Etoposide

St. Jude finds more than 100 gene variations linked with response to leukemia treatment

...interleukin." In addition, 21 of the 102 SNPs that predicted MRD also significantly associated with the pharmacokinetics of two antileukemic drugs, etoposide and methotrexate, which are representative of the array of antileukemic medications used to treat lymphoblastic leukemia. Pharmacokinetics comprises t...

Frost & Sullivan Recognizes Neotropix's Approach to the Treatment of Small Cell Lung Cancer and Neuroendocrine Cancers

...ally, for SCLC, chemotherapy dosing is usually given every day for three days, with the cycle repeated every 21 days. The combination of cisplatin and etoposide is inconveniently administered through an IV infusion. Comparatively, NTX-010 requires only one systemic dose because it can replicate itself and...

CSHL scientists correlate enzyme expression levels with chemotherapy drug response

...s by which cells divide and multiply. By interfering with topoisomerases in cancer cells, doxorubicin and other drugs in the same class including etoposide and camptothecin derivatives have been thought to prevent cancer cells from proliferating. Their effectiveness as front-line treatments is beyond dis...

Study Showed ALIMTA(R) (pemetrexed for injection) Improved Survival in Certain Types of Non-Small Cell Lung Cancer

... versus cisplatin alone) and a 21-day regimen (GEMZAR plus cisplatin versus etoposide plus cisplatin), respectively, were neutropenia (57 vs 4, 64 vs 76); thromb...ersus cisplatin alone) and the 21-day regimen (GEMZAR plus cisplatin versus etoposide plus cisplatin), respectively, were anemia (89 vs 67, 88 vs 77); leukopenia...

Sunesis Pharmaceuticals Presents Nonclinical Data on SNS-595 at the Annual Meeting of the American Association for Cancer Research

...ast and ovarian cancers and acute myeloid leukemia against other agents, SNS-595 demonstrated potent activity and compared favorably with doxorubicin, etoposide and platinum therapy at clinically relevant concentrations. SNS-595 is not a P-glycoprotein substrate and its activity is independent of the p53 famil...

High-Dose Chemo Fails Against Small Cell Lung Cancers

...the University Hospital in Lausanne, Switzerland, compared high-dose and standard-dose chemotherapy using the drug agents: ifosfamide, carboplatin and etoposide (ICE). The survival rates in the group were similar: 18 percent of the high-dose patients were alive after three years, 19 percent of standard-dos...

High-intensity chemotherapy does not improve survival in small cell lung cancer

...trial that compared high-dose and standard-dose chemotherapy. Both groups were treated with the same chemotherapy agents, ifosfamide, carboplatin, and etoposide (ICE). The 3-year survival rates in the two arms were similar, with 18 percent of patients in the high-dose arm and 19 percent of patients in the s...

Doctors Discover Hair-loss Prevention Drug for Cancer Patients

... the research said Monday . Toshiyuki Sakai said his team had found "alopestatin" reduced hair loss by 70 percent when used on rats also given etoposide anti-cancer drugs. Etoposide is widely used to treat lung and other cancers but can cause hair loss. Sakai, professor at Kyoto Prefect...

Amrubicin Shows Encouraging Results for Small Cell Lung Cancer Treatment

...single-agent therapy in patients refractory to first-line therapy; and one as single-agent or combination therapy with cisplatin versus cisplatin plus etoposide in previously untreated extensive stage patients. ...

Anti-Cancer Treatment Promises Hope in Bird Flu Treatment

...on autopsy examinations have also been reported. The researchers had previously developed a chemotherapy treatment in 1994, using the anti-cancer drug etoposide that destroyed the excess white blood cells. Although the 8-week treatment is associated with few side effects such as reduced blood count and nausea,...

Etoposide in Medical Technology

Ascenta Therapeutics Announces Multiple Presentations on AT-101 at 2009 ASCO Annual Meeting

...ell Disorders, May 30, 8:00 a.m.-12:00 p.m. Advanced Cancers Leal TB, et al. A phase I study of AT-101 in combination with cisplatin (P) and etoposide (E) in patients with advanced solid tumors and extensive-stage small cell lung cancer (ES-SCLC). Abstract #e13502; Publication only. Saleh M, et...

St. Jude Finds More Than 100 Gene Variations Linked With Response to Leukemia Treatment

...erleukin." In addition, 21 of the 102 SNPs that predicted MRD also significantly associated with the pharmacokinetics of two antileukemic drugs, etoposide and methotrexate, which are representative of the array of antileukemic medications used to treat lymphoblastic leukemia. Pharmacokinetics comprises t...

Cytopia Commences Second Phase II Study in Brain Cancer

...Study of CYT997 in Combination with Carboplatin and etoposide in Relapsed Glioblastoma Multiforme (CCL08001). P... given in combination with standard carboplatin and etoposide therapy (Ph Ib), and estimation of progression-free...

Pharmion Initiates Pivotal Phase 3 Study of Amrubicin in Small Cell Lung Cancer

...single-agent therapy in patients refractory to first-line therapy; and one as single-agent or combination therapy with cisplatin versus cisplatin plus etoposide in previously untreated extensive stage patients. "The Phase 2 studies in small cell lung cancer, in both sensitive and refractory patients, have thu...

Pharmion's Amrubicin Shows Encouraging Results Compared to Standard of Care in Second Line Treatment of Small Cell Lung Cancer

...single-agent therapy in patients refractory to first-line therapy; and one as single-agent or combination therapy with cisplatin versus cisplatin plus etoposide in previously untreated extensive stage patients. Data Published on ASCO Website A randomized phase 2 trial of Amrubicin vs. topotecan as second-l...

Etoposide in Biological Technology

Recommendations for Successful siRNA Library Screens

... Assays. HeLa cells were transfected with siRNA to nine different targets. One day post-transfection, cells were treated with etoposide to induce apoptosis. Three days post-transfection, cells were lysed and monitored for caspase 3 activity. Results for each well ...

Perform RNAi Library Screens on Any Budget

...nases, that when silenced, affected cell proliferation (orange bars). (B) In a separate experiment, cells were exposed to 25 M etoposide (Sigma) 24 hr post transfection. At 72 hr post transfection, levels of cellular apoptosis were monitored by assaying for caspase 3 ...

Are siRNA Pools Smart?

...gure 3), or apoptosis was induced using etoposide one day after transfection, and caspase 3 activity...day post-transfection, the cells were treated with etoposide to activate the apoptosis pathway. Thre...asured following siRNA transfection and etoposide treatment. Assaying for cell number was necessary ...