroblast Signal Transduction, (Lin, et al., J Periodont Res , 2008; 43: 440-449); ...

Histogen Aesthetics Launches ReGenica Rejuvenation System

...nation System for anti-aging and post-resurfacing. Histogen Aesthetics utilizes a proprietary manufacturing process in which newborn dermal fibroblast cells are grown on beads in controlled bioreactors that maintain an embryonic-like environment, including low oxygen and low gravity conditions. Durin...

InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF

...nidone Preclinical and in-vitro evidence had shown that pirfenidone inhibits collagen synthesis, down-regulates profibrotic cytokines and decreases fibroblast proliferation. Prior to the current results, data were presented from one Phase 3 study and four Phase 2 clinical trials in more than 400 patients wh...

Method to deliver molecules within embryonic stem cells improves differentiation

...arch scientist Nathan Bowen to conduct microarray gene expression studies to determine cell phenotype. The results revealed enhanced expression of fibroblast growth factor 5 (FGF-5) a marker for primitive ectoderm in the embryoid bodies mixed with retinoic acid-loaded microspheres compared to the other tr...

Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA

...EDIHONEY, Dr. Matt Regulski said, "Because of its capability as a debrider, anti-inflammatory, free-radical absorber, odor fighter, and properties for fibroblast and macrophage enhancement, this dressing is incredibly versatile and cost-effective. It takes the place of two or three dressings which saves money, ...

Human stem cells stand on their own

... Xu and his team explored the molecular interactions within the stem cell growth medium. He discovered that, in certain conditions, a protein known as fibroblast growth factor 2 (FGF2) accomplishes the same critical role that feeder cells are thought to play: ensuring that the stem cells remain in their undiffe...

Research Tools for Analysis of ZAP-70

...e 1 shows that Jurkat (human T cell line) and EL4 (mouse T cell line) cell lysates gave very good responses while there is no signal with A431 (human fibroblast cell line), Daudi (human B cell line), EB1 (human B cell line) or Ramos (human B cell line) cell lysates. Similar results were seen using BD IMag-puri...

Examples of Electro-Transfected Eukaryotic and Prokaryotic Cells

... Mammalian Hamster fibroblast (CHO) Human B Human, B l...uman, epithelial, cervix (HeLa) Human fibroblast Human, GCT, fibrous histocytoma ...s, fibroblasts Hybrid, mouse/human, A9 fibroblast Hybrid, rat/mouse, MEL cells ...

The Bio-Rad Silver Stain, Rev E

...8, 10211025 (1982) 24. Gospodarowicz D et al., Isolation of brain fibroblast growth factor by heparin- Sepharose affinity chromatography: identity with pituitary fibroblast growth factor, Proc Natl Acad Sci USA 81, 69636967 (1984) 25. Gro...

RNArticles: RNA Amplification Used to Develop a New In Vitro HCMV Assay

... right most triplicate is spotted with cellular housekeeping genes as controls. *Note: For the human fibroblast RNA, the gene expression profile did not vary significantly between amplified vs. unamplified samples. ...
Fibroblast in Biological Products

Rat Anti-Mouse Reticular Fibroblast (pan) Monoclonal Antibody, Unconjugated, Clone ER-TR7 from CEDARLANE Laboratories Limited

Description: Anti-Mouse Reticular Fibroblast, Purified (Clone ER-TR7) (rat IgG2a)...
Company:CEDARLANE Laboratories Limited

Mouse Anti-Human Complex IV, assembly factor SURF1 Monoclonal Antibody, Unconjugated, Clone 21H2BG4 from MitoScience LLC

Description:...ochrome c oxidase deficiency. The anti-SURF1 mAb reacts specifically in human and bovine tissues. The levels of SURF1 are low even in rapidly dividing fibroblast cell cultures (as well as in mature tissues e.g. heart or liver). The low copy number is consistent with it acting to catalyze Complex IV assembly. In...
Company:MitoScience LLC

Mechanical Cell Strain Instrument STREX ST-190-XY Microscope Mountable from B-Bridge International

Description:...on strain chamber to observe cells in real-time using light or fluorescence microscopy. Biaxial strain that is experienced by endothelial, muscle, and fibroblast cells can be simulated by mechanical stretching or compression along the X and Y axis of our strain chamber. Strain can be applied simultaneously or i...
Company:B-Bridge International

jetPEI-RGD + NaCl sol. from Polyplus Transfection

Description:...eir surface and mimic the integrins natural ligands, hence the targeting. Integrin binding was shown to increase transfection of epithelial (HeLa) and fibroblast (MRC5) cells up to 100- fold in the presence of serum....
Company:Polyplus Transfection

Neural Stem Cell Expansion Kit - Monolayer from R&D Systems

Description:...d N-2 Plus Media Supplement, which has been optimized for neural stem cell expansion (Johe, K.K. et al . (1996) Genes & Development 10 :3129). Human fibroblast growth factor basic (FGF basic) is included to promote the in vitro proliferation of neural precursors. Bovine Fibronectin, used to coat plates to p...
Company:R&D Systems

Neural Stem Cell Expansion Kit - Neurosphere from R&D Systems

Description:...ural stem cell expansion (Johe, K.K. et al . (1996) Genes & Development 10 :3129). Two growth factors, human epidermal growth factor (EGF) and human fibroblast growth factor basic (FGF basic), are included to promote the in vitro proliferation of neural precursors. The quantity of each component provided in ...
Company:R&D Systems

Neural Stem Cell Expansion Kit - Monolayer Plus from R&D Systems

Description:...d N-2 Plus Media Supplement, which has been optimized for neural stem cell expansion (Johe, K.K. et al . (1996) Genes & Development 10 :3129). Human fibroblast growth factor basic (FGF basic) is included to promote the in vitro proliferation of neural precursors. Human epidermal growth factor (EGF) is also ...
Company:R&D Systems

Mouse Interferon Alpha Bioassay Services from PBL InterferonSource

Description:...normally provided 2-3 weeks after receipt of samples, although assay times may vary. The bioactivity of mouse interferon alpha is measured using mouse fibroblast cells (L929) challenged with encephalomyocarditis (EMCV). Assay Sensitivity: 15-30 u/ml. Standard for Mouse IFN alpha (NIH reference: Ga02-901-511)....
Company:PBL InterferonSource

Rat Interferon Gamma Bioassay Services from PBL InterferonSource

Description:...e normally provided 2-3 weeks after receipt of samples, although assay times may vary. The bioactivity of rat interferon gamma is measured using mouse fibroblast cells (L929) challenged with encephalomyocarditis (EMCV). Assay Sensitivity: 5-10 u/ml. Units are determined with respect to the mouse IFN gamma sta...
Company:PBL InterferonSource

Rat Interferon Alpha Bioassay Services from PBL InterferonSource

Description:...e normally provided 2-3 weeks after receipt of samples, although assay times may vary. The bioactivity of rat interferon alpha is measured using mouse fibroblast cells (L929) challenged with encephalomyocarditis (EMCV). Assay Sensitivity: 25-50 u/ml. Units are determined with respect to the mouse IFN alpha/be...
Company:PBL InterferonSource
Fibroblast in Biological Dictionary

Fibroblast

A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and play a critical role in wound healing. They are the most common cells of... Fibroblast growth factor-1 interacts with the glucose-regulate...
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