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Epoxide in Medical News

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

... candidate, AR9281, an orally-administered soluble epoxide hydrolase (sEH) inhibitor that is in a Phase II cl...cribed as follows. -- "AR9281, a Soluble epoxide Hydrolase Inhibitor - Efficacy in a DIO Mou... 2 diabetes. -- "A Novel Inhibitor of Soluble epoxide Hydrolase, AR9281, Improves Glucose Homeost...

Arete Therapeutics Initiates Phase IIa Clinical Trial for AR9281, a Novel s-EH Inhibitor to Treat Type 2 Diabetes

...b. 10 /PRNewswire/ -- Arete Therapeutics Inc. today announced the initiation of a Phase IIa clinical trial for AR9281, an orally- administered soluble epoxide hydrolase (s-EH) inhibitor being developed for the treatment of type 2 diabetes. S-EH is an enzyme involved in the metabolism of arachidonic acid, a k...

Faulty DNA repair could be a risk factor for lung cancer in nonsmokers

...r smoked. They used the cells to conduct a host-cell reactivation assay, a complicated test that introduced a specific carcinogen, benzo[a]pyrene diol epoxide (BPDE) into the cells. BPDE is a hydrocarbon found in smoke of all kinds (tobacco, wood, etc.) that is highly carcinogenic and mutagenic, capable of c...

Arete Therapeutics Appoints Donald Santel to Board of Directors

... Arete Therapeutics Inc. is a privately held pharmaceutical Company discovering and developing first-in-class small molecule drugs directed at soluble epoxide hydrolase (s-EH), a novel target for cardiovascular, metabolic and inflammatory diseases. By targeting s-EH which plays a key role in the arachidonic ...

Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent

...irst-in-class," orally-active inhibitor of soluble epoxide hydrolase (s-EH), a novel target for the treatment...281 is a novel small molecule inhibitor of soluble epoxide hydrolase (s-EH), an enzyme which plays a key role...-in-class small molecule drugs directed at soluble epoxide hydrolase (s-EH), a novel target for cardiovascula...

Traffic Fumes Plus Genes Boosts Kids' Asthma Risk

...ave also been linked to the development of asthma and other respiratory diseases. In this new study, researchers analyzed the children's microsomal epoxide hydrolase (EPHX1) levels and genetic variations in gluathione S-transferase P1 (GSTP1) -- enzymes that help rid the body of toxins, including polyarom...

Genetic predisposition increases childhood asthma risk

...etween number of genetic variants and exposure to toxins among more than 3,000 study participants. Researchers found that high levels of microsomal epoxide hydrolase (EPHX1)an enzyme that metabolizes polyaromatic hydrocarbons (PAH) in vehicle emissionswas associated with an increased risk for lifetime ast...

Anti Cancer Drug from Blue Green Algae

...r the drug's anti-cancer activity—becomes attached to the molecule. The epoxide group can be attached in two configurations, designated as alpha and beta. ... characterization of an enzyme, cytochrome P450, that always introduces the epoxide in the desired beta configuration. Sherman, who is also the John G. Sea...

Insect Protein Effective for Treating Heart Enlargement, Arrythmias

...and entomology professor Bruce Hammock, identifies epoxide hydrolase inhibitors as novel and powerful chemica...ssure-induced cardiac hypertrophy to study soluble epoxide hydrolase inhibitors isolated in the laboratory of... the years Hammock’s lab has isolated thousands of epoxide hydrolase inhibitors, compounds that have cardiopr...

Pest Control research Leads to Pain Control Discovery

...on by Co administration of Nonsteroidal Anti-Inflammatory Drugs and Soluble epoxide Hydrolase Inhibitors,' published in the current edition of Proceedings of t...eatment with NSAIDs and enzyme inhibitors (a previously undescribed soluble epoxide hydrolase inhibitor or sEHIs) in lipopolysaccharide (LPS)-challenged mice. ...
Epoxide in Medical Products

Carbamazepine Epoxide & Total

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Heptachlor Epoxide

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Epoxide in Biological News

UC Davis grant zeroes in on novel asthma diagnosis and treatment

...tific basis to do human clinical trials on soluble epoxide hydrolase (sEH) inhibitors in asthma, which has re...hma management." The UC Davis grant, "Soluble epoxide Hydrolase Is a Novel Therapeutic Target in Asthm... at is very new. We are excited to see if soluble epoxide hydrolase inhibitors, with or without these other ...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

...s to treat diabetes, hypertension and inflammatory has entered Phase II of human clinical trials to evaluate its efficacy. The compound, a soluble epoxide hydrolase enzyme (s-EH) inhibitor, is "a first-in-class drug which may treat a suite of major cardiovascular and metabolic diseases," said entomologis...

UC Davis research shows that newly discovered drug reduces heart enlargement

...y disease," Hammock said. "When that occurs, a key enzyme called soluble epoxide hydrolase is increased." The initial research on the enzyme sprang from...heart size associated with extreme exercise does not increase levels of the epoxide hydrolase, and exercise induced heart enlargement fortunately is not blocke...

Genetic testing not cost-effective in guiding initial dosing of common blood thinner

...ide the initial, and possibly lower, dose of warfarin for patients found to possess certain variants of the genes cytochrome P450 CYP2C9 and vitamin K epoxide reductase, or VKORC1. The hope is that more accurate dosing will translate into decreased major bleeds during the initiation phase of warfarin dosing,...

Measuring the stress of forested areas

...btain antioxidants (from plants). Besides studying the VAZ cycle, Mr Txema Becerril's team has contributed to the discovery of a new cycle (the lutein epoxide cycle), present in many forest species such as beech, laurel, holm oak or oak and the team is currently studying what exactly is its protective functi...

Turning green gunk to gold, anti-cancer gold

...e drug's anti-cancer activity---becomes attached to the molecule. The epoxide group can be attached in two configurations, designated as alpha and beta. ... characterization of an enzyme, cytochrome P450, that always introduces the epoxide in the desired beta configuration. Sherman, who is also the John G. Se...

Pest control research leads to pain control discovery

...ion by Coadministration of Nonsteroidal Anti-Inflammatory Drugs and Soluble epoxide Hydrolase Inhibitors," published in the current edition of Proceedings of t...eatment with NSAIDs and enzyme inhibitors (a previously undescribed soluble epoxide hydrolase inhibitor or sEHIs) in lipopolysaccharide (LPS)-challenged mice. ...

Genetic variation alters response to common anti-clotting drug

...ant to predict dose, you need to know more about the genes that control variability," explained Rieder. The team focused on another gene: vitamin K epoxide reductase (VKORC1), which makes a protein that helps control clotting and is the key target of warfarin. The researchers analyzed the VKORC1 gene's DN...
Epoxide in Biological Technology

Arete Therapeutics Closes $16.7 Million in Final Tranche of Its Series A Financing

...and development of novel drugs to treat metabolic, inflammatory and cardiovascular disease. It is the world's leading company focused on s-EH (soluble epoxide hydrolase), an important enzyme for the metabolism of arachidonic acid that plays an essential role in metabolic, inflammatory and cardiovascular phys...

Arete Therapeutics Bolsters Management Team

...and development of novel drugs to treat metabolic, inflammatory and cardiovascular disease. It is the world's leading company focused on s-EH (soluble epoxide hydrolase), an important enzyme for the metabolism of arachidonic acid, that plays an essential role in metabolic, inflammatory and cardiovascular phy...

Arete Therapeutics Names James Sabry, M.D., Ph.D., President and Chief Executive Officer

...herapeutics is uniquely positioned to develop its pipeline of novel soluble epoxide hydrolase inhibitors for multiple disease indications and I look forward to...ring and developing first-in-class small molecule drugs directed at soluble epoxide hydrolase (s-EH), a unique enzyme which plays a key role in the arachidonic...
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