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Escalation in Medical News

Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer

...rall survival and progression-free survival will be performed. Dose escalation and Compliance Overall compliance with study medication was excellent wi...ated dose, as defined in study protocol, was never established despite dose escalation reaching a dose that was four times (40g/day) the previously evaluated Phas...

BioMarin Announces Second Quarter 2009 Financial Results

...rin initiated the Phase I/II trial in mid-April 2009 and completed enrollment in mid-July. The Phase I/II study is an open-label, within-patient dose escalation trial followed by a treatment continuation phase. The company expects to report initial results in the first half of 2010. Assuming positive results...

Fastrack Automates Workflow For Homecare Providers

... new patients and orders, orders not being processed in a timely fashion and more. Reduces paper handling. Task Manager - Due date management with escalation plus prioritized task lists for each user with automatic reminders. Fastrack Healthcare Systems, Inc. is the leading provider of integrated homeca...

Patient Enrollment Complete for Phase I/II Clinical Trial for GALNS for Morquio A Syndrome

... The Phase I/II study is designed as an open-label, within-patient dose escalation trial in 20 patients followed by a treatment continuation period. During the dose escalation phase of the study, subjects will receive weekly intravenous infusions of B...

Peregrine Pharmaceuticals Completes Planned Patient Enrollment in Bavituximab Phase I Cancer Trial

...ollow-up continue in this study and in our three ongoing Phase II bavituximab cancer trials." The objectives of this multi-center open label dose escalation study are to determine the safety and tolerability of bavituximab in patients with advanced cancer, to characterize the pharmacokinetic profile of bav...

U.S. Women's Chamber of Commerce Advocates Strong Healthcare Reforms in Support of American Values

...ystemic business and financial collapse fueled by unwarranted and oversized growth of executive compensation, shadow banking, credit card fee and rate escalation and other spurious financial manipulation that has nearly ground America's economy to a halt." The report details troubling statistics regarding ...

PAREXEL Enhances Study Start-Up and Recruitment Capabilities With Appointment of Dr. Lars-Olof Eriksson, Formerly With Merck

...patient populations, and use of proprietary recruitment tools, data assets, and processes as well as implementation of sophisticated contingency-based escalation strategies." Dr. Eriksson has more than 30 years of experience in patient recruitment, site implementation, project management, and global dru...

Neudesic Works With Microsoft to Provide HIPAA 4010/5010 Support for BizTalk Server

...ms can be reviewed in a queue; sluggish claims can be expedited; missing data can be located; and other flaws can be corrected. User collaboration and escalation is simple, and based on highly customizable business rules. Trading partner integration for payers and providers is also possible, including all HIPAA...

FDA Approves Lamictal(R)XR(TM); An Extended-Release Once-Daily, New Generation Treatment for Epilepsy

...our to six seizures per week prior to being randomized to either Lamictal XR or placebo. The treatment period of the study consisted of a seven-week escalation Phase and a 12-week Maintenance Phase. Study results showed that the new once-daily, extended-release formulation of Lamictal XR reduced part...

Seattle Radiologists Raise Workflow Performance and Results with Corepoint Integration Engine

...flows." In implementing Corepoint Integration Engine, Seattle Radiologists is able to monitor their IT environment with powerful alerting and escalation features that provide real-time notifications for addressing critical application interface issues. "Our previous point-to-point setup lacked...
Escalation in Medical Technology

CIMZIA(R) (Certolizumab Pegol) Provides Long-Term Benefit Without Dose Escalation in Crohn's Disease Patients

Several abstracts highlighting CIMZIA's long-term benefits and value in moderate to severe Crohn's disease patients presented at American College of Gastroenterology (ACG) ORLANDO, Fla. Oct. 7 /PRNewswire-FirstCall/ -- Data from two studies presented this week by UCB at the American College ...

Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Dose Escalation Trial with Tovaxin for Multiple Sclerosis

THE WOODLANDS, Texas--(BUSINESS WIRE)--Apr 3, 2007 - Opexa Therapeutics, Inc. (NASDAQ: OPXA), a company involved in the development and commercialization of cell therapies, today announced positive top-line data in an open-label Phase I/II dose escalation clinical trial of the investigational T-cel...

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

...LTO, Calif., Aug. 3 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK ) today announced that the positive results from a Phase 1 multicenter, dose escalation study of ezatiostat hydrochloride (TELINTRA, TLK199) tablets in patients with Myelodysplastic Syndrome (MDS) have been published in a leading peer rev...

Cytokine PharmaSciences Initiates Phase I Study of Oral Anti-Inflammatory Agent, CPSI-2364

...dy of CPSI-2364, its orally active, small-molecule inhibitor of the production of TNF-alpha and other pro-inflammatory cytokines. Results of the dose escalation and safety study in healthy volunteers are expected before the end of the year. "Based on extensive work with the predecessor compound, we be...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

...han 40% are eligible for this study. The study has been designed as a dose escalation study to determine the maximum tolerated dose (MTD) of perifosine alone in recurrent/progressive pediatric tumors. A standard 3+3 dose escalation design will be employed with 3 to 6 patients at each dose level. All patie...

Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

...has not yet been established and dose-escalation continues. These data were presented today in a poster titled "PX-171-006: Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low-dose dexamethasone in relapsed and refractory multiple myeloma: Preliminary results" (Abstract #8541)....

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

...sentation, data were available for 26 patients enrolled in the Phase 1 dose escalation trial, all of whom had received an average of 6.5 prior treatments, includi...arch 2008. The open-label clinical trial has two components: a Phase 1 dose escalation study designed to evaluate the safety, tolerability and pharmacokinetics of...

Celladon Corporation Announces Presentation of First-in-Human Gene Transfer to Treat Heart Failure at the 12th Annual Meeting of the American Society of Gene Therapy

...ution of safe and efficient gene transfer technology, have placed heart failure within reach of gene-based therapy. A Phase 1/2 clinical trial of dose escalation of MYDICAR administered directly to heart cells with minimally invasive cardiac catheterization is currently underway. This clinical study represents ...

BioVex to Report Phase I/II Clinical Trial Results for the Front Line Treatment of Head and Neck Cancer With OncoVEX GM-CSF at the 2009 American Society of Clinical Oncology Meeting

...l take place May 29, 2009 - June 2, 2009 in Orlando, FL. The results are to be presented in an abstract (number 6018) entitled, "Phase I/II dose escalation study of OncoVEX GM-CSF and chemoradiotherapy (CRT) in untreated stage III/IV squamous cell cancer of the head and neck (SCCHN)," at a poster session ...

Circassia Begins Phase II Clinical Trial With Ragweed Allergy Therapy

...onfirmed ragweed allergies, and will compare a range of ToleroMune doses with placebo. Unlike most current immunotherapies, which require careful dose escalation over many months and several years of maintenance doses, patients will receive just four standardized doses of ToleroMune treatment over a number of w...
Escalation in Medical Products

Aegis Checkpoint Temperature Reporting and Alarm System

Features:... Alert suppression by time and day Alert email can be sent to multiple recipients by equipment name Automatic data back up Alert escalation Scheduled preventive maintenance and task reminder alerts Automatic alert if an equipment is not turned off after a specified number of hours, regar...
Company:Aegis Scientific, Inc.

Novalis

Features:... sub-millimeter accuracy and to position patients automatically and with a higher degree of precision than previously possible. With Novalis Body dose escalation protocols and SRT treatments for spine, lung, liver and other body lesions can be carried out quickly and efficiently. Novalis proven photon beam tech...
Company:BrainLAB Inc.
Escalation in Biological News

Using 'dominance' to explain dog behavior is old hat

... pinning the dog to the floor, grabbing jowls, or blasting hooters at dogs will make dogs anxious, often about their owner, and potentially lead to an escalation of aggression. Dr Rachel Casey, Senior Lecturer in Companion Animal Behaviour and Welfare at Bristol University, said: "The blanket assumption th...

Joining forces to improve lung cancer treatment

...urvival (UK). Promising results from a study of accelerated hypofractionated three-dimensional conformal radiotherapy (3D-CRT) with dose-per-fraction escalation for treatment of stage III non-small-cell lung cancer (Poland) Confirmation that EGFR mutations (deletion in exon 19, missense L858R) are the most im...

Researchers solve piece of large-scale gene silencing mystery

...picuously large because of a dramatic increase in the transcription of rRNAs, which in turn leads to an increase in the production of ribosomes. This escalation in ribosome activity means that the cell can synthesize proteins at an alarmingly rapid rate, which contributes to the out-of-control cell proliferati...

Milkweed's evolutionary approach to caterpillars: Counter appetite with fast repair

...nd State University biologist, found evolutionary declines in milkweed's three most important resistance traits (hairs, cardenolides and latex) and an escalation in the plant's ability to regrow. Agrawal was surprised, he said, to find that the plant became more tolerant rather than more diverse in its defen...

Pediatricians alerted to the developmental nature of underage drinking in special journal supplement

... and Health Education at Emory University in Atlanta, and his group examined pre- and mid-teen groups during the time when the initial initiation and escalation of alcohol use commonly occurs, in relation to puberty, structural and functional maturation of the brain, and changes in social contexts. Looking ...

Humans have caused profound changes in Caribbean coral reefs

...e significantly affecting all major groups of coral reef organisms. The simultaneous effect of human threats on coral reef organisms and the potential escalation of their effects to the entire ecosystem highlight the critical situation of coral reefs and the need to adopt an ecosystem-based approach for conserv...

HIV-1's high virulence might be an accident of evolution

...rheostat,' allowing high enough levels of T cell activation to ensure sufficient viral replication and transmission, while at the same time preventing escalation of immune activation to levels that may be harmful to the host," the researchers said. The results also raise the possibility that treatments that ...

Spring migration of pink-footed geese under threat

...n used data from ringed geese collected between 1991 and 2003 to model the impact of organised scaring of pink-footed geese. They found that any rapid escalation of bird scaring could be catastrophic for the birds, especially for less experienced individuals. According to Klaassen: "The model predicts that ...
Escalation in Biological Technology

Oncolytics Biotech Inc. Completes Dose Escalation in Combination REOLYSIN(R)/Docetaxel Trial

CALGARY, Aug. 11 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) has completed patient enrolment in the dose escalation portion of its U.K. clinical trial to evaluate the anti-tumour effects of systemic administration of REOLYSIN(R) in combination with do...

Oncolytics Biotech Inc. Completes Dose Escalation in Combination REOLYSIN(R)/Paclitaxel and Carboplatin Trial

CALGARY, April 14 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ:ONCY) has completed patient enrolment in the dose escalation portion of its U.K. clinical trial to evaluate the anti-tumour effects of systemic administration of REOLYSIN(R) in combination with p...

Curis and Debiopharm Sign an Exclusive License Agreement Covering the HSP90 Inhibitor CUDC-305

...to continue to seek to internally develop CUDC-101, our first-in-class HDAC/EGFR/Her2 inhibitor that is currently enrolling patients in a Phase I dose escalation trial, as well as our other promising preclinical multi-targeted development programs. We believe that the up-front license fee and near-term continge...

United States FDA Clears the REGEN Trial to Test Bioheart's Combination Gene and Stem Cell Therapy in Heart Failure Patients

...Cell SDF-1 (Stromal Derived Factor - 1) to treat congestive heart failure. The REGEN trial will enroll 15 patients in a multicenter, randomized, dose escalation study to assess the safety and cardiovascular effects of the implantation of MyoCell SDF-1 in congestive heart failure patients post myocardial infarc...

Proteolix Presents Clinical Data from Two Clinical Studies of Carfilzomib in Multiple Myeloma at the 14th Congress of the European Hematology Association

...hase 1b clinical trial during the Novel Therapeutics and Drug Resistance session in an oral talk, titled "#1070: PX-171-006: Phase IB Multicenter Dose escalation Study of Carfilzomib (CFZ) plus Lenalidomide (LEN) and Low Dose Dexamethasone (LODEX) in Relapsed and Refractory Multiple Myeloma (MM) - Preliminary R...

Mersana Reports Preliminary Phase 1 Results of XMT-1001 in Patients with Advanced Solid Tumors

...g XMT-1001 into a Phase 2 trial in a solid tumor indication." About the XMT-1001 Preliminary Study The Phase 1 trial is an open label, dose escalation study of XMT-1001 administered as an IV infusion once every three weeks in patients with advanced solid tumors. The objectives of the study are to de...

Oncolytics Biotech(R) Inc. Collaborators Present Positive Phase II Sarcoma Trial Results at ASCO Annual Meeting

...4-8 cycles, for a total disease control rate (CR (Complete Response)+PR+SD) of 70%. Dr. Sanjay Goel and colleagues delivered a poster entitled "Dose escalation and Pharmacodynamic Study of Intravenous Administration of REOLYSIN, a Live Replication Competent RNA Virus in Patients with Advanced Solid Tumors." T...

OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial

...ease in blood clearance of OGX-427 as doses were escalated. The combination of 800 mg OGX-427 with docetaxel was also well tolerated and escalation to 1000 mg OGX-427 with docetaxel will be evaluated next. Circulating Tumor Cell and Tumor Marker Results Circulating tumor cells (CTCs), an...

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...lization of disease in previously progressing patients, as well as clearcut inhibition of PI-3 kinase activity, even in the early cohorts in this dose escalation trial," said Dr. Kirkman. "We believe these findings may reflect the fact that PX-866 is an irreversible inhibitor of PI-3 kinase, which distinguishes...

Proteolix to Present Carfilzomib Clinical Data During the 2009 ASCO Annual Meeting

...FZ) in patients with relapsed myeloma: An efficacy update. (Abstract #8537) -- PX-171-006: Phase Ib multicenter dose escalation study of carfilzomib (CFZ) plus lenalidomide (LEN) and low-dose dexamethasone (loDex) in relapsed and refractory multiple myel...
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