Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1/2 Study of MM-111, a Bispecific Antibody to ErbB2/3
...haracterized by overexpression or amplification of erbb2
(also known as HER2). MM-111 is the first bispecif... novel biologic with a unique approach to treating erbb2
amplification in tumors," said Ulrik B. Niels...o address the complex signaling dynamics between erbb2
and ErbB3 and to exquisitely target cancer cells...
Research Finds 'New Crop' of Breast Cancer Genes
...human breast cancers. In fact, AGTR1, which was found in 10 percent to 20 percent of the breast tumors, was found in excess only in tumors that lacked erbb2
and that expressed the estrogen receptor, known as ER-positive.
"AGTR1 is very analogous to HER2 or ERBB2," said Chinnaiyan, who is also director o...
Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer
...lone (8.2 months versus 3.0 months respectively, HR=0.71, p=0.019).
"The encouraging positive results seen in women who are HR positive and erbb2
positive shows that the lapatinib and letrozole combination has the potential to become a first-line, oral treatment option for clinicians and patient...
Genetic Mutations Linked to Deadly Cancers
...er Cancer Institute and Harvard Medical School, and colleagues found three major gene mutations in glioblastoma, namely NF1 (a tumor suppressor gene), erbb2
(a protein tyrosine kinase gene), and PIK3R1 (a lipid kinase gene) among 206 GBM patients.
"These findings will guide glioblastoma therapies," Me...
Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis
...o Ras-induced breast cancer cells, for example, they saw a greater than 75 percent reduction in cell migration. Cells turned cancerous by the oncogene erbb2
showed a 50 percent drop in migration. Cells made cancerous by Myc also had 50 percent less migration.
The researchers performed a proteomic analys...
Suppression of Enzyme Delays a Type of Breast Cancer
... by Michel L.Tremblay along with Sophie Julien of McGill cancer Center, Quebec delayed the advancement of a particular kind of breast cancer linked to erbb2
gene. In this case, the breast tumor appeared almost eight weeks later and lung metastases did not happen. In some mice cancer did not develop at all....
Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
...mpanies that they target specific receptors when manufacturing drugs for chemotherapy. The above research could help them formulate drugs for EGFR and erbb2
and target secondary pathways in oncogenesis.