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Excretion in Medical News

Immunoglobulin Can Predict Some Diabetic Complications

... Increased excretion of IgM foretells serious cardiovascular issues: s...y to investigate the impact of increased urine IgM excretion on DN disease progression in type 1 diabetes patie...e. "We found that those with increased urinary IgM excretion had a higher mortality from cardiovascular causes ...

A Curse or Two Might Quell the Pain

... Typically, taboo words arise from sex, excretion, religion, death, illness and social groups, such as racial or ethnic minorities. Though sex and excretion get the most play in the United States, Stephens said, the Dutch have been reported to use such words as tering (tuberculosis) and kanker (cancer)...

Hyperion Therapeutics Raises $60 Million Series C

...uid form, is under clinical investigation as providing a potential alternative pathway to the urea cycle for the disposal of ammonia through the renal excretion of phenylacetylglutamine, which is formed from phenylacetic acid and glutamine. About Urea Cycle Disorders Urea cycle disorders are inherited, ...

Discovery Points to Regulation of Calcium Metabolism

...DN14 and the metabolism of calcium, a key component of bone and of most kidney stones. They concluded that the SNP may contribute to increased calcium excretion in urine, a major risk factor for kidney stones and also a sign of bone loss. The study appears online June 28 and in an upcoming print edition of ...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

...etylglutamine (PAGN). PAGN mediates waste nitrogen excretion and ammonia removal. The extent of plasma exposure...as given fasting on day 1 or with a meal on day 8. excretion of the main metabolite PAGN was similar between he...2-49% of the administered dose, and the mean total excretion of PAGN after the last dose in the study (day 15) ...

Intestinal bacteria associated with non-alcoholic fatty liver disease

...of small intestinal bacterial overgrowth in each participant using glucose breath testing. They assessed intestinal permeability by looking at urinary excretion of Cr-EDTA. And they examined the integrity of tight junctions within the gut through duodenal biopsies. "The main findings of this study are that...
Excretion in Medical Technology

Covance Announces Integrated Radiolabeled Clinical Pharmacology Studies

...nd Drug Administration (FDA) guidance on Metabolites in Safety Testing (MIST). Recent MIST guidance requires earlier human absorption, metabolism and excretion (AME) testing in support of Investigative New Drug/Clinical Trial Application (IND/CTA) submissions. "Integrated human AME services are designed...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

...ighest dose accompanied by a significant increase (>100-fold) in glucose excretion in the urine in multiple species including monkeys Secondary improv...the activity of the drug by measuring the effect of ISIS-SGLT2Rx on glucose excretion in urine. We are excited to continue to move this drug forward through dev...

Hyperion Therapeutics Announces Results for Phase II Study in Urea Cycle Disorders

... HPN-100, which is dosed orally in liquid form, provides an alternative pathway to the urea cycle for the disposal of waste nitrogen through the renal excretion of phenylacetylglutamine, which is formed from phenylacetic acid and glutamine. Hyperion and Ucyclyd Pharma, Inc., a subsidiary of Medicis Pharma...

Hyperion Therapeutics Completes Enrollment in Phase 1/2 Clinical Trial in Patients With Urea Cycle Disorders

... HPN-100, which is dosed orally in liquid form, provides an alternative pathway to the urea cycle for the disposal of waste nitrogen through the renal excretion of phenylacetylglutamine, which is formed from PAA and glutamine. About BUPHENYL(R) BUPHENYL(R) is indicated as adjunctive therapy in the chronic ...

Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference

...ose re-absorption in the kidney. Decreasing SGLT2 function promotes glucose excretion to help reduce blood sugar levels, making it an attractive target for the t...ced target mRNA levels in several animal species, increased urinary glucose excretion and consequently lowered blood glucose levels and HbA1c (in hyperglycemic a...

Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594

...ptake of uric acid ex vivo and increases uric acid excretion in animal models. These effects are believed to re...h RDEA806 in healthy volunteers, increased urinary excretion of uric acid was observed in the first 24 hours af... to be under-excretors of uric acid, so increasing excretion may provide the most physiologically appropriate t...
Excretion in Medical Products

MM-PTH RIA Test

Description:... secreted in response to decreased extracellular calcium concentrations. PTH prevents hypocalcemia by enhancing bone resorption and decreasing calcium excretion by the kidney. Following release into the circulation, intact PTH is rapidly degraded into 4 fragments: N-terminal (residues 1-34), C-terminal (residu...
Company:Diagnostic Systems Laboratories, Inc.

C-PTH RIA Test

Description:... secreted in response to decreased extracellular calcium concentrations. PTH prevents hypocalcemia by enhancing bone resorption and decreasing calcium excretion by the kidney. Following release into the circulation, intact PTH is rapidly degraded into 4 fragments: N-terminal (residues 1-34), C-terminal (residu...
Company:Diagnostic Systems Laboratories, Inc.

I-PTH IRMA Test

Description:... secreted in response to decreased extracellular calcium concentrations. PTH prevents hypocalcemia by enhancing bone resorption and decreasing calcium excretion by the kidney. Following release into the circulation, intact PTH is rapidly degraded into 4 fragments: N-terminal (residues 1-34), C-terminal (residu...
Company:Diagnostic Systems Laboratories, Inc.

I-PTH ELISA Test

Description:... secreted in response to decreased extracellular calcium concentrations. PTH prevents hypocalcemia by enhancing bone resorption and decreasing calcium excretion by the kidney. Following release into the circulation, intact PTH is rapidly degraded into 4 fragments: N-terminal (residues 1-34), C-terminal (residu...
Company:Diagnostic Systems Laboratories, Inc.

Unconjugated Estriol, Ultra-Sensitive EIA Test

Description:...of magnitude greater than non-pregnant levels [1,2]. In the maternal circulation, estriol undergoes rapid conjugation in the liver followed by urinary excretion with a half-life of ~20 minutes [2]. Since normal estriol production depends on an intact maternal-placental-fetal circulation and functional fetal me...
Company:Diagnostic Systems Laboratories, Inc.

Unconjugated Estriol, Ultra-Sensitive RIA Test

Description:...of magnitude greater than non-pregnant levels [1,2]. In the maternal circulation, estriol undergoes rapid conjugation in the liver followed by urinary excretion with a half-life of ~20 minutes [2]. Since normal estriol production depends on an intact maternal-placental-fetal circulation and functional fetal me...
Company:Diagnostic Systems Laboratories, Inc.
Excretion in Medical Dictionary

Urinary Incontinence

...dications. Surgery ... Urinary incontinence is generally categorized into the following types: ... Urinary incontinence is the involuntary excretion of urine from one's body. ... 3.1 Urinary incontinence in women. 4 Treatment. 4.1 Exercises. 4.2 Vaginal cone ... Because the prevalence ...

Red urine

...t Pigment? Sandi Ackerman in consultation with Barbara Deeb, DVM, MS ... Red urine is not a medical problem. ... ... APPROACH The intermittent excretion of red to brown urine can be seen in a ... Things that go red in the urine ; and others that don't (editorial). Lancet ... INTRODUCTION One...

Oliguria

...e to ... The etiology of oliguria may result by neurohormonal, pre-, post or intra ... oliguria ( ′älə′gyu̇rēə ) ( medicine ) Diminished excretion of urine. ... Oliguria is defined as a urine output that is less than 1 mL/kg/h in infants, ... List of 106 disease causes of Oliguria , pa...

Nephrosis

...osy, etc... Nephrosis . Causes. Nephrotic syndrome is caused by various disorders that damage the kidneys, ... This immediately causes abnormal excretion of protein in the urine. ... Nephrosis - Definition of Nephrosis at Dictionary.com a free online dictionary ... Link To nephrosis . What is...

Nephrocalcinosis

...phrocalcinosis is a kidney disorder in which there is an increased amount of ... Nephrocalcinosis may be caused by a number of conditions: Excess excretion of ... ...

Fecal fat

...levels include enemas and laxatives, ... Excessive excretion of fecal fat is called steatorrhea, a conditio...The ... Table 1 - Mean ( SD) 24-hour fecal fat excretion in 1 7-day run-in period ... West Shore Endosc...hers, ... Effect of orlistat dose on fecal fat excretion ... ... is that dietary calcium increases f...
Excretion in Biological News

Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers

...cantaloupe, grapefruit, papaya, okra, winter and zucchini squash, granola and oatmeal. No supplements were used. "The reduction of urinary calcium excretion on high-fiber diets tells us that the amount of dietary fiber has a direct impact on calcium absorption," Dr. Garg said. "In other words, the particip...

Common gene variants increase risk of hypertension, may lead to new therapies

...re involved in the production of atrial and B-type natriuretic peptides (ANP and BNP) proteins known to relax blood vessels and to be involved in the excretion of dietary sodium. Animals in which both copies of NPPA have been knocked out are hypertensive, and even those with a single functional copy will deve...

Researchers may have found why women have an edge on salt-sensitive hypertension

...ys compared to males and actually increases sodium excretion without increasing blood pressure. Researchers fou...the ETB receptor increased urine output and sodium excretion in both sexes, suggesting that it was not a player...to look at how ETA receptor blockers impact sodium excretion in humans. ...

Calcium and vitamin D may not be the only protection against bone loss

... Chevy Chase, MDDiets that are high in protein and cereal grains produce an excess of acid in the body which may increase calcium excretion and weaken bones, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism ( JCEM...

Toxic bile damages the liver

...ness can begin in childhood or at an adult age and lead to death. The gene ensures the production of a transporter protein that is responsible for the excretion of phosphatidylcholine into bile. Phosphatidylcholine protects the liver from toxic substances in the bile; a low concentration can thus lead to liver...

Athletes' 'sweat and tears' linked to asthma

...of EIA. Researchers also found a correlation between the net sweat fluid excretion and net sweat sodium excretion, with sodium excretion rates being higher in subjects who were unresponsive to methacholine compar...
Excretion in Biological Technology

deCODE Discovers a Gene Linked to Risk of Kidney Stones and Osteoporosis

...team examined the relationship between CLDN14 and the metabolism of calcium. The results suggest that the SNP may be contributing to increased calcium excretion in urine, a major risk factor for kidney stones and also a sign of bone loss. "This is an exciting finding because it uncovers a highly plausib...

First H1N1 Swine Flu Vaccine, Replikins-Based, Is Ready Now for Testing Worldwide

...t H5N1 avian flu, produced in a 7-day period, was recently tested at the University of Georgia and shown to block H5N1 virus entry, replication, and excretion in chickens (paper submitted for publication). Institutions requesting Replikins' H1N1 vaccine for testing should contact John McKenney at jmcken...

H1N1 Influenza "Swine Flu" Peptide Vaccine Now Available For Testing Worldwide

... against avian flu, produced in a 7 day period, was recently tested at the University of Georgia and shown to block H5N1 virus entry, replication, and excretion in chickens (paper submitted for publication). Institutions requesting Replikins' H1N1 vaccine for testing should contact: jmckenney @ replikins.c...

Biotechnology Company, Replikins Ltd., Provided Advance Warning of Mexican H1N1 'Swine Flu' Virus Outbreak

... is available for testing. A similar synthetic Replikin Vaccine has been shown to successfully block the entry of H5N1 virus into, replication in, and excretion from chickens. The company is able to produce these vaccines in as little as 7 days, rather than the many months needed for traditional vaccines, beca...

Biotechnology Company Provided Advance Warning of Mexican H1N1 "Swine Flu" Virus Outbreak

... is available for testing. A similar synthetic Replikin Vaccine has been shown to successfully block the entry of H5N1 virus into, replication in, and excretion from chickens. Another synthetic Replikin Vaccine has been shown to protect 91% of shrimp from the lethal Taura Syndrome Virus. The company is able to...

Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug

... kidney. Decreasing SGLT2 levels promotes glucose excretion in the urine and reduces blood sugar levels, makin...2Rx's activity by evaluating its effect on glucose excretion in urine. "In several preclinical models, we ...ney and decreasing SGLT2 function promotes glucose excretion to help reduce blood sugar levels, making it an at...
Excretion in Biological Definition

Excretion

Excretion is the biological process by which an organism separates waste products from its body. The waste products are then usually expelled from the body by elimination . In mammals , for example, the two major excretory processes are the formation of urine in the kidneys and the fo...

Albumin

...) Buffers pH Causes of albumin deficiency: Cirrhosis of the liver (most commonly) Decreased production (as in starvation) Excess excretion by the kidneys (as in nephrotic syndrome ) Excess loss in bowel (protein losing enteropathy) Mutation causing albuminemia (very rare) L...

Hormone

...ostatic control system, generally by negative feedback . Homeostatic regulation of hormones depends, apart from production, on the metabolism and excretion of hormones. Hormone secretion can be stimulated and inhibited by: Other hormones ( stimulating or releasing -hormones) Plasma concentratio...

Kidney

... bladder . The ureter carries urine from the kidneys to the bladder by means of peristalsis . Renal functions Renal functions include the excretion of waste material from the bloodstream, secretion of hormones - particularly erythropoietin and renin and maintaining serum electrolyte, acid-bas...

Metabolism

...metabolism Nitrogen metabolism includes the pathways for turnover and excretion of nitrogen in organisms as well as the biological processes of the biogeochemical nitrogen cycle : Urea cycle , important for excretion of nitrogen as urea. Biological nitrogen fixation Nitrogen assimil...

Osmoregulation

...d the convoluted tubules. secretion - the remaining fluid becomes urine which travels down collecting ducts to the medullary region of the kidney. excretion - the urine (in mammals) is stored in the urinary bladder and exits via the urethra; in other vertebrates the urine mixes with other wastes in the clo...
Excretion in Biological Dictionary

Excretion

Excretion is the process of eliminating waste products of metabolism and other non-useful materials. It is an essential process in all forms of life. It contrasts secretion, where the substance may have specific tasks after... the process by which animals rid themselves of waste products a...

Osmoregulation

...s that serve also for the ... Thus, urination is a mechanism of both waste excretion and osmoregulation . ... Definition of osmoregulation from the Merri...nal information on Osmoregulation from Biology-Online.org dictionary. ... excretion and Osmoregulation in Phylum Platyhelminthes? ... This page investig...

Homeostasis

...entury ... Homeostasis (a Greek term meaning same state), is the maintenance of constant ... Mechanisms of Sodium Homeostasis : Sodium and Water excretion in Mammals; ... ...

Deamination

...ng places at Britannica. Assorted References amino acid degradation ( in excretion (biology): Products of excretion ) ...deal is used as a source of energy to drive other vital processes. Th...

Coelom

...rmine the identifying physiological characteristics of Mollusks, identify ... coelom . soft body. head-footvisceral massmantle. radula. Digestion and excretion ... In the Amphioxus the coelom is developed in the embryo as a series of bilateral ... In the intestinal region the coelom is only present o...
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