Elusive HIV shape change revealed; Key clue to how virus infects cells
Structural biologists at Children's Hospital Boston and Harvard Medical School have shown how a key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue of the journal Nature, offer clues that will help guide vaccine and treatment approaches. Researchers led...Timing is everything: First step in protein building revealed
Timing is everything, it seems, even inscience. A team led by Johns Hopkins scientists has unraveled the firststep in translating genetic information in order to build a protein,only to find that it's not one step but two.In a series of experiments, the scientists found that when yeast'sprotein-building machinery recognizes the starting line for a gene'sinstructions, it first alters its str...Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
The replenishment of missing neurons in thebrain as a treatment for Parkinson disease reached the stage of humantrials over 15 years ago, however the field is still in its infancy.Researchers from Kyoto University have now shown thatdopamine-producing neurons (DA neurons) generated from monkey embryonicstem cells and transplanted into areas of the brain where these neuronshave degenerated i...A much-needed shot in the arm for HIV vaccine development
International efforts towards developing avaccine against HIV infection have been given a much-needed boost bythe publication today of the Global HIV/AIDS Vaccine Enterprise'sscientific strategic plan, published online in the freely available,open-access global health journal PLoS Medicine.The Global HIV/AIDS Vaccine Enterprise is an international alliance ofindependent agencies and organiz...NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis
New York University biologists have uncovered how the innate immune system in mice's brains fights viral infection of neurons. The findings, published as the cover study in the latest issue of Virology, show that proteins in neurons fight the virus at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brai...Alsever's Solution from Sigma-Aldrich
Description:Alsevers solution is an isotonic, balanced salt solution. It is routinely used as an anticoagulant/blood preservative, which permits the storage of whole blood at refrigerator temperatures for approximately 10 weeks.1 For usage, an equal volume of blood is collected into a container of this product and gently, but thoroughly, mixed. The solution is placed in a refrigerator at 2-8 C for 2 weeks. T...Hybridoma Development from QED Bioscience Inc.
Description:QED Bioscience has over 23 years of experience in the development of hybridoma cells lines. We have made antibodies to large and small peptides, proteins, haptens, carbohydrates, bacterial and viral antigens, and plasmid DNA-encoded antigens. We understand and appreciate that every antigen is unique, so our hybridoma development programs are never "cookbook". We will tailor a program to your need...Reverse-iT One-Step Kit, ReddyMix from ABgene
Description:The Reverse-iT One-Step Kit is the ultimate in convenience, sensitivity and reproducibility in RT-PCR. It has been specifically designed to streamline the RT-PCR process. The Reverse-iT One-Step Kit combines the unique Reverse-iT Blend of RTases and ABgene®s Thermoprime Plus DNA Polymerase to provide a highly sensitive, reproducible and easy-to-use system for the det...Equine TNF alpha ELISA development Kit, Screening Set from Endogen
Description:Endogens Screening Sets contain the basic components and protocol required to develop five colorimetric sandwich ELISA plates for quantitation of a specific protein in 100 l/well of cell culture supernate. Every Screening Set contains Coating and Detection Antibodies, Recombinant Standard (5 individual standards), Streptavidin-HRP, TMB Substrate Solution (one-step) and Stop Solution. Each standar...High-Level Expression of Peanut Allergens Affected by Rare Codon Usage
Biochemical & Molecular Allergology, Research Center Borstel, Germany By using Stratagenes BL21-CodonPlus(DE3)-RIL cells * withextra copies of E. coli, argU, ileY, and leuW tRNA genes,it is possible to attain high-level expression...High-Level Protein Expression, One-Column Purification, and FLAG Epitope Tagging in E. coli
Epitope Tagging in E. coli Katherine Felts Denise Wyborski John Bauer PeterVaillancourt Stratagene LIC cloning kit...Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons*
N.Y. Zachariah Department of BiomedicalSciences, University of North Texas Health Science Center This article...Enzyme Immunoassay for Studying Intracellular Levels of cAMP
Sensitive, nonradioactive cyclic-AMP detection kit and adenylate cyclase(AC) toxin Stratagene Cloning Systems, Inc. American Qualex Stratagenes EIA cAMP Kit is a highly sensitive and specificantibody-based assay kit for no...Evolutionary developmental biology
in an attempt to determine the ancestral re...Asthma may actually be prevented by Dust and Dirt
National Jewish Medical and Research Center researchers in USA say that a little dust and dirt in the home may help prevent asthma later in life. Environmental endotoxin may have an allergy-protective effect in some infants whose homes have high levels of the bacteria by-product. "Endotoxin seems to drive the immune system to produce cytokines that inhibit certain processes in the body th...Virus Level could Predict Cervical Cancer Risk
Cervical cancer is one of the most common cancers in women. If it is caught and treated early, it is curable in most cases.// The Pap smear is the standard screening method for the disease. It is used to detect unusual, precancerous changes in cervical cells. Two strains of the human papilloma virus (HPV) are associated with an increased chance of getting the cancer, but not all women who...Human Genome Project Achieves Technological Triumph
The completion of rough draft sequence of the human genes is a major scientific milestone and was achieved on 26.06.2000. The project began more than 10 years ago to map out almost 35 billion chemical letters that make up the recipe of human life. This breakthrough is expected to revolutionize the practice of medicine by paving the way for new drugs and medical therapies.Specific sequ...Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
It is not high levels of cholesterol but low levels that are making news. Recent reports are indicating that Low levels of Cholesterol maybe linked to depression and violent behavior. A new study shows that men with relatively low cholesterol levels were up to seven times more likely to report symptoms of severe depression. Edward Suarez, PhD from Duke University Medical Center in Durha...Developmental, neurologic problems common in extremely preterm infants
Extremely preterm infants born before 25 weeks' gestation often have severe neurologic and developmental disabilities, researchers report in the August 10th issue of The New EnglandJournal of Medicine.The EPICure Study Group identified 308 children born at the gestational age of 25 weeks or earlier in the UK and Ireland. Of these, 283 were assessed for neurologic function Based on their l...Stevenson Lacrimal Sac Retractor
Description:Solid 13.5 mm wide by 5 mm deep blades. Edge of blades serrated. Dull finish....Shepard Reversible Open Blade Speculum
Description:Open blade speculum designed for both temporal and superior approach ocular surgery. Thumb screw adjusting mechanism. Manufactured in titanium....Monitoring Patient Glucose Levels: New Advances in software make it easier
Monitoring patient glucose levels and determining the response to intervention is critical when working with diabetic clients. The benefit of doing so in improved outcomes for both type 1 and type 2 diabetes has been clearly established by clinical trials conducted in both the U.S. and the UK1. Self- monitoring by patients of glucose levels, and the data provided is especially important for p...New Quality Control Systems for Every Laboratory Application
Quality Control (QC) materials and procedures are key to meeting the needs of doctors and patients by verifying accuracy and precision of analytical methods. Vendors of these systems can be a valuable resource, designing customized QC materials and protocols to help lab managers ensure that analytical error st...Urinalysis Analyzers: Large Capabilities in Every Size Device
Urine chemistry analysis, often conducted in a physicians office practice, can be instrumental in the detection of a wide array of ailments; UTIs, diabetes, several cancers, metabolic disorders, cardiovascular and kidney diseases. The estimated global market for urinalysis tests is well in excess of $600 million per year and is growing strongly. For such a fundamental, extensive and economic...