Navigation Links
Extracellular in Medical News

Seahorse XF96 Extracellular Flux Analyzer Wins Best New Product Award for DRUG DISCOVERY at 2009 Molecular Medicine Conference

BILLERICA, Mass., March 12 /PRNewswire/ -- Seahorse Bioscience, Inc., leader in the real-time measurement of cellular bioenergetics, announced today that the XF96 Extracellular Flux Analyzer, the first analytical instrument for the kinetic measure of mitochondrial oxygen consumption and cytoplasmi...

Human cells secrete cancer-killing protein, UK study finds

...TRAIL, also exerts cancer-cell-specific effects. However, Rangnekar's most recent study discovered that apoptosis inducible by TRAIL is dependent upon extracellular Par-4 signaling via cell surface GRP78. Thus, the researchers conclude, Par-4 activates a novel pathway involving cell surface GRP78 receptor for ind...

DNA-damaged cells communicate with neighbors to let them know they're in trouble

...ng cancer according to Judith Campisi, PhD, lead author of the study and a faculty member at the Buck Institute for Age Research. The discovery of the extracellular signaling mechanism, which sets off an inflammatory response, explains how unsuccessful DNA repair at the cellular level impacts tissues, which are th...

Dynamic molecular mechanism to keep brain activity stable

...n contrast, DHHC2 are located mainly in dendrites of neurons. Dendritically localized DHHC2 mediates dynamic palmitoylation of PSD-95 at synapses upon extracellular signals. When synaptic activity decreases, DHHC2 translocates to the synaptic site to facilitate palmitoylation of synaptic proteins to keep synaptic ...

Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer

...n action through GPR30 had a more profound effect on tumor cell survival. They found that GPR30 promoted the assembly of what is called a "provisional extracellular matrix" -- a crucial event in cellular survival. More specifically, they found that release of growth factor by GPR30 required the activation of a lat...

ThromCat(R) XT(TM) Thrombectomy Catheter System Receives CE Mark

...he impact of product recalls and other manufacturing issues, the Company's success in its research and development efforts in its cartilage repair and extracellular matrix technologies programs and competition from other technologies, among other important risks. For a detailed discussion of factors that could aff...
Extracellular in Medical Technology

Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics

Novel technology opens the door to the understanding of and possible treatments for obesity, diabetes, ageing and cancer BILLERICA, Mass., Oct. 6 /PRNewswire/ -- Seahorse Bioscience today announced the release of the first ever analytical instrument for the kinetic measurement of mi...

St. Francis Surgeon Uses Tissue Regeneration Technology to Rebuild Patients' Heart Structures

...708/DE43062LOGO-a ) (Logo: http://www.newscom.com/cgi-bin/prnh/20090708/DE43062LOGO-b ) Marc Gerdisch, M.D., is using the CorMatrix extracellular Matrix (ECM)(TM) to modify and repair cardiac structures, allowing heart tissue to re-grow inside the beating hearts of heart surgery patients. The Co...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

...P is released from cells under physiologic and pathophysiologic conditions; extracellular ATP acts as a local physiologic regulator by activating cell surface receptors called P2 receptors. extracellular ATP plays an important role in sperm maturation in the male reproductive tr...

Access Pharmaceuticals Presents new Combination Data on the Company's Angiolix(R) Therapeutic Monoclonal Antibody

...noclonal antibody which has considerable potential for the treatment of cancer through its affinity for a novel target, lactadherin. Lactadherin is an extracellular matrix protein that is released by numerous types of tumor cells, including most breast cancers, ovarian cancers and prostate cancer. Lactadherin has ...

Halozyme Therapeutics Begins Phase 1 Clinical Trial of Bisphosphonate Administered With rHuPH20 Enzyme

...harmaceutical company developing and commercializing products targeting the extracellular matrix for the endocrinology, oncology, dermatology, and drug delivery mark...harmaceutical company developing and commercializing products targeting the extracellular matrix for the endocrinology, oncology, dermatology and drug delivery marke...

Halozyme Therapeutics Announces Roche Begins Phase 1 Clinical Trial and Selects Fourth Exclusive Biologic Target

...harmaceutical company developing and commercializing products targeting the extracellular matrix, today announced that Roche has dosed the first patient in a Phase 1...harmaceutical company developing and commercializing products targeting the extracellular matrix for the endocrinology, oncology, dermatology and drug delivery marke...
Extracellular in Medical Products

Streptozyme® Streptococcal Antibody Test

Description:... Hemagglutination slide test for the qualitative detection and quantitative determination of antibodies to streptococcal extracellular antigens in serum, plasma, or whole blood....
Company:Inverness Medical Innovations

Colorcard® Streptozyme® Streptococcal Antibody Test

Description:... Color-enhanced slide test for the rapid qualitative and semi-quantitative detection of antibodies to streptococcal extracellular antigens in serum, plasma and peripheral blood....
Company:Inverness Medical Innovations

Osteocalcin IRMA Test

Description:...t produced by odontoblasts in dentin, and hypertrophic chondrocytes [1]. During bone formation, newly synthesized osteocalcin is incorporated into the extracellular bone matrix and a small fraction is released into circulation. Because serum osteocalcin originates exclusively from bone, serum osteocalcin levels re...
Company:Diagnostic Systems Laboratories, Inc.

Osteocalcin ELISA Test

Description:...t produced by odontoblasts in dentin, and hypertrophic chondrocytes [1]. During bone formation, newly synthesized osteocalcin is incorporated into the extracellular bone matrix and a small fraction is released into circulation. Because serum osteocalcin originates exclusively from bone, serum osteocalcin levels re...
Company:Diagnostic Systems Laboratories, Inc.

MM-PTH RIA Test

Description:... Parathyroid hormone (PTH) is synthesized by the parathyroid glands [1,2] and secreted in response to decreased extracellular calcium concentrations. PTH prevents hypocalcemia by enhancing bone resorption and decreasing calcium excretion by the kidney. Following release into ...
Company:Diagnostic Systems Laboratories, Inc.

C-PTH RIA Test

Description:... Parathyroid hormone (PTH) is synthesized by the parathyroid glands [1,2] and secreted in response to decreased extracellular calcium concentrations. PTH prevents hypocalcemia by enhancing bone resorption and decreasing calcium excretion by the kidney. Following release into ...
Company:Diagnostic Systems Laboratories, Inc.
Extracellular in Medical Definition

Cryostasis (clathrate hydrates)

...s. Eventually, the solute concentration inside the cells reaches the eutectic and freezes. The final state of frozen tissues is pure ice in the former extracellular spaces, and inside the cell membranes a mixture of concentrated cellular components in ice and bound water. In general, this process is not reversible...
Extracellular in Medical Dictionary

Sodium

...period and so is in Group IA. ... Sodium metal has a body centered cubic structure. ... Sodium is the primary electrolyte that regulates the extracellular fluid levels in the body. ... Sodium is essential for hydration because this mineral pumps ... 1000Bulbs.com offers high pressure sodium bulbs...

Slit

...on of slit from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games. Slit is a complex extracellular protein containing at ... Slit protein is made by ... Slit has been identified as the midline repellent for the ... slit . Definition fro...

Renin

...Renin , also known as Angiotensinogenase, is a circulating enzyme that participates in the body's renin -angiotensin system (RAS) that mediates extracellular volume, and arterial vasoconstriction. Thus it regulates the body's mean arterial blood pressure. The renin -angiotensin system (RAS) or th...

PTH

...://en.wikipedia.org /wiki/ PTH " Categories: Disambiguation pages ... of PTH with newer, more reliable assays. ... more PTH at a given extracellular calcium concentration, ... The PTH levels begin to rise earlier in gesta ... PTH Manufacturing Inc is a fully integrated manufacturer of cop...

Pneumocystis Carinii

...HIV = human immunodeficiency syndrome; ... Pneumocystis carinii , an extracellular protozoan, has been observed in three forms. ... Pneumocystis carinii c...neumonia is a common infection in ... Pneumocystis carinii is an extracellular lung pathogen, which causes pneumonia ... Searching the Pneumocystis c...

Lipofuscin

...e and Research Links ... Lipofuscin is one of the many different types of extracellular ... Lipofuscin is one of the many different types of extracellular aggregates that ... Thus, back we come to lipofuscin , via a release at Eu...
Extracellular in Biological News

Scientists open doors to diagnosis of emphysema

... the foreign material, and chronic exposure causes inflammation. MMP12 is an enzyme secreted by macrophages which usually helps them to break down the extracellular matrix (the complex network of proteins and fibers that surround and support the cells of the body), a process important for normal wound healing. How...

Sticky protein helps reinforce fragile muscle membranes

... dystroglycan as the "glue" that binds muscle membranes to a tough layer of extracellular proteins called the basal lamina. Just as a piece of sticky tape can pre...ve that glycosylated dystroglycan is required to attach the membrane to the extracellular proteins and thus reinforce the membrane integrity," said Campbell, who als...

Neural stem cell differentiation factor discovered

...ch family play a significant role in this process. So far, only stimulating extracellular ligands of Notch receptors had been described. Biochemists of Goethe Univer...of blood vessels. It was a surprise when we discovered that EGFL7 bound the extracellular domains of Notch receptors and competed with known Notch ligands" explains ...

Why the thumb of the right hand is on the left hand side

...unctions at the cilium. "By using high-resolution fluorescence microscopy, we have now shown that in the new mutants a small genetic alteration at the extracellular part of this protein inhibits localization in the cilia and that while the cells identify the Hedgehog signals, they interpret the concentration incor...

Progress toward artificial tissue?

...r organs, obtain their mechanical support from the extracellular matrix, a network of protein-based nanofibers. Different protein morphologies in the extracellular matrix produce tissue with a wide range of stiffne...mble the collagen fiber networks of the biological extracellular matrix. They can also be knotted, braided, or wove...

UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants

...ypothesis is that it may not be the bone-forming cells themselves that are growing abnormally, but that the environment surrounding them, known as the extracellular matrix, may be providing improper instructions to the cells. "If we can deliver a different matrix one that promotes the growth of healthy tissue ou...
Extracellular in Biological Technology

Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor

Sylviane Komesli, Martine Page, and Patrick Dutartre Dpartement dImmunologie, Laboratoires Fournier S.A., France Abstract TGF- type I and type II receptors form ligand dependent heteromeric signaling complexes, in which transforming growth fact...

Kensey Nash Announces Agreement to Acquire Rights to OsseoFit Product

...he impact of product recalls and other manufacturing issues, the Company's success in its research and development efforts in its cartilage repair and extracellular matrix technologies programs, the completion of additional clinical trials in both the U.S. and Europe to support regulatory approval of future genera...

Histogen Hair Regrowth Clinical Trial Presented at ISHRS Annual Meeting

...ts rich product portfolio. Histogen has two product families - a proprietary liquid complex of embryonic-like proteins and growth factors, and a human extracellular Matrix (ECM) material, ExCeltrix. For more information, please visit http://www.histogeninc.com . # # # Read the full story at http://www....

Histogen Aesthetics Launches ReGenica Rejuvenation System

...atinocyte Growth Factor and Vascular Endothelial Growth Factor, and soluble extracellular matrix proteins such as collagens, laminin and decorin, which are associate...lio. Histogen has two product families - Exceltrix™, Histogen's human extracellular Matrix (ECM) and ReGenica™, Histogen's proprietary liquid formula. Fo...

aTyr Pharma to Present at ChinaBio(R) Investor Forum in Hong Kong

...roles and functions for this ancient class of enzymes and reported the first evidence that fragments and splice variants of these proteins have latent extracellular activities distinct from their intracellular roles in protein synthesis. With a wide variety of cell signaling activities, this class of unexplored p...

Dr. James Cai Joins aTyr Pharma to Drive Clinical Development in Asia

...roles and functions for this ancient class of enzymes and reported the first evidence that fragments and splice variants of these proteins have latent extracellular activities distinct from their intracellular roles in protein synthesis. With a wide variety of cell signaling activities, this class of unexplored p...
Extracellular in Biological Products

Mouse Anti-Bovine CD335 Monoclonal Antibody, ALEXA FLUOR 488 Conjugated, Clone AKS1 from AbD Serotec

Description:... MOUSE ANTI BOVINE CD335:ALEXA 488 Immunogen: Fusion protein consisting of the extracellular region of bovine CD335....
Company:AbD Serotec

Anti-PEBP Polyclonal Antibody, unconjugated, Clone ZLK.17 from Invitrogen

Description:... chymotrypsin. Serine proteases are involved in many processes during development and tissue homeostasis. Serine proteases degrade components of the extracellular matrix to allow outgrowth of neuronal processes or cell migration, promote cell death, and act as mitogenic or survival factors. The activity of the ...
Company:Invitrogen

Rabbit Anti-Human Parathyroid Hormone Receptor 2 Polyclonal Antibody, Unconjugated from Abcam

Description:...onal to Parathyroid Hormone Receptor 2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AFRHCNPNGTWDFMHSLN, corresponding to extracellular amino acids 99-116 of Human Parathyroid Hormone Receptor 2 Entrez Gene ID: 5746 Swiss Protein ID: P49190...
Company:Abcam

Rabbit Anti-JNK1, phospho (Thr183 / Tyr185) Polyclonal Antibody, Unconjugated from GeneTex

Description:...Background Information MAP kinases consist of several subgroups, including the ERK, JNK, and p38 kinases. The members are regulated by many different extracellular cues ranging from cytokines, growth factors, and neuropeptides. These stimuli activate cell surface receptors to stresses such as cold, heat, osmolari...
Company:GeneTex

jetPEI-RGD + NaCl sol. from Polyplus Transfection

Description:...esion processes. Many integrins, including a51 and most aV-containing proteins, bind multiple Arg-Gly-Asp (RGD) peptide sequences present in serum and extracellular matrix proteins. jetPEI-RGD/DNA complexes present many short RGD peptides on their surface and mimic the integrins natural ligands, hence the targetin...
Company:Polyplus Transfection

Anti-Integrin alphaVbeta3 (CD51 / CD61) Monoclonal Antibody, Biotin Conjugated, Clone LM609 from CHEMICON

Description:...eractions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor.3 Due to its involvement in angiogenesis, the integrin aVb...
Company:CHEMICON
Extracellular in Biological Definition

Animal

...alled metazoans, or eumetazoans when the former is used for animals in general. All animals have eukaryotic cells, surrounded by a characteristic extracellular matrix composed of collagen and elastic glycoproteins . This may be calcified to form structures like shells, bones, and spicules. During deve...

Apoptosis

...or pathogenic infection (cell death by necrosis ). Instead of swelling and bursting - hence spilling their possibly damaging internal contents into extracellular space - apoptotic cells and their nuclei shrink, and often fragment. In this way, they can be efficiently phagocytosed (and, as a consequence of t...

Cytosol

... pressure. Details The cytosol is 20% to 30% protein . Normal human cytosolic pH is (roughly) 7.0 (i.e. neutral), whereas the pH of the extracellular fluid is 7.4. ...

Depolarization

... In biology, depolarization refers to the event a cell undergoes when its membrane potential grows more positive with respect to the extracellular solution. Depolarization typically results from the influx of positively charged ions (such as sodium or calcium ) into the cell. Alternatively, ...

Electrophysiology

...orming "in-vivo" recording from live animals. 2. extracellular recording. In this technique an electrode is placed on the extracellular medium and field-potentials contributed by the act...re recorded. Some popular clinical applications of extracellular recording are the electrocardiogram (ECG) and th...

Endosymbiont

...biosis is a term which is used for both intra- and extracellular symbionts. In marine oligochaetes (e.g Olavius or Inanidrillus) the endosymbionts are extracellular and they fill the entire body of their host. These...ial endosymbionts in other marine invertebrates extracellular endosymbionts are also represented in all 5 extant...
Extracellular in Biological Dictionary

Zona pellucida

... binding sites is suggested as an ... the structure and function of the extracellular zona pellucida . ... In mice and humans, this matrix is known as the zona pellucida ... The mammalian zona pellucida is an extracellular matrix that ... altered mice lacking a zona pellucida due to loss of ZP...

Transmembrane receptor

...r Transmembrane receptors are specialized integral membrane proteins that take part in communication between the the cell and the outside world. extracellular signaling molecules attach to the receptor , triggering... G protein-coupled receptors (GPCRs), also known as seven- transmembrane domain recepto...

Transmembrane proteins

...r Transmembrane receptors are specialized integral membrane proteins that take part in communication between the the cell and the outside world. extracellular signaling molecules attach to the receptor, triggering... Transmembrane protein A transmembrane protein is a protein that spans the entir...

Sarcolemma

... sarcolemma , separates the sarcoplasm (muscle cell cytoplasm) from the extracellular surroundings. Within the sarcoplasm of each... A T-tubule is a deep in...ing of sarcolemma , sarcoplasmic reticulum, and myofibrils. Remodelling of extracellular matrix and sarcolemma as well as changes in signal ... ... the Na+-Ca2...

Proto-oncogene

...ell. The RET proto - oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules. RET loss of function mutations are associated with the... ... of this gene is "ret proto - oncogene ." RET is the gene's o...

Plasmalemma

...he plasmalemma (Fig 6b) ... Peripheral proteins are not attached to the plasmalemma . ... I already noted that the plasmalemma separates the extracellular fluid space ... and the plasmalemma acting as a barrier, but with a great variety of doors ... Myo' and 'sarco' are adjectives for muscle, thus...
Other Tags
(Date:4/17/2014)... NEW YORK, NY (April 16, 2014) The cause ... but a new study proposes that neurons may be ... own immune system, similar to the way autoimmune diseases ... attack the body,s cells. The study was published April ... is a new, and likely controversial, idea in Parkinson,s ...
(Date:4/17/2014)... Irvine, Calif., April 17, 2014 By discovering a ... immediately after a stroke, researchers at UC Irvine and ... therapies that may limit or prevent stroke-induced brain damage. ... the fourth-leading cause of death and primary reason for ... damaged in a stroke and lets blood-borne material into ...
(Date:4/17/2014)... 2014 EcoHealth Alliance, a nonprofit organization that focuses ... comprehensive review today examining the current state of knowledge ... calls for improved global surveillance strategies to combat the ... of Ebola in West Africa that has claimed the ... and Liberia. According to the World Health Organization ...
(Date:4/17/2014)... potential to ward off depression among retirees, particularly among ... in The Journals of Gerontology, Series B: ... article " Internet Use and Depression Among Retired Older ... the authors report that Internet use reduced the probability ... study sample. , Late-life depression affects between 5 ...
(Date:4/17/2014)... Population Council scientists and their partners have found that ... prevent the transmission of multiple sexually transmitted infections (STIs) ... herpes simplex virus 2 (HSV-2), and human papillomavirus (HPV). ... the gel is effective against multiple strains of HIV, ... against all three viruses of at least eight hours ...
Breaking Medicine News(10 mins):Health News:Is Parkinson's an autoimmune disease? 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:Internet use may cut retirees' depression 2Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2
(Date:4/17/2014)... Respiratory syncytial virus (RSV) is a leading cause ... in very young and elderly populations. Despite great ... cells through the fusion protein RSV F, which ... that prevent bundle formation limit RSV infection in ... degradation. In this issue of the Journal ...
(Date:4/17/2014)... Luca Razzari of the nergie Matriaux Tlcommunications Research ... the John R. Evans Leaders Fund of the ... of state-of-the-art biotech and nanophotonics equipment. To this ... Ministre de l,Enseignement suprieur, de la Recherche, de ... new laboratories will help us develop new approaches ...
(Date:4/17/2014)... marrow need to produce hydrogen sulfide in order to ... new study from the Center for Craniofacial Molecular Biology ... , Professor Songtao Shi, principal investigator on the project, ... cells governs the flow of calcium ions. The essential ... in osteogenesis, or the creation of new bone tissue, ...
Breaking Biology News(10 mins):JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6New state-of-the-art biotech and nanotech equipment for INRS 2
Other Contents