Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1/2 Study of MM-111, a Bispecific Antibody to ErbB2/3

...haracterized by overexpression or amplification of erbb2 (also known as HER2). MM-111 is the first bispecif... novel biologic with a unique approach to treating erbb2 amplification in tumors," said Ulrik B. Niels...o address the complex signaling dynamics between erbb2 and ErbB3 and to exquisitely target cancer cells...

Research Finds 'New Crop' of Breast Cancer Genes

...human breast cancers. In fact, AGTR1, which was found in 10 percent to 20 percent of the breast tumors, was found in excess only in tumors that lacked erbb2 and that expressed the estrogen receptor, known as ER-positive. "AGTR1 is very analogous to HER2 or ERBB2," said Chinnaiyan, who is also director o...

Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer

...lone (8.2 months versus 3.0 months respectively, HR=0.71, p=0.019). "The encouraging positive results seen in women who are HR positive and erbb2 positive shows that the lapatinib and letrozole combination has the potential to become a first-line, oral treatment option for clinicians and patient...

Genetic Mutations Linked to Deadly Cancers

...er Cancer Institute and Harvard Medical School, and colleagues found three major gene mutations in glioblastoma, namely NF1 (a tumor suppressor gene), erbb2 (a protein tyrosine kinase gene), and PIK3R1 (a lipid kinase gene) among 206 GBM patients. "These findings will guide glioblastoma therapies," Me...

Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis

...o Ras-induced breast cancer cells, for example, they saw a greater than 75 percent reduction in cell migration. Cells turned cancerous by the oncogene erbb2 showed a 50 percent drop in migration. Cells made cancerous by Myc also had 50 percent less migration. The researchers performed a proteomic analys...

Suppression of Enzyme Delays a Type of Breast Cancer

... by Michel L.Tremblay along with Sophie Julien of McGill cancer Center, Quebec delayed the advancement of a particular kind of breast cancer linked to erbb2 gene. In this case, the breast tumor appeared almost eight weeks later and lung metastases did not happen. In some mice cancer did not develop at all....

Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells

...mpanies that they target specific receptors when manufacturing drugs for chemotherapy. The above research could help them formulate drugs for EGFR and erbb2 and target secondary pathways in oncogenesis. ...

ErbB2 in Medical Technology

Pharmacyclics Reports Multiple Presentations at AACR on Its HDAC and Selective HDAC Inhibitors

...reatment with PCI-24781. "These studies demonstrate that PCI-24781 may have a role in the treatment of cancers associated with overexpression of erbb2 or HER2," said Joseph J. Buggy, Ph.D., vice president of research for Pharmacyclics. "We look forward to results from our ongoing Phase 1 study of thi...

ErbB2 in Biological News

Protein identified as critical to insulating the body's wiring could also become treatment target

...neuregulin 1, stabilizing and interacting with the erbb2 receptor on Schwann cells so they can make myelin,...eakens muscles. Cancer is an issue because the erbb2 receptor also is an oncogene highly expressed in tumors. erbb2 helps cancer cells grow and spread so finding its ...

CSHL scientists identify new drug target against virulent type of breast cancer

...er patients churn out too much of a protein called erbb2 -- also often called HER2 -- which drives the cell...eave plenty of room for improvement: they suppress erbb2 but are effective against less than half of ErbB2-...ts helped the group confirm that the expression of erbb2 and Brk was directly linked. By forcing the pr...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...responses of the cell line panel to lapatinib, a duel inhibitor of EGFR and erbb2 and CI-1040, a MEK enzyme inhibitor. These studies defined molecular signat... Tykerb is an enzyme inhibitor that effectively blocks two cell receptors, erbb2 and EGFR, from receiving molecular signals. By blocking these signals, Tyke...

ErbB2 in Biological Technology

Novocell Announces Discovery Linking Key Cancer Cell Signaling Pathways With Proliferation and Self-Renewal of Human Embryonic Stem Cells

...ine August 29, 2007 in Blood First Edition Paper titled "Self-Renewal of Human Embryonic Stem Cells Requires Insulin-like Growth Factor-1 Receptor and erbb2 Receptor Signaling." Researchers studying the self-renewal of hESCs discovered a link with insulin-like growth factor-1 (IGF-1R), and ERBB2/3. Both p...