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Estradiol in Medical News

Hormonal Therapies Offer Effective Solutions for Many Adult Women With Acne

...en approved by the U.S. Food and Drug Administration (FDA) for the treatment of acne. All combination oral contraceptives contain an estrogen (ethinyl estradiol for most contraceptive pills) and a progestin. The estrogen component decreases the production of testosterone and other androgens by the ovaries and ...

New Data: Efficacy and Responder Analyses of Divigel(R) (estradiol gel) 0.1 percent for the Treatment of Menopause

...ted various menopausal symptoms. Divigel(R) doses studied included 1.0 mg, 0.5 mg and 0.25 mg of estradiol/day - the lowest effective approved dose of estradiol available for the treatment of MSVMS. The analysis showed a significantly greater percentage of women in all treatment groups versus placebo experienc...

Novel biomarkers in heart failure

... to be useful in prognostic evaluation of these patients estrogens it has been recently shown that both low and high concentrations of circulating estradiol are powerful predictors of a poor prognosis in men with chronic HF; subjects with either reduced or increased concentrations of serum E2 have differen...

Neurocrine Announces Full Year Results from 603 Study (Petal Study) of Elagolix for Treatment of Endometriosis Pain

...is improvement was sustained post-treatment. estradiol and Ovulation: The previously reported pharmacodynamic effect of elagolix was confirmed. Median estradiol values were maintained in the low baseline range w...significant bone loss. As reported, Week 24 median estradiol was 47 pg/ml for elagolix once daily and 29 pg/ml ...

Estrogen May Help Men's Hearts

... reduced left-ventricular ejection fraction, high and low concentrations of estradiol [estrogen] compared with the middle quintile of estradiol are related to an increased mortality," the researchers wrote. However...

New Study Shows Women Experience Significantly Less Unscheduled Bleeding With the ORTHO TRI-CYCLEN(R) LO Birth Control Pill Versus Another Pill

...re professionals and patients with products such as ORTHO TRI-CYCLEN (R) LO (norgestimate/ethinyl estradiol), ORTHO EVRA (R) (norelgestromin/ethinyl estradiol transdermal system) and ELMIRON (R) (pentosan polysulfate sodium). For more information on these products, birth control, bladder health or general ...

Birth Control Pills Linked to Lupus Risk

...icine at the University of California, Los Angeles, thinks the new study can be helpful in prescribing oral contraceptives. "The higher the dose of estradiol in women who have been started on oral contraceptives in the past three months, the higher the risk for developing" lupus, Hahn said. "That's the high...

Oral contraceptives associated with increased risk of lupus

...s is associated with an increased risk of incident SLE (albeit of lower magnitude) and that current use of contraceptives with higher doses of ethinyl estradiol is associated with an increased risk of incident SLE, suggest a possible dose-response effect of estrogen on SLE onset, which could be an alternative ...

Men's Sex Lives May Suffer as Waistlines Expand

...xual quality of life were correlated with increased BMI," Hammoud said. "Subjects who lost weight through bariatric surgery experienced a reduction in estradiol [hormone] levels, an increase in testosterone levels and an increase in ratings of sexual quality of life." The study will appear in the Journal o...

Obesity linked to hormone imbalance that impacts sexual quality of life

... quality of life were correlated with increased BMI," said Dr. Hammoud. "Subjects who lost weight through bariatric surgery experienced a reduction in estradiol levels, an increase in testosterone levels and an increase in ratings of sexual quality of life." Dr. Hammoud points out that results from this stu...
Estradiol in Medical Technology

Divigel(R) (estradiol gel) 0.1 Percent Offers Lowest Approved Dose of Estradiol for Treatment of Moderate to Severe Hot Flashes Associated with Menopause

-Estrogen Continues to be Gold Standard for Management of Hot Flashes- MAPLE GROVE, Minn., May 5 /PRNewswire/ -- Medical specialists from around the country will gather this week to discuss the latest research in obstetrics and gynecology, and menopause and estrogen therapy will be among the ...

Estrogen Getting Cool Reception From Dermatologists for Mixed Results in Improving Appearance of Skin

...ausal women? A randomized, double-blind, double-dummy, placebo-controlled multicenter study assessing the effects of norethindrone acetate and ethinyl estradiol in the improvement of mild to moderate age-related skin changes in postmenopausal women. Journal of the American Academy of Dermatology 2008...

Neurocrine Biosciences Presents Elagolix Data

...urs per day with a return to baseline each morning for 42 days. The effect on gonadotropins translated in a dose related fashion to maintenance of low estradiol levels over the six week period without inducing severe hot flashes or excessive bone resorption as determined by n-telopeptide. Consistent pharmacoki...

New Study Suggests Rx Estrogen Delivery Through the Skin May Show Safety Benefits as Opposed to Oral Delivery

... form of gels, sprays and patches. Some include: estradiol gel 0.1% available in three doses 0.25, 0.5, and 1.0 mg estradiol; estradiol patches available in .025mg, .0375mg, .05mg, .075mg; and .1mg a transdermal estradiol mist spray. For more information about menopause m...

Neurocrine Announces Top-Line Results From 702 Study (Lilac PETAL Study) of Elagolix for Treatment of Endometriosis Pain

...che and nausea, which were typically mild and transient. Consistent with previous clinical studies, elagolix showed a dose dependent decrease in mean estradiol levels and minimal impact on bone mineral density and related serum n-telopeptide levels during the initial three months of treatment. Conferen...

Reproductive Partners Participates in New IVF Progesterone Delivery System Study

..., including those undergoing ICSI, Blastocyst and PGD, who are age 18-42 who have had less than three prior IVF cycles and an FSH less than 15IU/L and estradiol less than 80 pg/mL. Other exclusion criteria exist. For more information, please visit www.reproductivepartners.com or call Reproductive Part...

New Analyses Indicate that Divigel(R) (estradiol gel) 0.1% Is a Valuable Option for Certain Postmenopausal Women With Hot Flashes

...ing in Orlando, Florida. Divigel(R) is a transdermal estrogen therapy that was approved by the FDA in June 2007. It offers the lowest approved dose of estradiol gel for the treatment of moderate to severe hot flashes associated with menopause. "These analyses indicate that Divigel(R) (estradiol gel) 0.1% is ...

Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis

...golix has the potential to be an ideal advanced medical therapy for endometriosis-associated pelvic pain and dysmenorrhea. Intermediate suppression of estradiol by a well-tolerated drug appears attainable affording endometriosis symptom reduction without bone loss." Neurocrine Biosciences would like to thank...

Sosei Announces Completion of Phase III Trial for NorLevo(R)

...nisation (WHO) demonstrated that levonorgestrel mono therapy, such as NorLevo(R), was well-tolerated and more effective than the Yuzpe method (ethinyl estradiol and levonorgestrel), a traditional emergency contraception method used since 1977. Levonorgestrel mono therapy for emergency contraception is listed a...

ORTHO EVRA(R) Prescribing Information Updated

...ormation for ORTHO EVRA(R) (norelgestromin/ethinyl estradiol transdermal system) to include further epidemiolog...d lower peak concentrations (25% lower) of ethinyl estradiol (EE) compared with an oral contraceptive containin... estradiol), ORTHO EVRA(R) (norelgestromin/ethinyl estradiol transdermal system), and ELMIRON(R)(pentosan polys...
Estradiol in Medical Products

Double Antibody Estradiol RIA

Description: Double Antibody Estradiol is an 125I radioimmunoassay designed for in vitro diagnostic use in the quantitative measurement of estradiol in serum, for the investigation of precocious puberty in girls and gynecomastia in men, and for the differential diagnosis of amenorrhea. It is also ...
Company:Siemens Medical Solutions Diagnostics

BioCheck Estradiol (E2) Enzyme Immunoassay

Description: For the quantitative determination of Estradiol (E2) concentration in human serum or plasma....
Company:BioCheck, Inc.

Coat-a-Count Estradiol RIA

Description: Coat-A-Count Estradiol is a no-extraction, solid-phase 125I radioimmunoassay designed for in vitro diagnostic use in the quantitative measurement of estradiol in serum, for the differential diagnosis of amenorrhea and for monitoring of ovulation induction with and without stimulation ...
Company:Siemens Medical Solutions Diagnostics

3rd Generation Estradiol EIA

Description: The DSL-10-39100 3rd Generation Estradiol EIA is intended to measure estradiol in serum. Estradiol measurements are used in the diagnosis and treatment of various hormonal sexual disorders and in assessing placental function in complicated pregnancy. This assay is intended for in vitro diagnostic u...
Company:Diagnostic Systems Laboratories, Inc.

3rd Generation Estradiol RIA Test

Description: Estradiol (E2) is the most potent, naturally secreted estrogen and is the major estrogen produced by the ovary [1]. In the ovary, estradiol is produced from testosterone [1,2], and from estrone, a less potent estrogen derived from androstenedione. Estrone and estradiol are interconverted in many bo...
Company:Diagnostic Systems Laboratories, Inc.

SHBG IRMA Test

Description:...elatively high specificity and low capacity, including testosterone and dihydrotestosterone (combined 95% bound to SHBG) and, to a much lesser extent, estradiol [1]. SHBG specifically binds C18 and C19 steroid structures and regulates the bioavailability of sex steroids. SHBG is produced primarily in the liver...
Company:Diagnostic Systems Laboratories, Inc.

Unconjugated Estriol, Ultra-Sensitive EIA Test

Description:... (E3) is one of the 3 major naturally occurring estrogens (the others being estradiol and estrone). In terms of estrogenic activity, estriol is much less potent than estradiol [1]. Estriol is produced almost exclusively during pregnancy, and is the ma...
Company:Diagnostic Systems Laboratories, Inc.

Unconjugated Estriol, Ultra-Sensitive RIA Test

Description:... (E3) is one of the 3 major naturally occurring estrogens (the others being estradiol and estrone). In terms of estrogenic activity, estriol is much less potent than estradiol [1]. Estriol is produced almost exclusively during pregnancy, and is the ma...
Company:Diagnostic Systems Laboratories, Inc.

Estrone RIA Test

Description:...curring estrogens. Other natural estrogens include estradiol and estriol. Estrone is produced primarily from an...of androstenedione. Interconversion of estrone and estradiol also occurs in peripheral tissues. During pregnanc..., estrone levels do not decline as dramatically as estradiol levels, possibly due to increased conversion of an...
Company:Diagnostic Systems Laboratories, Inc.

Estrone Sulfate EIA

Description:... Direct assays, no sample extraction, hydrolysis or other pretreatment required. Highly specific antiserum, minimal cross-reactivity with estrone, estradiol and other estrogen metabolites....
Company:Diagnostic Systems Laboratories, Inc.

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Estradiol in Medical Dictionary

Estradiol

Estradiol is a sex hormone. Mislabelled the "female" hormone, it is also present in males; it represents the major estrogen in humans. Estradiol has not only a critical impact on reproductive and sexual functioning, but also... Deciphers the medication estradiol (Estrace, Clim...

Sertoli

... estradiol - aromatase from Sertoli cells convert testosterone to 17 beta ... The tight junctions of Sertoli cells form the blood-testis barrier, a s...

FSH

...ormally regulates the growth and development of an egg. ... INCIID (pronounced inside) is a nonprofit organization that helps individuals ... The estradiol level for the FSH -only cycles was significantly higher, 720 pg/mL ... FSH is given by specific protocols individualized for all patients. ......
Estradiol in Biological News

Plastics chemical retards growth, function of adult reproductive cells

... follicle growth was impaired after 48 hours of exposure to BPA, Peretz said. Reductions in three key steroid hormones progesterone, testosterone and estradiol were also seen after 120 hours of exposure to BPA. The drop in steroid hormone production was quite dramatic. After 120 hours in a medium that in...

Stress puts double whammy on reproductive system, fertility

...own of the release of the gonadotropins luteinizing hormone and follicle-stimulating hormone by the pituitary, and then a suppression of testosterone, estradiol and sexual behavior. In 2000, however, a new reproductive hormone was discovered in birds and dubbed gonadotropin-inhibitory hormone (GnIH) because...

HWI scientist first in world to unravel structure of key breast cancer target enzyme

...b as part of this project were estrone sulfatase (2003) and 17beta-hydroxysteroid dehydrogenase type 1 (1996). All three enzymes control the levels of estradiol in different tissues. "This is a dream come true," Dr. Debashis Ghosh, an HWI senior research scientist and a principal investigator who also holds...

Clue to genetic cause of fatal birth defect

... UIC researchers had previously discovered this novel enzyme and were focused on its role in converting the weak hormone estrogen into the more potent estradiol in the ovaries and its possible role in breast cancer. Recent research has shown that the HSD17b7 enzyme has an additional role in the last steps ...

Sex hormones link to heart risk

...arently healthy men. "Our studies showed that one of the sex hormones - estradiol - was associated positively with total cholesterol and negatively with HDL-...-cholesterol. "Thus, men with the highest concentrations of estrone and estradiol may have the highest level of cardiovascular risk as their levels of detrim...

Chronic exposure to estrogen impairs some cognitive functions

...nitive functions. Rats exposed to a steady dose of estradiol were impaired on tasks involving working memory an...rs made the discovery when studying the effects of estradiol on activities mediated by the prefrontal cortex, a...ever twice in a row got no reward. Rats exposed to estradiol performed worse than their counterparts on this ta...

Quest for better treatment for effects of menopause

...e by a group of women from Bizkaia to two treatments: on the one hand, to raloxifene and, on the other, to a substitutive hormonal treatment combining estradiol (a type of oestrogen) and progesterone (another female sex hormone). The conclusions of Doctor Ruiz del Aguas thesis point to raloxifene, while in...

High levels of estrogen associated with breast cancer recurrence

...s blood for concentrations of the steroid hormones estradiol (the primary human estrogen) and testosterone. They analyzed different forms of estradiol and testosterone in the blood, such as how much wa...to enter a cell. Researchers found that higher estradiol concentrations, in all forms, significantly predic...

Study shows lizard moms dress their children for success

...blotched lizards give an extra dose of the hormone estradiol to their eggs in certain social circumstances. The...nt hormones. That revealed a striking influence of estradiol on back patterns. She also tested eggs from lizard...wild and found a wide range of naturally occurring estradiol concentrations in the egg yolks. The researc...

Ultra low-dose estrogen shown safe for post-menopausal women

...ease in bone density, without adverse health effects, in the women who took estradiol compared to the women who took placebo. The current study was a pre-planned...ast, the women studied by Yaffe and her associates received a daily dose of estradiol ?pure human estrogen ?that was over 44 times smaller and delivered through ...
Estradiol in Biological Technology

Elagolix Successful in Six Month Lilac Petal Study; Safety and Efficacy Confirmed in Patients With Endometriosis

...his study based upon predictions generated from extensive modeling of dose, estradiol and bone mineral density relationships. Prior to this study we anticipated... Adverse Events. After six months of treatment, the median values for serum estradiol were 41 pg/ml (150 mg) and 21 pg/ml (250 mg) in keeping with the dose-respo...

Schering-Plough Announces Phase II and III Data for Corifollitropin Alfa

...f this trial was ovarian response. The observed number of follicles, serum estradiol levels and number of oocytes indicated a relatively high ovarian response. ...(+/-5.5) and 18.3 (+/-6.4), respectively on the day of hCG and median serum estradiol levels of 10,019 and 10,221 pmol/L, respectively.(6) The mean (SD) ...

Bionovo Announces Publication of Positive Phase 2 Trial Results for Menerba(TM)

...fferences in incidents of vaginal bleeding between the placebo group and the two treatment groups of Menerba. Likewise, there was no increase in blood estradiol levels. This finding further supports that Menerba will not lead to an increased risk for breast or uterine cancers. This Phase 2 trial of Mene...

Azur Pharma Ltd. Enters Into Definitive Agreement With BioSante Pharmaceuticals Inc [nasdaq: BPAX], to Acquire U.S. Rights to Elestrin (TM)

...(TM). Elestrin is a fast drying gel formulation of estradiol which is indicated for the treatment of moderate t...topical application on the upper arm, and delivers estradiol to the bloodstream evenly over time in a non-irrit...2.5 micrograms of estradiol, one of the two lowest estradiol doses approved by the FDA for the treatment of hot...

FDA Approves Duramed's LoSEASONIQUE(R) Oral Contraceptive

...y Duramed Pharmaceuticals, Inc.'s New Drug Application (NDA) for LoSEASONIQUE(R) (levonorgestrel/ethinyl estradiol tablets 0.10 mg/0.02 mg and ethinyl estradiol tablets 0.01 mg) extended-cycle oral contraceptive. LoSEASONIQUE(R) is the first lower-dose, extended-cycle oral contraceptive indicated for the preve...

Barr Announces Approval of Generic Yasmin(R)

...e Federal Circuit. Yasmin is a 28-day oral contraceptive consisting of 21 active tablets each containing 3 mg of drospirenone and 0.03 mg of ethinyl estradiol and 7 inert tablets. Yasmin is indicated for the prevention of pregnancy in women who elect to use an oral contraceptive. The product had annual sales...

Ortho Evra Patch Makers Settling Cases

... /PRNewswire/ -- Ortho Evra is an adhesive, transdermal birth control patch. It is intended to release 150 mcg of norelgestromin and 20 mcg of ethinyl estradiol into the bloodstream per 24 hours. It is replaced once a week for three weeks, and no patch is worn during the fourth week. Ortho Evra was approved by...

Watson Files FDA Application for Generic LYBREL(R)

... an Abbreviated New Drug Application (ANDA) with the U.S. Food and Drug Administration (FDA) seeking approval to market its Levonorgestrel and Ethinyl estradiol tablets, USP (0.09 mg/0.02 mg) extended-cycle oral contraceptive product prior to the expiration of patents owned by Wyeth. Watson's Levonorgestrel an...

Duramed's Lo SEASONIQUE(R) NDA Accepted for Filing by FDA

...(NDA) for Lo SEASONIQUE(R) (levonorgestrel/ethinyl estradiol tablets 0.10 mg/0.02 mg and ethinyl estradiol tablets 0.01 mg) extended-cycle oral contraceptive...blets of 0.10 mg levonorgestrel/0.02 mg of ethinyl estradiol for 84 consecutive days, followed by seven days of...

Cell Therapeutics, Inc. (CTI) Projects Zevalin(R) Sales of $15 Million With Cash Flow Breakeven for Commercial Operations in 2008

...lts from this study are expected in the second half of 2009. The clinical trial of XYOTAX in combination with carboplatin in women with pre-menopausal estradiol levels who have first-line non-small cell lung cancer, known as the PGT307 trial, will be limited to U.S. sites only, until either approval of the MAA...
Estradiol in Biological Definition

Hormone

...rone dehydroepiandrosterone (DHEA) dehydroepiandrosterone sulfate (DHEAS) androstenedione dihydrotestosterone (DHT) Estrogens estradiol Progestagens progesterone Progestins Sterol hormones Vitamin D derivatives calcitriol Lipid and p...
Estradiol in Biological Dictionary

Estrogen

...s, and the use of estrogens and ... Brief and Straightforward Guide: What is Estrogen ? ... What Is Natural Estrogen ? What Are the Most Common estradiol Side Effects? ... Estrogen receptor refers to a group of receptors that are activated by the ... Two types of estrogen receptor exist: ER w...
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