Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007

Currently, Over 370 Agents are in Active Clinical Development, Addressing Over 190 Targets LAKE FOREST, Calif., Nov. 27 /PRNewswire/ -- Six ErbB (EGFr/HEr2)-pathway inhibitors, marketed for the treatment of several major solid tumor indications, generated global sales...

Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1/2 Study of MM-111, a Bispecific Antibody to ErbB2/3

...ds to ErbB3 (also known as HER3). Both ErbB2 and ErbB3 are members of the erbb family of receptors, a complex molecular network whose activation is commo...3, Merrimack researchers identified ErbB3 as a highly sensitive node in the erbb signaling network and also found it played a dominant role in activation of...

Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer

... Brentford, Middlesex TW8 9GS References (1) Normanno N, Bianco C, De Luca A, Maiello MR, Salomon, DS. Target-based agents against erbb receptors and their ligands: a novel approach to cancer treatment. Endocrine-Related Cancer 2003; 10;1-21 (2) Bedard PE, Freedman OC, Howell A et ...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...geted agents may appear in several groups) are: 41 agents targeting the vascular endothelial growth factor (VEGF) pathway 18 agents targeting the erbb family (EGFr, HEr2, etc.) 13 agents targeting the Aurora kinase family 11 histone deacetylase inhibitors (HDAC) 13 agents targeting PDGF/PDGFr 11 ...

New Mechanism Identified for Resistance to Targeted Lung Cancer Drugs

..."This method of reactivating the EGFR signalling pathway with MET may be a common resistance mechanism in other therapies that target receptors of the erbb family, which are used against breast cancer, colon cancer, head and neck cancer, and the brain tumor glioblastoma multiforme," says J?nne, who is an ...

Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells

... co-author of the paper. The researchers tracked the activity of four human erbb receptors, which have been implicated in a wide variety of cancers. They fo...miscuous' triggering a haywire biochemical reaction. 'These two promiscuous erbb proteins are known to be overactive in many human cancers, suggesting that ...

ErbB in Medical Technology

RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial

... these patients. RAD001 works through direct antitumor activity and through its influence on two of the most important pathways for breast cancer, the erbb receptor and the HER2 pathways. "We are encouraged by the benefit RAD001 provided to advanced breast cancer patients in these early trials," s...

Oncology Drug Development Update - Molecular Profiling Redefines the Nature of Malignancy and Increases the Adoption of Targeted Therapeutics

...ncer indications. Future Oncology Series Details erbb Pathway-targeted Therapeutics To date, erbb pathway abnormalities, which occur in a large numb...d as contributing to the success or failure of the erbb pathway inhibitors. A series of reports ( http://w...

Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development

...s targeting this pathway are in development. "The erbb Pathway in Cancer" is a series of comprehensive re...-- Treatment costs in the USA and ROW -- Detailed erbb pathway analyses -- Associations of erbb expression and mutations with specific indications...

ErbB in Biological News

AACR, BCRF award inaugural grants in translational breast cancer research

...lead to individualized therapeutic options for breast cancer treatment in the near future. Mayers research project, titled Combined Endocrine and erbb Inhibition in ER+/HER2+ Breast Cancers, will address resistance to endocrine therapies. Through a Phase II study, she seeks to learn if the combinati...

ErbB in Biological Technology

Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121, an ErbB3 Antagonist

...gned to block signaling of the ErbB3 receptor. ErbB3 is a receptor in the erbb family, a pathway that plays a critical role in cancer signaling. With the ...tibody designed to block signaling of the ErbB3 receptor, a receptor in the erbb family, a pathway that plays a critical role in cancer signaling. Upon init...

ErbB in Biological Products

Sheep Anti-Human ErbB 2 Polyclonal Antibody, Unconjugated from Abcam

Description: Sheep polyclonal to ErbB 2 ( Abpromise for all tested applications). Antigen: Recombinant full length c-ErbB2 protein (Human). Entrez GeneID: 2064 Swiss Protein ID: P04626...
Company:Abcam

Rabbit Anti-Herstatin Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to erbb 2 ( Abpromise for all tested applications). entrezGeneID: 2064 SwissProtID: P04626...
Company:Abcam

Rabbit Anti-ErbB2, phospho (Tyr1248) Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to erbb 2 (phospho Y1248) ( Abpromise for all tested applications). entrezGeneID: 2064 SwissProtID: P04626...
Company:Abcam

Rabbit Anti-ErbB 2 BSA and Azide Free Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to erbb 2 - BSA and Azide free ( Abpromise for all tested applications). Antigen: Synthetic peptide: AENPEYLGLDVPV conjugated to KLH, corresponding to C ...
Company:Abcam