3 studies confirm the value of etanercept therapy in treating juvenile idiopathic arthritis
Copenhagen, Denmark, Friday 12 June 2009: Three new studies have individually shown the anti-TNF (tumour necrosis factor) therapy etanercept
to be effective, with a good safety profile, in children under four years of age with juvenile idiopathic arthritis (JIA), and associated with improved Healt...
New Immune Approach for Treatment of Alzheimer's Disease
...hin minutes (1-6).
Localized administration of etanercept
for treatment of neurological disorders is a novel...(8, 9), which include both perispinal and epidural etanercept
for treatment of sciatica (see INR sciatica websi...er's is exciting. Recent reports of the ability of etanercept
to penetrate rapidly into the cerebrospinal fluid ...
New Hope for Relief of Chronic Sciatica
...olds promise as a treatment for sciatica. Epidural etanercept
for sciatica was invented by a California physicia...olds promise as a treatment for sciatica. Epidural etanercept
for sciatica was invented by a California physicia...-controlled data supporting the novel concept that etanercept
could be used locally for a neurology indication. ...
New clues to healing arthritis caused by traumatic injury
...NF-α at all over time.
"Current treatments on the market for rheumatoid arthritist include anakinra (Kineret, an IL-1 receptor antagonist) and etanercept
(Enbrel, a tumor necrosis factor blocker)," said Farshid Guilak, Ph.D., study scientist and director of the Orthopaedic Bioengineering Laboratory in t...
Rheumatoid Arthritis Drugs Raise Shingles Risk
...n Rheumatism Research Centre in Berlin looked at 5,040 people taking the TNF blockers infliximab (Remicade) or adalimumab (Humira), the fusion protein etanercept
(Enbrel) or the monotherapeutic drug anakinra (Kineret).
Although generally considered a TNF blocker, Enbrel was not put in that category for the...
Current and Emerging Therapies Have No Advantage Over Enbrel in Reducing the Signs and Symptoms of Rheumatoid Arthritis
...to Tap Significant Market Opportunity finds that an oral disease-modifying drug with a novel mechanism of action that is priced 20 percent lower than etanercept
plus methotrexate would earn a 25 percent patient share in the United States and a 20 percent patient share in Europe, according to surveyed U.S. and ...
Etanercept, Methotrexate Safe for Juvenile RA
MONDAY, Oct. 27 (HealthDay News) -- The drugs etanercept
and methotrexate are safe and effective for long-t... the children took methotrexate alone, others took etanercept
alone, and another group took both drugs. etanercept
was given as either a 0.4 mg/kg injection twice we...
World Alzheimer's Day 2008 Special Report: New Alzheimer Targets Take Center Stage
...in the brain(Rember®).
Among these agents etanercept
is unique, because it was designed to correct an a...n Los Angeles], which has developed the perispinal etanercept
anti-TNF strategy for dementia.
References: Do...in verbal fluency and aphasia following perispinal etanercept
in Alzheimer's disease. BMC Neurol, 2008. 8(1): p....
New Drug May Help Combat Alzheimer's
...ses on the effects of perispinal administration of etanercept
in dementia. etanercept
is an immune molecule which inactivates excess lev...umor necrosis factor (TNF). This use of perispinal etanercept
for dementia and Alzheimer's is beyond the FDA lab...
Adalimumab therapy effective in AS, RA and PsA patients refractory to other anti-TNF therapies
...o anti-tumour necrosis factor (anti-TNF) therapies etanercept
and infliximab, according to results of research p...Disease Activity Index) of -2.4 following previous etanercept
and/or infliximab treatment, and a reduction of -2...) of -1.9 following previous treatment with either etanercept
Lead researcher, Dr G R Burmeste...
Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome
...ti-TNF-a therapy (etanercept), PR-957 mediated a more rapid resolution of clinical symptoms, including joint inflammation, and was more effective than etanercept
in a model of aggressive arthritis.
These data were published in the June 14, 2009 online edition of Nature Medicine and will be published i...
New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients
... that patients previously treated with adalimumab, etanercept
or infliximab responded to and tolerated SIMPONI r...ha agent previously used in treatment (adalimumab, etanercept
or infliximab), the findings were consistent and s...ab, 41 percent of patients previously treated with etanercept
and 41 percent of patients previously treated with...
Mayo Clinic Seeks New Therapies for Alcoholic Hepatitis
...from Mayo Clinic finds the use of the drug therapy etanercept
ineffective in treating alcoholic hepatitis, an ac...pound which blocks the effects of toxic cytokines. etanercept
is approved for treatment of inflammatory arthriti... liver regeneration, and another is the effects of etanercept
on immune function," says Dr. Shah.
CHMP Recommends Approval of New Indication for Enbrel(R) as Treatment for Severe Psoriasis in Paediatric Patients
concomitant therapy for the long-term management of Psoriasis patients
Arch Dermatol Res (2006)
5. Paller, AS et al. etanercept
treatment for children and adolescents
with plaque psoriasis. N Engl J Med 2008;358:241-51
Musculoskeletal center wins $2.2 million for drug safety
...ers. Among the studied drugs is what's called anti-TNF agents, or anti-tumor necrosis factor alpha agents. This category includes adalimumab (Humira), etanercept
(Enbrel) and infliximab (Remicade). Five additional biologics will be studied.
The analysis will include patients who live in rural areas, and thos...
New guidelines for treating rheumatoid arthritis
...ation, and biologics work to interrupt the chain of events that leads to inflammation.
Newer biologics called anti-TNF agents adalimumab (Humira), etanercept
(Enbrel) and infliximab (Remicade) prevent the production of an immunity protein that plays a role in inflammation.
Some of the key recommendation...
A new jump start for aging blood vessels
Csiszar and collegues treated aged rats with etanercept
to test the hypothesis that anti-TNFa treatment exerts vasculoprotective effects in aging. etanercept
(Enbrel) is an FDA-approved drug that binds and in...pressure.
Second, blocking TNFa via chronic etanercept
treatment decreased cell death in aged vessels, de...