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Febrile in Medical News

Most babies with uncomplicated febrile seizures can avoid spinal tap

When babies develop a fever high enough or abrupt enough to cause a seizure, frightened parents often rush them to the emergency room, where their workup frequently includes a lumbar puncture (spinal tap) to rule out bacterial meningitis. Now, in the largest study to date, researchers at Children'...

NCCN Updates Infection Guidelines to Include Information About H1N1 Virus (Swine Flu)

...ts with cancer. The H1N1 reference is located in the section of the NCCN Guidelines that lists recommendations for treating lung infiltrates in febrile neutropenic patients. The updated NCCN Guidelines note that certain tests and antiviral treatments that are effective in more common strains of influe...

Therapy should extend beyond childhood

...t through urine in this disease. In addition, intensive emergency treatment of the metabolism must be carried out to prevent a metabolic crisis during febrile infections. For their study, an international interdisciplinary research group of neuroradiologists and pediatricians headed by Dr. Stefan Klker fr...

Cell Therapeutics Completes Pixantrone NDA Submission and Requests Priority Review

...erse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3/4 febrile neutropenia was only 7.4% versus 3.0% in the comparator arm. Grade 3/4 infections had a similar incidence in both study arms (18% vs. 13%). Although t...

Amgen Highlights Data to Be Presented at ASCO

... risk of mortality in cancer patients experiencing febrile neutropenia (neutropenia with fever) based on clin... of mortality in patients with cancer experiencing febrile neutropenia Lead Author: Barron R ...rease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignan...

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

...reactions were thrombocytopenia (37%), neutropenia (37%), anemia (23%), and elevated lipase (17%). Other serious adverse reactions included pneumonia, febrile neutropenia, leukopenia, intracranial hemorrhage, and pyrexia (Grade 3/4: 2%). Dose adjustments or modifications Tasigna may need to be tempora...

Barr's BLA for Adenovirus Type 4 and 7 Live Oral Vaccines Accepted for Filing by FDA

... the oral Type 4 and Type 7 ADV vaccines, the efficacy of the oral Type 4 ADV vaccine in reducing the attack rate of wild type 4 adenovirus-associated febrile ARD and the ability of Type 7 ADV vaccine to produce neutralizing antibodies. Barr/DOD Project Summary In 2001, Barr entered into a mul...

Celator(R) Pharmaceuticals Presents Phase 1 Results With CPX-351 in Patients With Advanced Leukemia at the American Society of Hematology Meeting

...study was considered favorable. The most frequent and severe adverse events were those related to potential or documented infections including fever, febrile neutropenia, bacteremia, pneumonia and sepsis, common occurrences in the treatment of patients with AML. Although, mortality related to treatment is ...

Novel treatments show improvements in survival and response rates for leukemia and lymphoma

... for more than one year. Given the refractory nature of these patients' lymphoma, the toxicity profile was quite favorable. There were four cases of febrile neutropenia with eight patients requiring a dose-modification due to neutropenia, hypertension, liver function test abnormalities, fever, and mucositi...

Novel Treatments Demonstrate Improvements in Overall Survival and Response Rates in Difficult-To-Treat Forms of Leukemia and Lymphoma

...py for more than one year. Given the refractory nature of these patients' lymphoma, the toxicity profile was quite favorable. There were four cases of febrile neutropenia with eight patients requiring a dose-modification due to neutropenia, hypertension, liver function test abnormalities, fever, and mucositi...
Febrile in Medical Technology

Responses After Completion of Therapy Increase Pixantrone Complete Remission (CR)/Unconfirmed Complete Remission (CRu) Rate to 24% and Overall Response Rate (ORR) to 40% Compared to 7% and 14% for Comparator Agents in Phase III EXTEND Trial in 3rd Line Th

...se event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3, 4 febrile neutropenia was only 7.4% versus 3.0% in the comparator arm. Grade 3, 4 infections had a similar incidence in both study arms (18% vs. 13%). Although...

Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients with Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival

...de effects included neutropenia [25/57 in patients treated with GC and BSI-201; 31/59 patients treated with GC alone], thrombocytopenia and anemia. No febrile neutropenia was observed in patients receiving BSI-201 combined with chemotherapy. BSI-201 did not add to the frequency or severity of adverse events ...

Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment

...se event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3, 4 febrile neutropenia was only 7.4% versus 3.0% in the comparator arm. Grade 3, 4 infections had a similar incidence in both study arms (18% vs. 13%). Although...

Induction Chemotherapy Followed by ChemoRadiotherapy Increased Time-to-Treatment Failure Compared to ChemoRadiotherapy Alone in Patients With Unresectable Locally Advanced Head & Neck Cancer

...ts treated with CRT alone (p=0.002). The most frequent severe (grade 3-4) adverse reactions were stomatitis (44% for IC+CRT vs. 31% for CRT) and febrile neutropenia (10% for IC+CRT vs. 1% for CRT). Other adverse events included neutropenia and asthenia. "These study results illustrate that this c...

Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer

...c toxicities, thrombocytopenia and neutropenia were more frequent and severe with the FOLPI regimen compared with FOLFOX. However, only one episode of febrile neutropenia and no bleeding complications have been observed to date. In addition, 83 percent of the planned picoplatin dose of 150 mg/meter squared w...

Cell Therapeutics and IDIS Announce Agreement for a European Named Patient/Compassionate Use Program for Pixantrone

...he treatment assignments. The most common serious toxicities (>5%) seen in previous trials of pixantrone include grade 3 and 4 neutropenia and febrile neutropenia. Complete safety information is not yet available for the study, however, the study was monitored on an ongoing basis by an independent Da...

Pixantrone Increases Progression-Free Survival by 81% Compared to Standard Chemotherapeutic Agents in Phase III Relapsed Aggressive non-Hodgkin's Lymphoma Trial

... treatment assignments. The most common serious toxicities (>5%) seen in previous trials of pixantrone include grade 3 and 4 neutropenia and febrile neutropenia. Complete safety information is not yet available for the study, however, the study was monitored on an ongoing basis by an independent Da...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

... * Hematological toxicities and infections, including: - Neutropenia - 66% (Grade 3/4 57%) versus 65% (Grade 3/4 59%), with febrile neutropenia reported in 7% versus 6% of patients - Anemia - 20% (Grade 3/4 2%) versus 17% (Grade 3/4 1%) - Infection - 30% (Grade 3/...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

...reactions were thrombocytopenia (37%), neutropenia (37%), anemia (23%), and elevated lipase (17%). Other serious adverse reactions included pneumonia, febrile neutropenia, leukopenia, intracranial hemorrhage, and pyrexia (Grade 3/4: 2%). Dose adjustments or modifications Tasigna may need ...

Dacogen(R) (decitabine for injection) Data Presented on a Phase II Clinical Trial in Elderly Patients with Acute Myeloid Leukemia (AML)

...sults reported." Besides myelosuppression, the most commonly reported adverse events considered possibly related to decitabine treatment were febrile neutropenia, fatigue, pneumonia, sepsis, dyspnea and bacteraemia. The five-day dosing regimen of Dacogen(R) is currently being further evalua...
Febrile in Medical Products

Arctic Sun® 2000 Temperature Management System

Description:... Arctic Sun System rapidly induces mild hypothermia in those patients who would benefit from therapeutic hypothermia or rapidly reduces temperature in febrile patients. The Arctic Sun precisely monitors and maintains core body temperature in a range of 33C (91.4F) to 37C (98.6F). The Arctic Sun functio...
Company:Medivance
Febrile in Medical Dictionary

Febrile

User-generated article about fever, also known as pyrexia, a febrile response for unnatural changes within the body. A febrile seizure, also known as a fever fit or febrile convulsion is a convulsion triggered by a rise in body temperature. They most commonly occur in children betwe...

Viral Hemorrhagic Fever

...the ... Overview: Viral hemorrhagic fevers (VHFs) are a group of febrile illnesses ... Cases of viral hemorrhagic fever in the United States ...verse viral diseases unified by common underlying pathophysiology. These febrile diseases ... Viral hemorrhagic fevers — Comprehensive ...

Vasoconstriction

...e opposite of vasodilation, the widening of blood vessels. When blood vessels... User-generated article about fever, also known as pyrexia, a febrile response for unnatural changes ... Prevention of heat loss, such as vasoconstriction . ... Diesel Exhaust Inhalation Elicits Acute Vasoconstr...

Transfusion reaction

... hemolytic transfusion reaction ... Transfusion reaction An allergic reaction to some of the cells or proteins in another person's ... febrile non-hemolytic transfusion reaction ... ... goal of treatment is to prevent or treat severe effects of transfusion reaction . ... be teste...

Toxocariasis

... Overview: Toxocariasis is an infection caused by the ingestion of larvae of the ... In children, covert toxocariasis is a mild, subclinical, febrile illness. ... In humans, toxocariasis is considered an aberrant infection because ... Toxocariasis ... Toxocariasis is caused by Toxocara ...

Syndrome

... causes delays in the way a child develops, both physically and mentally. Kawasaki syndrome (KS), also known as kawasaki disease, is an acute febrile illness of unknown etiology that primarily affects children younger than 5 years of age. WHAT IS EVANS SYNDROME ? Evans syndrome is a rare a...

Seizure

...izure . ... Epilepsy and seizure disorders information page compiled by the National ... Having a seizure does not necessarily mean that a ... febrile Seizures Fact Sheet ... ...

Rickettsialpox

...mmon. ... Overview: Rickettsialpox is a mild, self-limited, zoonotic febrile illness ... Rickettsialpox ... Serologic evidence of rickettsialpox exposure was found in 16 ... rickettsialpox A febrile disease of humans marked by a vesiculopapular eruption, clinically resem...

Retropharyngeal abscess

...ropharyngeal abscess , a classic widened soft tissue shadow anterior to ... Retropharyngeal abscess is in the differential diagnosis of a febrile infant ... ...

Relapsing fever

...arated by ... Fatalities from tick-borne relapsing fever are rare in treated patients, as are ... Overview: Relapsing fever is an acute febrile illness caused by spirochetes of ... Large outbreaks of louse-borne relapsing fever have occurred throughout the past ... Relapsing fever ...
Febrile in Biological News

NIH expands Human Microbiome Project; funds sequencing centers and disease projects

...from immunodeficiency syndromes. Gregory A. Storch, M.D., Washington University School of Medicine, Saint Louis Nose, digestive tract and blood: febrile Illness $950,000 This team of investigators will examine if there is a relationship between the immune system and viral microbiome of groups of chi...

Eribulin mesylate demonstrated anti-tumor activity in patients with advanced breast cancer

... 3 (severe) or Grade 4 (disabling or life- threatening) adverse events were neutropenia (a decrease in the number of granular white blood cells, 54%); febrile neutropenia, 5.5%, leukopenia (low white blood cell count, 14%), and weakness/fatigue (10%; no Grade 4 events). Grade 3 peripheral neuropathy (a fun...

Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas

...s, says van Riet. These studies indicate for the first time that influenza virus infections are frequent in Gabon, and suggest that many cases of febrile illness incorrectly diagnosed and mistreated as malaria may actually be due to influenza. In addition, these studies suggest that influenza vaccinatio...

Fever causing headaches for Aussie parents

...cation for parents and the health professionals who give them information. "All parents should learn how to manage fever before their child's first febrile episode," she said. "Many parents see these medications as having magical qualities such as calming upset children, sedating them or lifting a chil...

'GreeneChip' -- New diagnostic tool that rapidly and accurately identifies multiple pathogens

...nknown sample from a patient with a viral hemorrhagic fever (VHF)-like syndrome. Within six to eight days of infection, Marburg virus causes an acute febrile illness that frequently progresses to liver failure, delirium, shock, and hemorrhage. From October 2004 through July 2005, a Marburg outbreak in Ango...

Molecular mechanism may explain how fevers spark seizures

...iscovered a molecular mechanism that could explain febrile seizures. The research, published March 1st in The...ay lead to new approaches for preventing recurrent febrile seizures in vulnerable children. febrile seizures affect as many as one in 15 children worl...
Febrile in Biological Technology

Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma

...rse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3, 4 febrile neutropenia was only 7.4% versus 3.0% in the comparator arm. Grade 3, 4 infections had a similar incidence in both study arms (18% vs. 13%). Although ...

Naglazyme Approved by Brazil's National Health Surveillance Agency

...dered prior to the initiation of treatment. Consideration to delay Naglazyme infusion should be given when treating patients who present with an acute febrile or respiratory illness. Additional information can be found at www.naglazyme.com . About BioMarin BioMarin develops and commercializes ...

Sunesis Pharmaceuticals Provides Year-End Clinical Update on Voreloxin

...loxin was generally well-tolerated at 48 and 60 mg/m2, with an incidence of febrile neutropenia of below 10%. An increase in febrile neutropenia is observed at 75 mg/m2, although the incidence remains below 2...

High-Dose Zevalin(R) With Tandem Stem Cell Infusion Produces 87 Percent Overall Survival in Relapsed/Refractory or High Risk Non-Hodgkin's Lymphoma

...minor non-hematologic toxicities were observed. Infections, none greater than grade 3, were noted in 8 patients (27 %) but hospitalization for grade 3 febrile neutropenia was required in only 3 patients. The authors concluded "the mild hematologic toxicity was unprecedented for a myeloablative regimen." The ...

Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia

...reactions were thrombocytopenia (37%), neutropenia (37%), anemia (23%), and elevated lipase (17%). Other serious adverse reactions included pneumonia, febrile neutropenia, leukopenia, intracranial hemorrhage, and pyrexia (Grade 3/4: 2%). Dose adjustments or modifications Tasigna may need to be temporaril...

First Taxane-Based Non-Anthracycline Containing Chemotherapy in Combination With Herceptin (TCH) for HER2 Positive Early Breast Cancer Patients Obtains Approval From the FDA

...tatistically significant difference in OS between the two experimental arms (TCH and AC-TH). Tolerance The most common adverse event was grade 3-4 febrile neutropenia (AC-T: 9.1%, AC-TH: 11.0%, TCH: 9.8%). Other common grade 3-4 adverse events included diarrhea (3.0% in the AC-T arm, 5.1% in the AC-TH ar...

Naglazyme Approved by Japanese Ministry of Health

...dered prior to the initiation of treatment. Consideration to delay Naglazyme infusion should be given when treating patients who present with an acute febrile or respiratory illness. Additional information can be found at http://www.naglazyme.com . About BioMarin BioMarin develops and commercializes inn...

Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results

...our patients had partial responses (two unconfirmed). -- SNS-595 has been generally well tolerated in this trial, with a low rate of febrile neutropenia or other Grade 3/4 adverse events and manageable Grade 1/2 nausea or vomiting. Based on the drug's observed safety profile ...

EMEA Accepts for Review Vidaza(R) Marketing Authorization Application for Higher-Risk Myelodysplastic Syndromes

...ema (35.0%), constipation (33.6%), neutropenia (32.3%) and ecchymosis (30.5%). Other adverse reactions included dizziness (18.6%), chest pain (16.4%), febrile neutropenia (16.4%), myalgia (15.9%), injection site reaction (13.6%), aggravated fatigue (12.7%) and malaise (10.9%). The most common adverse reactio...

Taxotere(R)-Based Chemotherapy Significantly Improved Overall Survival Compared With Standard Anthracycline-Based Chemotherapy in Early Stage Breast Cancer

...en in the TC group, and in 54% and 59% of younger and older women, respectively, in the AC group. Among younger patients, the frequencies of Grade 3-4 febrile neutropenia were 4.4% with TC and 2.3% with AC, while in older patients the frequencies were 7.7% and 3.7% for TC and AC, respectively. Grade 3-4 naus...
Febrile in Biological Dictionary

Dengue fever

... Dengue fever and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics, and caused by four closely related virus ...endemic" to certain regions, which means it is ... Dengue fever is a febrile illness that affects infants, young children and adults. ... Dengue / deng...
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