A gene's first 'kiss' sets off that affair known as puberty
Puberty, that awkward phase when boys and girls are primed for their sexual reproductive years as men and women, appears to be triggered by the brain's own version of "It takes two to tango," whereby a signal literally gets turned on by a molecule that is produced by a gene aptly named KiSS-1. The couple ?a biochemical equivalent to Adam and Eve ?makes its sudden appearance in a region of...UW's Rosetta software to unlock secrets of many human proteins
University of Washington TechTransferrecently licensed software that will give scientists a huge advantagein the fight against disease.The software, known as Rosetta, predicts how proteins fold, informationthat is highly valuable to biological and biomedical researchers.UW Tech Transfer's Digital Ventures licensed Rosetta software withoutcharge to the Institute for Systems Biology (ISB), a...A bacterial genome reveals new targets to combat infectious disease
More than a billion people are at risk for infection with filarial nematodes, parasites that cause elephantiasis, African river blindness, and other debilitating diseases in more than 150 million people worldwide. The nematodes themselves play host to bacteria that live within their cells, but in this case, the relationship is classic mutualism, with each benefiting from the other. Indeed, the Wo...Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
As you read this, cells in your eye are transmitting information to your brain, while cells in your heart and arteries work just as hard to keep that brain alive. Every one of these cells -- and others throughout the body -- depends on an internal process called endocytosis to keep the flow of cellular nutrients and information healthy and strong. It's an incredibly important life process,...Scientists reveal molecular secrets of the malaria parasite
In an innovative project with implicationsfor malaria vaccine development, scientists have used genomics,proteomics and gene expression studies to trace how malaria parasitesevolve on a molecular level as they move between their hosts and insectvectors.That focus on the parasites' complex life cycle is helping researchersunderstand when different genes switch on and off as the pathogensmet...Orfmer Sets - S. aureus from Sigma-Genosys
Description:In an effort to help promote genomics-based research with S. aureus, Sigma-Genosys has developed the Staphylococcus aureus ORFmer set that contains PCR primers to amplify all open reading frames (ORFs) in the COL strain1. In addition, primer pairs are included to amplify ORFs that are unique to both the Mu50 and N315 strains of S. aureus. The ORFmer set contains primers to amplify all 2,731 ORFs...Orfmer Sets - S. typhimurium from Sigma-Genosys
Description:The recent sequencing of Salmonella genomes has allowed the development of the S. enterica Typhimurium ORFmer PCR* primer pairs. The S. enterica Typhimurium (strain LT2) genome consists of a single chromosome (4,857,432 bp; 4,440 ORFs) and a plasmid, pSLT (93,939 bp; 107 ORFs). These ORFmers from Sigma-Genosys have been designed to amplify all putative open reading frames (ORFs) in S. enterica se...jetSI-ENDO-FluoR from Polyplus Transfection
Description:jetSI-ENDO-FluoR is a tetramethylrhodamine-conjugated jetSI-ENDO (excitation at 555 nm; emission at 580 nm), the powerful siRNA transfection reagent. These reagents are used to determine the transfection efficiency or investigate the intracellular delivery and trafficking of siRNAs. More than 95 % of the cell population is transfected....jetSI-ENDO from Polyplus Transfection
Description:jetSI-ENDO is an easy-to-use siRNA transfection reagent that has been shown to knock out endogenous genes in a variety of cell lines. jetSI-ENDO is serum compatible and comes with an optimized, straightforward protocol. High levels of gene silencing (up to 80%) are obtained following transfection of 20 to 100 nM of siRNA in a stably expressing reporter gene cell line, A549Luc....jetSI-ENDO-FluoF from Polyplus Transfection
Description:jetSI-ENDO-FluoF is a fluorescein-conjugated jetSI-ENDO (excitation at 490 nm; emission at 520 nm), the powerful siRNA transfection reagent. These reagents are used to determine the transfection efficiency or investigate the intracellular delivery and trafficking of siRNAs. More than 95 % of the cell population is transfected....RT-PCR Primer Sets for Human and Mouse Mismatch Repair Genes
Stratagene Cloning Systems from the cDNAsequences of mismatch repair genes. These genes code for specialized proteinsthat participate in correcting areas of base mispairing in DNA. We have...Enhanced Amplification of Long Targets with PfuTurbo DNA Polymerase
DNAPolymerase Stratagene DNA polymerase* by making simple modifications to PCR reactionconditions. In this update, we d...Printable CELLocate Log Sheets for Easily Locating Adhererent Cells
Log Sheets for Easily Locating Adhererent Cells CELLocate is the ideal solution for relocating adherent cells that have been used for microinjection. These sterile coverslips come with a microgrid pattern. Using the CELLocate proto...Development of Radioligand Binding Assays for the Motilin Receptor Using ScreenReady Targets.
Recent advances in combinatorial chemistry and genomics programs have led to an unprecedented increase in both the number of compounds and potential drug targets that can be screened. The development of automated liquid h...Calcium Plus Assay Kit, Superior Detection for Specialized Targets
HIGHER MAXIMUM SIGNAL RAPID PROCEDURE COMPATIBLE WITH MORE TARGETS SUITABLE FOR HTS APPLICATONS The Calcium Plus Assay Kit provides a reliableand homogeneous method for detecting changesin intracellula...Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
Huntingtons disease is an inherited disease of the nervous system due to the progressive gradual deterioration of the same, initially causing symptoms such as involuntary movements and balance problems and later on leading to declination of functions of speech as well. All these days, until now, it was thought that this disease is due to a mutated form of the protein 'huntingtin' which i...Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
Huntingtons disease is an inherited disease of the nervous system due to the progressive gradual deterioration of the same, initially causing symptoms such as involuntary movements and balance problems and later on leading to declination of functions of speech as well. All these days, until now, it was thought that this disease is due to a mutated form of the protein 'huntingtin' which i...Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
Drug abuse,has been at its best of raise over the past decade or two and with the increased incidence of consumption of drugs in teens.Researchers at a conference sponsored by the National Institute on Drug Abuse said that the drug known as ecstasy has a negative impact on blood flow to parts of the brain and that the effect can persist for weeks. ECSTASY is the name in vogue for the c...Foot and mouth disease sets foot in China
After the much talked about bird flu in Asia there comes news from China about the foot and mouth disease. The Ministry of Agriculture of China has given the info that an outbreak of Asia// Type One foot-and-mouth disease on a farm in Changqing District of Jinan City, capital of east China's Shandong Province, has occurred. The incidence was reported when some cattle on the farm began...Sheets-McPherson Angled Tying Forceps
Description:Angled 45 degree shafts with 10.5 mm tying platform. 1 mm of tip is crisscross serrated. Serrated handle with dull finish. Most popular size or model. Overall length 3.2 inches....Sheets-Kelman-McPherson Forceps
Description:Angled 45 degree shafts with 10.5 mm tying and 1 mm of tip crisscross serrated. Serrated handle with dull finish. Manufactured in titanium. Overall length 3.2 inches....Tumbling E Pad(100 sheets) BCE
Description:Printed with large 20/200 E on one side and a series of five 20/20 tumbling Es on the other- calibrated to a 20 ft. distance. May be used to test and train peripheral awareness....ENDEAVOR IV Clinical Trial Meets Primary Endpoint
MINNEAPOLIS--(BUSINESS WIRE)--Jul 2, 2007 - Medtronic, Inc.,(NYSE:MDT) today announced that a review of data from the ENDEAVORIV Clinical Trial indicates that the trial has met its primary,non-inferiority endpoint. The ENDEAVOR IV Clinical Trial is a randomized, single-blindtrial evaluating the safety and efficacy of the Endeavor(TM) DrugEluting Coronary Stent as compared to the TAXUS Pac...Neoprobe Phase 2 Lymphoseek Trial Meets Primary Endpoint
DUBLIN, Ohio--(BUSINESS WIRE)--Jun 20, 2007 - Neoprobe Corporation(OTCBB:NEOP), a diversified developer of innovative oncology andcardiovascular surgical and diagnostic products, today announcedpositive preliminary results from a multicenter Phase 2 clinicalstudy of its lead clinical candidate, Lymphoseek(R) (TechnetiumTc99m DTPA-mannosyl-dextran). Lymphoseek is a proprietaryradioactive tar...