Mouth may tell the tale of lung damage caused by smoking

...onths. The researchers tracked whether either p16, fhit or both had been silenced by methylation - the att... the lungs of 23 percent of study participants, of fhit in 17 percent and of either of the two genes in 35...in oral tissue, with p16 methylated in 19 percent, fhit in 15 percent and one of the two in 31 percent. ...

Simple Test Detects Genetic Signs of Lung Cancer in a Patient’s Sputu

...in 71 percent of tumors. But the loss of HYAL2 and fhit in a patient’s tumor could be detected in that per...he investigators specifically found that HYAL2 and fhit were deleted in 84 percent and 79 percent of tumor...hed sputum, respectively. Combining both HYAL2 and fhit deletions increased sensitivity to 76 percent (com...

FHIT in Biological News

Building a better mouse model of lung cancer: FHIT counts

Scientists have identified some of the very earliest genetic changes involved in the development of lung cancer and have incorporated them into a new strain of mouse that develops the disease in much the same way that humans do. The discoveries, reported in the August 1 issue of Cancer Research, ...

FHIT in Biological Products

adenosine 5'-O-(3-thiotriphosphate), BODIPY FL conjugated/tagged from Molecular Probes (Invitrogen)

Description:...Gamma-thiol of ATP-Gamma-S. In addition to its potential use for binding studies the BODIPY FL ATP-Gamma-S thioether is an important new substrate for fhit a member of the histidine triad superfamily of nucleotide-binding proteins....
Company:Molecular Probes (Invitrogen)

FHIT in Biological Dictionary

MSH2

...romoter Mutation Analysis ... Immunohistochemical analysis of Msh2 and fhit protein expression in 62 CRC cases ... Loss of Msh2 protein correlated significantly with loss of fhit protein (P ... of MSH2 is performed in both forward and reverse dire...