Research yields potential target for cancer, wound healing and fibrosis
...particular functions of the integrin may be a key to preventing the progression of diseases associated with abnormal integrin signaling or fibronectin fibril
formation such as in cancer and fibrosis.
"Based upon these studies, the aim of my current research at the LSU Health Sciences Center New Orleans S...
Seeing Alzheimer's amyloids
...rils is that the same peptide will exasperatingly assemble differently from fibril
to fibrilunlike normal proteins, which reliably fold up the same way every ...acromolecular machines, Grigorieff said his lab made an image of the A-beta fibril
at a resolution of eight Angstroms, revealing useful detail at a magnificat...
Research at Argonne's Advanced Photon Source reveals structure and behavior of collagen
... discovered that it had a triple-stranded helical structure. However, researches had never before had the ability to study the structure of an entire fibril
in the same way that they could study an individual collagen molecule, according to Orgel.
Orgel and his team performed diffraction studies on in...
Biophysical Society announces winners of 2008 Student Travel Awards
...tijn E. van Raaij, University of Twente, Enschede, The Netherlands, Quantitative Atomic Force Microscopy Establishes Free Energy Parameters of Amyloid fibril
James A. Svetlovics, University of North Carolina Wilmington, Domain Formation of POPC/DPPC Binary System Investigated by Fluorescen...
Scripps research study reveals structural dynamics of single prion molecules
...ceedings of the National Academy of Sciences, offer significant insights into normal folding mechanisms as well as those that lead to abnormal amyloid fibril
conversion. The new insights may lead to the discovery of novel therapeutic targets for neurodegenerative diseases.
Intriguingly, certain prions and...
Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
...vered that the particular shape of a prion amyloid fibril
was the determining factor in whether one species ...case with the preseeded mice fibrils, a particular fibril
shape in Saccharomyces cerevisiae yeast allowed pr...at could in turn infect Saccharomyces.
shape appears to be the deciding infective factor,...
Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease
...evolution of fibrils, They can thus develop a better understanding of amyloid aggregation.
The scientists are also seeking the precise point during fibril
formation when interactions between monomers become irreversible. Defining that point is important because "the fibrils are virtually indestructible o...