Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007
Currently, Over 370 Agents are in Active Clinical Development, Addressing Over 190 Targets
LAKE FOREST, Calif., Nov. 27 /PRNewswire/ -- Six ErbB
(EGFr/HEr2)-pathway inhibitors, marketed for the treatment of several major
solid tumor indications, generated global sales...
Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1/2 Study of MM-111, a Bispecific Antibody to ErbB2/3
...ds to ErbB3 (also known as HER3). Both ErbB2 and ErbB3 are members of the erbb
family of receptors, a complex molecular network whose activation is commo...3, Merrimack researchers identified ErbB3 as a highly sensitive node in the erbb
signaling network and also found it played a dominant role in activation of...
Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer
... Brentford, Middlesex
(1) Normanno N, Bianco C, De Luca A, Maiello MR, Salomon, DS. Target-based agents against erbb
receptors and their ligands: a novel approach to cancer treatment. Endocrine-Related Cancer 2003; 10;1-21
(2) Bedard PE, Freedman OC, Howell A et ...
Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success
...geted agents may appear in
several groups) are:
41 agents targeting the vascular endothelial growth factor (VEGF) pathway 18 agents targeting the erbb
family (EGFr, HEr2, etc.) 13 agents targeting the Aurora kinase family 11 histone deacetylase inhibitors (HDAC) 13 agents targeting PDGF/PDGFr 11 ...
New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs
..."This method of reactivating the EGFR signalling pathway with MET may be a common resistance mechanism in other therapies that target receptors of the erbb
family, which are used against breast cancer, colon cancer, head and neck cancer, and the brain tumor glioblastoma multiforme," says J?nne, who is an ...
Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
... co-author of the paper. The researchers tracked the activity of four human erbb
receptors, which have been implicated in a wide variety of cancers. They fo...miscuous' triggering a haywire biochemical reaction. 'These two promiscuous erbb
proteins are known to be overactive in many human cancers, suggesting that ...
ErbB in Medical Technology
ErbB in Biological News
AACR, BCRF award inaugural grants in translational breast cancer research
...lead to individualized therapeutic options for breast cancer treatment in the near future.
Mayers research project, titled Combined Endocrine and erbb
Inhibition in ER+/HER2+ Breast Cancers, will address resistance to endocrine therapies. Through a Phase II study, she seeks to learn if the combinati...
ErbB in Biological Technology
ErbB in Biological Products