When cancer cells can't let go
...rily attaching to the ECM through focal adhesions. fak
spurs focal adhesions to disengage, and it is more abundant in metastatic tumors. Whether fak
also regulates invadopodia was unknown.
When Ch...ly sticky. The protein Src serves as FAK's helper. fak
and Src work together to phosphorylate tyrosines i...
JCI online early table of contents: Jan. 19, 2009
ONCOLOGY: Role for the protein fak
in breast cancer
A team of researchers, led b...pathways are under development. In this study, the fak
gene was found to be amplified in a substantial nu...ving a role in tumor development, mice lacking the fak
gene in breast tissue were protected in a model of...
Dense tissue promotes aggressive cancers
...h the motors themselves are not present in the drilling structures.
The investigators also implicated the activities of two signaling proteins called fak
and p130Cas in the rigidity-induced invadopodia activity. These signaling proteins were present in an activated state in the invadopodia, suggesting t...
Leading cause of death in 'preemies' might be controlled by resetting a molecular switch
...arm in mice with NEC by interfering with production of a focal adhesion kinase (FAK) that the researchers found associated with TLR4. By shutting down fak
with small interfering RNA, the TLR4 siren was silenced. Under these conditions, the researchers watched enterocytes regain the ability to migrate, a ...
Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial
... They received liposomes that contained either the fak
siRNA, a control siRNA, or were empty. Some mice ...h and penetrating cells.
The next step for the fak
siRNA-DOPC liposome is toxicity testing. "So far ...n the future."
In addition to ovarian cancer, fak
is overexpressed in colon, breast, thyroid, and he...
Molecular force field helps cancer cells defend against attack
...s of tumor survival. These medicines would prevent fak
from linking with the protein known as vascular en...rs.
Cance and colleagues were the first to pull fak
out of human tumors and to show that human cancers...ntists also have identified some protein receptors fak
binds to; VEGFR-3 is the latest they've discovered...